Binding of Isaac: Rebirth Wiki
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Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure Room Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed. Players, with the advent of modding, have created their own Custom Challenges too.

General Strategy

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like Computer Savvy are quite easy to beat. Some challenges do compensate for this by being especially punishing; Solar System is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
    • Added in Repentance If other players join the game in the first room for true co-op, they will not get to select a character and will be forced to play as the character the challenge has you play as, ex. for Blue Bomber, all players will be forced to play as ??? ??? no matter what. (This excludes untrue co-op because of co-op babies.)
  • Due to the lack of Treasure Room Treasure Rooms, Devil Room Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
    • Some rooms (including Crawl Space Crawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, trinkets and items that generate more coins, along with upgraded Shop Shops, can help Isaac acquire a greater range of powerful items.
  • The Bible The Bible instantly kills Mom Mom and Mom's Heart Mom's Heart / It Lives It Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
  • Curse Room Curse Rooms can spawn items, making them valuable.
  • Removed in Afterbirth In some challenges, Dice Room Dice Rooms and the D4 D4 are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • Added in Afterbirth †Butter! Butter! can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like Daddy Longlegs Daddy Longlegs, Lil Brimstone Lil Brimstone, and Added in AfterbirthIncubus Incubus are therefore highly useful items.
    • The Boomerang The Boomerang, The Candle The Candle, and Red Candle Red Candle are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • Removed in RepentanceClicker Clicker can allow Isaac to change into Added in Afterbirth Lilith Lilith, whose Added in AfterbirthIncubus Incubus overrides the blindfolded effect by default.
    • Some active items like Tammy's Head Tammy's Head can be really helpful, providing an alternative method of dealing damage.
  • Added in AfterbirthChaos Chaos is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart Mom's Heart when the goal is to defeat Mom Mom) will still spawn the trophy.
    • Added in Afterbirth / Removed in Repentance In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice Room Sacrifice Room until it teleports Isaac to the Dark Room Dark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating The Lamb The Lamb.
      • Added in Afterbirth † / Removed in Repentance In a similar vein, all runs can be completed by killing , meaning that the player can beat a challenge through an alternative method such as defeating Added in Afterbirth Hush Hush then traveling to The Void The Void; however, this is generally extremely difficult given the restrictions challenges place on the player.

