Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
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Chapter 4 (Bosses)

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Bosses
Chapter 1 (in Repentance) Chapter 1.5 Chapter 2 (in Repentance) Chapter 2.5 Chapter 3 (in Repentance) Chapter 3.5 Chapter 4 (in Repentance) Corpse (except in Rebirth) ??? Chapter 5 Chapter 6 (in Afterbirth † and Repentance) The Void (in Repentance) Home
(except in Rebirth)Greed mode only Chapter 1 (except in Rebirth)Greed mode only Chapter 2 (except in Rebirth)Greed mode only Chapter 3 (except in Rebirth)Greed mode only Chapter 4 (except in Rebirth)Greed mode only Chapter 5 (except in Rebirth)Greed mode only The Shop (except in Rebirth)Greed mode only Ultra Greed
Harbingers Alternate Bosses Universal Devil and Angel Room Seven Deadly Sins All Mini-Bosses All Bosses

WombWomb[]

Boss Blastocyst portrait
Boss Lokii portrait
Boss Mama Gurdy portrait
Boss Mr. Fred portrait
Blastocyst Lokii Mama Gurdy Mr. Fred
Boss Scolex portrait
Boss The Bloat portrait
Boss Daddy Long Legs portrait
Boss Triachnid portrait
Scolex The Bloat (except in Repentance) Daddy Long Legs (except in Repentance) Triachnid (except in Repentance) Needs to be unlocked
Boss Teratoma portrait
Boss Death portrait
Boss Conquest portrait
Boss Headless Horseman portrait
Teratoma (except in Repentance) Death Needs to be unlocked Conquest Needs to be unlocked Headless Horseman Needs to be unlocked
Boss The Fallen portrait
Boss The Matriarch portrait
Boss Sisters Vis portrait
The Fallen Devil Room Icon The Matriarch (in Afterbirth † and Repentance) Needs to be unlocked Sisters Vis (in Afterbirth †) Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
Boss Dingle portrait
Boss The Cage portrait
Boss The Fallen portrait
Boss The Gate portrait
(Double Trouble)
Dingle 		(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy portrait
Boss Dangle portrait
Boss Little Horn portrait
(Double Trouble)
Gurdy 		(Double Trouble)
Dangle (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked

UteroUtero[]

Boss Lokii portrait
Boss The Bloat portrait
Boss Daddy Long Legs portrait
Boss Triachnid portrait
Lokii The Bloat Daddy Long Legs Triachnid Needs to be unlocked
Boss Teratoma portrait
Boss Mr. Fred portrait
Boss Mama Gurdy portrait
Boss Blastocyst portrait
Teratoma Mr. Fred (except in Repentance) Mama Gurdy (except in Repentance) Blastocyst (except in Repentance)
Boss Death portrait
Boss Conquest portrait
Boss Headless Horseman portrait
Boss The Fallen portrait
Death Needs to be unlocked Conquest Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon
Boss Sisters Vis portrait
Boss The Matriarch portrait
Sisters Vis (in Afterbirth †) Needs to be unlocked The Matriarch (in Afterbirth †) Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
Boss The Cage portrait
Boss The Fallen portrait
Boss The Gate portrait
(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy portrait
Boss Loki portrait
Boss Little Horn portrait
(Double Trouble)
Gurdy 		(Double Trouble)
Loki 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked

(except in Rebirth) Scarred WombScarred Womb[]

Boss Blastocyst portrait
Boss Mama Gurdy portrait
Boss Scolex portrait
Boss Triachnid portrait
Blastocyst Mama Gurdy Scolex Triachnid Needs to be unlocked
Boss Daddy Long Legs portrait
Boss Teratoma portrait
Boss The Bloat portrait
Boss Death portrait
Daddy Long Legs (except in Repentance) Teratoma (except in Repentance) The Bloat (except in Repentance) Death Needs to be unlocked
Boss Conquest portrait
Boss Headless Horseman portrait
Boss The Fallen portrait
Boss The Matriarch portrait
Conquest Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon The Matriarch (in Afterbirth † and Repentance) Needs to be unlocked
Boss Sisters Vis portrait
Boss Lokii portrait
Boss Mr. Fred portrait
Sisters Vis (in Afterbirth †) Needs to be unlocked Lokii (in Repentance) Mr. Fred (in Repentance)

Double Trouble[]

Double Trouble Bosses
Boss Gurdy portrait
(Double Trouble)
Gurdy

Final Boss[]

Mom's Heart will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active. Once It Lives is unlocked, it will appear instead of Mom's Heart.

