Binding of Isaac: Rebirth Wiki
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Cards and runes are usable items with a wide variety of effects. They take up the same slot as Pills.

Runes and special cards are unlocked by completing challenges.

Cards

Major Arcana Cards

When on the ground, these cards look like: TarotCard.png

Name ID Icon Message Description
0 - The Fool 5.300.1 0 - The Fool Where journey begins Teleports Isaac back to the starting room of a floor.
I - The Magician 5.300.2 I - The Magician May you never miss your goal Grants homing tears and Added in Repentance +3 Range for the current room (same effect as Telepathy for Dummies Telepathy for Dummies).
II - The High Priestess 5.300.3 II - The High Priestess Mother is watching you Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress 5.300.4 III - The Empress May your rage bring power Triggers the Whore of Babylon Whore of Babylon effect (+1.5 Damage, +0.3 Speed) for the current room, regardless of Isaac's health total.
IV - The Emperor 5.300.5 IV - The Emperor Challenge me! Teleports Isaac into the Boss Room Boss Room of a floor. Added in Repentance In Home Home, this will act as a random teleport.
V - The Hierophant 5.300.6 V - The Hierophant Two prayers for the lost Drops 2 full Soul Heart Soul Hearts on the ground.
VI - The Lovers 5.300.7 VI - The Lovers May you prosper and be in good health Drops 2 full Red Heart Red Hearts on the ground.
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Grants the temporary invulnerability effect of My Little Unicorn My Little Unicorn.
VIII - Justice 5.300.9 VIII - Justice May your future become balanced Drops a random Red Heart Red Heart, Key (except Key Ring), Bomb, and Coin pickup on the ground. Sometimes drops an Eternal-, Gold- Soul-, or Rotten Heart in place of the Red Heart. Sometimes drops a Troll Bomb Troll Bomb or Mega Troll Bomb Mega Troll Bomb in place of the Bomb.
IX - The Hermit 5.300.10 IX - The Hermit May you see what life has to offer Teleports Isaac to the Shop Shop. If there is no Shop, this will act as a random teleport.
X - Wheel of Fortune 5.300.11 X - Wheel of Fortune Spin the wheel of destiny Creates a Slot Machine.png Slot Machine or Fortune Telling Machine.png Fortune Telling Machine near Isaac.
XI - Strength 5.300.12 XI - Strength May your power bring rage Grants the effects of Magic Mushroom Magic Mushroom (minus the health restoration) for one room. The added Red Heart container is not removed if doing so would kill Isaac.
XII - The Hanged Man 5.300.13 XII - The Hanged Man May you find enlightenment Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as Transcendence Transcendence).
XIII - Death 5.300.14 XIII - Death Lay waste to all that oppose you Deals 40 damage to all enemies in the room (same effect as The Necronomicon The Necronomicon).
XIV - Temperance 5.300.15 XIV - Temperance May you be pure in heart Creates a Blood Donation Machine.png Blood Donation Machine near Isaac. Added in Afterbirth Spawns a Devil Beggar.png Devil Beggar instead in Greed mode.
XV - The Devil 5.300.16 XV - The Devil Revel in the power of darkness Grants Isaac a temporary +2 increase to Damage for the current room (same effect as The Book of Belial The Book of Belial).
XVI - The Tower 5.300.17 XVI - The Tower Destruction brings creation Drops 6 Troll Bomb Troll Bombs randomly around the room (same effect as the Anarchist Cookbook Anarchist Cookbook).
XVII - The Stars 5.300.18 XVII - The Stars May you find what you desire Teleports Isaac to the Treasure Room Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room if there is an active Curse of the Labyrinth.png Curse of the Labyrinth. Added in Repentance If there is a Planetarium Planetarium, teleports Isaac there instead.
XVIII - The Moon 5.300.19 XVIII - The Moon May you find all you have lost Teleports Isaac to the Secret Room Secret Room. This card will open one random wall once inside the Secret Room, so Isaac can leave even if he doesn't have any Bomb Bombs available. Added in Afterbirth Does nothing in Greed Mode.
XIX - The Sun 5.300.20 XIX - The Sun May the light heal and enlighten you Restores Isaac to full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except for the Super Secret Room Super Secret Room. Added in Repentance Removes Curse of Darkness.png Curse of Darkness for the current floor and does not reveal the Ultra Secret Room Ultra Secret Room.
XX - Judgement 5.300.21 XX - Judgement Judge lest ye be judged Spawns a Beggar.png Beggar or, more rarely, a Devil Beggar.png Devil Beggar near Isaac.
XXI - The World 5.300.22 XXI - The World Open your eyes and see Reveals the entire floor, except for the Super Secret Room Super Secret Room. Added in Repentance Does not reveal the Ultra Secret Room Ultra Secret Room.

