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Item icon
Item altar
Table dividing line 1.png
Item ID
Character Appearance
Character appearance
Table dividing line 2.png
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Collection Grid
Removed in Repentance(page 4, column 1, row 6)
Added in Repentance(page 4, column 2, row 6)
Added in Afterbirth †

Contagion is a passive item added in The Binding of Isaac: Afterbirth †.

Effects[edit | edit source]

  • In each room, the first enemy killed will release a gas explosion and poison nearby enemies.
    • Poisoned enemies will also release gas upon death, spreading the effect.
      • Poisoned enemies do not need to die while the poison is still active to spread the effect.
    • The effect will also activate if a shopkeeper is destroyed before killing any enemies.
      • Re-entering a room and destroying another shopkeeper inside it will trigger the effect for the second time.

Notes[edit | edit source]

  • The initial gas explosion deals 5 damage, and the poison deals Isaac's tear damage per tick, for 6 ticks.
  • The gas explosion and poison can damage friendly enemies.

Interactions[edit | edit source]

  • 15►Dr. Fetus Dr. Fetus: Bomb damage does not apply to poison damage.
  • 15►Epic Fetus Epic Fetus: Missile damage does not apply to poison damage.
  • 15►Ipecac Ipecac: Ipecac only applies a 2x multiplier as opposed to +40 to poison damage.
  • Poison tears: No effect. Gas explosions will only be triggered by poison caused by Contagion
  • Second Hand Second Hand: Poison duration is not affected.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

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