The Chest can be accessed with three methods: Touching the chest dropped by Isaac while having The Polaroid (always dropped by Mom after beating Isaac five times) equipped, or, while in the Cathedral, by using Telepills or another item that acts like Telepills, and being sent to the I AM ERROR room, or finding a black market on the Cathedral and going into the beam of light.
Like the Cathedral before it, The Chest consists of only one floor. In The Chest, it is not possible to bomb doors open to skip rooms. The Chest's rooms are mainly filled with bosses and mini-bosses. The boss of the floor is always ???.
The first room in The Chest will automatically contain 4 golden chests. These special chests always contain treasure room items. Rarely, these chests can also be Mega Chests. Additionally, all brown and golden chests spawned in The Chest will always contain Treasure Room Items. This means that a lot of different items can be found in The Chest when clearing rooms with items or effects that raise the chance of spawning chests. This can be useful when trying to complete the collection page. Destroying Slot Machines, Fortune Telling Machines, and all types of Beggars with the exception of a Shell Game Beggar will also spawn items.
After completing The Chest or the Dark Room for the first time, the first room of The Chest will always contain a large golden door, which can be unlocked with either the Key Pieces (combination of Key Piece 1 and Key Piece 2), Dad's Key, Get out of Jail Free Card, or Mr. ME!, allowing access to Mega Satan.
||259.0||Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.|
||227.0||Wanders around the room and throws a bone at Isaac when he is in sight.|
||212.0||Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.|
||57.0||Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Splits into 2 Brains upon death.|
||217.0||Slowly dashes in random directions, dealing contact damage.|
||223.0||Slowly moves around the room, occasionally hopping to spawn Dips or fire 8 Brown shots in all directions. Splits 2 Squirts upon death.|
||208.1||Slowly walks towards Isaac. Occasionally farts and shoots 6 blood shots in all directions. Has a chance to turn into a Blubber or Half Sack upon death.|
||18.0||Red fly that follows Isaac and deals contact damage.|
||10.0||Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes and pursue Isaac faster. Usually turns into a Pacer or a Gusher upon death.|
||252.0||Walks towards Isaac, dealing contact damage. Upon getting near Isaac, it will open its eyes and pursue Isaac faster. Fades into and out of visibility.|
||237.0||Charges towards Isaac when he lines up with them, leaving a trail of Red Creep and shooting 6 blood shots.|
||283.0||Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.|
||26.1||Floats quickly towards Isaac and releases 4 blood shots in the cardinal directions upon death.|
||213.0||Falls from the ceiling. If it lands on Isaac, it deals damage and teleports him back to the spawn room of the floor. Entering a room containing Mom's Hand will warn Isaac with Mom's laugh.|
||226.1||Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself. Spawns a Bony or two Attack Flies upon death.|
||85.0||Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage.|
||224.0||When Isaac lines up with it horizontally, it charges across the room once. When Isaac is not horizontal to it, it spawns Brains.|
||219.0||Disappears, then appears near Isaac and spits a cluster of spectral tears at him.|
||260.0||Floats toward Isaac and occasionally fires a blood shot at him, predicting his movements.|
||44.1||Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.|
||404.1||Floats towards Isaac, doing contact damage.|
|Blue Conjoined Fatty
||257.1||Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.|
||284.0||Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.|
|Rag Man's Ragling
||246.1||Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.|
||305.0||Hops towards Isaac, occasionally spitting out a cluster of disorganized shots.|
||38.3||Dashes towards Isaac at high speed and fires three blood shots in his direction once stopped.|
||15.3||Quickly and randomly wanders around the room, firing four flame shots in the cardinal directions at a slight angle.|
||22.2||Wanders around the room, avoiding Isaac and spawning Small Angelic Babies if he gets close. Spawns 1-2 Embryos upon death.|
||881.0||Pops out of the ground and lunges towards Isaac, dealing contact damage.|
- If Isaac gets Key Piece 1 and Key Piece 2, the key will open the golden gate to fight Mega Satan, but if Isaac uses Forget Me Now, the floor will reset and Isaac won't get both Key Pieces back, making it so that the golden gate won't open again.
- It is possible to create trapdoors thanks to reward plate (found for example in a secret room). Upon entering them, the floor is restarted. If the large golden door was opened before restarting, it will be closed afterward.
- This may result in a softlock on a Daily Run to Mega Satan, if no other way of opening the door is found.
- The I AM ERROR room cannot be reached by any method in The Chest and the Dark Room.
- If a Red Chest is placed in the starting room, it will contain a Devil Deal, similar to the Dark Room.
- Dead Boy - Complete Chapter 6 without taking damage.
- The Chest and its boss, ???, are based on the in-game backstory of Isaac locking himself in his toy chest and asphyxiating to death.
- The sprite appearance of ??? is a reference to Edmund McMillen's Dead Baby games, which are often referenced throughout The Binding Of Isaac.
- The texture of the floor may have a small chance of showing two small glowing dots that look like eyes.
- Like in the Dark Room, bombing the doors to open them doesn't work on this floor.
- The shadow cast on the floor most likely resembles Isaac's head while opening the chest.
- In The Void, during Delirium's death animation, its boss room switches between different environments, and it always ends with a Chest layout.
- The music for the Chest is titled Sketches of Pain.
|Isaac (Boss) Unlocks|
|Chapter 1||Chapter 2||Chapter 3||Chapter 4||Optional||Chapter 5||Chapter 6||Endgame|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|