Challenges

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Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which make normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed.

General Strategy

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like Computer Savvy are quite easy to beat. Some challenges do compensate for this by being especially punishing; Solar System is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
  • Due to the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
    • Some rooms (including Crawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, trinkets and items that generate more coins, along with upgraded Shops, can help Isaac acquire a greater range of powerful items.
  • 15►The Bible The Bible instantly kills Mom and Mom's Heart / It Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
    • 15►Pandora's Box Pandora's Box will spawn The Bible if used in Womb II, Utero II, or Added in Afterbirth Scarred Womb II, making it a reliable way to acquire The Bible.
  • Curse Rooms can spawn items, making them valuable.
  • Removed in Afterbirth In some challenges, Dice Rooms and the 15►D4 D4 are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • Added in Afterbirth †Butter! Butter! can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like 15►Daddy Longlegs Daddy Longlegs, 12►Lil Brimstone▼3►Lil' Brimstone Lil Brimstone, and Added in Afterbirth15►Incubus Incubus are therefore highly useful items.
    • 15►The Boomerang The Boomerang, 15►The Candle The Candle, and 15►Red Candle Red Candle are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • Added in Afterbirth †15►Clicker Clicker can allow Isaac to change into Lilith, whose Added in Afterbirth15►Incubus Incubus overrides the blindfolded effect by default.
    • Some spacebar items like 15►Tammy's Head Tammy's Head can be really helpful, providing an alternative method of dealing damage.
  • Added in Afterbirth15►Chaos Chaos is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still spawn the trophy.
    • Added in Afterbirth In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice Room until it teleports Isaac to the Dark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating The Lamb.
      • Added in Afterbirth † In a similar vein, all runs can be completed by killing Delirium, meaning that the player can beat a challenge through an alternative method such as defeating Hush then traveling to The Void; however, this is generally extremely difficult given the restrictions challenges place on the player.

Notes

  • Apart from the achievement related to beating the challenge, all achievements are locked. Also, no Donation Machines will appear in any challenge.
  • The challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited.
  • Isaac will not start any challenge with 15►The D6 The D6.

