Due to the homing lasers setup given, this challenge is considered the easiest of all the challenges. The only problem you will encounter will be rocks and obstacles getting in the way of your lasers, but this is something most runs have to deal with anyway.
- Getting an item that can break obstacles like Thunder Thighs or Leo will make the challenge trivial.
- Be aware of Isaac's position so lasers can be shot in the right direction to either get a direct hit or have it curve to hit enemies.
- Spectral tears, such as from Dead Dove (found in Angel Rooms), Spirit of the Night or Ouija Board (both found in Devil Rooms), are also very helpful.
|1. Pitch Black||2. High Brow||3. Head Trauma||4. Darkness Falls||5. The Tank|
|6. Solar System||7. Suicide King||8. Cat Got Your Tongue||9. Demo Man||10. Cursed!|
|11. Glass Cannon||12. When Life Gives You Lemons||13. Beans!||14. It's in the Cards||15. Slow Roll|
|16. Computer Savvy||17. Waka Waka||18. The Host||19. The Family Man||20. Purist|
|21. XXXXXXXXL||22. SPEED!||23. Blue Bomber||24. PAY TO PLAY||25. Have a Heart|
|26. I RULE!||27. BRAINS!||28. PRIDE DAY!||29. Onan's Streak||30. The Guardian|
|31. Backasswards||32. Aprils Fool||33. Pokey Mans||34. Ultra Hard||35. Pong|
|36. Scat Man||37. Bloody Mary||38. Baptism by Fire||39. Isaac's Awakening||40. Seeing Double|
|41. Pica Run||42. Hot Potato||43. Cantripped!||44. Red Redemption||45. DELETE THIS|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|