Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

Colostomia is a boss introduced in The Binding of Isaac: Repentance and can appear in Dross Dross.


Phase 1[]

Colostomia alternates between the following attacks:

  • Hops in place and then slides toward Isaac in the closest cardinal direction, firing projectiles in both perpendicular directions as she moves and leaving trails of explosive gas.
    • The slide can be at a slight angle if Isaac isn't perfectly aligned with it.
    • Colostomia continuously performs this attack until ~40% of the room is covered in explosive gas.
  • Launches a 15►Butt Bombs Butt Bombs Bomb towards Isaac that ignites any gas clouds its explosion hits, causing a chain of explosions.
    • This is always her first attack upon spawning.
    • Unlike Isaac's Butt Bombs, these do not fog the room.

Phase 2[]

After dropping to half health, the bag containing Colostomia explodes, creating explosive clouds and leaving her adhering to the floor.

  • Jumps to another nearby location, firing 8 projectiles in a radial burst and creating a puddle of harmful Brown Creep where she lands.
    • Only 2 puddles of Brown Creep can persist at once.
  • Spits two 15►Butt Bombs Butt Bombs Bombs at Isaac. The range of these bombs is dependent on how close Isaac is to her.
  • Farts, creating a ring of explosive gas around her location.



  • Colostomia is based on a Colostomy bag, a removable, disposable bag that attaches to the exterior opening of a colostomy to permit sanitary collection and disposal of bodily wastes.
  • Colostomia's 1st phase charge attack is similar to an attack from The Witness in Antibirth.
  • Colostomia is confirmed female according to messages from Not Your Sagittarius in the official Binding of Isaac Discord.[1]
  • Upon death, Colostomia diffuses into the water of the arena, turning it from green to a murky brown.


Bosses Boss Monstro.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png
Lil BlubWormwoodThe RainmakerMin-MinClogColostomiaTurdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png
FistulaChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png
Reap CreepTuff TwinsHornfelGreat GideonSingeThe ShellThe Pile
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Sisters Vis
Reap CreepThe Pile
Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png
The SirenThe HereticThe VisageThe Horny BoysMomMom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Stage Corpse icon.png
ChimeraThe ScourgeRotgutMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
Chapter 6
Stage Dark Room icon.pngStage Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Stage Home icon.png
DogmaThe BeastUltra DeathUltra FamineUltra PestilenceUltra War
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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