Challenges List

Name Conditions Goal Unlocked by Unlocks


1. Pitch Black
Isaac
Full red heartFull red heartFull red heart
Curse of Darkness
Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom.png Default Rune of Hagalaz Rune of Hagalaz
2. High Brow
Isaac
Full red heartFull red heartFull red heart
Starts with:
Number One Number One
E Coli E Coli
Butt Bombs Butt Bombs
Flush! Flush!
Petrified Poop Petrified Poop
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Jera Rune of Jera
3. Head Trauma
Isaac
Full red heartFull red heartFull red heart
Starts with:
Tiny Planet Tiny Planet
Soy Milk Soy Milk
The Small Rock The Small Rock
Iron Bar Iron Bar
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Ehwaz Rune of Ehwaz
4. Darkness Falls
Eve
Full red heartFull red heart
Starts with:
15►Pentagram Pentagram
15►Dead Bird Dead Bird
15►Whore of Babylon Whore of Babylon
15►Razor Blade Razor Blade
15►Sacrificial Dagger Sacrificial Dagger
15►Dark Matter Dark Matter
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Eve's Bird Foot Defeat Isaac as Eve Eve Rune of Dagaz Rune of Dagaz
5. The Tank
Magdalene
Full red heartFull red heartFull red heartFull red heart
Starts with:
15►Infamy Infamy
15►Bucket of Lard Bucket of Lard
15►Thunder Thighs Thunder Thighs
15►Yum Heart Yum Heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Tank Have 7 or more Red Heart containers at one time Rune of Ansuz Rune of Ansuz
6. Solar System
Isaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Distant Admiration Distant Admiration
Forever Alone Forever Alone
Halo of Flies Halo of Flies
Transcendence Transcendence
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Solar System Defeat Mom's Heart 3 times Rune of Perthro Rune of Perthro
7. Suicide King
Lazarus
Full red heartFull red heartFull red heart
Starts with:
Ipecac Ipecac
Mr. Mega Mr. Mega
My Reflection My Reflection
1 random pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac Suicide King 2 Defeat Mom's Heart 11 times Suicide King Suicide King
8. Cat Got Your Tongue
Isaac
Full red heartFull red heartFull red heartFull black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
Guppy's Hair Ball Guppy's Hair Ball
Guppy's Head Guppy's Head
Guppy's Tail Guppy's Tail
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Cat Got Your Tongue Become Guppy Rune of Algiz Rune of Algiz
9. Demo Man
Isaac
Full red heartFull red heartFull red heart
Starts with:
15►Dr. Fetus Dr. Fetus
15►Remote Detonator Remote Detonator
Match Stick Match Stick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Demo Man Defeat Mom's Heart 9 times Chaos Card Chaos Card
10. Cursed!
Magdalene
Full red heartFull red heartFull red heartFull red heart
Starts with:
Blue Map Blue Map
The Compass The Compass
Raw Liver Raw Liver
Treasure Map Treasure Map
Yum Heart Yum Heart
Child's Heart Child's Heart
Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom.png Cursed! Have 7 or more Red Heart Containers at one time Credit Card Credit Card
11. Glass Cannon
Judas
Full red heart
Starts with:
Epic Fetus Epic Fetus
Loki's Horns Loki's Horns
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Glass Cannon Beat The Family Man (challenge #19) and defeat Lokii Rules Card Rules Card
12. When Life Gives You Lemons
Isaac
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt
Habit Habit
Lemon Mishap Lemon Mishap
1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Card Against Humanity Card Against Humanity
13. Beans!
Isaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
9 Volt 9 Volt
The Bean The Bean
The Black Bean The Black Bean
Butt Bombs Butt Bombs
Pyro Pyro
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Burnt Penny Burnt Penny
14. It's in the Cards
Isaac
Full red heartFull red heartFull red heart
Starts with:
9 Volt 9 Volt
The Battery The Battery
Deck of Cards Deck of Cards
Starter Deck Starter Deck
2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default SMB Super Fan SMB Super Fan
15. Slow Roll
Isaac
Full red heartFull red heartFull red heart
Starts with:
Cupid's Arrow Cupid's Arrow
My Reflection My Reflection
Polyphemus Polyphemus
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Swallowed Penny Swallowed Penny
16. Computer Savvy
Isaac
Full red heartFull red heartFull red heart
Starts with:
Spoon Bender Spoon Bender
Technology Technology
Technology 2 Technology 2
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Robo-Baby 2.0 Robo-Baby 2.0
17. Waka Waka
Isaac
Full red heartFull red heartFull red heart
Starts with:
Anti-Gravity Anti-Gravity
Strange Attractor Strange Attractor
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Death's Touch Death's Touch
18. The Host
Isaac
Full red heartFull red heartFull red heart
Starts with:
15►The Mulligan The Mulligan
15►Spiderbaby Spiderbaby
Tick Tick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Technology .5 Technology .5
19. The Family Man
Isaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
BFFS! BFFS!
Brother Bobby Brother Bobby
Dad's Key Dad's Key
Rotten Baby Rotten Baby
Sister Maggy Sister Maggy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac The Family Man Pick up both Key Pieces from the Angels in one run Epic Fetus Epic Fetus
20. Purist
Isaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Purist Defeat Mom Rune of Berkano Rune of Berkano
Added in Afterbirth 21. XXXXXXXXL
Isaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthXXXXXXXXL Defeat Mom Added in AfterbirthGold Heart Gold Heart
Added in Afterbirth 22. SPEED!
Isaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png / Boss It Lives.png
within 16 minutes, otherwise under constant periodic damage every 10 seconds.
Added in AfterbirthSPEED! Defeat Mom Added in AfterbirthGet out of Jail Free Card Get out of Jail Free Card
Added in Afterbirth 23. Blue Bomber
???
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
15►Brother Bobby Brother Bobby
15►Kamikaze! Kamikaze!
15►Pyromaniac Pyromaniac
15►Mr. Mega Mr. Mega
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Added in AfterbirthBlue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Added in AfterbirthGold Bomb Gold Bomb
Added in Afterbirth 24. PAY TO PLAY
Isaac
Full red heartFull red heartFull red heart
Starts with:
15►Money = Power Money = Power
15►Sack of Pennies Sack of Pennies
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Isaac Added in AfterbirthPAY TO PLAY Defeat Isaac as Cain Cain Added in Afterbirth2 new pills 2 new pills
Added in Afterbirth 25. Have a Heart
Isaac
Full red heart
Starts with:
15►Charm of the Vampire Charm of the Vampire
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of Red Hearts. Many items that restore Red Hearts have no effect.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthHave a Heart Defeat Mom Added in Afterbirth2 new pills 2 new pills
Added in Afterbirth 26. I RULE!
Isaac
Full red heartFull red heartFull red heart
Starts with:
The Boomerang The Boomerang
Key Piece 1 Key Piece 1
Key Piece 2 Key Piece 2
The Ladder The Ladder
Mom's Knife Mom's Knife
Trinity Shield Trinity Shield
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png Added in AfterbirthI RULE! Defeat ??? or The Lamb, and defeat Satan as Isaac Isaac Added in AfterbirthPoker Chip Poker Chip
Added in Afterbirth 27. BRAINS!
???
Full soul heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
3 15►Bob's Brain Bob's Brain
15►Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
??? Added in AfterbirthBRAINS! Defeat Isaac 5 times Added in AfterbirthStud Finder Stud Finder
Added in Afterbirth 28. PRIDE DAY!
Isaac
Full red heartFull red heartFull red heart
Starts with:
15►3 Dollar Bill 3 Dollar Bill
15►Rainbow Baby Rainbow Baby
Added in AfterbirthRainbow Worm Rainbow Worm
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthPRIDE DAY! Defeat Mom Added in AfterbirthD8 D8
Added in Afterbirth 29. Onan's Streak
Judas
Full red heart
Starts with:
15►The Book of Belial The Book of Belial
15►Chocolate Milk Chocolate Milk
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Isaac Added in AfterbirthOnan's Streak Defeat Mom Added in AfterbirthKidney Stone Kidney Stone
Added in Afterbirth 30. The Guardian
Isaac
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►Holy Grail Holy Grail
15►Isaac's Heart Isaac's Heart
15►Punching Bag Punching Bag
Added in Afterbirth15►Spear of Destiny Spear of Destiny
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow 15►Punching Bag Punching Bag instead of Isaac.
Boss Mom's Heart.png / Boss It Lives.png Added in AfterbirthThe Guardian Defeat Mom Added in AfterbirthBlank Rune Blank Rune
Added in Afterbirth † 31. Backasswards
Isaac
Full red heartFull red heartFull red heart
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All chapters progress in reverse order, losing 1 item and 1 Red Heart container each floor ascended.
The Basement The Basement/The Cellar The Cellar/Burning Basement Burning Basement I Added in Afterbirth †Backasswards Defeat ??? or The Lamb Added in Afterbirth †Laz Bleeds More! Character Lazarus icon.png Laz Bleeds More!
Added in Afterbirth † 32. Aprils Fool
Isaac
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Stoneys have a chance of being replaced by Cross Stonies. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.
Boss Mom's Heart.png / Boss It Lives.png Added in Afterbirth †Aprils fool Defeat Mom Added in Afterbirth †Maggy Now Holds a Pill! Character Magdalene icon.png Maggy Now Holds a Pill!
Added in Afterbirth † 33. Pokey Mans
Isaac
Full red heartFull red heartFull red heart
Starts with:
Added in Afterbirth15►Friendly Ball Friendly Ball
15►Mom's Eyeshadow Mom's Eyeshadow
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Isaac Added in Afterbirth †Pokey Mans Defeat Mom's Heart 11 times Added in Afterbirth †Charged Key Charged Key
Added in Afterbirth † 34. Ultra Hard
Isaac
Full red heartFull red heartFull red heart
Starts with:
15►Key Piece 1 Key Piece 1
15►Key Piece 2 Key Piece 2
Curse of the Labyrinth
Curse of the Blind
Curse of the Lost
Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan.png Added in Afterbirth †Ultra Hard Defeat ??? or The Lamb. Possession of 15►The Polaroid The Polaroid/15►The Negative The Negative is required, barring getting to Dark Room Dark Room through a Sacrifice Room. Added in Afterbirth †Samson Feels Healthy! Samson Samson Feels Healthy!
Added in Afterbirth † 35. Pong
Isaac
Full red heartFull red heartFull red heart
Starts with:
15►Cupid's Arrow Cupid's Arrow
15►Rubber Cement Rubber Cement
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
??? Added in Afterbirth †PONG Defeat Isaac 5 times Added in Afterbirth †Greed's Gullet Greed's Gullet
Added in Repentance 36. Scat Man
Isaac
Full red heartFull red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►The Poop The Poop
15►9 Volt 9 Volt
15►Skatole Skatole
15►E Coli E Coli
3 15►Butt Bombs Butt Bombs
15►BFFS! BFFS!
15►Thunder Thighs Thunder Thighs
Added in Repentance15►Dirty Mind Dirty Mind
Mysterious Candy Mysterious Candy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Added in RepentanceDirty Mind Dirty Mind
Added in Repentance 37. Bloody Mary
Bethany
Full red heartFull red heartFull red heartFull red heart
Starts with:
15►The Book of Belial The Book of Belial