Notes

Challenges List

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Curse of Darkness.png Curse of Darkness
Curse of the Unknown.png Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom portrait.png Default Rune of Hagalaz Rune of Hagalaz
2. High Brow
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Number One Number One
E. Coli E. Coli
Butt Bombs Butt Bombs
Flush! Flush!
Petrified Poop Petrified Poop
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Rune of Jera Rune of Jera
3. Head Trauma
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Tiny Planet Tiny Planet
Soy Milk Soy Milk
The Small Rock The Small Rock
Iron Bar Iron Bar
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Rune of Ehwaz Rune of Ehwaz
4. Darkness Falls
Character Eve appearance.png
Full red heartFull red heart
Starts with:
Pentagram Pentagram
Dead Bird Dead Bird
Whore of Babylon Whore of Babylon
Razor Blade Razor Blade
Sacrificial Dagger Sacrificial Dagger
Dark Matter Dark Matter
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan portrait.png Darkness Falls Removed in Repentance Defeat Mom's Heart 11 times
Added in Repentance Defeat Satan and ??? as Eve Eve
Rune of Dagaz Rune of Dagaz
5. The Tank
58.5px
Full red heartFull red heartFull red heartFull red heart
Starts with:
Infamy Infamy
Bucket of Lard Bucket of Lard
Thunder Thighs Thunder Thighs
Yum Heart Yum Heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png The Tank Have 7 or more Red Heart Containers at one time Rune of Ansuz Rune of Ansuz
6. Solar System
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Distant Admiration Distant Admiration
Forever Alone Forever Alone
Halo of Flies Halo of Flies
Transcendence Transcendence
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart portrait.png Solar System Defeat Mom's Heart 3 times Rune of Perthro Rune of Perthro
7. Suicide King
43.5px
Full red heartFull red heartFull red heart
Starts with:
Ipecac Ipecac
Mr. Mega Mr. Mega
My Reflection My Reflection
1 random pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Isaac portrait.png Suicide King Defeat Mom's Heart 11 times Suicide King Suicide King
8. Cat Got Your Tongue
Character Isaac appearance.png
Full red heartFull red heartFull red heartFull black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Guppy's Hair Ball Guppy's Hair Ball
Guppy's Head Guppy's Head
Guppy's Tail Guppy's Tail
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Cat Got Your Tongue Become Guppy Rune of Algiz Rune of Algiz
9. Demo Man
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Dr. Fetus Dr. Fetus
Remote Detonator Remote Detonator
Match Stick Match Stick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart portrait.png Demo Man Defeat Mom's Heart 9 times Chaos Card Chaos Card
10. Cursed!
58.5px
Full red heartFull red heartFull red heartFull red heart
Starts with:
Blue Map Blue Map
The Compass The Compass
Raw Liver Raw Liver
Treasure Map Treasure Map
Yum Heart Yum Heart
Child's Heart Child's Heart
Curse of the Cursed.png Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom portrait.png Cursed! Have 7 or more Red Heart Containers at one time Credit Card Credit Card
11. Glass Cannon
Character Judas appearance.png
Full red heart
Starts with:
Epic Fetus Epic Fetus
Loki's Horns Loki's Horns
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan portrait.png Glass Cannon Beat The Family Man (challenge #19) and defeat Lokii Rules Card Rules Card
12. When Life Gives You Lemons
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt
Habit Habit
Lemon Mishap Lemon Mishap
1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Card Against Humanity Card Against Humanity
13. Beans!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
9 Volt 9 Volt
The Bean The Bean
The Black Bean The Black Bean
Butt Bombs Butt Bombs
Pyro Pyro
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Burnt Penny Burnt Penny
14. It's in the Cards
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt
The Battery The Battery
Deck of Cards Deck of Cards
Starter Deck Starter Deck
2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default SMB Super Fan SMB Super Fan
15. Slow Roll
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's Arrow
My Reflection My Reflection
Polyphemus Polyphemus
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Swallowed Penny Swallowed Penny
16. Computer Savvy
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Spoon Bender Spoon Bender
Technology Technology
Technology 2 Technology 2
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Robo-Baby 2.0 Robo-Baby 2.0
17. Waka Waka
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Anti-Gravity Anti-Gravity
Strange Attractor Strange Attractor
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Death's Touch Death's Touch
18. The Host
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
The Mulligan The Mulligan
Spiderbaby Spiderbaby
Tick Tick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Technology .5 Technology .5
19. The Family Man
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
BFFS! BFFS!
Brother Bobby Brother Bobby
Dad's Key Dad's Key
Rotten Baby Rotten Baby
Sister Maggy Sister Maggy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Isaac portrait.png The Family Man Pick up both Key Pieces from the Angels in one run Epic Fetus Epic Fetus
20. Purist
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart portrait.png Purist Defeat Mom Rune of Berkano Rune of Berkano
Added in Afterbirth 21. XXXXXXXXL
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart portrait.png XXXXXXXXL Defeat Mom Gold Heart Gold Heart
Added in Afterbirth 22. SPEED!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch Broken Watch effect. After the game timer reaches 16 minutes, Isaac starts taking damage every 10 seconds.
Boss Mom's Heart portrait.png SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
Added in Afterbirth 23. Blue Bomber
Character ??? appearance.png
Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Brother Bobby Brother Bobby
Kamikaze! Kamikaze!
Pyromaniac Pyromaniac
Mr. Mega Mr. Mega
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan portrait.png Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
Added in Afterbirth 24. PAY TO PLAY
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Money = Power Money = Power
Sack of Pennies Sack of Pennies
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Boss Isaac portrait.png PAY TO PLAY Defeat Isaac as Cain Cain 2 new pills 2 new pills
Added in Afterbirth 25. Have a Heart
Character Isaac appearance.png
Full red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Empty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Starts with:
Charm of the Vampire Charm of the Vampire
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Penny Pennies drop instead of Red Heart Red Hearts. Many items that restore Red Heart Red Hearts have no effect.
Boss Mom's Heart portrait.png Have a Heart Defeat Mom 2 new pills 2 new pills
Added in Afterbirth 26. I RULE!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
The Boomerang The Boomerang
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
The Ladder The Ladder
Mom's Knife Mom's Knife
Trinity Shield Trinity Shield
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan portrait.png I RULE! Removed in Repentance Defeat ??? or The Lamb, and defeat Satan as Isaac Isaac
Added in Repentance Defeat Mega Satan
Poker Chip Poker Chip
Added in Afterbirth 27. BRAINS!
Character ??? appearance.png
Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
3 Bob's Brain Bob's Brain
Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss ??? portrait.png BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
Added in Afterbirth 28. PRIDE DAY!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
3 Dollar Bill 3 Dollar Bill
Rainbow Baby Rainbow Baby
Rainbow Worm Rainbow Worm
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm Rainbow Worm.
Boss Mom's Heart portrait.png PRIDE DAY! Defeat Mom D8 D8
Added in Afterbirth 29. Onan's Streak
Character Judas appearance.png
Full red heart
Starts with:
The Book of Belial The Book of Belial
Chocolate Milk Chocolate Milk
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas Judas.
Boss Isaac portrait.png Onan's Streak Added in Afterbirth / Removed in Repentance Defeat Mom Mom
Added in Repentance Unlock Judas Judas and It Lives It Lives.
Kidney Stone Kidney Stone
Added in Afterbirth 30. The Guardian
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Holy Grail Holy Grail
Isaac's Heart Isaac's Heart
Punching Bag Punching Bag
Spear of Destiny Spear of Destiny
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart Isaac's Heart will follow Punching Bag Punching Bag instead of Isaac.
Boss Mom's Heart portrait.png The Guardian Defeat Mom Blank Rune Blank Rune
Added in Afterbirth † 31. Backasswards
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All chapters progress in reverse order, losing 1 item and 1 Red Heart container each floor ascended.
Basement Basement/Cellar Cellar/Burning Basement Burning Basement I Backasswards Removed in Repentance Defeat ??? or The Lamb
Added in Repentance Defeat Mega Satan
Laz Bleeds More! Laz Bleeds More!
Added in Afterbirth † 32. Aprils Fool
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King Suicide King). Items with no charge time (i.e. How to Jump How to Jump, IV Bag IV Bag, etc) can be used repeatedly for random effects. Added in Afterbirth † Stoney Stonies have a chance of being replaced by a Added in Afterbirth † Cross Stoney Cross Stoney. Every boss is The Bloat The Bloat. Isaac's health is not what it appears to be. Key Key and Bomb Bomb numbers are accurate.
Boss Mom's Heart portrait.png Aprils fool Defeat Mom Maggy Now Holds a Pill! Maggy Now Holds a Pill!
Added in Afterbirth † 33. Pokey Mans
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Friendly Ball Friendly Ball
Mom's Eyeshadow Mom's Eyeshadow
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Boss Isaac portrait.png Pokey Mans Defeat Mom's Heart 11 times Charged Key Charged Key
Added in Afterbirth † 34. Ultra Hard
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
Curse of the Labyrinth.png Curse of the Labyrinth
Curse of the Blind.png Curse of the Blind
Curse of the Lost.png Curse of the Lost
Curse of the Maze.png Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan portrait.png Ultra Hard Removed in Repentance Defeat ??? or The Lamb. Possession of The Polaroid The Polaroid / The Negative The Negative is required, barring getting to Dark Room Dark Room through a Sacrifice Room Sacrifice Room.
Added in Repentance Defeat Mega Satan
Samson Feels Healthy! Samson Feels Healthy!
Added in Afterbirth † 35. Pong
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's Arrow
Rubber Cement Rubber Cement
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
Boss ??? portrait.png PONG Defeat Isaac 5 times Greed's Gullet Greed's Gullet
Added in Repentance 36. Scat Man
Character Isaac appearance.png
Full red heartFull red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
The Poop The Poop
9 Volt 9 Volt
Skatole Skatole
E. Coli E. Coli
3 Butt Bombs Butt Bombs
BFFS! BFFS!
Thunder Thighs Thunder Thighs
Dirty Mind Dirty Mind
Mysterious Candy Mysterious Candy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom portrait.png Default Dirty Mind Dirty Mind
Added in Repentance 37. Bloody Mary
Character Bethany appearance.png
Full red heartFull red heartFull red heartFull red heart
Starts with:
The Book of Belial The Book of Belial
Blood Bag Blood Bag
Anemic Anemic
Blood Oath Blood Oath
Child's Heart Child's Heart

