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Binding of Isaac: Rebirth Wiki
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Changes: Challenges

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'''Challenges''' are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult. You will not find [[Rooms#Treasure Rooms|Treasure Rooms]] (with the exception of a select few challenges). Completing one of the thirty five challenges unlocks new content for the game, such as [[Runes]].
 +
'''Challenges''' are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, [[Treasure Room]]s are not available during challenges. Each challenge unlocks new content for the game, such as [[rune]]s when completed. Players, with the advent of modding, have created their own [[Custom Challenges]] too.
   
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==General Strategy==
 +
== General Strategy ==
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Most challenges are geared to make a run difficult in some form. Sometimes, these challenges are easy, like [[Computer Savvy]]. Other times, they can be vicious, like [[Solar System]]. Each challenge has a certain strategy that can make the run easier. However, there are a few strategies that can apply to all challenges.<br>
 +
Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like [[Computer Savvy]] are quite easy to beat. Some challenges do compensate for this by being especially punishing; [[Solar System]] is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.
−
* You can play in [[co-op]] for every challenge, making it easier for the ones where you cannot fire tears - especially for [[Cat Got Your Tongue]], since it will spawn flies.
 +
* Challenges can be played in [[co-op]], allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is [[Blindfolded]], as the second player will be allowed to fire tears normally.
  +
**{{dlc|r}} If other players join the game in the first room for true co-op, they will not get to select a character and will be forced to play as the character the challenge has you play as, ex. for [[Blue Bomber]], all players will be forced to play as {{c|???}} no matter what. (This excludes untrue co-op because of co-op babies.)
−
* Because of the lack of Treasure Rooms, [[Devil Room|Devil Rooms]] become much more valuable. Some challenges can be made much easier by making just one deal.<br>
 +
* Due to the lack of Treasure Rooms, [[Devil Room]]s become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
−
* You can also be more liberal with your use of keys for the same reason. [[Trinkets]] and [[Items]] that generate more coins, along with upgraded [[Shop|shops]], can help reduce the difficulty in many challenge runs.
 
  +
** Some rooms (including [[Crawl Space]]s) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
−
* {{i|The Bible}} can make the end of some runs extremely easy. Because of how some challenges operate, the run may only require defeating [[Mom]] or [[Mom's Heart]] / [[It Lives]]. Since {{i|The Bible}} is a one-hit kill against these, getting it when you have the chance is usually a good investment for these runs.<br>
  
  +
** Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, [[trinket]]s and [[item]]s that generate more coins, along with upgraded [[Shop]]s, can help Isaac acquire a greater range of powerful items.
⚫
** {{i|Pandora's Box}} will spawn {{i|The Bible}} if used in Womb II, Utero II, or {{dlc|a}} Scarred Womb II, which may then be used against [[Mom's Heart]] / [[It Lives]].
  
  +
* {{i|The Bible}} instantly kills [[Mom]] and [[Mom's Heart]] / [[It Lives]]. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
−
* [[Curse Room|Curse Rooms]] gain value since they can spawn items. You may wish to restart on the first floor until your [[Curse Room]] spawns an item worth 1 heart of damage.
  
  ⚫
** {{i|Pandora's Box}} will spawn The Bible if used in Womb II, Utero II, or {{dlc|a}} Scarred Womb II, making it a reliable way to acquire The Bible.
−
* [[Dice Room|Dice Rooms]] and the {{i|D4}} are very useful, as in some cases you can reroll your entire build and remove (or add) difficulty.
  
  +
* [[Curse Room]]s can spawn items, making them valuable.
−
** {{dlc|a}} Dice rooms do not re-roll starter challenge items or remove [[Blindfolded]].
  
  +
* {{dlc|na}} In some challenges, [[Dice Room]]s and the {{i|D4}} are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
−
** {{I|Butter!}} can remove starter items.
+
** {{t|Butter!}} can also remove starter items.
−
* In [[Blindfolded]] challenges, familiars can make the run easier, as they are your only source of conventional damage. Powerful familiars like {{i|Daddy Longlegs}}, {{i|Lil Brimstone}}, and {{i|Incubus}} are very good items to pick up. Some of the strongest familiars need to be unlocked first, so it may be wise to take the time to unlock them beforehand.
 
