Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Challenges are unique runs in the game. Isaac typically starts each challenge with one or more specific items which makes normal play more difficult. With few exceptions, Treasure Rooms are not available during challenges. Each challenge unlocks new content for the game, such as runes when completed. Players, with the advent of modding, have created their own Custom Challenges too.

General Strategy

Most challenges are designed to increase the difficulty of the game in a unique fashion. This doesn't mean all challenges are difficult, however; challenges like Computer Savvy are quite easy to beat. Some challenges do compensate for this by being especially punishing; Solar System is a good example of this. Each challenge has certain strategies that can be employed to make the run easier. However, there are a few strategies that can apply to all challenges.

  • Challenges can be played in co-op, allowing a second player to contribute to the run without being hindered in the same way Isaac is. This is especially useful in any challenge where Isaac is Blindfolded, as the second player will be allowed to fire tears normally.
    • Added in Repentance If other players join the game in the first room for true co-op, they will not get to select a character and will be forced to play as the character the challenge has you play as, ex. for Blue Bomber, all players will be forced to play as ??? ??? no matter what. (This excludes untrue co-op because of co-op babies.)
  • Due to the lack of Treasure Rooms, Devil Rooms become much more valuable. Some challenges can be made much easier by making just one deal, but it is worth noting that other challenges reduce Isaac's health to the extent that Devil Deals become too risky.
    • Some rooms (including Crawl Spaces) may have Treasure Room items by default. Since these items are random, results can vary from run to run.
    • Because locked Treasure Rooms won't spawn, keys can be used far more liberally. Also, trinkets and items that generate more coins, along with upgraded Shops, can help Isaac acquire a greater range of powerful items.
  • 15►The Bible The Bible instantly kills Mom and Mom's Heart / It Lives. All challenges require defeating Mom, and most require defeating Mom's Heart or It Lives, making this an extremely powerful item, especially in challenges where Mom or Mom's Heart / It Lives is the final boss.
    • 15►Pandora's Box Pandora's Box will spawn The Bible if used in Womb II, Utero II, or Added in Afterbirth Scarred Womb II, making it a reliable way to acquire The Bible.
  • Curse Rooms can spawn items, making them valuable.
  • Removed in Afterbirth In some challenges, Dice Rooms and the 15►D4 D4 are very useful, allowing that challenge's starting items to be rerolled, thus removing most of the difficulty. NOTE: This changes depending on the challenge. Most challenge pages contain details on the results of rerolling.
    • Added in Afterbirth †Butter! Butter! can also remove starter items.
  • Blindfolded challenges are arguably the most difficult challenges due to Isaac's inability to fire tears. There are several methods to work around this.
    • Familiars can provide an alternative method of dealing damage. Powerful familiars like 15►Daddy Longlegs Daddy Longlegs, 12►Lil Brimstone▼3►Lil' Brimstone Lil Brimstone, and Added in Afterbirth15►Incubus Incubus are therefore highly useful items.
    • 15►The Boomerang The Boomerang, 15►The Candle The Candle, and 15►Red Candle Red Candle are also useful for blindfolded challenges, since they recharge based on a timer, rather than an amount of cleared rooms.
    • Added in Afterbirth †15►Clicker Clicker can allow Isaac to change into Added in AfterbirthLilith Lilith, whose Added in Afterbirth15►Incubus Incubus overrides the blindfolded effect by default.
    • Some spacebar items like 15►Tammy's Head Tammy's Head can be really helpful, providing an alternative method of dealing damage.
  • Added in Afterbirth15►Chaos Chaos is a powerful item in challenges, as it can allow powerful items to be found more commonly, such as in the Shop or after defeating bosses.
  • Defeating a boss beyond the specified end of the challenge (e.g. defeating Mom's Heart when the goal is to defeat Mom) will still spawn the trophy.
    • Added in Afterbirth In some longer challenges (e.g. XXXXXXXXL), using a Sacrifice Room until it teleports Isaac to the Dark Room is a viable strategy. Once in the Dark Room, the trophy can be spawned by defeating The Lamb.
      • Added in Afterbirth † In a similar vein, all runs can be completed by killing Delirium, meaning that the player can beat a challenge through an alternative method such as defeating Hush then traveling to The Void; however, this is generally extremely difficult given the restrictions challenges place on the player.

