Contagion is a passive item added in The Binding of Isaac: Afterbirth †.
Effects[]
- In each room, the first enemy killed will release a gas explosion and poison nearby enemies.
- Poisoned enemies will also release gas upon death, spreading the effect.
- Poisoned enemies do not need to die while the poison is still active to spread the effect.
- The effect will also activate if a shopkeeper is destroyed before killing any enemies.
- Re-entering a room and destroying another shopkeeper inside it will trigger the effect for a second time.
- Poisoned enemies will also release gas upon death, spreading the effect.
Notes[]
- The initial gas explosion deals 5 damage, and the poison deals Isaac's tear damage per tick, for 6 ticks.
- The gas explosion and poison can damage friendly enemies.
Interactions[]
Dr. Fetus: Bomb damage does not apply to poison damage.- Epic Fetus: Missile damage does not apply to poison damage.
- Ipecac: Ipecac only applies a 2x multiplier as opposed to +40 to poison damage.
- Poison tears: No effect. Gas explosions will only be triggered by poison caused by Contagion
- Second Hand: Poison duration is not affected.
In-game Footage[]
Trivia[]
- Its sprite is a recolor of Toxic Shock.
- This item may be a reference to the movies Contagion and Outbreak, or the game Plague Inc..
 The Binding of Isaac: Rebirth
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