Binding of Isaac: Rebirth Wiki
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Added in Afterbirth

Items in this pool can spawn in the Curse Room Curse Room in Greed mode. This does not apply to Red Chest Red Chests.

Activated Collectibles[]

Name ID Icon Weight Description
Guppy's Head 5.100.145
Guppy's Head
1 rooms
1
Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw 5.100.133
Guppy's Paw
Unlimited
1
Upon use, converts one Red Heart Container into three Soul Heart Soul Hearts.
Added in Repentance Magic Skin 5.100.642
Magic Skin
6 rooms
1
Consumes one heart container or two soul hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items.
Added in Repentance Razor Blade 5.100.126
Razor Blade
Unlimited
1
On use, takes one heart of health and grants +1.2 damage for the current room.
Added in Repentance Sacrificial Altar 5.100.536
Sacrificial Altar
One time use
1
Sacrifices up to 2 familiars and spawns an item from the Devil Room pool for each familiar sacrificed. Converts all friendly spiders and flies into coins.
Added in Repentance Plan C 5.100.475
Plan C
One time use
0.2
Kills all enemies in the room, then kills Isaac three seconds later.

Passive Collectibles[]

Name ID Icon Weight Description
Cube of Meat 5.100.73 Cube of Meat
1
Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage.
Dead Cat 5.100.81 Dead Cat
1
Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Guppy's Collar 5.100.212 Guppy's Collar
1
Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Tail 5.100.134 Guppy's Tail
1
Room Clear Awards have a 1/3 chance of being replaced with a Chest and a 1/3 chance being replaced with nothing.
Added in Repentance Athame 5.100.408 Athame
1
When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies.
Added in Repentance Black Candle 5.100.260 Black Candle
1
Prevents curses. Grants one Black Heart. Increases the chance for a Devil or Angel Room to appear.
Added in Repentance Blood Oath 5.100.569 Blood Oath
1
Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.
Added in Repentance Blood Puppy 5.100.565 Blood Puppy
1
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Attacking it returns it to normal.
Added in Repentance Ceremonial Robes 5.100.216 Ceremonial Robes
1
Grants 3 Black Heart Black Hearts, and +1 damage.
Added in Repentance Curse of the Tower 5.100.371 Curse of the Tower
1
Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower XVI - The Tower.
Added in Repentance Dark Prince's Crown 5.100.442 Dark Prince's Crown
1
When at exactly one Red Heart, increases tears, range, tear height, and shot speed.
Added in Repentance Euthanasia 5.100.496 Euthanasia
1
Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Added in Repentance Gimpy 5.100.225 Gimpy
1
Gives chance of spawning a Soul Heart Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart Half Red Heart after being killed.
Added in Repentance Little Horn 5.100.503 Little Horn
1
Removed in Repentance Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Added in Repentance Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Added in Repentance The Mark 5.100.79 The Mark
1
Removed in Repentance Grants one Soul Heart Soul Heart, +1 damage, and +0.2 speed.
Added in Repentance Grants one Black Heart Black Heart, +1 damage, and +0.2 speed.
Added in Repentance The Pact 5.100.80 The Pact
1
Removed in Repentance Grants two Soul Heart Soul Hearts, +0.5 damage, and +0.7 tears.
Added in Repentance Grants two Black Heart Black Hearts, +0.5 damage, and +0.7 tears.
Added in Repentance Pentagram 5.100.51 Pentagram
1
+1 damage, increases Devil Room / Angel Room chance by 10%.
Added in Repentance Sanguine Bond 5.100.692 Sanguine Bond
1
Spawns a special set of spikes in the Devil Room Devil Room. Taking damage from the spikes has a chance to grant a reward.
Added in Repentance Shade 5.100.468 Shade
1
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
Added in Repentance Tarot Cloth 5.100.451 Tarot Cloth
1
Drops a random card or rune. Removed in Repentance Doubles the effects of most cards and runes. Added in Repentance Doubles the effects of tarot cards.
Added in Repentance Vengeful Spirit 5.100.702 Vengeful Spirit
1
After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
Added in Repentance False PHD 5.100.654 False PHD
0.5
Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart Black Heart.
Added in Repentance Heartbreak 5.100.694 Heartbreak
0.5
Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.


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