  +
* [[Blindfolded]] challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
⚫
** {{i|The Boomerang}}, {{i|The Candle}}, and {{i|Red Candle}} are also useful for blindfolded challenges, since they deal damage and recharge based on a timer.
  
  +
** Familiars can provide an alternative method of dealing damage. Powerful familiars like {{i|Daddy Longlegs}}, {{i|Lil Brimstone}}, and {{i|Incubus}} are therefore highly useful items.
−
*** {{dlc|a}} In [[Blindfolded]] challenges, if possible finding and using the {{i|Clicker}}, change yourself into the character [[Lilith]], will make these challenges incredibly easy with access to tears through her {{i|Incubus}} you gain.
  
  ⚫
** {{i|The Boomerang}}, {{i|The Candle}}, and {{i|Red Candle}} are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
  +
** {{i|Clicker}} can allow Isaac to change into {{Dlc|a}}{{C|Lilith}}, whose {{i|Incubus}} overrides the blindfolded effect by default.
  +
** Some spacebar items like {{i|Tammy's Head}} can be really helpful, providing an alternative method of dealing damage.
  +
* {{i|Chaos}} is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating bosses.
  +
* Defeating a boss beyond the specified end of the challenge (e.g. defeating [[Mom's Heart]] when the goal is to defeat [[Mom]]) will still spawn the trophy.
  ⚫
**{{dlc|a}} In some longer challenges (e.g. [[XXXXXXXXL]]), using a [[Sacrifice Room]] until it teleports Isaac to the [[Dark Room]] is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating [[The Lamb]].
  +
***{{dlc|a+}} In a similar vein, all runs can be completed by killing [[Delirium]], meaning that the player can beat a challenge through an alternative method such as defeating [[Hush]] then traveling to [[The Void]]; however, this is generally extremely difficult given the restrictions challenges place on the player.
   
  ⚫
== Notes ==
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* {{dlc|a}} In challenges that remove Treasure Rooms, {{i|Chaos}} has more potential to be useful by potentially making Treasure Room (among other rare items) items purchasable from the shop. On the downside, it may replace the Devil/Angel Room items with something less valuable.
  
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* Defeating a boss beyond the specified end of the challenge (e.g. defeating [[Mom's Heart]] when the goal is to defeat [[Mom]]) will still cause them to drop the trophy.
 +
* Apart from the achievement related to beating the challenge, all achievements are locked. Also, no [[Donation Machine]]s will appear in any challenge.
  ⚫
* The challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to [[Sheol]] or the [[Cathedral]], the unlock will be forfeited.
⚫
** {{dlc|a}} This means a legitimate tactic for some of the longer challenges (e.g. [[XXXXXXXXL]]) is to use the [[Sacrifice Room]] until it teleports you to the [[Dark Room]], then going through and defeating [[The Lamb]], completing the challenge regardless of what floor you were teleported from.
  
  ⚫
* [[Isaac]] will not start any challenge with {{i|The D6}}.
   
  ⚫
== Challenges List ==
⚫
==Notes==
  
  ⚫
{{challenge table}}
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* New content, other than the Challenge Reward, cannot be unlocked. Likewise, you will not find a [[Donation Machine]] anywhere.
  
⚫
* The Challenge reward will not be unlocked unless you pick up the trophy, meaning that if a Devil Room or Angel Room appears and allows you to go to [[Sheol]] or the [[Cathedral]], you will be forfeiting the unlock if you fail to complete the floor.
  
⚫
* Any challenge featuring [[Isaac]] will not start with {{i|The D6}}.
  