Added in Repentance Reversed Major Arcana Cards

These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, a different message, the narrator sound clip reversed, and give different effects.

When on the ground, these cards look like: ReverseTarotCard.png

Name ID Icon Unlock method Message Description
0 - The Fool? 5.300.56 0 - The Fool? The Fool Defeat Ultra Greedier as Tainted Lost Tainted Lost Let go and move on Drops all Hearts and pickups Isaac currently possesses on the floor, leaving Isaac at half a heart. Pickups may be dropped as items such as A Quarter A Quarter and Boom! Boom!.
I - The Magician? 5.300.57 I - The Magician? The Magician Defeat Ultra Greedier as Tainted Judas Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like The Soul The Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 II - The High Priestess? The High Priestess Defeat Ultra Greedier as Tainted Lilith Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding Broken Shovel Broken Shovel.
III - The Empress? 5.300.59 III - The Empress? The Empress Defeat Ultra Greedier as Tainted Eve Tainted Eve May your love bring protection Grants 2 temporary Red Heart Containers and +1.35 Tears for one minute, along with Magdalene Magdalene's hairstyle. The effect does not stack with itself. On characters that can't have Red Heart Containers, they will get Soul Heart Soul Hearts / Black Heart Black Hearts / Bone Heart Bone Hearts accordingly. When the effect ends, if the removal of the Heart Containers would kill Isaac, he gets left with one instead.
IV - The Emperor? 5.300.60 IV - The Emperor? The Emperor Defeat Ultra Greedier as Tainted ??? Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room Boss Room from the boss pool two floors deeper than the current floor (but never a final boss). The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used it.
V - The Hierophant? 5.300.61 V - The Hierophant? The Hierophant Defeat Ultra Greedier as Tainted Bethany Tainted Bethany Two prayers for the forgotten Drops 2 Bone Heart Bone Hearts on the ground.
VI - The Lovers? 5.300.62 VI - The Lovers? The Lovers Defeat Ultra Greedier as Tainted Magdalene Tainted Magdalene May your heart shatter to pieces Creates a random item from the current room's item pool. Turns one Red Heart Container or two Soul Heart Soul Hearts into a Broken Heart, potentially fatally; no downside for any character who has no health bar. Keeper Keeper and Tainted Keeper Tainted Keeper lose a Coin Heart and gain a Broken Coin Heart; that lost Coin Heart can't be replaced while the Broken Coin Heart remains.
VII - The Chariot? 5.300.63 VII - The Chariot? The Chariot Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
VIII - Justice? 5.300.64 VIII - Justice? Justice Complete Cantripped (challenge #43) May your sins come back to torment you Creates 2 to 4 Locked Chest Locked Chests near Isaac.
IX - The Hermit? 5.300.65 IX - The Hermit? The Hermit Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual Shop Shop price, spawning a matching amount of Coins. If there is nothing to sell, drops a Penny Penny.
X - Wheel of Fortune? 5.300.66 X - Wheel of Fortune? Wheel of Fortune Defeat Ultra Greedier as Tainted Cain Tainted Cain Throw the dice of fate Invokes a random Dice Room Dice Room effect.
XI - Strength? 5.300.67 XI - Strength? Strength Defeat Ultra Greedier as Tainted Samson Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.
XII - The Hanged Man? 5.300.68 XII - The Hanged Man? The Hanged Man Defeat Ultra Greedier as Tainted Keeper Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper Keeper for 30 seconds, with triple shot, no damage bonus, and -0.1 Speed. Killed enemies drop random Coins.
XIII - Death? 5.300.69 XIII - Death? Death Defeat Ultra Greedier as Tainted Forgotten Tainted Forgotten May life spring forth from the fallen Invokes the Book of the Dead Book of the Dead effect.
XIV - Temperance? 5.300.70 XIV - Temperance? Temperance Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random Pills in quick succession.
XV - The Devil? 5.300.71 XV - The Devil? The Devil Defeat Ultra Greedier as Tainted Azazel Tainted Azazel Bask in the light of your mercy Invokes The Bible The Bible (which can kill Mom), and grants Isaac flight and a Seraphim Seraphim familiar for 30 seconds.
XVI - The Tower? 5.300.72 XVI - The Tower? The Tower Defeat Ultra Greedier as Tainted Apollyon Tainted Apollyon Creation brings destruction Creates 6 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of finding more than one in the same room. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 XVII - The Stars? The Stars Defeat Ultra Greedier as Tainted Isaac Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item (ignoring starting items) and creates 2 random items from the current room's item pool. Does nothing if Isaac has no items.
XVIII - The Moon? 5.300.74 XVIII - The Moon? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May you remember lost memories Teleports Isaac to the Ultra Secret Room Ultra Secret Room. The pathway back to the normal rooms will be made of Red Room Red Rooms.
XIX - The Sun? 5.300.75 XIX - The Sun? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May the darkness swallow all around you Gain Spirit of the Night Spirit of the Night and +1.5 Damage for the current floor. Turns Isaac's Red Hearts into Bone Hearts, but they revert once the effect ends. Also causes Curse of Darkness.png Curse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 XX - Judgement? Judgement Defeat Ultra Greedier as Tainted Lazarus Tainted Lazarus May you redeem those found wanting Creates a Shop Restock Machine.png Shop Restock Machine near Isaac.
XXI - The World? 5.300.77 XXI - The World? The World Defeat Ultra Greedier as Tainted Eden Tainted Eden Step into the abyss Creates a trap door which always leads to a Crawl Space Crawl Space.