Boss Mom's Heart portrait
Boss It Lives portrait
Mom's Heart It Lives Needs to be unlocked

Notes[]


Boss Monstro portrait Bosses Boss Monstro portrait
Chapter 1
Stage Basement iconStage Cellar iconStage Burning Basement icon 		Monstro • Gemini • Steven • Dingle • Gurglings • Larry Jr. • The Duke of Flies • Widow • Blighted Ovum • The Haunt • Pin • Famine • The Fallen • Headless Horseman
(except in Rebirth) Dangle • Turdlings • Little Horn • Rag Man
(in Repentance) Baby Plum
(in Repentance) Chapter 1.5
Stage Downpour iconStage Dross icon 		(in Repentance) The Rainmaker • Min-Min • Lil Blub • Wormwood • Clog • Colostomia • Turdlet
Chapter 2
Stage Caves iconStage Catacombs iconStage Flooded Caves icon 		Fistula • Chub • C.H.A.D. • Gurdy • Mega Fatty • Mega Maw • Gurdy Jr. • Peep • The Husk • The Hollow • Carrion Queen • Dark One • Polycephalus • The Wretched • Pestilence • The Fallen • Headless Horseman
(except in Rebirth) The Stain • The Frail • The Forsaken
(in Afterbirth † and Repentance) Big Horn • Rag Mega
(in Repentance) Bumbino
(in Repentance) Chapter 2.5
Stage Mines iconStage Ashpit icon 		(in Repentance) Reap Creep • Tuff Twins • Hornfel • Great Gideon • The Pile • The Shell • Singe • Clutch
Chapter 3
Stage Depths iconStage Necropolis iconStage Dank Depths icon 		Monstro II • Gish • The Cage • The Gate • Loki • The Adversary • The Bloat • Mask of Infamy • War • The Fallen • Headless Horseman • Mom
(except in Rebirth) Brownie
(in Afterbirth † and Repentance) Sisters Vis
(in Repentance) Reap Creep • The Pile
(in Repentance) Chapter 3.5
Stage Mausoleum iconStage Gehenna icon 		(in Repentance) The Siren • The Heretic • The Visage • The Horny Boys • Mom • Mom's Heart
Chapter 4
Stage Womb iconStage Utero iconStage Scarred Womb icon 		Blastocyst • Mama Gurdy • Scolex • Mr. Fred • Lokii • The Bloat • Daddy Long Legs • Triachnid • Teratoma • Death • Conquest • The Fallen • Headless Horseman • Mom's Heart • It Lives
(in Afterbirth † and Repentance) The Matriarch
(except in Rebirth) ???
??? 		(except in Rebirth) Hush
(in Repentance) Corpse
Stage Corpse icon 		(in Repentance) Chimera • The Scourge • Rotgut • Mother
Chapter 5
Stage Sheol iconStage Cathedral icon 		Satan • Isaac
Chapter 6
Stage Dark Room iconChest 		??? • The Lamb • Mega Satan
(in Afterbirth † and Repentance) The Void
Stage The Void icon 		(in Afterbirth † and Repentance) Delirium
(in Repentance) Home
Stage Home icon 		(in Repentance) Dogma • Ultra Famine • Ultra Pestilence • Ultra War • Ultra Death • The Beast
(except in Rebirth) Greed Mode
Ultra Greed 		(except in Rebirth) Ultra Greed
(in Afterbirth † and Repentance) Ultra Greedier
SmallIsaacThe Binding of Isaac: RebirthSmallIsaac
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