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Binding of Isaac: Rebirth Wiki
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in: Modified in Repentance, Modified in Afterbirth, Modified in Afterbirth+, Bosses
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Chapter 3 (Bosses)

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Bosses
Chapter 1 (in Repentance) Chapter 1.5 Chapter 2 (in Repentance) Chapter 2.5 Chapter 3 (in Repentance) Chapter 3.5 Chapter 4 (in Repentance) Corpse (except in Rebirth) ??? Chapter 5 Chapter 6 (in Afterbirth † and Repentance) The Void (in Repentance) Home
(except in Rebirth)Greed mode only Chapter 1 (except in Rebirth)Greed mode only Chapter 2 (except in Rebirth)Greed mode only Chapter 3 (except in Rebirth)Greed mode only Chapter 4 (except in Rebirth)Greed mode only Chapter 5 (except in Rebirth)Greed mode only The Shop (except in Rebirth)Greed mode only Ultra Greed
Harbingers Alternate Bosses Universal Devil and Angel Room Seven Deadly Sins All Mini-Bosses All Bosses

DepthsDepths

Boss The Cage
Boss The Gate
Boss Monstro II
Boss Gish
The Cage The Gate Monstro II Gish Needs to be unlocked
Boss Loki
Boss The Adversary
Boss War
Boss Headless Horseman
Loki The Adversary (except in Repentance) War Needs to be unlocked Headless Horseman Needs to be unlocked
Boss The Fallen
Boss Brownie
Boss Sisters Vis
Boss Reap Creep
The Fallen Devil Room Icon Brownie (except in Rebirth) Needs to be unlocked Sisters Vis (in Afterbirth † and Repentance) Needs to be unlocked Reap Creep (in Repentance) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss Chub
Boss Gurdy Jr.
Boss The Haunt
(Double Trouble)
Chub 		(Double Trouble)
Gurdy Jr. 		(Double Trouble)
The Haunt
Boss The Hollow
Boss The Husk
Boss Larry Jr.
(Double Trouble)
The Hollow 		(Double Trouble)
The Husk 		(Double Trouble)
Larry Jr.
Boss The Wretched
Boss Little Horn
Boss Rag Man
(Double Trouble)
The Wretched 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked
Boss Dark One
(Double Trouble)
Dark One (in Repentance)

NecropolisNecropolis

Boss The Adversary
Boss The Bloat
Boss Mask Of Infamy
Boss Loki
The Adversary The Bloat Mask Of Infamy Loki
Boss The Gate
Boss War
Boss Headless Horseman
Boss The Fallen
The Gate (except in Repentance) War Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon
Boss Brownie
Boss Sisters Vis
Boss The Pile
Brownie (except in Rebirth) Needs to be unlocked Sisters Vis (in Afterbirth † and Repentance) Needs to be unlocked The Pile (in Repentance) Needs to be unlocked

Double Trouble

Double Trouble Bosses
Boss Blighted Ovum
Boss The Haunt
Boss The Husk
Boss Larry Jr.
(Double Trouble)
Blighted Ovum 		(Double Trouble)
The Haunt 		(Double Trouble)
The Husk 		(Double Trouble)
Larry Jr.
Boss Dangle
Boss Little Horn
Boss Rag Man
(Double Trouble)
Dangle (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked

(except in Rebirth)Dank DepthsDank Depths

Boss Loki
Boss Monstro II
Boss Gish
Boss The Adversary
Loki Monstro II Gish Needs to be unlocked The Adversary (except in Repentance)
Boss War
Boss Headless Horseman
Boss The Fallen
Boss Brownie
War Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon Brownie Needs to be unlocked
Boss Sisters Vis
Boss The Cage
Boss The Gate
Boss Reap Creep
Sisters Vis (in Afterbirth † and Repentance) Needs to be unlocked The Cage (in Repentance) The Gate (in Repentance) Reap Creep (in Repentance) Needs to be unlocked

Double Trouble

Double Trouble Bosses
The Haunt
Boss Little Horn
(Double Trouble)
The Haunt 		(Double Trouble)
Little Horn Needs to be unlocked

Final Boss

Mom will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active.

Boss Mom
Mom

Notes


Boss Monstro Bosses Boss Monstro
Chapter 1
Stage basementStage cellarStage burning basement 		Monstro • Gemini • Steven • Dingle • Gurglings • Larry Jr. • The Duke of Flies • Widow • Blighted Ovum • The Haunt • Pin • Famine • The Fallen • Headless Horseman
(except in Rebirth) Dangle • Turdlings • Little Horn • Rag Man
(in Repentance) Baby Plum
(in Repentance) Chapter 1.5
Stage Downpour iconStage Dross icon 		(in Repentance) The Rainmaker • Min-Min • Lil Blub • Wormwood • Clog • Colostomia • Turdlet
Chapter 2
Stage cavesStage catacombsStage flooded caves 		Fistula • Chub • C.H.A.D. • Gurdy • Mega Fatty • Mega Maw • Gurdy Jr. • Peep • The Husk • The Hollow • Carrion Queen • Dark One • Polycephalus • The Wretched • Pestilence • The Fallen • Headless Horseman
(except in Rebirth) The Stain • The Frail • The Forsaken
(in Afterbirth † and Repentance) Big Horn • Rag Mega
(in Repentance) Bumbino
(in Repentance) Chapter 2.5
Stage Mines iconStage Ashpit icon 		(in Repentance) Reap Creep • Tuff Twins • Hornfel • Great Gideon • The Pile • The Shell • Singe • Clutch
Chapter 3
Stage depthsStage necropolisStage dank depths 		Monstro II • Gish • The Cage • The Gate • Loki • The Adversary • The Bloat • Mask of Infamy • War • The Fallen • Headless Horseman • Mom
(except in Rebirth) Brownie
(in Afterbirth † and Repentance) Sisters Vis
(in Repentance) Reap Creep • The Pile
(in Repentance) Chapter 3.5
Stage Mausoleum iconStage Gehenna icon 		(in Repentance) The Siren • The Heretic • The Visage • The Horny Boys • Mom • Mom's Heart
Chapter 4
Stage wombStage uteroStage scarred womb 		Blastocyst • Mama Gurdy • Scolex • Mr. Fred • Lokii • The Bloat • Daddy Long Legs • Triachnid • Teratoma • Death • Conquest • The Fallen • Headless Horseman • Mom's Heart • It Lives
(in Afterbirth † and Repentance) The Matriarch
(except in Rebirth) ???
??? 		(except in Rebirth) Hush
(in Repentance) Corpse
Stage Corpse icon 		(in Repentance) Chimera • The Scourge • Rotgut • Mother
Chapter 5
Stage sheolStage cathedral 		Satan • Isaac
Chapter 6
Stage dark roomChest 		??? • The Lamb • Mega Satan
(in Afterbirth † and Repentance) The Void
Stage the void 		(in Afterbirth † and Repentance) Delirium
(in Repentance) Home
Stage Home icon 		(in Repentance) Dogma • Ultra Famine • Ultra Pestilence • Ultra War • Ultra Death • The Beast
(except in Rebirth) Greed Mode
Ultra Greed 		(except in Rebirth) Ultra Greed
(in Afterbirth † and Repentance) Ultra Greedier
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