   
  +
{{nav|challenge}}
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==Challenge list==
  
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{{Table | Challenge |
  
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{{Chlg|Pitch Black|table}}
  
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{{Chlg|High Brow|table}}
  
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{{Chlg|Head Trauma|table}}
  
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{{Chlg|Darkness Falls|table}}
  
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{{Chlg|The Tank|table}}
  
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{{Chlg|Solar System|table}}
  
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{{Chlg|Suicide King|table}}
  
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{{Chlg|Cat Got Your Tongue|table}}
  
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{{Chlg|Demo Man|table}}
  
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{{Chlg|Cursed!|table}}
  
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{{Chlg|Glass Cannon|table}}
  
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{{Chlg|When Life Gives You Lemons|table}}
  
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{{Chlg|Beans!|table}}
  
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{{Chlg|It's in the Cards|table}}
  
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{{Chlg|Slow Roll|table}}
  
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{{Chlg|Computer Savvy|table}}
  
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{{Chlg|Waka Waka|table}}
  
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{{Chlg|The Host|table}}
  
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{{Chlg|The Family Man|table}}
  
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{{Chlg|Purist|table}}
  
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{{Chlg|XXXXXXXXL|table}}
  
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{{Chlg|SPEED!|table}}
  
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{{Chlg|Blue Bomber|table}}
  
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{{Chlg|PAY TO PLAY|table}}
  
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{{Chlg|Have a Heart|table}}
  
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{{Chlg|I RULE!|table}}
  
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{{Chlg|BRAINS!|table}}
  
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{{Chlg|PRIDE DAY!|table}}
  
−
{{Chlg|Onan's Streak|table}}
  
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{{Chlg|The Guardian|table}}
  
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{{Chlg|Backasswards|table}}
  
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{{Chlg|Aprils Fool|table}}
  
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{{Chlg|Pokey Mans|table}}
  
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{{Chlg|Ultra Hard|table}}
  
⚫
{{Chlg|Pong|table}}
  
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}}
  
−  
−  
−
{{ChallengeNav}}
  
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{{MasterNav}}
  
⚫
[[fr:Challenges]]
  

Revision as of 06:01, 30 May 2021

Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed. Players, with the advent of modding, have created their own Custom Challenges too.

General Strategy

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like Computer Savvy are quite easy to beat. Some challenges do compensate for this by being especially punishing; Solar System is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
    • (in Repentance) If other players join the game in the first room for true co-op, they will not get to select a character and will be forced to play as the character the challenge has you play as, ex. for Blue Bomber, all players will be forced to play as Character ??? (Character) icon??? no matter what. (This excludes untrue co-op because of co-op babies.)
  • Due to the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
    • Some rooms (including Crawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, trinkets and items that generate more coins, along with upgraded Shops, can help Isaac acquire a greater range of powerful items.
  • Collectible The Bible iconThe Bible instantly kills Mom and Mom's Heart / It Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
    • Collectible Pandora's Box iconPandora's Box will spawn The Bible if used in Womb II, Utero II, or (except in Rebirth) Scarred Womb II, making it a reliable way to acquire The Bible.
  • Curse Rooms can spawn items, making them valuable.
  • (in Rebirth) In some challenges, Dice Rooms and the Collectible D4 iconD4 are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • (in Afterbirth † and Repentance)Butter!Butter! can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like Collectible Daddy Longlegs iconDaddy Longlegs, Collectible Lil Brimstone iconLil Brimstone, and (except in Rebirth)Collectible Incubus iconIncubus are therefore highly useful items.
    • Collectible The Boomerang iconThe Boomerang, Collectible The Candle iconThe Candle, and Collectible Red Candle iconRed Candle are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • (in Afterbirth † and Repentance)Collectible Clicker iconClicker can allow Isaac to change into (except in Rebirth) Character Lilith iconLilith, whose (except in Rebirth)Collectible Incubus iconIncubus overrides the blindfolded effect by default.
    • Some spacebar items like Collectible Tammy's Head iconTammy's Head can be really helpful, providing an alternative method of dealing damage.
  • (except in Rebirth)Collectible Chaos iconChaos is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still spawn the trophy.
    • (except in Rebirth) In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice Room until it teleports Isaac to the Dark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating The Lamb.
      • (in Afterbirth † and Repentance) In a similar vein, all runs can be completed by killing Delirium, meaning that the player can beat a challenge through an alternative method such as defeating Hush then traveling to The Void; however, this is generally extremely difficult given the restrictions challenges place on the player.

