Chapter 4 (Bosses)

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Bosses
Chapter 1 Added in Repentance Chapter 1.5 Chapter 2 Added in Repentance Chapter 2.5 Chapter 3 Added in Repentance Chapter 3.5 Added in Repentance Corpse Chapter 4 Added in Afterbirth ??? Chapter 5 Chapter 6 Added in Afterbirth † The Void Added in Repentance Home
Harbingers Alternate Bosses Universal Devil and Angel Room Seven Deadly Sins Added in Afterbirth Greed Mode All Mini-Bosses All Bosses

The Womb The Womb[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Lokii.png
Blastocyst The Bloat Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Scolex.png
Boss Teratoma.png
Mama Gurdy Mr. Fred Scolex Teratoma
Boss Death.png
Boss Triachnid.png
Boss Conquest.png
Boss The Headless Horseman.png
Death Needs to be unlocked Triachnid Needs to be unlocked Removed in Repentance Conquest Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss The Fallen.png
Boss The Matriarch.png
Boss Sisters Vis.png
The Fallen Requires previous entry into a devil room The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Cage.png
Boss The Fallen.png
Boss The Gate.png
(Double Trouble)
Dingle 		(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy.png
Boss Dangle.png
Boss Little Horn.png
(Double Trouble)
Gurdy 		(Double Trouble)
Dangle Added in Afterbirth Needs to be unlocked 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Utero Utero[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Lokii.png
Blastocyst The Bloat Daddy Long Legs Lokii
Boss Mama Gurdy.png
Boss Mr. Fred.png
Boss Teratoma.png
Boss The Fallen.png
Mama Gurdy Mr. Fred Teratoma The Fallen Requires previous entry into a devil room
Boss Death.png
Boss Triachnid.png
Boss Conquest.png
Death Needs to be unlocked Triachnid Needs to be unlocked Conquest Needs to be unlocked
Boss The Headless Horseman.png
Boss The Matriarch.png
Boss Sisters Vis.png
The Headless Horseman Needs to be unlocked The Matriarch Added in Afterbirth † Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss The Cage.png
Boss The Fallen.png
Boss The Gate.png
(Double Trouble)
The Cage 		(Double Trouble)
The Fallen 		(Double Trouble)
The Gate
Boss Gurdy.png
Boss Loki.png
Boss Little Horn.png
(Double Trouble)
Gurdy 		(Double Trouble)
Loki 		(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Scarred Womb Scarred Womb Added in Afterbirth[edit | edit source]

Boss Blastocyst.png
Boss The Bloat.png
Boss Daddy Long Legs.png
Boss Mama Gurdy.png
Blastocyst The Bloat Daddy Long Legs Mama Gurdy
Boss Scolex.png
Boss Teratoma.png
Boss Death.png
Boss Conquest.png
Scolex Teratoma Death Needs to be unlocked Conquest Needs to be unlocked
Boss Triachnid.png
Boss The Headless Horseman.png
Boss The Fallen.png
Boss The Matriarch.png
Triachnid Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room The Matriarch Added in Afterbirth † Needs to be unlocked
Boss Sisters Vis.png
Sisters Vis Added in Afterbirth † Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Gurdy.png
(Double Trouble)
Gurdy

Greed mode only The Womb The Womb Added in Afterbirth[edit | edit source]

Final Boss[edit | edit source]

Mom's Heart will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active. Once It Lives is unlocked, it will appear instead of Mom's Heart.

Boss Mom's Heart.png
Boss It Lives.png
Mom's Heart It Lives Needs to be unlocked

Notes[edit | edit source]


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png 		Gemini • Steven • Blighted Ovum • Dingle • The Duke of Flies • Famine • Gurglings • The Haunt • Larry Jr. • Monstro • Pin • Widow • The Fallen • The Headless Horseman
Dangle • Little Horn • Rag Man • Turdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png 		Lil Blub • Wormwood • The Rainmaker • Min-Min • Clog • Colostomia • Turdlet
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png 		Fistula • Chub • C.H.A.D. • Carrion Queen • Dark One • Gurdy • Gurdy Jr. • The Hollow • The Husk • Mega Fatty • Mega Maw • Peep • Pestilence • Polycephalus • The Wretched • The Fallen • The Headless Horseman
The Forsaken • The Frail • The Stain
Big Horn • Rag Mega
Bumbino
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png 		Reap Creep • Tuff Twins • Hornfel • Great Gideon • Singe • The Shell • The Pile
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png 		The Adversary • The Bloat • The Cage • The Gate • Monstro II • Gish • Loki • Mask of Infamy • War • The Fallen • The Headless Horseman • Mom
Brownie
Sisters Vis
Reap Creep • The Pile
Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png 		The Siren • The Heretic • The Visage • The Horny Boys • Mom • Mom's Heart
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png 		Blastocyst • The Bloat • Conquest • Daddy Long Legs • Triachnid • Death • Lokii • Mama Gurdy • Mr. Fred • Scolex • Teratoma • The Fallen • The Headless Horseman • Mom's Heart • It Lives
Sisters Vis • The Matriarch
???
??? 		Hush
Corpse
Stage Corpse icon.png 		Chimera • The Scourge • Rotgut • Mother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png 		Satan • Isaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png 		??? • The Lamb • Mega Satan
The Void
Stage The Void icon.png 		Delirium
Home
Stage Home icon.png 		Dogma • The Beast • Ultra Death • Ultra Famine • Ultra Pestilence • Ultra War
Greed Mode
Ultra Greed 		Ultra Greed
Ultra Greedier
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