Binding of Isaac: Rebirth Wiki
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CavesCaves[ | ]

Boss Chub
Boss C.H.A.D.
Boss Gurdy
Boss Gurdy Jr.
Chub C.H.A.D. Needs to be unlocked Gurdy Gurdy Jr.
Boss Mega Fatty
Boss Mega Maw
Boss Peep
Boss Dark One
Mega Fatty Mega Maw Peep Dark One (except in Repentance)
Boss Pestilence
Boss Headless Horseman
Boss The Fallen
Boss The Stain
Pestilence Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon The Stain (except in Rebirth) Needs to be unlocked
Boss The Frail
Boss The Forsaken
Boss Big Horn
Boss Rag Mega
The Frail (in Afterbirth and Afterbirth †) Needs to be unlocked The Forsaken (in Afterbirth and Afterbirth †) Needs to be unlocked Big Horn (in Afterbirth † and Repentance) Needs to be unlocked Rag Mega (in Afterbirth † and Repentance) Needs to be unlocked
Boss Fistula
Boss Bumbino
Fistula (in Repentance) Bumbino (in Repentance) Needs to be unlocked

Double Trouble[ | ]

Double Trouble Bosses
Boss Dingle
Boss The Duke of Flies
Boss Gemini
Boss Larry Jr.
(Double Trouble)
Dingle
(Double Trouble)
The Duke of Flies
(Double Trouble)
Gemini
(Double Trouble)
Larry Jr.
Boss Monstro
Boss Pin
Boss Polycephalus
Boss Rag Man
(Double Trouble)
Monstro
(Double Trouble)
Pin
(Double Trouble)
Polycephalus
(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked

CatacombsCatacombs[ | ]

Boss Carrion Queen
Boss Dark One
Boss Gurdy Jr.
Boss The Hollow
Carrion Queen Dark One Gurdy Jr. The Hollow
Boss The Husk
Boss Peep
Boss Polycephalus
Boss The Wretched
The Husk Peep Polycephalus The Wretched
Boss Pestilence
Boss Headless Horseman
Boss The Fallen
Boss The Forsaken
Pestilence Needs to be unlocked Headless Horseman Needs to be unlocked The Fallen Devil Room Icon The Forsaken (except in Rebirth) Needs to be unlocked
Boss The Frail
Boss The Stain
Boss Big Horn
Boss Rag Mega
The Frail (except in Rebirth) Needs to be unlocked The Stain (in Afterbirth and Afterbirth †) Needs to be unlocked Big Horn (in Afterbirth † and Repentance) Needs to be unlocked Rag Mega (in Afterbirth † and Repentance) Needs to be unlocked
Boss Bumbino
Bumbino (in Repentance) Needs to be unlocked

Double Trouble[ | ]

Double Trouble Bosses
Boss Dingle
Boss The Duke of Flies
Boss Gemini
Boss Larry Jr.
(Double Trouble)
Dingle
(Double Trouble)
The Duke of Flies
(Double Trouble)
Gemini
(Double Trouble)
Larry Jr.
Boss Monstro
Boss Pin
Boss Rag Man
Boss Gurglings
(Double Trouble)
Monstro
(Double Trouble)
Pin
(Double Trouble)
Rag Man (except in Rebirth) Needs to be unlocked
(Double Trouble)
Gurglings (in Repentance)

(except in Rebirth)Flooded CavesFlooded Caves[ | ]

Boss Chub
Boss C.H.A.D.
Boss Gurdy
Boss Gurdy Jr.
Chub C.H.A.D. Needs to be unlocked Gurdy Gurdy Jr.
Boss Peep
Boss Polycephalus
Boss Dark One
Boss Pestilence
Peep Polycephalus (except in Repentance) Dark One (except in Repentance) Pestilence Needs to be unlocked
Boss Headless Horseman
Boss The Fallen
Boss The Forsaken
Boss The Frail
Headless Horseman Needs to be unlocked The Fallen Devil Room Icon The Forsaken Needs to be unlocked The Frail Needs to be unlocked
Boss The Stain
Boss Big Horn
Boss Rag Mega
Boss Fistula
The Stain Needs to be unlocked Big Horn (in Afterbirth † and Repentance) Needs to be unlocked Rag Mega (in Afterbirth † and Repentance) Needs to be unlocked Fistula (in Repentance)
Boss Mega Maw
Boss Mega Fatty
Boss Bumbino
Mega Maw (in Repentance) Mega Fatty (in Repentance) Bumbino (in Repentance) Needs to be unlocked

Double Trouble[ | ]

Double Trouble Bosses
Boss The Duke of Flies
Boss Monstro
Boss Rag Man
Boss Pin
(Double Trouble)
The Duke of Flies
(Double Trouble)
Monstro
(Double Trouble)
Rag Man Needs to be unlocked
(Double Trouble)
Pin (in Repentance)

Notes[ | ]


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