Notes

  • Apart from the achievement related to beating the challenge, all achievements are locked. Also, no Donation Machines will appear in any challenge.
  • The challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited.
  • Isaac will not start any challenge with Collectible The D6 iconThe D6.

Challenges List

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Character Isaac appearance
Full red heartFull red heartFull red heart 		Curse of DarknessCurse of Darkness
Curse of the UnknownCurse of the Unknown 		Item Pool Treasure Room: yes
Item Pool Shop: no
Boss Mom portrait Default Rune of Hagalaz Rune of Hagalaz
2. High Brow
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Number One iconNumber One
Collectible E. Coli iconE. Coli
Collectible Butt Bombs iconButt Bombs
Collectible Flush! iconFlush!
Petrified PoopPetrified Poop 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Rune of Jera Rune of Jera
3. Head Trauma
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Tiny Planet iconTiny Planet
Collectible Soy Milk iconSoy Milk
Collectible The Small Rock iconThe Small Rock
Collectible Iron Bar iconIron Bar 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Rune of Ehwaz Rune of Ehwaz
4. Darkness Falls
Character Eve appearance
Full red heartFull red heart 		Starts with:
Collectible Pentagram iconPentagram
Collectible Dead Bird iconDead Bird
Collectible Whore of Babylon iconWhore of Babylon
Collectible Razor Blade iconRazor Blade
Collectible Sacrificial Dagger iconSacrificial Dagger
Collectible Dark Matter iconDark Matter 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Darkness Falls (except in Repentance) Defeat Mom's Heart 11 times and unlock Character Eve iconEve
(in Repentance) Defeat Mom's Heart 11 times and defeat ??? as Character Eve iconEve 		Rune of Dagaz Rune of Dagaz
5. The Tank
58
Full red heartFull red heartFull red heartFull red heart 		Starts with:
Collectible Infamy iconInfamy
Collectible Bucket of Lard iconBucket of Lard
Collectible Thunder Thighs iconThunder Thighs
Collectible Yum Heart iconYum Heart 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait The Tank Have 7 or more Red Heart Containers at one time Rune of Ansuz Rune of Ansuz
6. Solar System
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded 		Starts with:
Collectible Distant Admiration iconDistant Admiration
Collectible Forever alone iconForever alone
Collectible Halo of Flies iconHalo of Flies
Collectible Transcendence iconTranscendence 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom's Heart portrait Solar System Defeat Mom's Heart 3 times Rune of Perthro Rune of Perthro
7. Suicide King
43
Full red heartFull red heartFull red heart 		Starts with:
Collectible Ipecac iconIpecac
Collectible Mr. Mega iconMr. Mega
Collectible My Reflection iconMy Reflection
1 random pill 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Isaac portrait Suicide King Defeat Mom's Heart 11 times and unlock Character Lazarus iconLazarus Suicide King Suicide King
8. Cat Got Your Tongue
Character Isaac appearance
Full red heartFull red heartFull red heartFull black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded 		Starts with:
Collectible Guppy's Hairball iconGuppy's Hairball
Collectible Guppy's Head iconGuppy's Head
Collectible Guppy's Tail iconGuppy's Tail 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Cat Got Your Tongue Become Guppy Rune of Algiz Rune of Algiz
9. Demo Man
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Dr. Fetus iconDr. Fetus
Collectible Remote Detonator iconRemote Detonator
Match StickMatch Stick 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom's Heart portrait Demo Man Defeat Mom's Heart 9 times Chaos Card Chaos Card
10. Cursed!
58
Full red heartFull red heartFull red heartFull red heart 		Starts with:
Collectible Blue Map iconBlue Map
Collectible The Compass iconThe Compass
Collectible Raw Liver iconRaw Liver
Collectible Treasure Map iconTreasure Map
Collectible Yum Heart iconYum Heart
Child's HeartChild's Heart
Curse of the CursedCurse of the Cursed 		Item Pool Treasure Room: yes
Item Pool Shop: yes
Boss Mom portrait Cursed! Have 7 or more Red Heart Containers at one time Credit Card Credit Card
11. Glass Cannon
Character Judas appearance
Full red heart 		Starts with:
Collectible Epic Fetus iconEpic Fetus
Collectible Loki's Horns iconLoki's Horns 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Glass Cannon Beat The Family Man (challenge #19), defeat Lokii, and unlock Character Judas iconJudas Rules Card Rules Card
12. When Life Gives You Lemons
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible 9 Volt icon9 Volt
Collectible Habit iconHabit
Collectible Lemon Mishap iconLemon Mishap
1 Lemon Party pill 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Card Against Humanity Card Against Humanity
13. Beans!
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded 		Starts with:
Collectible 9 Volt icon9 Volt
Collectible The Bean iconThe Bean
Collectible The Black Bean iconThe Black Bean
