Cathedral

The Cathedral is one of two unlockable floors following Womb/ Utero/ Scarred Womb, the other being Sheol. After defeating Mom's Heart, an Angel Room may spawn containing a beam of light leading upwards to the Cathedral. Unlocking and defeating It Lives will always spawn a beam of light leading to the Cathedral, as well as a trapdoor leading to Sheol.

The Cathedral has only one floor, featuring mostly undead and/or holy enemies, and the boss is always Isaac.

Monsters[]

Entity	ID	Description
Angelic Baby	38.1.0	Slowly floats towards Isaac and fires three spread shots. Occasionally teleports and reappears elsewhere.
Bony	227.0	Wanders around the room and throws a bone at Isaac when he is in sight.
Death's Head	212.0	Invulnerable enemy that moves diagonally around the room, dealing contact damage. Dies when the room is cleared.
Dip	217.0	Slowly dashes in random directions, dealing contact damage.
Squirt	220.0	Dashes towards Isaac and deals contact damage. Spawns 2 Dips upon death.
Dinga	223.0	Slowly moves around the room, occasionally hopping to spawn Dips or fire 8 Brown shots in all directions. Splits 2 Squirts upon death.
Clot	15.1	Randomly wanders around the room, firing 4 tar shots in the ordinal directions.
I.Blob	15.2	Randomly wanders around the room, firing 8 shots in all directions.
Pale Fatty	208.1	Slowly walks towards Isaac. Occasionally farts and shoots 6 blood shots in all directions. Has a chance to turn into a Blubber upon death.
Fat Sack	209.0	Slowly walks towards Isaac. Occasionally leaps off-screen and attempts to land on Isaac, leaving a puddle of Red Creep and shooting 6 blood shots in all directions where it lands. Has a chance to turn into a Blubber upon death.
Fly	13.0	Hovers in place. Does not deal contact damage and is harmless but can turn into Pooters if they stay around Poop.
Eternal Fly	96.0	Invulnerable fly that circles Corny Poop and various monsters. Deals contact damage. Turns into a vulnerable Attack Fly after the object or monster it circles is destroyed.
Pooter	14.0	Slowly drifts toward Isaac, occasionally firing a single blood shot at him. Does not deal contact damage.
Red Boom Fly	25.1	Flies across the room in straight diagonal lines, dealing contact damage. Creates a ring of 6 blood shots upon death.
Spit	61.1	Flies slowly towards Isaac, firing an Ipecac shot towards Isaac upon death.
Floating Knight	254.0	Behaves like the Knight but slower, and can fly over all obstacles.
Gazing Globin	24.1	Quickly chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, which will slide away from Isaac and can be killed. Will regenerate after a short period of time if not killed quickly.
Gurgling	237.0	Charges towards Isaac when he lines up with them, leaving a trail of Red Creep and shooting 6 blood shots.
Hanger	90.0	Floats around the room, firing 3 spread blood shots at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3. Spawns with an Eternal Fly circling around it.
Keeper	86.0	Hops around the room, firing 2 blood shots in a V formation at Isaac. Upon damaging Isaac, Isaac drops 2 coins on the ground but loses 3.
Leech	55.0	Quickly charges towards Isaac when he gets in its line of sight.
Holy Leech	55.2	Quickly charges towards Isaac when he gets in its line of sight. Explodes upon death. Spawns with an Eternal Fly circling it, which instantly dies when the Holy Leech explodes.
Mr. Maw	35.0	Walks towards Isaac and attacks by launching its head towards him. Turns into a Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Mom's Hand	213.0	Falls from the ceiling. If it lands on Isaac, it deals damage and teleports him back to the spawn room of the floor. Entering a room containing Mom's Hand will warn Isaac with Mom's laugh.
Splasher	238.0	Walks aimlessly around the room, firing Ipecac shots in random directions.
Rotty	226.1	Slowly walks towards Isaac, leaving short-lasting Red Creep behind itself. Spawns a Bony or two Attack Flies upon death.
Spider	85.0	Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage.
Big Spider	94.0	Erratically moves around the room. If Isaac gets close to it, it chases him, trying to deal contact damage. Spawns two Spiders upon death.
Ragling	246.0	Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Psy Tumor	253.0	Moves around the room diagonally, occasionally firing 6 homing shots in all directions. Fires more often upon getting damaged.
Psychic Horf	248.0	Stationary enemy that fires a homing shot at Isaac when he gets in range of them.
Psychic Maw	26.2	Slowly floats towards Isaac, firing homing shots at him when he is in their range. Spawns with an Eternal Fly orbiting around it.
Wizoob	219.0	Disappears, then appears near Isaac and spits a cluster of spectral tears at him.
Lil' Haunt	260.0	Floats toward Isaac and occasionally fires a blood shot at him, predicting his movements.
Poky	44.0	Slides around the room aimlessly, damaging Isaac by contact. Disappears when the room is cleared.
Slide	44.1	Quickly slides towards Isaac when he gets in its line of sight, then moves slowly back to its original position. Cannot be destroyed.
Wall Hugger	218.0	Moves around the room like Guts, damaging Isaac by contact. Cannot be destroyed.
Stone Grimace	42.0	Stationary and invulnerable monster that occasionally fires a blood shot at Isaac. Stops firing when room is cleared.
Constant Stone Shooter	202.0	Stationary and invulnerable monster that continuously fires shots in a single direction.
Red Ghost	285.0	Disappears, then reappears near Isaac and fires a brimstone laser.
Suction Pitfall	291.1	Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Mr. Red Maw	35.2	Walks towards Isaac and attacks by launching its head towards him. Turns into a Red Maw or Gusher upon death depending on the killed body segment. Occasionally separates at will.
Stoney	302.0	Chases Isaac and blocks tears, but does not deal contact damage. Temporarily pauses in exhaustion after a certain amount of time. Invulnerable; dies when the room is cleared.
Cross Stone Shooter	202.10	Stationary and invulnerable monster that continuously fires shots in four directions, alternating between cardinal and ordinal.
Bishop	805.0	Shields all enemies in the room, preventing them from taking damage. Fires shots in the cardinal directions when it takes damage.
Holy Bony	227.1	Wanders around the room, throwing a bone at Isaac when he is in sight. The thrown bone leaves behind a blue flame that deals contact damage, blocks Isaac’s shots, and despawns after some time.
Candler	833.0	Flies around the room and propels itself by spawning flames.
Bulb	61.5	Flies in erratic, angled movements toward Isaac if his active item has charges; on contact, they drain up to 2 charges, but never deal contact damage. If he has no active item, or no charges, they wander around the room aimlessly.
Holy Eye	60.2	Rapidly summons several beams of light around Isaac every few seconds.
Holy Mulligan	22.2	Wanders around the room, avoiding Isaac and spawning Small Angelic Babies if he gets close. Spawns 1-2 Embryos upon death.
Polty	816.0	Picks up and throws rocks and props at Isaac.
Triple Grimace	42.2	Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.