Notes

  • Apart from the achievement related to beating the challenge, all achievements are locked. Also, no Donation Machines will appear in any challenge.
  • The challenge reward will not be unlocked unless the trophy is picked up. If a Devil Room or Angel Room appears allowing Isaac to go to Sheol or the Cathedral, the unlock will be forfeited.
  • Isaac will not start any challenge with 15►The D6 The D6.

Challenges List

Name Conditions Goal Unlocked by Unlocks
1. Pitch Black
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Curse of Darkness
Curse of the Unknown
Item Pool Treasure Room.png: yes
Item Pool Shop.png: no
Boss Mom.png Default Rune of Hagalaz Rune of Hagalaz
2. High Brow
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Number One Number One
15►E Coli E Coli
15►Butt Bombs Butt Bombs
15►Flush! Flush!
Petrified Poop Petrified Poop
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Jera Rune of Jera
3. Head Trauma
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Tiny Planet Tiny Planet
15►Soy Milk Soy Milk
15►The Small Rock The Small Rock
15►Iron Bar Iron Bar
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Rune of Ehwaz Rune of Ehwaz
4. Darkness Falls
Character Eve appearance.png
Full red heartFull red heart
Starts with:
15►Pentagram Pentagram
15►Dead Bird Dead Bird
15►Whore of Babylon Whore of Babylon
15►Razor Blade Razor Blade
15►Sacrificial Dagger Sacrificial Dagger
15►Dark Matter Dark Matter
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Darkness Falls Removed in Repentance Defeat Mom's Heart 11 times
Added in Repentance Defeat Satan and ??? as Eve Eve
Rune of Dagaz Rune of Dagaz
5. The Tank
58.5px
Full red heartFull red heartFull red heartFull red heart
Starts with:
15►Infamy Infamy
15►Bucket of Lard Bucket of Lard
15►Thunder Thighs Thunder Thighs
15►Yum Heart Yum Heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Tank Have 7 or more Red Heart Containers at one time Rune of Ansuz Rune of Ansuz
6. Solar System
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►Distant Admiration Distant Admiration
15►Forever Alone Forever Alone
15►Halo of Flies Halo of Flies
15►Transcendence Transcendence
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png Solar System Defeat Mom's Heart 3 times Rune of Perthro Rune of Perthro
7. Suicide King
Character Lazarus appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Ipecac Ipecac
15►Mr. Mega Mr. Mega
15►My Reflection My Reflection
1 random pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Isaac.png Suicide King Defeat Mom's Heart 11 times Suicide King Suicide King
8. Cat Got Your Tongue
Character Isaac appearance.png
Full red heartFull red heartFull red heartFull black heartFull black heartFull black heartFull soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
15►Guppy's Hair Ball Guppy's Hair Ball
15►Guppy's Head Guppy's Head
15►Guppy's Tail Guppy's Tail
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Cat Got Your Tongue Become Guppy Rune of Algiz Rune of Algiz
9. Demo Man
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Dr. Fetus Dr. Fetus
15►Remote Detonator Remote Detonator
Match Stick Match Stick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png Demo Man Defeat Mom's Heart 9 times Chaos Card Chaos Card
10. Cursed!
58.5px
Full red heartFull red heartFull red heartFull red heart
Starts with:
15►Blue Map Blue Map
15►The Compass The Compass
15►Raw Liver Raw Liver
15►Treasure Map Treasure Map
15►Yum Heart Yum Heart
Child's Heart Child's Heart
Curse of the Cursed
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mom.png Cursed! Have 7 or more Red Heart Containers at one time Credit Card Credit Card
11. Glass Cannon
Character Judas appearance.png
Full red heart
Starts with:
15►Epic Fetus Epic Fetus
15►Loki's Horns Loki's Horns
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Glass Cannon Beat The Family Man (challenge #19) and defeat Lokii Rules Card Rules Card
12. When Life Gives You Lemons
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►9 Volt 9 Volt
15►Habit Habit
15►Lemon Mishap Lemon Mishap
1 Lemon Party pill
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Card Against Humanity Card Against Humanity
13. Beans!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►9 Volt 9 Volt