15►Blood Bag Blood Bag
15►Anemic Anemic
Added in Repentance15►Blood Oath Blood Oath

Child's Heart Child's Heart

4 soul charges

Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Added in RepentanceBloody Mary Defeat Mom's Heart/It Lives on hard mode as Lazarus Lazarus, without dying, defeat Mom's Heart 11 times and unlock 15►Blood Bag Blood Bag Added in RepentanceSigil of Baphomet Sigil of Baphomet
Added in Repentance 38. Baptism by Fire
Bethany
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Added in Repentance15►Urn of Souls Urn of Souls
Added in Afterbirth †15►Schoolbag Schoolbag
15►Guppy's Paw Guppy's Paw
Maggy's Faith Maggy's Faith
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac Added in RepentanceBaptism by Fire Defeat Satan as Bethany, defeat Mom's Heart 11 times and unlock Maggy's Faith Maggy's Faith Added in RepentancePurgatory Purgatory
Added in Repentance 39. Isaac's Awakening
Isaac
Full red heartFull red heartFull red heart
Starts with:
Added in Repentance15►Spirit Sword Spirit Sword
15►Trinity Shield Trinity Shield
Added in Repentance15►Mom's Bracelet Mom's Bracelet
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Mother Added in RepentanceJacob and Esau Defeat Mother Added in RepentanceSpirit Sword Spirit Sword
Added in Repentance 40. Seeing Double
Jacob and Esau
Full red heartFull red heartFull red heartFull red heartFull soul heart
Starts with:
Jacob: 15►20/20 20/20
Esau: 15►20/20 20/20
15►X-Ray Vision X-Ray Vision
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png / Boss It Lives.png Added in RepentanceSeeing Double Defeat Mother Added in RepentanceBroken Glasses Broken Glasses
Added in Repentance 41. Pica Run
Isaac
Full red heartFull red heartFull red heart
Starts with:
Added in Afterbirth15►Mom's Box Mom's Box
Added in Afterbirth †15►Marbles Marbles
15►Mom's Purse Mom's Purse
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Isaac Added in RepentancePica Run Defeat Mom's Heart 11 times and Unlock Marbles Added in RepentanceIce Cube Ice Cube
Added in Repentance 42. Hot Potato

Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Added in RepentanceThe Fettered Use the Red Key or Cracked Key in Home as The Forgotten The Forgotten Added in RepentanceThe Chariot The Chariot
Added in Repentance 43. Cantripped!

Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Added in RepentanceThe Hoarder Use the Red Key or Cracked Key in Home as Cain Cain Added in RepentanceJustice Justice
Added in Repentance 44. Red Redemption

Full red heartFull red heartFull red heart
Starts with:
15►Dad's Key Dad's Key
Added in Repentance15►Red Key Red Key
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Mother Added in RepentanceThe Deserter Use the Red Key or Cracked Key in Home as Jacob and Esau Jacob and Esau Added in RepentanceThe Hermit The Hermit
Added in Repentance 45. DELETE THIS
Isaac
Full red heartFull red heartFull red heart
Starts with:
Added in Repentance15►TMTRAINER TMTRAINER
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
??? Added in RepentanceDELETE THIS Use the Red Key or Cracked Key in Home as Eden Eden Added in RepentanceTemperance Temperance


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
8. Cat Got Your Tongue 9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards
15. Slow Roll 16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
Repentance
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets