Binding of Isaac: Rebirth Wiki
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(in Afterbirth † and Repentance)

Contagion is a passive item added in The Binding of Isaac: Afterbirth †.

Effects[ | ]

  • In each room, the first enemy killed will release a gas explosion and poison nearby enemies.
    • Poisoned enemies will also release gas upon death, spreading the effect.
      • Poisoned enemies do not need to die while the poison is still active to spread the effect.
    • The initial gas explosion deals 5 damage, and the poison deals Isaac's tear damage per tick, for 6 ticks.

Notes[ | ]

  • The effect will also activate if a ShopkeeperShopkeeper is destroyed before killing any enemies.
    • Re-entering a room and destroying another ShopkeeperShopkeeper inside it will trigger the effect for a second time.
  • The gas explosion and poison can damage friendly enemies.

Synergies[ | ]

  • (in Repentance)Gigante BeanGigante Bean: Greatly increases the size of the gas explosions, making the poison spread much more effective.

Interactions[ | ]

  • (in Repentance) Ace Cards: Enemies that are turned into pickups can't create a gas explosion.
  • Collectible Dr. Fetus iconDr. Fetus/Collectible Epic Fetus iconEpic Fetus: Explosion damage does not apply to poison damage.
  • Collectible E. Coli iconE. Coli/Collectible Flush! iconFlush!: Enemies that are turned into poop can't create a gas explosion.
  • (in Repentance) Freeze Effects: Enemies that are frozen are still "alive" and can create a gas explosion when they are the first ice statue broken before any other enemy in the room dies.
  • Collectible Ipecac iconIpecac: Ipecac only applies a 2x multiplier as opposed to +40 to poison damage.
  • Poison tears: No effect. Gas explosions will only be triggered by poison caused by Contagion.
  • Second HandSecond Hand: Poison duration is not affected.

In-game Footage[ | ]

Trivia[ | ]


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