Degraded Bosses:

Name	ID	Notes
Baby Plum	908.0
The Bloat	68.1
Bumbino	916.0
Chub	28.0
Conquest	65.1
Daddy Long Legs	101.0
Death	66.0
Dingle	261.0
The Duke of Flies	67.0
Envy	51.0
Famine	63.0
Fistula	71.0	Small- and large-form only
Gabriel	272.0
Gemini	79.0
Gluttony	49.0
Greed	50.0
Gurdy Jr.	99.0
The Haunt	260.0
The Headless Horseman	82.0
Loki	69.0
The Matriarch	413.0
Mega Fatty	264.0
Mega Maw	262.0
Monstro	20.0
Monstro II	43.0
Peep	68.0
Pestilence	64.0
Pride	52.0
Rag Man	405.0
Sloth	46.0
Super Envy	51.1
Super Greed	50.1
Super Sloth	46.1
Super Wrath	48.1
Uriel	271.0
War	65.0
Widow	100.0
Wrath	48.0
The Wretched	100.1

Boss[]

Isaac

Notes[]

Some rooms contain Angel Statues that can be bombed to summon the Angels and acquire key pieces.
If a trapdoor appears, it will lead to Chest.

Trivia[]

In the original Binding of Isaac, the windows along the walls were much larger and had different patterns resembling Isaac and a crucifix.
One of the interpretations of this floor's theme Everlasting Hymn includes the sentence "Harm yourself and God will grant you strength" many consider this translation "Too extreme" or somehow having no parallels with this game's story, however all the original endings (based on the items Isaac collects) end with Isaac finding several objects and using them to harm himself, which indeed does increase his power in-game
The theme of Cathedral (Everlasting Hymn), is noticeably shorter than other floor themed soundtracks. The second layer of the theme (for when entering a room with enemies and bosses with a high HP count), wasn't added in the official Ost, with the in-game second track being barely noticeable chants. Dark Room's theme (Devoid) is also shorter, but actually lacks the second, intense part of the track.