Chapter 4 (Bosses)

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The Womb The Womb[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Lokii.png
Blastocyst The Bloat Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Scolex.png
Boss Teratoma.png
Mama Gurdy Mr. Fred Scolex Teratoma
Boss Death.png
Boss Triachnid.png
Boss Conquest.png
Boss The Headless Horseman.png
Death Needs to be unlocked Triachnid Needs to be unlocked Removed in Repentance Conquest Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss The Fallen.png
Boss The Matriarch.png
Boss Sisters Vis.png
The Fallen Requires previous entry into a devil room The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Cage.png
Boss The Fallen.png
Boss The Gate.png
(Double Trouble)
Dingle
(Double Trouble)
The Cage
(Double Trouble)
The Fallen
(Double Trouble)
The Gate
Boss Gurdy.png
Boss Dangle.png
Boss Little Horn.png
(Double Trouble)
Gurdy
(Double Trouble)
Dangle Added in Afterbirth Needs to be unlocked
(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Utero Utero[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Lokii.png
Blastocyst The Bloat Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Teratoma.png
Boss The Fallen.png
Mama Gurdy Mr. Fred Teratoma The Fallen Requires previous entry into a devil room
Boss Death.png
Boss Triachnid.png
Boss Conquest.png
Death Needs to be unlocked Triachnid Needs to be unlocked Conquest Needs to be unlocked
Boss The Headless Horseman.png
Boss The Matriarch.png
Boss Sisters Vis.png
The Headless Horseman Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss The Cage.png
Boss The Fallen.png
Boss The Gate.png
(Double Trouble)
The Cage
(Double Trouble)
The Fallen
(Double Trouble)
The Gate
Boss Gurdy.png
Boss Loki.png
Boss Little Horn.png
(Double Trouble)
Gurdy
(Double Trouble)
Loki
(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Scarred Womb Scarred Womb Added in Afterbirth[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Mama Gurdy.png
Blastocyst The Bloat Daddy Long Legs Mama Gurdy
Boss Scolex.png
Boss Teratoma.png
Boss Death.png
Boss Conquest.png
Scolex Teratoma Death Needs to be unlocked Conquest Needs to be unlocked
Boss Triachnid.png
Boss The Headless Horseman.png
Boss The Fallen.png
Boss The Matriarch.png
Triachnid Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room The Matriarch Added in Afterbirth † Needs to be unlocked
Boss Sisters Vis.png
Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Gurdy.png
(Double Trouble)
Gurdy

Greed mode only The Womb The Womb Added in Afterbirth[edit | edit source]

Final Boss[edit | edit source]

Mom's Heart will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active. Once It Lives is unlocked, it will appear instead of Mom's Heart.

Boss Mom's Heart.png
Boss It Lives.png
Mom's Heart It Lives Needs to be unlocked

Notes[edit | edit source]


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png
Lil BlubWormwoodThe RainmakerMin-MinClogColostomiaTurdlet
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
FistulaChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Bumbino
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png
Reap CreepTuff TwinsHornfelGreat GideonSingeThe ShellThe Pile
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Brownie
Sisters Vis
Reap CreepThe Pile
Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png
The SirenThe HereticThe VisageThe Horny BoysMomMom's Heart
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
???
???
Hush
Corpse
Stage Corpse icon.png
ChimeraThe ScourgeRotgutMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Delirium
Home
Stage Home icon.png
DogmaThe BeastUltra DeathUltra FamineUltra PestilenceUltra War
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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