15►The Bean The Bean
15►The Black Bean The Black Bean
15►Butt Bombs Butt Bombs
15►Pyro Pyro
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Burnt Penny Burnt Penny
14. It's in the Cards
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►9 Volt 9 Volt
15►The Battery The Battery
15►Deck of Cards Deck of Cards
15►Starter Deck Starter Deck
2 random tarot cards
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default SMB Super Fan SMB Super Fan
15. Slow Roll
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Cupid's Arrow Cupid's Arrow
15►My Reflection My Reflection
15►Polyphemus Polyphemus
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Swallowed Penny Swallowed Penny
16. Computer Savvy
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Spoon Bender Spoon Bender
15►Technology Technology
15►Technology 2 Technology 2
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Robo-Baby 2.0 Robo-Baby 2.0
17. Waka Waka
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Anti-Gravity Anti-Gravity
15►Strange Attractor Strange Attractor
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Death's Touch Death's Touch
18. The Host
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►The Mulligan The Mulligan
15►Spiderbaby Spiderbaby
Tick Tick
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Technology .5 Technology .5
19. The Family Man
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►BFFS! BFFS!
15►Brother Bobby Brother Bobby
15►Dad's Key Dad's Key
15►Rotten Baby Rotten Baby
15►Sister Maggy Sister Maggy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Isaac.png The Family Man Pick up both Key Pieces from the Angels in one run Epic Fetus Epic Fetus
20. Purist
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png Purist Defeat Mom Rune of Berkano Rune of Berkano
Added in Afterbirth 21. XXXXXXXXL
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Every floor is the size of an XL Womb floor, but does not combine the floors of each chapter.
Boss Mom's Heart.png XXXXXXXXL Defeat Mom Gold Heart Gold Heart
Added in Afterbirth 22. SPEED!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Everything is sped up like the Broken Watch effect.
Boss Mom's Heart.png SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
Added in Afterbirth 23. Blue Bomber
Character ??? appearance.png
Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
15►Brother Bobby Brother Bobby
15►Kamikaze! Kamikaze!
15►Pyromaniac Pyromaniac
15►Mr. Mega Mr. Mega
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
Added in Afterbirth 24. PAY TO PLAY
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Money = Power Money = Power
15►Sack of Pennies Sack of Pennies
50 coins
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Boss Isaac.png PAY TO PLAY Defeat Isaac as Cain Cain 2 new pills 2 new pills
Added in Afterbirth 25. Have a Heart
Character Isaac appearance.png
Full red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Empty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Starts with:
15►Charm of the Vampire Charm of the Vampire
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Pennies drop instead of Red Hearts. Many items that restore Red Hearts have no effect.
Boss Mom's Heart.png Have a Heart Defeat Mom 2 new pills 2 new pills
Added in Afterbirth 26. I RULE!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►The Boomerang The Boomerang
15►Key Piece 1 Key Piece 1
15►Key Piece 2 Key Piece 2
15►The Ladder The Ladder
15►Mom's Knife Mom's Knife
15►Trinity Shield Trinity Shield
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mega Satan.png I RULE! Removed in Repentance Defeat ??? or The Lamb, and defeat Satan as Isaac Isaac
Added in Repentance Defeat Mega Satan
Poker Chip Poker Chip
Added in Afterbirth 27. BRAINS!
Character ??? appearance.png
Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Starts with:
3 15►Bob's Brain Bob's Brain
15►Thunder Thighs Thunder Thighs
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Blue Baby.png BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
Added in Afterbirth 28. PRIDE DAY!
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►3 Dollar Bill 3 Dollar Bill
15►Rainbow Baby Rainbow Baby
Added in AfterbirthRainbow Worm Rainbow Worm
