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Creep is a liquid created by the attacks of certain monsters and bosses, or may be spawned by Isaac. Creep appears on the ground as a glowing or "shiny" puddle or line. There are a few different kinds of Creep which can affect enemies or Isaac. Having the ability to fly or the Trinket Callus icon.png Callus trinket nullifies the effects of Creep.

Creep that will affect Isaac is shown flickering rapidly. When all enemies inside a room are defeated, the creep they produced will quickly disappear.

Red Creep

Red Creep is the most common type of Creep in the game. It can be created by various different enemies, champions, or Isaac himself. When spawned by enemies, it damages Isaac but not other enemies in the room. When spawned by Isaac, it damages walking enemies but not Isaac himself. It deals half a heart of damage to the player. Red Creep is representative of blood.

Green Creep

Green Creep is spawned by various enemies, Ultra Pride, Pestilence, green champion monsters, and Dlc a indicator.png Dangle and Brownie (when they are poisoned). When spawned by enemies, it is functionally equivalent to Red Creep, however some forms spawned by Isaac deal damage at a faster rate. It can be spawned by Isaac with Dlc a indicator.png Trinket Bob's Bladder icon.png Bob's Bladder, Dlc a indicator.png Collectible Toxic Shock icon.png Toxic Shock, Collectible Mysterious Liquid icon.png Mysterious Liquid, or Dlc a† indicator.png Collectible 7 Seals icon.png 7 Seals' Pestilence familiar. (Notably, the Dlc a indicator.png Bob transformation actually generates red creep that is just colored green.) Green Creep is representative of acid, bile, or poison.

Yellow Creep

Yellow Creep is spawned only by Peep, Collectible Lemon Mishap icon.png Lemon Mishap, Lemon Party pills, and Dlc r indicator.png Collectible Free Lemonade icon.png Free Lemonade. When spawned by Peep, it deals half a heart of damage to the player. When spawned by Isaac, it continuously damages walking enemies and seems to do more damage than any other type of creep that Isaac can create. Yellow Creep is representative of urine.

Black Creep

Black Creep is spawned by various enemies, Gish, the Dlc a† indicator.png Something's Wrong... pill, Collectible Ball of Tar icon.png Ball of Tar, and Dlc a† indicator.png Collectible 7 Seals icon.png 7 Seals' Famine familiar. It slows the movement speed of affected enemies or the player. When spawned by enemies, it affects Isaac but not other enemies. When spawned by Isaac, it affects enemies but not Isaac, bypassing the status resistances of Bosses. Black Creep is likely representative of tar or oil, though in the case of the Dlc a† indicator.png Something's Wrong... pill, it may be fecal matter with blood in it.

White Creep

White Creep is functionally similar to Black Creep. White Creep is spawned by several bosses, including Widow, The Wretched, Triachnid, and Dlc a indicator.png The Frail, as well as Small Baby Long Legs. Isaac can spawn white creep with Collectible Juicy Sack icon.png Juicy Sack, Dlc a† indicator.png Collectible Large Zit icon.png Large Zit, and Dlc a† indicator.png Collectible Parasitoid icon.png Parasitoid. White Creep could be representative of a liquid form of Cobweb.

Blue Creep

Blue Creep is spawned by Dlc a† indicator.png Collectible Depression icon.png Depression, or Collectible Holy Water icon.png Holy Water. Collectible Aquarius icon.png Aquarius also causes Isaac to leave a trail of blue creep wherever he walks. Blue creep created by Isaac damages enemies that walk over it. It is likely representative of water or tears.

Dlc r indicator.png Blue creep spawned by Collectible Holy Water icon.png Holy Water petrifies enemies.

Dlc r indicator.png Blue creep spawned by Collectible Aquarius icon.png Aquarius synergizes with tear effects.

Dark Blue Creep

Dark Blue Creep is spawned by Dlc a indicator.png Hush during his beam attack. Blue creep spawned by Hush makes Isaac slide, and does not affect other enemies.

Grey Creep

Grey Creep is spawned only by The Cage. It damages Isaac like Red Creep but does not affect other enemies. It may be representative of some type of rotten fluid.

Orange Creep

Orange Creep is spawned only by Mama Gurdy. It slows down Isaac like Black Creep, but does not affect other enemies. Unlike other types of Creep, Orange Creep does not flicker rapidly, even though it only affects Isaac. Due to its nature, it may be representative of vomit, pus, or some other bodily liquid.

Dlc a indicator.png Brown Creep

Brown Creep is spawned by Character Tainted ??? icon.png Tainted ??? and Dlc r indicator.png Collectible IBS icon.png IBS's mechanic, or by bosses such as Brownie, Dangle, Turdlings, Dlc a† indicator.png X-Lax pill, and Dlc a† indicator.png Sisters Vis. Hostile Brown Creep and the Creep spawn by X-Lax will make Isaac slide, affecting his ability to stop moving or change directions while moving. This kind of Brown Creep does not flicker rapidly even though it only affects Isaac. Friendly Brown Creep spawned by Character Tainted ??? icon.png Tainted ??? or Dlc r indicator.png Collectible IBS icon.png IBS would give damage and tears boost if Isaac is standing on it, and will synergize with other kinds of poop spawned by those mechanic. It is representative of liquid poop, likely to be diarrhea.

Dlc r indicator.png Static Creep

Static Creep is spawned exclusively by Dogma's first phase. It appears underneath the boss as they move. It functions the same as Red Creep, harming Isaac for half a heart. Rather than being representative of a certain type of liquid, it represents visual static, most commonly seen on televisions with no signal.

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