Chapter 2 (Bosses)

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The Caves The Caves[edit | edit source]

Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
Boss Gurdy Jr..png
Chub Dark One Gurdy Gurdy Jr.
Boss Mega Fatty.png
Boss Mega Maw.png
Boss Peep.png
Boss Pestilence.png
Mega Fatty Mega Maw Peep Pestilence Needs to be unlocked
Boss C.H.A.D..png
Boss The Headless Horseman.png
Boss The Fallen.png
Boss The Forsaken.png
C.H.A.D. Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room The Forsaken Added in Afterbirth Needs to be unlocked
Boss The Frail.png
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked
Boss Bumbino.png
Bumbino Added in Repentance Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Duke of Flies.png
Boss Gemini.png
Boss Larry Jr..png
(Double Trouble)
Dingle
(Double Trouble)
The Duke of Flies
(Double Trouble)
Gemini
(Double Trouble)
Larry Jr.
Boss Monstro.png
Boss Pin.png
Boss Polycephalus.png
(Double Trouble)
Monstro
(Double Trouble)
Pin
(Double Trouble)
Polycephalus

The Catacombs The Catacombs[edit | edit source]

Boss Carrion Queen.png
Boss Dark One.png
Boss Gurdy Jr..png
Boss The Hollow.png
Carrion Queen Dark One Gurdy Jr. The Hollow
Boss The Husk.png
Boss Peep.png
Boss Polycephalus.png
Boss The Wretched.png
The Husk Peep Polycephalus The Wretched
Boss Pestilence.png
Boss The Headless Horseman.png
Boss The Fallen.png
Boss The Forsaken.png
Pestilence Needs to be unlocked The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room The Forsaken Added in Afterbirth Needs to be unlocked
Boss The Frail.png
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
The Frail Added in Afterbirth Needs to be unlocked The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked
Boss Bumbino.png
Bumbino Added in Repentance Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Dingle.png
Boss The Duke of Flies.png
Boss Gemini.png
(Double Trouble)
Dingle
(Double Trouble)
The Duke of Flies
(Double Trouble)
Gemini
Boss Larry Jr..png
Boss Monstro.png
Boss Pin.png
(Double Trouble)
Larry Jr.
(Double Trouble)
Monstro
(Double Trouble)
Pin

Flooded Caves Flooded Caves Added in Afterbirth[edit | edit source]

Boss Chub.png
Boss Dark One.png
Boss Gurdy.png
Boss Gurdy Jr..png
Chub Dark One Gurdy Gurdy Jr.
Boss Peep.png
Boss Polycephalus.png
Boss Pestilence.png
Boss C.H.A.D..png
Peep Polycephalus Pestilence Needs to be unlocked C.H.A.D. Needs to be unlocked
Boss The Headless Horseman.png
Boss The Fallen.png
Boss The Forsaken.png
Boss The Frail.png
The Headless Horseman Needs to be unlocked The Fallen Requires previous entry into a devil room The Forsaken Added in Afterbirth Needs to be unlocked The Frail Added in Afterbirth Needs to be unlocked
Boss The Stain.png
Boss Big Horn.png
Boss Rag Mega.png
Boss Bumbino.png
The Stain Added in Afterbirth Needs to be unlocked Big Horn Added in Afterbirth † Needs to be unlocked Rag Mega Added in Afterbirth † Needs to be unlocked Bumbino Added in Repentance Needs to be unlocked

Double Trouble[edit | edit source]

Double Trouble Bosses
Boss Monstro.png
(Double Trouble)
Monstro

Greed mode only The Caves The Caves Added in Afterbirth[edit | edit source]

Notes[edit | edit source]


Bosses Boss Monstro.png
Chapter 1
Stage The Basement icon.pngStage The Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png
Lil BlubWormwoodThe RainmakerMin-MinClogColostomiaTurdlet
Chapter 2
Stage The Caves icon.pngStage The Catacombs icon.pngStage Flooded Caves icon.png
FistulaChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Bumbino
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png
Reap CreepTuff TwinsHornfelGreat GideonSingeThe ShellThe Pile
Chapter 3
Stage The Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Brownie
Sisters Vis
Reap CreepThe Pile
Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png
The SirenThe HereticThe VisageThe Horny BoysMomMom's Heart
Chapter 4
Stage The Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
???
???
Hush
Corpse
Stage Corpse icon.png
ChimeraThe ScourgeRotgutMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
SatanIsaac
Chapter 6
Stage Dark Room icon.pngStage The Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Delirium
Home
Stage Home icon.png
DogmaThe BeastUltra DeathUltra FamineUltra PestilenceUltra War
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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