Chapter 3 (Bosses)

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The Depths The Depths[edit | edit source]

Boss The Adversary.png
Boss The Cage.png
Boss The Gate.png
Boss Loki.png
The Adversary The Cage The Gate Loki
Boss Monstro II.png
Boss War.png
Boss Gish.png
Boss The Headless Horseman.png
Monstro II War Needs to be unlocked Gish Needs to be unlocked The Headless Horseman Needs to be unlocked
Boss The Fallen.png
Boss Brownie.png
Boss Sisters Vis.png
Boss Reap Creep.png
The Fallen Requires previous entry into a devil room Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked Reap Creep Added in Repentance

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Chub.png
Boss Gurdy Jr..png
The Haunt
(Double Trouble)
Chub
(Double Trouble)
Gurdy Jr.
(Double Trouble)
The Haunt
Boss The Hollow.png
Boss The Husk.png
Boss Larry Jr..png
(Double Trouble)
The Hollow
(Double Trouble)
The Husk
(Double Trouble)
Larry Jr.
Boss The Wretched.png
Boss Little Horn.png
Boss Rag Man.png
(Double Trouble)
The Wretched
(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked
(Double Trouble)
Rag Man Added in Afterbirth Needs to be unlocked

Necropolis Necropolis[edit | edit source]

Boss The Adversary.png
Boss The Bloat.png
Boss The Gate.png
Boss Loki.png
The Adversary The Bloat The Gate Loki
Boss Mask Of Infamy.png
Boss War.png
Boss The Headless Horseman.png
Boss The Fallen.png
Mask of Infamy War Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room
Boss Brownie.png
Boss Sisters Vis.png
Boss The Pile.png
Brownie Added in Afterbirth Needs to be unlocked Sisters Vis Added in Afterbirth † Needs to be unlocked The Pile Added in Repentance

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Blighted Ovum.png
The Haunt
Boss The Husk.png
Boss Larry Jr..png
(Double Trouble)
Blighted Ovum
(Double Trouble)
The Haunt
(Double Trouble)
The Husk
(Double Trouble)
Larry Jr.
Boss Dangle.png
Boss Little Horn.png
Boss Rag Man.png
(Double Trouble)
Dangle Added in Afterbirth Needs to be unlocked
(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked
(Double Trouble)
Rag Man Added in Afterbirth Needs to be unlocked

Dank Depths Dank Depths Added in Afterbirth[edit | edit source]

Boss The Adversary.png
Boss Loki.png
Boss Monstro II.png
Boss War.png
The Adversary Loki Monstro II War Needs to be unlocked
Boss Gish.png
Boss The Headless Horseman.png
Boss The Fallen.png
Boss Brownie.png
Gish Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room Brownie Added in Afterbirth Needs to be unlocked
Boss Sisters Vis.png
Boss Reap Creep.png
Sisters Vis Added in Afterbirth † Needs to be unlocked Reap Creep Added in Repentance

Double Trouble[edit | edit source]

Double Trouble Bosses
The Haunt
Boss Little Horn.png
(Double Trouble)
The Haunt
(Double Trouble)
Little Horn Added in Afterbirth Needs to be unlocked

Greed mode only The Depths The Depths Added in Afterbirth[edit | edit source]

Final Boss[edit | edit source]

Mom will always appear in the second floor of this chapter or in the last boss room if Curse of the Labyrinth is active.

Boss Mom.png
Mom

Notes[edit | edit source]


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png
Lil BlubWormwoodThe RainmakerMin-MinClogColostomiaTurdlet
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
FistulaChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Bumbino
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png
Reap CreepTuff TwinsHornfelGreat GideonSingeThe ShellThe Pile
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Brownie
Sisters Vis
Reap CreepThe Pile
Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png
The SirenThe HereticThe VisageThe Horny BoysMomMom's Heart
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
???
???
Hush
Corpse
Stage Corpse icon.png
ChimeraThe ScourgeRotgutMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Delirium
Home
Stage Home icon.png
DogmaThe BeastUltra DeathUltra FamineUltra PestilenceUltra War
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
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