4 soul charges
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan portrait.png Bloody Mary Unlock Bethany Bethany, Blood Bag Blood Bag, and It Lives! Sigil of Baphomet Sigil of Baphomet
Added in Repentance 38. Baptism by Fire
Character Bethany appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Added in RepentanceUrn of Souls Urn of Souls
Added in Afterbirth †Schoolbag Schoolbag
Guppy's Paw Guppy's Paw
Maggy's Faith Maggy's Faith
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Isaac portrait.png Baptism by Fire Defeat Satan as Bethany Bethany, defeat Mom's Heart 11 times, and unlock Maggy's Faith Maggy's Faith Purgatory Purgatory
Added in Repentance 39. Isaac's Awakening
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Added in RepentanceSpirit Sword Spirit Sword
Trinity Shield Trinity Shield
Added in RepentanceMom's Bracelet Mom's Bracelet
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mother portrait.png Isaac's Awakening Defeat Mother Spirit Sword Spirit Sword
Added in Repentance 40. Seeing Double
Character Jacob appearance.png
Full red heartFull red heartFull red heartFull red heartFull soul heart
Starts with:
Jacob: 20/20 20/20
Esau: 20/20 20/20
X-Ray Vision X-Ray Vision
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies and bosses are doubled.
Boss Mom's Heart portrait.png Seeing Double Defeat Mother Broken Glasses Broken Glasses
Added in Repentance 41. Pica Run
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Added in AfterbirthMom's Box Mom's Box
Added in Afterbirth †Marbles Marbles
Mom's Purse Mom's Purse
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All item pedestals are replaced by random trinkets.

