Binding of Isaac: Rebirth Wiki
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Chemical Peel is a passive item.

Effects[ | ]

  • +2 flat damage to tears fired from Isaac's left eye.

Notes[ | ]

  • The damage bonus is unaffected by both positive and negative damage multipliers.
  • Character Cain iconCain has a 50% chance of firing a shot with the effects of Chemical Peel whenever he fires.
  • Collectible Blood Clot iconBlood Clot applies to the same eye and the effects stack.
    • Generally every interaction and synergy that applies to Chemical Peel also applies to Blood Clot. See its page for any differences to what is listed here.

Synergies[ | ]

  • Collectible 20 20 icon20/20/Collectible The Inner Eye iconThe Inner Eye/Collectible Mutant Spider iconMutant Spider: Every other set of tears has the Chemical Peel effect.
  • Collectible Brimstone iconBrimstone: The entire laser has a high chance to have the Chemical Peel effect, with no visual difference.
  • Collectible Dr. Fetus iconDr. Fetus: The damage bonus applies to every bomb, with no visual difference.
  • Collectible Epic Fetus iconEpic Fetus: The missiles have a high chance to deal 40 points extra damage, with no visual difference.
  • (in Afterbirth † and Repentance)Collectible Lead Pencil iconLead Pencil: All tears in the tear barrage will gain the Chemical Peel effect.
  • Collectible The Ludovico Technique iconThe Ludovico Technique: The tear flashes between normal and the higher-damaging Chemical Peel tear.
  • Collectible Mom's Knife iconMom's Knife: Each tick of the Knife's damage has a high chance to gain the bonus, with no visual difference.
  • Collectible Soy Milk iconSoy Milk: Chemical Peel is unaffected by Soy Milk's damage down modifier, greatly increasing DPS.
  • Collectible Tech.5 iconTech.5: Chemical Peel has a chance to apply to the laser, with no visual difference.
  • Collectible Technology iconTechnology: Lasers have a high chance to gain extra damage, with no visual difference.
  • Collectible Technology 2 iconTechnology 2: Every tear fired has Chemical Peel applied to it, but the laser is unaffected.

Interactions[ | ]

  • (except in Rebirth)Collectible Incubus iconIncubus: Has a 50% chance of firing a shot with the Chemical Peel effect.
  • Collectible Sad Bombs iconSad Bombs: The last type of tear fired is used for the burst.
  • (in Repentance)Collectible Stapler iconStapler: Gives a 50% chance of firing a Chemical Peel shot, similar to Cain.
  • (except in Rebirth)Collectible Tech X iconTech X: Overrides Chemical Peel.
  • (in Afterbirth † and Repentance)Collectible Varicose Veins iconVaricose Veins: The last type of tear fired is used for the burst.

In-game Footage[ | ]

Trivia[ | ]

  • Isaac's face looks similar to a DopleDople when this item is obtained.
  • Chemical Peel may be a reference to the DC Comics character Two-Face, who had the left side of his face burned by a chemical product in a way similar to the item costume effect


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