Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
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Chapter 3 (Bosses)

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Bosses
Chapter 1 (in Repentance) Chapter 1.5 Chapter 2 (in Repentance) Chapter 2.5 Chapter 3 (in Repentance) Chapter 3.5 Chapter 4 (in Repentance) Corpse (except in Rebirth) ??? Chapter 5 Chapter 6 (in Afterbirth † and Repentance) The Void (in Repentance) Home
(except in Rebirth)Greed mode only Chapter 1 (except in Rebirth)Greed mode only Chapter 2 (except in Rebirth)Greed mode only Chapter 3 (except in Rebirth)Greed mode only Chapter 4 (except in Rebirth)Greed mode only Chapter 5 (except in Rebirth)Greed mode only The Shop (except in Rebirth)Greed mode only Ultra Greed
Harbingers Alternate Bosses Universal Devil and Angel Room Seven Deadly Sins All Mini-Bosses All Bosses

DepthsDepths[]
The Cage The Gate Monstro II Gish Needs to be unlocked
Loki The Adversary (except in Repentance) War Needs to be unlocked Headless Horseman Needs to be unlocked
The Fallen Brownie (except in Rebirth) Needs to be unlocked Sisters Vis (in Afterbirth † and Repentance) Needs to be unlocked Reap Creep (in Repentance) Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
(Double Trouble)
Chub 		(Double Trouble)
Gurdy Jr. 		(Double Trouble)
The Haunt
(Double Trouble)
The Hollow 		(Double Trouble)
The Husk 		(Double Trouble)
Larry Jr.
(Double Trouble)
The Wretched 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked
(Double Trouble)
Dark One (in Repentance)

NecropolisNecropolis[]
The Adversary The Bloat Mask Of Infamy Loki
The Gate (except in Repentance) War Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen
Brownie (except in Rebirth) Needs to be unlocked Sisters Vis (in Afterbirth † and Repentance) Needs to be unlocked The Pile (in Repentance) Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
(Double Trouble)
Blighted Ovum 		(Double Trouble)
The Haunt 		(Double Trouble)
The Husk 		(Double Trouble)
Larry Jr.
(Double Trouble)
Dangle (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Little Horn (except in Rebirth) Needs to be unlocked 		(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked

(except in Rebirth) Dank DepthsDank Depths[]
Loki Monstro II Gish Needs to be unlocked The Adversary (except in Repentance)
War Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Brownie Needs to be unlocked
Sisters Vis (in Afterbirth † and Repentance) Needs to be unlocked The Cage (in Repentance) The Gate (in Repentance) Reap Creep (in Repentance) Needs to be unlocked

Double Trouble[]

Double Trouble Bosses
The Haunt
The Haunt
(Double Trouble)
The Haunt 		(Double Trouble)
Little Horn Needs to be unlocked 		(Double Trouble)
Baby Plum

Final Boss[]

Mom will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active.

Mom

Notes[]


Bosses
Chapter 1
 Monstro • Gemini • Steven • Dingle • Gurglings • Larry Jr. • The Duke of Flies • Widow • Blighted Ovum • The Haunt • Pin • Famine • The Fallen • Headless Horseman
(except in Rebirth) Dangle • Turdlings • Little Horn • Rag Man
(in Repentance) Baby Plum
(in Repentance) Chapter 1.5
 (in Repentance) The Rainmaker • Min-Min • Lil Blub • Wormwood • Clog • Colostomia • Turdlet
Chapter 2
 Fistula • Chub • C.H.A.D. • Gurdy • Mega Fatty • Mega Maw • Gurdy Jr. • Peep • The Husk • The Hollow • Carrion Queen • Dark One • Polycephalus • The Wretched • Pestilence • The Fallen • Headless Horseman
(except in Rebirth) The Stain • The Frail • The Forsaken
(in Afterbirth † and Repentance) Big Horn • Rag Mega
(in Repentance) Bumbino
(in Repentance) Chapter 2.5
 (in Repentance) Reap Creep • Tuff Twins • Hornfel • Great Gideon • The Pile • The Shell • Singe • Clutch
Chapter 3
 Monstro II • Gish • The Cage • The Gate • Loki • The Adversary • The Bloat • Mask of Infamy • War • The Fallen • Headless Horseman • Mom
(except in Rebirth) Brownie
(in Afterbirth † and Repentance) Sisters Vis
(in Repentance) Reap Creep • The Pile
(in Repentance) Chapter 3.5
 (in Repentance) The Siren • The Heretic • The Visage • The Horny Boys • Mom • Mom's Heart
Chapter 4
 Blastocyst • Mama Gurdy • Scolex • Mr. Fred • Lokii • The Bloat • Daddy Long Legs • Triachnid • Teratoma • Death • Conquest • The Fallen • Headless Horseman • Mom's Heart • It Lives
(in Afterbirth † and Repentance) The Matriarch
(except in Rebirth) ???
??? 		(except in Rebirth) Hush
(in Repentance) Corpse
 (in Repentance) Chimera • The Scourge • Rotgut • Mother
Chapter 5
 Satan • Isaac
Chapter 6
Chest 		??? • The Lamb • Mega Satan
(in Afterbirth † and Repentance) The Void
 (in Afterbirth † and Repentance) Delirium
(in Repentance) Home
 (in Repentance) Dogma • Ultra Famine • Ultra Pestilence • Ultra War • Ultra Death • The Beast
(except in Rebirth) Greed Mode
Ultra Greed 		(except in Rebirth) Ultra Greed
(in Afterbirth † and Repentance) Ultra Greedier
The Binding of Isaac: Rebirth
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