Collectible Butt Bombs iconButt Bombs
Collectible Pyro iconPyro 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Burnt Penny Burnt Penny
14. It's in the Cards
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible 9 Volt icon9 Volt
Collectible The Battery iconThe Battery
Collectible Deck of Cards iconDeck of Cards
Collectible Starter Deck iconStarter Deck
2 random tarot cards 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default SMB Super Fan SMB Super Fan
15. Slow Roll
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Cupid's Arrow iconCupid's Arrow
Collectible My Reflection iconMy Reflection
Collectible Polyphemus iconPolyphemus 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Swallowed Penny Swallowed Penny
16. Computer Savvy
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Spoon Bender iconSpoon Bender
Collectible Technology iconTechnology
Collectible Technology 2 iconTechnology 2 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Robo-Baby 2 Robo-Baby 2.0
17. Waka Waka
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Anti-Gravity iconAnti-Gravity
Collectible Strange Attractor iconStrange Attractor 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Death's Touch Death's Touch
18. The Host
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible The Mulligan iconThe Mulligan
Collectible Spiderbaby iconSpiderbaby
TickTick 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Technology Technology .5
19. The Family Man
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded 		Starts with:
Collectible BFFS! iconBFFS!
Collectible Brother Bobby iconBrother Bobby
Collectible Dad's Key iconDad's Key
Collectible Rotten Baby iconRotten Baby
Collectible Sister Maggy iconSister Maggy 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Isaac portrait The Family Man Pick up both Key Pieces from the Angels in one run Epic Fetus Epic Fetus
20. Purist
Character Isaac appearance
Full red heartFull red heartFull red heart 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom's Heart portrait Purist Defeat Mom Rune of Berkano Rune of Berkano
(except in Rebirth) 21. XXXXXXXXL
Character Isaac appearance
Full red heartFull red heartFull red heart 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		Every floor is the size of an XL WombWomb floor, but does not combine the floors of each chapter.
Boss Mom's Heart portrait XXXXXXXXL Defeat Mom Gold Heart Gold Heart
(except in Rebirth) 22. SPEED!
Character Isaac appearance
Full red heartFull red heartFull red heart 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		Everything is sped up like the Collectible Broken Watch iconBroken Watch effect. After the game timer reaches 16 minutes, Isaac starts taking damage every 10 seconds.
Boss Mom's Heart portrait SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
(except in Rebirth) 23. Blue Bomber
Character ??? appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded 		Starts with:
Collectible Brother Bobby iconBrother Bobby
Collectible Kamikaze! iconKamikaze!
Collectible Pyromaniac iconPyromaniac
Collectible Mr. Mega iconMr. Mega 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
(except in Rebirth) 24. PAY TO PLAY
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Money = Power iconMoney = Power
Collectible Sack of Pennies iconSack of Pennies
50 coins 		Item Pool Treasure Room: no
Item Pool Shop: yes 		Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Boss Isaac portrait PAY TO PLAY Defeat Isaac as Character Cain iconCain and destroy 10 Tinted Rocks 2 new pills 2 new pills
(except in Rebirth) 25. Have a Heart
Character Isaac appearance
Full red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Empty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart 		Starts with:
Collectible Charm of the Vampire iconCharm of the Vampire 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		PennyPennies drop instead of Red HeartRed Hearts. Many items that restore Red HeartRed Hearts have no effect.
Boss Mom's Heart portrait Have a Heart Defeat Mom 2 new pills 2 new pills
(except in Rebirth) 26. I RULE!
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible The Boomerang iconThe Boomerang
Collectible Key Piece 1 iconKey Piece 1
Collectible Key Piece 2 iconKey Piece 2
Collectible The Ladder iconThe Ladder
Collectible Mom's Knife iconMom's Knife
Collectible Trinity Shield iconTrinity Shield 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mega Satan portrait I RULE! (in Rebirth and Afterbirth) Defeat ??? or The Lamb, defeat Satan as Character Isaac iconIsaac, and unlock Collectible The Negative iconThe Negative
(in Afterbirth †) Defeat ??? or The Lamb, and defeat Satan as Character Isaac iconIsaac
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative 		Poker Chip Poker Chip
(except in Rebirth) 27. BRAINS!
Character ??? appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded 		Starts with:
3 Collectible Bob's Brain iconBob's Brain
