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Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
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in: Modified in Repentance, Modified in Afterbirth+, Modified in Afterbirth, Bosses
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Chapter 4 (Bosses)

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The Quarry - The Loop
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Bosses
Chapter 1 Added in Repentance Chapter 1.5 Chapter 2 Added in Repentance Chapter 2.5 Chapter 3 Added in Repentance Chapter 3.5 Chapter 4 Added in Repentance Corpse Added in Afterbirth ??? Chapter 5 Chapter 6 Added in Afterbirth † The Void Added in Repentance Home
Added in Afterbirth Greed mode only Chapter 1 Added in Afterbirth Greed mode only Chapter 2 Added in Afterbirth Greed mode only Chapter 3 Added in Afterbirth Greed mode only Chapter 4 Added in Afterbirth Greed mode only Chapter 5 Added in Afterbirth Greed mode only The Shop Added in Afterbirth Greed mode only Ultra Greed
Harbingers Alternate Bosses Universal Devil and Angel Room Seven Deadly Sins All Mini-Bosses All Bosses

Womb Womb[]

Boss Blastocyst portrait.png
Boss Lokii portrait.png
Boss Mama Gurdy portrait.png
Boss Mr. Fred portrait.png
Blastocyst Lokii Mama Gurdy Mr. Fred
Boss Scolex portrait.png
Boss The Bloat portrait.png
Boss Daddy Long Legs portrait.png
Boss Triachnid portrait.png
Scolex The Bloat Removed in Repentance Daddy Long Legs Removed in Repentance Triachnid Removed in Repentance Needs to be unlocked
Boss Teratoma portrait.png
Boss Death portrait.png
Boss Conquest portrait.png
Boss The Headless Horseman portrait.png
Teratoma Removed in Repentance Death Needs to be unlocked Conquest Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss The Fallen portrait.png
Boss The Matriarch portrait.png
Boss Sisters Vis portrait.png
The Fallen Devil Room Icon.png The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † / Removed in Repentance Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
Boss Dingle portrait.png
Boss The Cage portrait.png
Boss The Fallen portrait.png
Boss The Gate portrait.png
(Double Trouble)
Dingle 		(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy portrait.png
Boss Dangle portrait.png
Boss Little Horn portrait.png
(Double Trouble)
Gurdy 		(Double Trouble)
Dangle Added in Afterbirth Needs to be unlocked 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Utero Utero[]

Boss Lokii portrait.png
Boss The Bloat portrait.png
Boss Daddy Long Legs portrait.png
Boss Triachnid portrait.png
Lokii The Bloat Daddy Long Legs Triachnid Needs to be unlocked
Boss Teratoma portrait.png
Boss Mr. Fred portrait.png
Boss Mama Gurdy portrait.png
Boss Blastocyst portrait.png
Teratoma Mr. Fred Removed in Repentance Mama Gurdy Removed in Repentance Blastocyst Removed in Repentance
Boss Death portrait.png
Boss Conquest portrait.png
Boss The Fallen portrait.png
Boss The Headless Horseman portrait.png
Death Needs to be unlocked Conquest Needs to be unlocked The Fallen Devil Room Icon.png The Headless Horseman Needs to be unlocked
Boss Sisters Vis portrait.png
Boss The Matriarch portrait.png
Sisters Vis Added in Afterbirth † / Removed in Repentance Needs to be unlocked The Matriarch Added in Afterbirth † / Removed in Repentance Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
Boss The Cage portrait.png
Boss The Fallen portrait.png
Boss The Gate portrait.png
(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy portrait.png
Boss Loki portrait.png
Boss Little Horn portrait.png
(Double Trouble)
Gurdy 		(Double Trouble)
Loki 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Scarred Womb Scarred Womb Added in Afterbirth[]

Boss Blastocyst portrait.png
Boss Mama Gurdy portrait.png
Boss Scolex portrait.png
Boss Triachnid portrait.png
Blastocyst Mama Gurdy Scolex Triachnid Needs to be unlocked
Boss Daddy Long Legs portrait.png
Boss Teratoma portrait.png
Boss The Bloat portrait.png
Boss Death portrait.png
Daddy Long Legs Removed in Repentance Teratoma Removed in Repentance The Bloat Removed in Repentance Death Needs to be unlocked
Boss Conquest portrait.png
Boss The Headless Horseman portrait.png
Boss The Fallen portrait.png
Boss The Matriarch portrait.png
Conquest Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Devil Room Icon.png The Matriarch Added in Afterbirth † Needs to be unlocked
Boss Sisters Vis portrait.png
Boss Lokii portrait.png
Boss Mr. Fred portrait.png
Sisters Vis Added in Afterbirth † / Removed in Repentance Needs to be unlocked Lokii Added in Repentance Mr. Fred Added in Repentance

Double Trouble[]

Double Trouble Bosses
Boss Gurdy portrait.png
(Double Trouble)
Gurdy

Final Boss[]

Mom's Heart will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active. Once It Lives is unlocked, it will appear instead of Mom's Heart.

Boss Mom's Heart portrait.png
Boss It Lives portrait.png
Mom's Heart It Lives Needs to be unlocked

Notes[]


Boss Monstro portrait.png Bosses Boss Monstro portrait.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png 		Monstro • Gemini • Steven • Dingle • Gurglings • Larry Jr. • The Duke of Flies • Widow • Blighted Ovum • The Haunt • Pin • Famine • The Fallen • The Headless Horseman
Added in Afterbirth Dangle • Turdlings • Little Horn • Rag Man
Added in Repentance Baby Plum
Added in Repentance Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png 		Added in Repentance The Rainmaker • Min-Min • Lil Blub • Wormwood • Clog • Colostomia • Turdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png 		Fistula • Chub • C.H.A.D. • Gurdy • Mega Fatty • Mega Maw • Gurdy Jr. • Peep • The Husk • The Hollow • Carrion Queen • Dark One • Polycephalus • The Wretched • Pestilence • The Fallen • The Headless Horseman
Added in Afterbirth The Stain • The Frail • The Forsaken
Added in Afterbirth † Big Horn • Rag Mega
Added in Repentance Bumbino
Added in Repentance Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png 		Added in Repentance Reap Creep • Tuff Twins • Hornfel • Great Gideon • The Pile • The Shell • Singe • Clutch
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		Monstro II • Gish • The Cage • The Gate • Loki • The Adversary • The Bloat • Mask of Infamy • War • The Fallen • The Headless Horseman • Mom
Added in Afterbirth Brownie
Added in Afterbirth † Sisters Vis
Added in Repentance Reap Creep • The Pile
Added in Repentance Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png 		Added in Repentance The Siren • The Heretic • The Visage • The Horny Boys • Mom • Mom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Blastocyst • Mama Gurdy • Scolex • Mr. Fred • Lokii • The Bloat • Daddy Long Legs • Triachnid • Teratoma • Death • Conquest • The Fallen • The Headless Horseman • Mom's Heart • It Lives
Added in Afterbirth † The Matriarch
Added in Afterbirth ???
??? 		Added in Afterbirth Hush
Added in Repentance Corpse
Stage Corpse icon.png 		Added in Repentance Chimera • The Scourge • Rotgut • Mother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Satan • Isaac
Chapter 6
Stage Dark Room icon.pngChest 		??? • The Lamb • Mega Satan
Added in Afterbirth † The Void
Stage The Void icon.png 		Added in Afterbirth † Delirium
Added in Repentance Home
Stage Home icon.png 		Added in Repentance Dogma • Ultra Famine • Ultra Pestilence • Ultra War • Ultra Death • The Beast
Added in Afterbirth Greed Mode
Ultra Greed 		Added in Afterbirth Ultra Greed
Added in Afterbirth † Ultra Greedier
SmallIsaac.pngThe Binding of Isaac: RebirthSmallIsaac.png

MainPageAchievements.png Achievements MainPageChallenges.png Challenges MainPageCMarks.png Completion Marks MainPageItems Small.png Items Trinket The Left Hand icon.png Trinkets Character Isaac appearance.png Characters
MainPageChapters.png Chapters MainPageRooms.png Rooms Transformation Guppy appearance.png Transformations MainPageAttributes.png Attributes MainPageBosses.png Bosses MainPageMonsters.png Monsters
Pickups Pickups Greed Donation Machine.pngModes Curse of Darkness.png Curses Objects Objects MainPageSeeds2.png Seeds Confusion Effect.png Effects Collectible The Polaroid icon.png Endings

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