Binding of Isaac: Rebirth Wiki
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Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure RoomTreasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed. Players, with the advent of modding, have created their own Custom Challenges too.

General Strategy[ | ]

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are especially difficult. Challenges like Computer Savvy can be quite easy to beat, other challenges compensate for this by being especially punishing; Solar System being a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
    • (in Repentance) If other players join the game in the first room for true co-op, they will not get to select a character and will be forced to play as the character the challenge has you play as, ex. for Blue Bomber, all players will be forced to play as Character ??? (Character) icon??? no matter what. (This excludes untrue co-op because of co-op babies.)
  • Due to the lack of Treasure RoomTreasure Rooms, Devil RoomDevil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
    • Some rooms (including Crawl SpaceCrawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, trinkets and items that generate more coins, along with upgraded ShopShops, can help Isaac acquire a greater range of powerful items.
  • Collectible The Bible iconThe Bible instantly kills Boss Mom ingameMom and Boss Mom's Heart ingameMom's Heart / Boss It Lives ingameIt Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
  • Curse RoomCurse Rooms can spawn items, making them valuable.
  • (in Rebirth) In some challenges, Dice RoomDice Rooms and the Collectible D4 iconD4 are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • (in Afterbirth † and Repentance)Butter!Butter! can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like Collectible Lil Brimstone iconLil Brimstone, (except in Rebirth)Collectible Succubus iconSuccubus ,(except in Rebirth)Collectible Incubus iconIncubus and (in Repentance)Collectible Twisted Pair iconTwisted Pair are therefore highly useful items.
    • Collectible The Boomerang iconThe Boomerang, Collectible The Candle iconThe Candle, and Collectible Red Candle iconRed Candle are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • (except in Rebirth) Golden BombGolden Bomb also provides a powerful damage output method for a floor.
    • (except in Repentance)Collectible Clicker iconClicker can allow Isaac to change into (except in Rebirth) Character Lilith iconLilith, whose (except in Rebirth)Collectible Incubus iconIncubus overrides the blindfolded effect by default.
    • Some active items like Collectible Tammy's Head iconTammy's Head can be really helpful, providing an alternative method of dealing damage.
    • (in Repentance) Collectible Maw Of The Void iconMaw Of The Void, Collectible Revelation iconRevelation and Collectible Montezuma's Revenge iconMontezuma's Revenge can be charged and fired even while Blindfolded, giving you very powerful attacks when you're not supposed to be able to shoot.
  • (except in Rebirth)Collectible Chaos iconChaos is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Boss Mom's Heart ingameMom's Heart when the goal is to defeat Boss Mom ingameMom) will still spawn the trophy.
    • (in Afterbirth and Afterbirth †) In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice RoomSacrifice Room until it teleports Isaac to the Dark RoomDark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating Boss The Lamb ingameThe Lamb.
      • (in Afterbirth †) In a similar vein, all runs can be completed by killing Boss Delirium ingameDelirium, meaning that the player can beat a challenge through an alternative method such as defeating Boss Hush ingameHush then traveling to The VoidThe Void; however, this is generally extremely difficult given the restrictions challenges place on the player.

Notes[ | ]

Challenges List[ | ]

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Character Isaac appearance
Full red heartFull red heartFull red heart
Curse of DarknessCurse of Darkness
Curse of the UnknownCurse of the Unknown
Item Pool Treasure Room: yes
Item Pool Shop: no
Boss Mom portrait Default Rune of Hagalaz Rune of Hagalaz
2. High Brow
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Number One iconNumber One
Collectible E. Coli iconE. Coli
Collectible Butt Bombs iconButt Bombs
Collectible Flush! iconFlush!
Petrified PoopPetrified Poop
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Rune of Jera Rune of Jera
3. Head Trauma
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Tiny Planet iconTiny Planet
Collectible Soy Milk iconSoy Milk
Collectible The Small Rock iconThe Small Rock
Collectible Iron Bar iconIron Bar
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Rune of Ehwaz Rune of Ehwaz
4. Darkness Falls
Character Eve appearance
Full red heartFull red heart
Starts with:
Collectible Pentagram iconPentagram
Collectible Dead Bird iconDead Bird
Collectible Whore of Babylon iconWhore of Babylon
Collectible Razor Blade iconRazor Blade
Collectible Sacrificial Dagger iconSacrificial Dagger
Collectible Dark Matter iconDark Matter
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Darkness Falls (except in Repentance) Defeat Mom's Heart 11 times and unlock Character Eve iconEve
(in Repentance) Defeat Mom's Heart 11 times and defeat ??? as Character Eve iconEve
Rune of Dagaz Rune of Dagaz
5. The Tank
58
Full red heartFull red heartFull red heartFull red heart
Starts with:
Collectible Infamy iconInfamy
Collectible Bucket of Lard iconBucket of Lard
Collectible Thunder Thighs iconThunder Thighs
Collectible Yum Heart iconYum Heart
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait The Tank Have 7 or more Red Heart Containers at one time Rune of Ansuz Rune of Ansuz
6. Solar System
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible Distant Admiration iconDistant Admiration
Collectible Forever alone iconForever alone
Collectible Halo of Flies iconHalo of Flies
Collectible Transcendence iconTranscendence
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom's Heart portrait Solar System Defeat Mom's Heart 3 times Rune of Perthro Rune of Perthro
7. Suicide King
43
Full red heartFull red heartFull red heart
Starts with:
Collectible Ipecac iconIpecac
Collectible Mr. Mega iconMr. Mega
Collectible My Reflection iconMy Reflection
1 random pill
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Isaac portrait Suicide King Defeat Mom's Heart 11 times and unlock Character Lazarus iconLazarus Suicide King Suicide King
8. Cat Got Your Tongue
Character Isaac appearance
Full red heartFull red heartFull red heartFull black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded
Starts with:
Collectible Guppy's Hairball iconGuppy's Hairball
Collectible Guppy's Head iconGuppy's Head
Collectible Guppy's Tail iconGuppy's Tail
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Cat Got Your Tongue Become Guppy Rune of Algiz Rune of Algiz
9. Demo Man
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Dr. Fetus iconDr. Fetus
Collectible Remote Detonator iconRemote Detonator
Match StickMatch Stick
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom's Heart portrait Demo Man Defeat Mom's Heart 9 times Chaos Card Chaos Card
10. Cursed!
58
Full red heartFull red heartFull red heartFull red heart
Starts with:
Collectible Blue Map iconBlue Map
Collectible The Compass iconThe Compass
Collectible Raw Liver iconRaw Liver
Collectible Treasure Map iconTreasure Map
Collectible Yum Heart iconYum Heart
Child's HeartChild's Heart
Curse of the CursedCurse of the Cursed
Item Pool Treasure Room: yes
Item Pool Shop: yes
Boss Mom portrait Cursed! Have 7 or more Red Heart Containers at one time Credit Card Credit Card
11. Glass Cannon
Character Judas appearance
Full red heart
Starts with:
Collectible Epic Fetus iconEpic Fetus
Collectible Loki's Horns iconLoki's Horns
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Glass Cannon Beat The Family Man (challenge #19), defeat Lokii, and unlock Character Judas iconJudas Rules Card Rules Card
12. When Life Gives You Lemons
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible 9 Volt icon9 Volt
Collectible Habit iconHabit
Collectible Lemon Mishap iconLemon Mishap
1 Lemon Party pill
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Card Against Humanity Card Against Humanity
13. Beans!
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible 9 Volt icon9 Volt
Collectible The Bean iconThe Bean
Collectible The Black Bean iconThe Black Bean
Collectible Butt Bombs iconButt Bombs
Collectible Pyro iconPyro
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Burnt Penny Burnt Penny
14. It's in the Cards
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible 9 Volt icon9 Volt
Collectible The Battery iconThe Battery
Collectible Deck of Cards iconDeck of Cards
Collectible Starter Deck iconStarter Deck
2 random tarot cards
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default SMB Super Fan SMB Super Fan
15. Slow Roll
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Cupid's Arrow iconCupid's Arrow
Collectible My Reflection iconMy Reflection
Collectible Polyphemus iconPolyphemus
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Swallowed Penny Swallowed Penny
16. Computer Savvy
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Spoon Bender iconSpoon Bender
Collectible Technology iconTechnology
Collectible Technology 2 iconTechnology 2
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Robo-Baby 2 Robo-Baby 2.0
17. Waka Waka
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Anti-Gravity iconAnti-Gravity
Collectible Strange Attractor iconStrange Attractor
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Death's Touch Death's Touch
18. The Host
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible The Mulligan iconThe Mulligan
Collectible Spiderbaby iconSpiderbaby
TickTick
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Technology Technology .5
19. The Family Man
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible BFFS! iconBFFS!
Collectible Brother Bobby iconBrother Bobby
Collectible Dad's Key iconDad's Key
Collectible Rotten Baby iconRotten Baby
Collectible Sister Maggy iconSister Maggy
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Isaac portrait The Family Man Pick up both Key Pieces from the Angels in one run Epic Fetus Epic Fetus
20. Purist
Character Isaac appearance
Full red heartFull red heartFull red heart
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom's Heart portrait Purist Defeat Mom Rune of Berkano Rune of Berkano
(except in Rebirth) 21. XXXXXXXXL
Character Isaac appearance
Full red heartFull red heartFull red heart
Item Pool Treasure Room: yes
Item Pool Shop: yes
Every floor is the size of an XL WombWomb floor, but does not combine the floors of each chapter.
Boss Mom's Heart portrait XXXXXXXXL Defeat Mom Gold Heart Gold Heart
(except in Rebirth) 22. SPEED!
Character Isaac appearance
Full red heartFull red heartFull red heart
Item Pool Treasure Room: yes
Item Pool Shop: yes
Everything is sped up like the Collectible Broken Watch iconBroken Watch effect. After the game timer reaches 16 minutes, Isaac starts taking damage every 10 seconds.
Boss Mom's Heart portrait SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
(except in Rebirth) 23. Blue Bomber
Character ??? appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded
Starts with:
Collectible Brother Bobby iconBrother Bobby
Collectible Kamikaze! iconKamikaze!
Collectible Pyromaniac iconPyromaniac
Collectible Mr. Mega iconMr. Mega
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
(except in Rebirth) 24. PAY TO PLAY
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Money = Power iconMoney = Power
Collectible Sack of Pennies iconSack of Pennies
50 coins
Item Pool Treasure Room: no
Item Pool Shop: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Boss Isaac portrait PAY TO PLAY Defeat Isaac as Character Cain iconCain and destroy 10 Tinted Rocks 2 new pills 2 new pills
(except in Rebirth) 25. Have a Heart
Character Isaac appearance
Full red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Empty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Starts with:
Collectible Charm of the Vampire iconCharm of the Vampire
Item Pool Treasure Room: yes
Item Pool Shop: yes
PennyPennies drop instead of Red HeartRed Hearts. Many items that restore Red HeartRed Hearts have no effect.
Boss Mom's Heart portrait Have a Heart Defeat Mom 2 new pills 2 new pills
(except in Rebirth) 26. I RULE!
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible The Boomerang iconThe Boomerang
Collectible Key Piece 1 iconKey Piece 1
Collectible Key Piece 2 iconKey Piece 2
Collectible The Ladder iconThe Ladder
Collectible Mom's Knife iconMom's Knife
Collectible Trinity Shield iconTrinity Shield
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mega Satan portrait I RULE! (in Rebirth and Afterbirth) Defeat ??? or The Lamb, defeat Satan as Character Isaac iconIsaac, and unlock Collectible The Negative iconThe Negative
(in Afterbirth †) Defeat ??? or The Lamb, and defeat Satan as Character Isaac iconIsaac
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative
Poker Chip Poker Chip
(except in Rebirth) 27. BRAINS!
Character ??? appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded
Starts with:
3 Collectible Bob's Brain iconBob's Brain
Collectible Thunder Thighs iconThunder Thighs
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss ??? portrait BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
(except in Rebirth) 28. PRIDE DAY!
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible 3 Dollar Bill icon3 Dollar Bill
Collectible Rainbow Baby iconRainbow Baby
Rainbow WormRainbow Worm
Item Pool Treasure Room: no
Item Pool Shop: yes
Cannot drop or replace Rainbow WormRainbow Worm.
Boss Mom's Heart portrait PRIDE DAY! Defeat Mom D8 D8
(except in Rebirth) 29. Onan's Streak
Character Judas appearance
Full red heart
Starts with:
Collectible The Book of Belial iconThe Book of Belial
Collectible Chocolate Milk iconChocolate Milk
Item Pool Treasure Room: yes
Item Pool Shop: yes
Missing a shot deals damage to Character Judas iconJudas.
Boss Isaac portrait Onan's Streak (in Afterbirth and Afterbirth †) Defeat Boss Mom ingameMom
(in Repentance) Unlock Character Judas iconJudas and Boss It Lives ingameIt Lives.
Kidney Stone Kidney Stone
(except in Rebirth) 30. The Guardian
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible Holy Grail iconHoly Grail
Collectible Isaac's Heart iconIsaac's Heart
Collectible Punching Bag iconPunching Bag
Collectible Spear Of Destiny iconSpear Of Destiny
Item Pool Treasure Room: no
Item Pool Shop: yes
Collectible Isaac's Heart iconIsaac's Heart will follow Collectible Punching Bag iconPunching Bag instead of Isaac.
Boss Mom's Heart portrait The Guardian Defeat Mom Blank Rune Blank Rune
(in Afterbirth † and Repentance) 31. Backasswards
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
8-10 random items
Item Pool Treasure Room: no
Item Pool Shop: yes
All chapters progress in reverse order, losing 1 item and 1 Red Heart container each floor ascended.
BasementBasement/CellarCellar/Burning BasementBurning Basement I Backasswards (except in Repentance) Defeat ??? or The Lamb
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative
Laz Bleeds More! Laz Bleeds More!
(in Afterbirth † and Repentance) 32. Aprils Fool
Character Isaac appearance
Full red heartFull red heartFull red heart
Item Pool Treasure Room: yes
Item Pool Shop: yes
The minimap displays the floor's layout accurately but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide KingSuicide King). Items with no charge time (i.e. Collectible How to Jump iconHow to Jump, Collectible IV Bag iconIV Bag, etc) can be used repeatedly for random effects. StoneyStonies have a chance of being replaced by a Cross StoneyCross Stoney. Every boss is Boss The Bloat ingameThe Bloat. Isaac's health is not what it appears to be. Inventory pickups numbers are accurate.
Boss Mom's Heart portrait Aprils fool Defeat Mom Maggy Now Holds a Pill! Maggy Now Holds a Pill!
(in Afterbirth † and Repentance) 33. Pokey Mans
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Friendly Ball iconFriendly Ball
Collectible Mom's Eyeshadow iconMom's Eyeshadow
Item Pool Treasure Room: no
Item Pool Shop: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Boss Isaac portrait Pokey Mans Defeat Mom's Heart 11 times Charged Key Charged Key
(in Afterbirth † and Repentance) 34. Ultra Hard
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Key Piece 1 iconKey Piece 1
Collectible Key Piece 2 iconKey Piece 2
Curse of the LabyrinthCurse of the Labyrinth
Curse of the BlindCurse of the Blind
Curse of the LostCurse of the Lost
Curse of the MazeCurse of the Maze
Item Pool Treasure Room: yes
Item Pool Shop: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan portrait Ultra Hard (except in Repentance) Defeat ??? or The Lamb. Possession of Collectible The Polaroid iconThe Polaroid / Collectible The Negative iconThe Negative is required, barring getting to Dark RoomDark Room through a Sacrifice RoomSacrifice Room.
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative
Samson Feels Healthy! Samson Feels Healthy!
(in Afterbirth † and Repentance) 35. Pong
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Cupid's Arrow iconCupid's Arrow
Collectible Rubber Cement iconRubber Cement
Item Pool Treasure Room: no
Item Pool Shop: yes
Damage fixed at 100, tear delay fixed at 150.
Boss ??? portrait PONG Defeat Isaac 5 times Greed's Gullet Greed's Gullet
(in Repentance) 36. Scat Man
Character Isaac appearance
Full red heartFull red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible The Poop iconThe Poop
Collectible 9 Volt icon9 Volt
Collectible Skatole iconSkatole
Collectible E. Coli iconE. Coli
3 Collectible Butt Bombs iconButt Bombs
Collectible BFFS! iconBFFS!
Collectible Thunder Thighs iconThunder Thighs
Collectible Dirty Mind iconDirty Mind
Mysterious CandyMysterious Candy
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mom portrait Default Dirty Mind Dirty Mind
(in Repentance) 37. Bloody Mary
Character Bethany appearance
Full red heartFull red heartFull red heartFull red heart
Starts with:
Collectible The Book of Belial iconThe Book of Belial
Collectible Blood Bag iconBlood Bag
Collectible Anemic iconAnemic
Collectible Blood Oath iconBlood Oath
Child's HeartChild's Heart

4 soul charges
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Bloody Mary Unlock Character Bethany iconBethany, Collectible Blood Bag iconBlood Bag, and It Lives! Sigil of Baphomet Sigil of Baphomet
(in Repentance) 38. Baptism by Fire
Character Bethany appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible Urn of Souls iconUrn of Souls
Collectible Schoolbag iconSchoolbag
Collectible Guppy's Paw iconGuppy's Paw
Maggy's FaithMaggy's Faith
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Isaac portrait Baptism by Fire Defeat Satan as Character Bethany iconBethany, defeat Mom's Heart 11 times, and unlock Maggy's FaithMaggy's Faith Purgatory Purgatory
(in Repentance) 39. Isaac's Awakening
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Spirit Sword iconSpirit Sword
Collectible Trinity Shield iconTrinity Shield
Collectible Mom's Bracelet iconMom's Bracelet
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mother portrait Isaac's Awakening Defeat Mother Spirit Sword Spirit Sword
(in Repentance) 40. Seeing Double
Character Jacob appearance
Full red heartFull red heartFull red heartFull red heartFull soul heart
Starts with:
Jacob: Collectible 20 20 icon20/20
Esau: Collectible 20 20 icon20/20
Collectible X-Ray Vision iconX-Ray Vision
Item Pool Treasure Room: yes
Item Pool Shop: yes
All enemies and bosses are doubled.
Boss Mom's Heart portrait Seeing Double Defeat Mother Broken Glasses Broken Glasses
(in Repentance) 41. Pica Run
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Mom's Box iconMom's Box
Collectible Marbles iconMarbles
Collectible Mom's Purse iconMom's Purse
Item Pool Treasure Room: yes
Item Pool Shop: yes
All items are replaced by random trinkets.

Collectible Marbles iconMarbles activates on every hit.

Boss Isaac portrait Pica Run Defeat Mom's Heart 11 times and unlock Collectible Marbles iconMarbles Ice Cube Ice Cube
(in Repentance) 42. Hot Potato
Character Tainted Forgotten appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded
Item Pool Treasure Room: no
Item Pool Shop: yes
The Forgotten cannot fire tears and explodes every 2.5 seconds. Explosion timer resets upon entering a room or picking up an item.
Boss Satan portrait The Fettered Use Collectible Red Key iconRed Key (etc.) to open the hidden closet in (in Repentance)HomeHome as Character The Forgotten iconThe Forgotten The Chariot The Chariot
(in Repentance) 43. Cantripped!
Character Tainted Cain appearance
Full red heartFull red heart
Item Pool Treasure Room: no
Item Pool Shop: yes
All cards and pills are replaced with item cards. Enemies also have a chance of dropping an item card when killed. The Collectible Bag of Crafting iconBag of Crafting now initially holds a maximum of 3 item cards at once. When picked up, each item card shows a preview of a random Active Item that, when used, activates the effect.

All boss item drops are replaced with Collectible Starter Deck iconStarter Deck, which increases the max card limit by 1 and drops 3 item cards.

Boss Mom portrait The Hoarder Use Collectible Red Key iconRed Key (etc.) to open the hidden closet in (in Repentance)HomeHome as Character Cain iconCain Justice Justice
(in Repentance) 44. Red Redemption
Character Tainted Jacob appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Dad's Key iconDad's Key
Collectible Red Key iconRed Key
Item Pool Treasure Room: yes
Item Pool Shop: yes
The starting room spawns with no rooms connected to it. Rooms spawn in clusters around the map and must be found via the Collectible Red Key iconRed Key. While the Red Key can be used an infinite number of times, it has 20 uses before Dark EsauDark Esau spawns. Each subsequent 5 uses will spawn another Dark Esau if Character Tainted Jacob iconTainted Jacob has yet to turn into his lost form. The Red Key cannot be used to open doors to I AM ERRORI AM ERROR rooms.

Each floor generates as a Curse of the LabyrinthCurse of the Labyrinth floor, with one shop, and two item and boss rooms, except the fourth floor, which has only one boss room. All rooms may be from any floor of the current chapter.

Boss Mother portrait The Deserter Use Collectible Red Key iconRed Key (etc.) to open the hidden closet in (in Repentance)HomeHome as Character Jacob and Esau iconJacob and Esau The Hermit The Hermit
(in Repentance) 45. DELETE THIS
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible TMTRAINER iconTMTRAINER
Item Pool Treasure Room: yes
Item Pool Shop: yes
All items are randomly generated due to Collectible TMTRAINER iconTMTRAINER. The theme of each area, its obstacles per area, and music are randomized. Some obstacle sprites are randomized even within a level and sometimes the music may be missing altogether. Occasionally, even the floor texture might glitch out, replacing it with a plain color. Shop item prices range from 1 cent to 99.

The challenge itself appears under the challenge list without any text, effectively rendering it invisible.

Boss ??? portrait DELETE THIS Unlock Character Tainted Eden iconTainted Eden Temperance Temperance


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