Collectible Thunder Thighs iconThunder Thighs 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss ??? portrait BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
(except in Rebirth) 28. PRIDE DAY!
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible 3 Dollar Bill icon3 Dollar Bill
Collectible Rainbow Baby iconRainbow Baby
Rainbow WormRainbow Worm 		Item Pool Treasure Room: no
Item Pool Shop: yes 		Cannot drop or replace Rainbow WormRainbow Worm.
Boss Mom's Heart portrait PRIDE DAY! Defeat Mom D8 D8
(except in Rebirth) 29. Onan's Streak
Character Judas appearance
Full red heart 		Starts with:
Collectible The Book of Belial iconThe Book of Belial
Collectible Chocolate Milk iconChocolate Milk 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		Missing a shot deals damage to Character Judas iconJudas.
Boss Isaac portrait Onan's Streak (in Afterbirth and Afterbirth †) Defeat Boss Mom ingameMom
(in Repentance) Unlock Character Judas iconJudas and Boss It Lives ingameIt Lives. 		Kidney Stone Kidney Stone
(except in Rebirth) 30. The Guardian
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded 		Starts with:
Collectible Holy Grail iconHoly Grail
Collectible Isaac's Heart iconIsaac's Heart
Collectible Punching Bag iconPunching Bag
Collectible Spear Of Destiny iconSpear Of Destiny 		Item Pool Treasure Room: no
Item Pool Shop: yes 		Collectible Isaac's Heart iconIsaac's Heart will follow Collectible Punching Bag iconPunching Bag instead of Isaac.
Boss Mom's Heart portrait The Guardian Defeat Mom Blank Rune Blank Rune
(in Afterbirth † and Repentance) 31. Backasswards
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
8-10 random items 		Item Pool Treasure Room: no
Item Pool Shop: yes 		All chapters progress in reverse order, losing 1 item and 1 Red Heart container each floor ascended.
BasementBasement/CellarCellar/Burning BasementBurning Basement I Backasswards (except in Repentance) Defeat ??? or The Lamb
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative 		Laz Bleeds More! Laz Bleeds More!
(in Afterbirth † and Repentance) 32. Aprils Fool
Character Isaac appearance
Full red heartFull red heartFull red heart 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		The minimap displays the floor's layout accurately but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide KingSuicide King). Items with no charge time (i.e. Collectible How to Jump iconHow to Jump, Collectible IV Bag iconIV Bag, etc) can be used repeatedly for random effects. StoneyStonies have a chance of being replaced by a Cross StoneyCross Stoney. Every boss is Boss The Bloat ingameThe Bloat. Isaac's health is not what it appears to be. Inventory pickups numbers are accurate.
Boss Mom's Heart portrait Aprils fool Defeat Mom Maggy Now Holds a Pill! Maggy Now Holds a Pill!
(in Afterbirth † and Repentance) 33. Pokey Mans
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Friendly Ball iconFriendly Ball
Collectible Mom's Eyeshadow iconMom's Eyeshadow 		Item Pool Treasure Room: no
Item Pool Shop: yes 		Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Boss Isaac portrait Pokey Mans Defeat Mom's Heart 11 times Charged Key Charged Key
(in Afterbirth † and Repentance) 34. Ultra Hard
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Key Piece 1 iconKey Piece 1
Collectible Key Piece 2 iconKey Piece 2
Curse of the LabyrinthCurse of the Labyrinth
Curse of the BlindCurse of the Blind
Curse of the LostCurse of the Lost
Curse of the MazeCurse of the Maze 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan portrait Ultra Hard (except in Repentance) Defeat ??? or The Lamb. Possession of Collectible The Polaroid iconThe Polaroid / Collectible The Negative iconThe Negative is required, barring getting to Dark RoomDark Room through a Sacrifice RoomSacrifice Room.
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative 		Samson Feels Healthy! Samson Feels Healthy!
(in Afterbirth † and Repentance) 35. Pong
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Cupid's Arrow iconCupid's Arrow
Collectible Rubber Cement iconRubber Cement 		Item Pool Treasure Room: no
Item Pool Shop: yes 		Damage fixed at 100, tear delay fixed at 150.
Boss ??? portrait PONG Defeat Isaac 5 times Greed's Gullet Greed's Gullet
(in Repentance) 36. Scat Man
Character Isaac appearance
Full red heartFull red heartFull red heartFull red heart
BlindfoldedBlindfolded 		Starts with:
Collectible The Poop iconThe Poop
Collectible 9 Volt icon9 Volt
Collectible Skatole iconSkatole
Collectible E. Coli iconE. Coli
3 Collectible Butt Bombs iconButt Bombs
Collectible BFFS! iconBFFS!
Collectible Thunder Thighs iconThunder Thighs
Collectible Dirty Mind iconDirty Mind
Mysterious CandyMysterious Candy 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Dirty Mind Dirty Mind
(in Repentance) 37. Bloody Mary
Character Bethany appearance
Full red heartFull red heartFull red heartFull red heart 		Starts with:
Collectible The Book of Belial iconThe Book of Belial
Collectible Blood Bag iconBlood Bag
Collectible Anemic iconAnemic
Collectible Blood Oath iconBlood Oath
Child's HeartChild's Heart