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Cannot drop or replace Rainbow Worm.
Boss Mom's Heart.png PRIDE DAY! Defeat Mom D8 D8
Added in Afterbirth 29. Onan's Streak
Character Judas appearance.png
Full red heart
Starts with:
15►The Book of Belial The Book of Belial
15►Chocolate Milk Chocolate Milk
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Missing a shot deals damage to Judas.
Boss Isaac.png Onan's Streak Defeat Mom Kidney Stone Kidney Stone
Added in Afterbirth 30. The Guardian
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►Holy Grail Holy Grail
15►Isaac's Heart Isaac's Heart
15►Punching Bag Punching Bag
15►Spear of Destiny Spear of Destiny
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Isaac's Heart will follow 15►Punching Bag Punching Bag instead of Isaac.
Boss Mom's Heart.png The Guardian Defeat Mom Blank Rune Blank Rune
Added in Afterbirth † 31. Backasswards
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
8-10 random items
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
All chapters progress in reverse order, losing 1 item and 1 Red Heart container each floor ascended.
Basement Basement/Cellar Cellar/Burning Basement Burning Basement I Backasswards Removed in Repentance Defeat ??? or The Lamb
Added in Repentance Defeat Mega Satan
Laz Bleeds More! Laz Bleeds More!
Added in Afterbirth † 32. Aprils Fool
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
The minimap displays the floor's layout accurately, but displays Isaac's position inaccurately. Pedestal items and pickups are not what they appear to be. Active items, pills, cards, and rune effects are randomized upon each use, making them very unreliable or deadly (for example Suicide King). Items with no charge time (i.e. How To Jump, IV Bag, etc) can be used repeatedly for random effects. Stoneys have a chance of being replaced by Cross Stonies. Every boss is The Bloat. Isaac's health is not what it appears to be. Key and bomb numbers are accurate.
Boss Mom's Heart.png Aprils fool Defeat Mom Maggy Now Holds a Pill! Maggy Now Holds a Pill!
Added in Afterbirth † 33. Pokey Mans
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Friendly Ball Friendly Ball
15►Mom's Eyeshadow Mom's Eyeshadow
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Each use of Friendly Ball causes a random monster to be spawned. Friendly Ball instantly charges once the spawned monster is killed.
Boss Isaac.png Pokey Mans Defeat Mom's Heart 11 times Charged Key Charged Key
Added in Afterbirth † 34. Ultra Hard
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Key Piece 1 Key Piece 1
15►Key Piece 2 Key Piece 2
Curse of the Labyrinth
Curse of the Blind
Curse of the Lost
Curse of the Maze
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
All enemies spawn as champions if possible. Boss fights will be double trouble if possible. No heart pickups drop.
Boss Mega Satan.png Ultra Hard Removed in Repentance Defeat ??? or The Lamb. Possession of 15►The Polaroid The Polaroid/15►The Negative The Negative is required, barring getting to Dark Room Dark Room through a Sacrifice Room.
Added in Repentance Defeat Mega Satan
Samson Feels Healthy! Samson Feels Healthy!
Added in Afterbirth † 35. Pong
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Cupid's Arrow Cupid's Arrow
15►Rubber Cement Rubber Cement
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Damage fixed at 100, tear delay fixed at 150.
Boss Blue Baby.png PONG Defeat Isaac 5 times Greed's Gullet Greed's Gullet
Added in Repentance 36. Scat Man
Character Isaac appearance.png
Full red heartFull red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
15►The Poop The Poop
15►9 Volt 9 Volt
15►Skatole Skatole
15►E Coli E Coli
3 15►Butt Bombs Butt Bombs
15►BFFS! BFFS!
15►Thunder Thighs Thunder Thighs
Added in Repentance15►Dirty Mind Dirty Mind
Mysterious Candy Mysterious Candy
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png Default Dirty Mind Dirty Mind
Added in Repentance 37. Bloody Mary
Character Bethany appearance.png
Full red heartFull red heartFull red heartFull red heart
Starts with:
15►The Book of Belial The Book of Belial
15►Blood Bag Blood Bag
15►Anemic Anemic
Added in Repentance15►Blood Oath Blood Oath
Child's Heart Child's Heart

4 soul charges
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png Bloody Mary Defeat Mom's Heart/It Lives on hard mode as Lazarus Lazarus, without dying, defeat Mom's Heart 11 times and unlock 15►Blood Bag Blood Bag Sigil of Baphomet Sigil of Baphomet
Added in Repentance 38. Baptism by Fire
Character Bethany appearance.png
Full red heartFull red heartFull red heart
Blindfolded.png Blindfolded
Starts with:
Added in Repentance15►Urn of Souls Urn of Souls
Added in Afterbirth †15►Schoolbag Schoolbag
15►Guppy's Paw Guppy's Paw
Maggy's Faith Maggy's Faith
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Isaac.png Baptism by Fire Defeat Satan as Bethany, defeat Mom's Heart 11 times and unlock Maggy's Faith Maggy's Faith Purgatory Purgatory
Added in Repentance 39. Isaac's Awakening
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Added in Repentance15►Spirit Sword Spirit Sword
15►Trinity Shield Trinity Shield
Added in Repentance15►Mom's Bracelet Mom's Bracelet
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mother.png Isaac's Awakening Defeat Mother Spirit Sword Spirit Sword
Added in Repentance 40. Seeing Double
Character Jacob appearance.png
Full red heartFull red heartFull red heartFull red heartFull soul heart
Starts with:
Jacob: 15►20/20 20/20
Esau: 15►20/20 20/20
15►X-Ray Vision X-Ray Vision
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom's Heart.png Seeing Double Defeat Mother Broken Glasses Broken Glasses
Added in Repentance 41. Pica Run
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Added in Afterbirth15►Mom's Box Mom's Box
Added in Afterbirth †15►Marbles Marbles
15►Mom's Purse Mom's Purse
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Isaac.png Pica Run Defeat Mom's Heart 11 times and Unlock Marbles Ice Cube Ice Cube
Added in Repentance 42. Hot Potato
Character Tainted Forgotten appearance.png
Full soul heartFull soul heartFull soul heart
Blindfolded.png Blindfolded
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Satan.png The Fettered Use the Red Key or Cracked Key in Home as The Forgotten The Forgotten The Chariot The Chariot
Added in Repentance 43. Cantripped!
Character Tainted Cain appearance.png
Full red heartFull red heart
Item Pool Treasure Room.png: no
Item Pool Shop.png: yes
Boss Mom.png The Hoarder Use the Red Key or Cracked Key in Home as Cain Cain Justice Justice
Added in Repentance 44. Red Redemption
Character Tainted Jacob appearance.png
Full red heartFull red heartFull red heart
Starts with:
15►Dad's Key Dad's Key
Added in Repentance15►Red Key Red Key
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Mother.png The Deserter Use the Red Key or Cracked Key in Home as Jacob and Esau Jacob and Esau The Hermit The Hermit
Added in Repentance 45. DELETE THIS
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Starts with:
Added in Repentance15►TMTRAINER TMTRAINER
Item Pool Treasure Room.png: yes
Item Pool Shop.png: yes
Boss Blue Baby.png DELETE THIS Use the Red Key or Cracked Key in Home as Eden Eden Temperance Temperance


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
8. Cat Got Your Tongue 9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards
15. Slow Roll 16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
Repentance
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets