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After picking up three distinct items from the following list, Isaac grows two tumor faces from his cheeks, which fire simultaneously and diagonally similar to the effect of Added in Afterbirth15►The Wiz The Wiz. Decreases Isaac's damage by 0.3 and slightly decreases Isaac's tears.

Name ID Icon Quote Description Added in Repentance Quality
Brother Bobby 5.100.8 Brother Bobby Friends 'till the end A familiar that follows Isaac around shooting normal tears. 0
Harlequin Baby 5.100.167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. 1
Headless Baby 5.100.269 Headless Baby Bloody friend Spawns a familiar that follows Isaac, leaving blood creep on the ground. 1
Little Steven 5.100.100 Little Steven Psychic friend Spawns a familiar who follows Isaac around and fires homing tears. 1
Mongo Baby 5.100.322 Mongo Baby Mongo friend Spawns a familiar that copies the tears of Isaac's other familiars. 2
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
Sister Maggy 5.100.67 Sister Maggy Friends 'till the end Spawns a familiar that follows Isaac around shooting normal tears. 0
Added in Repentance Boiled Baby 5.100.607 Boiled Baby Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
Added in Repentance Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Added in Repentance Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Added in Repentance Lil Abaddon 5.100.679 Lil Abaddon Abyssal friend Spawns a familiar that charges a miniature Added in Afterbirth15►Maw of the Void Maw of the Void attack while Isaac shoots. 3
Added in Repentance Quints 5.100.661 Quints They lurk inside Killing enemies spawns a stationary shooting familiar where they died for the current room. 1
Added in Repentance Twisted Pair 5.100.698 Twisted Pair Double trouble! Gives Isaac two familiars that stand by Isaac's side and fire tears that use Isaac's tears, range, shot speed, and tear effects and scale with Isaac's damage. 4

Added in RepentanceRepentance only:

Name ID Icon Quote Description Added in Repentance Quality
Abel 5.100.188 Abel Mirrored buddy Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction. 0
Demon Baby 5.100.113 Demon Baby Auto-turret friend Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. 2
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering 15►The Necronomicon The Necronomicon effect. 3
Ghost Baby 5.100.163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears. 1
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. 2
Lil Brimstone 5.100.275 Lil Brimstone Evil friend Grants a familiar that charges a thin 15►Brimstone Brimstone laser while Isaac is shooting. 3
Rainbow Baby 5.100.174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects. 1
Robo-Baby 5.100.95 Robo-Baby Friends 'till the bbbbzzzt Spawns a familiar that shoots 15►Technology Technology lasers. 1
Robo-Baby 2.0 5.100.267 Robo-Baby 2.0 We worked out all the kinks Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 0
Added in Afterbirth Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which Charms, Poisons, or knocks back nearby enemies. 1
Added in Afterbirth Fate's Reward 5.100.361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. 2
Added in Afterbirth Incubus 5.100.360 Incubus Dark friend Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. 4
Added in Afterbirth Multidimensional Baby 5.100.431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. 1
Added in Afterbirth Seraphim 5.100.390 Seraphim Sworn friend Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. 3
Added in Afterbirth Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room it drops an Eternal Heart. 3
Added in Afterbirth † Acid Baby 5.100.491 Acid Baby Pills pills pills! Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. 2
Added in Afterbirth † Buddy in a Box 5.100.518 Buddy in a Box What could it be?! Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. 2
Added in Afterbirth † King Baby 5.100.472 King Baby Hail to the king baby Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. 0

Notes[edit | edit source]

  • Isaac starts with this transformation in The Family Man challenge, but due to the challenge's blindfolded property, it's useless without Added in Afterbirth15►Incubus Incubus.
  • Added in RepentanceLilith's Added in Afterbirth15►Incubus Incubus doesn't count towards the transformation.
  • Added in RepentanceFamiliars acquired through Added in Afterbirth15►Cambion Conception Cambion Conception do not count towards the transformation.
  • Familiars acquired through 15►Monster Manual Monster Manual do not count towards the transformation.

Gallery[edit | edit source]

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