4 soul charges 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Bloody Mary Unlock Character Bethany iconBethany, Collectible Blood Bag iconBlood Bag, and It Lives! Sigil of Baphomet Sigil of Baphomet
(in Repentance) 38. Baptism by Fire
Character Bethany appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded 		Starts with:
Collectible Urn of Souls iconUrn of Souls
Collectible Schoolbag iconSchoolbag
Collectible Guppy's Paw iconGuppy's Paw
Maggy's FaithMaggy's Faith 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Isaac portrait Baptism by Fire Defeat Satan as Character Bethany iconBethany, defeat Mom's Heart 11 times, and unlock Maggy's FaithMaggy's Faith Purgatory Purgatory
(in Repentance) 39. Isaac's Awakening
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Spirit Sword iconSpirit Sword
Collectible Trinity Shield iconTrinity Shield
Collectible Mom's Bracelet iconMom's Bracelet 		Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mother portrait Isaac's Awakening Defeat Mother Spirit Sword Spirit Sword
(in Repentance) 40. Seeing Double
Character Jacob appearance
Full red heartFull red heartFull red heartFull red heartFull soul heart 		Starts with:
Jacob: Collectible 20 20 icon20/20
Esau: Collectible 20 20 icon20/20
Collectible X-Ray Vision iconX-Ray Vision 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		All enemies and bosses are doubled.
Boss Mom's Heart portrait Seeing Double Defeat Mother Broken Glasses Broken Glasses
(in Repentance) 41. Pica Run
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Mom's Box iconMom's Box
Collectible Marbles iconMarbles
Collectible Mom's Purse iconMom's Purse 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		All items are replaced by random trinkets.

Collectible Marbles iconMarbles activates on every hit.

Boss Isaac portrait Pica Run Defeat Mom's Heart 11 times and unlock Collectible Marbles iconMarbles Ice Cube Ice Cube
(in Repentance) 42. Hot Potato
Character Tainted Forgotten appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded 		Item Pool Treasure Room: no
Item Pool Shop: yes 		The Forgotten cannot fire tears and explodes every 2.5 seconds. Explosion timer resets upon entering a room or picking up an item.
Boss Satan portrait The Fettered Use Collectible Red Key iconRed Key (etc.) to open the hidden closet in (in Repentance)HomeHome as Character The Forgotten iconThe Forgotten The Chariot The Chariot
(in Repentance) 43. Cantripped!
Character Tainted Cain appearance
Full red heartFull red heart 		Item Pool Treasure Room: no
Item Pool Shop: yes 		All cards and pills are replaced with item cards. Enemies also have a chance of dropping an item card when killed. The Collectible Bag of Crafting iconBag of Crafting now initially holds a maximum of 3 item cards at once. When picked up, each item card shows a preview of a random Active Item that, when used, activates the effect.

All boss item drops are replaced with Collectible Starter Deck iconStarter Deck, which increases the max card limit by 1 and drops 3 item cards.

Boss Mom portrait The Hoarder Use Collectible Red Key iconRed Key (etc.) to open the hidden closet in (in Repentance)HomeHome as Character Cain iconCain Justice Justice
(in Repentance) 44. Red Redemption
Character Tainted Jacob appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible Dad's Key iconDad's Key
Collectible Red Key iconRed Key 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		The starting room spawns with no rooms connected to it. Rooms spawn in clusters around the map and must be found via the Collectible Red Key iconRed Key. While the Red Key can be used an infinite number of times, it has 20 uses before Dark EsauDark Esau spawns. Each subsequent 5 uses will spawn another Dark Esau if Character Tainted Jacob iconTainted Jacob has yet to turn into his lost form. The Red Key cannot be used to open doors to I AM ERRORI AM ERROR rooms.

Each floor generates as a Curse of the LabyrinthCurse of the Labyrinth floor, with one shop, and two item and boss rooms, except the fourth floor, which has only one boss room. All rooms may be from any floor of the current chapter.

Boss Mother portrait The Deserter Use Collectible Red Key iconRed Key (etc.) to open the hidden closet in (in Repentance)HomeHome as Character Jacob and Esau iconJacob and Esau The Hermit The Hermit
(in Repentance) 45. DELETE THIS
Character Isaac appearance
Full red heartFull red heartFull red heart 		Starts with:
Collectible TMTRAINER iconTMTRAINER 		Item Pool Treasure Room: yes
Item Pool Shop: yes 		All items are randomly generated due to Collectible TMTRAINER iconTMTRAINER. The theme of each area, its obstacles per area, and music are randomized. Some obstacle sprites are randomized even within a level and sometimes the music may be missing altogether. Occasionally, even the floor texture might glitch out, replacing it with a plain color. Shop item prices range from 1 cent to 99.

The challenge itself appears under the challenge list without any text, effectively rendering it invisible.

Boss ??? portrait DELETE THIS Unlock Character Tainted Eden iconTainted Eden Temperance Temperance


MainPageChallenges Challenges MainPageChallenges
Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank
6. Solar System 7. Suicide King 8. Cat Got Your Tongue 9. Demo Man 10. Cursed!
11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards 15. Slow Roll
16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart
26. I RULE! 27. BRAINS! 28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
Repentance
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double
41. Pica Run 42. Hot Potato 43. Cantripped! 44. Red Redemption 45. DELETE THIS
SmallIsaacThe Binding of Isaac: RebirthSmallIsaac
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