Added in Afterbirth †Marbles Marbles activates on every hit.

Boss Isaac portrait.png Pica Run Defeat Mom's Heart 11 times and unlock Marbles Marbles Ice Cube Ice Cube
Added in Repentance 42. Hot Potato
Character Tainted Forgotten appearance.png
Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
The Forgotten cannot fire tears and explodes every 2.5 seconds. Explosion timer resets upon entering a room or picking up an item.
Boss Satan portrait.png The Fettered Use Red Key Red Key (etc.) to open the hidden closet in Home Home as The Forgotten The Forgotten The Chariot The Chariot
Added in Repentance 43. Cantripped!
Character Tainted Cain appearance.png
Full red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All cards and pills are replaced with item cards. Enemies also have a chance of dropping an item card when killed. The Added in RepentanceBag of Crafting Bag of Crafting now initially holds a maximum of 3 item cards at once. When picked up, each item card shows a preview of a random item that, when used, either activates the effect once or for the rest of the room, depending on whether the item is active or passive respectively.

All boss item drops are replaced with Starter Deck Starter Deck, which increases the max card limit by 1 and drops 3 item cards.

Boss Mom portrait.png The Hoarder Use Red Key Red Key (etc.) to open the hidden closet in Home Home as Cain Cain Justice Justice
Added in Repentance 44. Red Redemption
Character Tainted Jacob appearance.png
Full red heartFull red heartFull red heart
Starts with:
Dad's Key Dad's Key
Added in RepentanceRed Key Red Key
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The starting room spawns with no rooms connected to it. Rooms spawn in clusters around the map and must be found via the Added in RepentanceRed Key Red Key. While the Red Key can be used an infinite number of times, it has 20 uses before Added in Repentance Dark Esau Dark Esau spawns. Each subsequent 5 uses will spawn another Dark Esau if Tainted Jacob Tainted Jacob has yet to turn into his lost form. The Red Key cannot be used to open doors to I AM ERROR I AM ERROR rooms.

Each floor generates as a Curse of the Labyrinth.png Curse of the Labyrinth floor, with one shop, and two item and boss rooms, except the fourth floor, which has only one boss room. All rooms may be from any floor of the current chapter.

Boss Mother portrait.png The Deserter Use Red Key Red Key (etc.) to open the hidden closet in Home Home as Jacob and Esau Jacob and Esau The Hermit The Hermit
Added in Repentance 45. DELETE THIS
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Added in RepentanceTMTRAINER TMTRAINER
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All items are randomly generated due to Added in RepentanceTMTRAINER TMTRAINER. The theme of each area, its obstacles per area, and music are randomized. Some obstacle sprites are randomized even within a level and sometimes the music may be missing altogether. Occasionally, even the floor texture might glitch out, replacing it with a plain color. Shop item prices range from 1 cent to 99.

The challenge itself appears under the challenge list without any text, effectively rendering it invisible.

Boss ??? portrait.png DELETE THIS Unlock Tainted Eden Tainted Eden Temperance Temperance


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