Playing Cards

When on the ground, these cards look like: FaceCard.png

Name ID Icon Unlock method Message Description
2 of Clubs 5.300.23 2 of Clubs Always available Item multiplier Doubles Isaac's Bombs. If he has no bombs, gives him 2 instead.
2 of Diamonds 5.300.24 2 of Diamonds Always available Item multiplier Doubles Isaac's Coins. If he has no coins, gives him 2 instead.
2 of Spades 5.300.25 2 of Spades Always available Item multiplier Doubles Isaac's Keys. If he has no keys, gives him 2 instead.
2 of Hearts 5.300.26 2 of Hearts Always available Item multiplier Doubles Isaac's current number of Red Hearts. Doesn't add new Red Heart containers, just fills empty ones. If Isaac has only empty Red Heart containers, he is healed for 1 Red Heart.
Added in Afterbirth † Ace of Clubs 5.300.27 Ace of Clubs Hat trick! Get a 3-win streak Convert all Turns all Pickups, Chests, and Added in Repentance non-boss enemies in the room into random Bomb pickups, including Troll Bomb Troll Bombs.
Added in Afterbirth † Ace of Diamonds 5.300.28 Ace of Diamonds ZIP! Defeat The Lamb in under 20 minutes Convert all Turns all Pickups, Chests, and Added in Repentance non-boss enemies in the room into random Coin pickups.
Added in Afterbirth † Ace of Spades 5.300.29 Ace of Spades It's the Key Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run Convert all Turns all Pickups, Chests, and Added in Repentance non-boss enemies in the room into random Key pickups (except Key Rings).
Added in Afterbirth † Ace of Hearts 5.300.30 Ace of Hearts Living on the edge Complete a Chapter (floors I and II) after Basement Basement, start-to-finish, with only half a Heart total (can use The Lost The Lost) Convert all Turns all Pickups, Chests, and Added in Repentance non-boss enemies in the room into random Hearts.
Joker 5.300.31 Joker Always available ??? Teleports Isaac to the Devil Room Devil Room or Angel Room Angel Room.
Suicide King 5.300.46 Suicide King Suicide King Complete Suicide King (challenge #7) A true ending? Kills Isaac and spawns lots of Pickups, items, and/or Chests in the same room.
Added in Repentance Queen of Hearts 5.300.79 Queen of Hearts Queen of Hearts Defeat Mega Satan as Tainted Magdalene Tainted Magdalene <3 Drops 1-20 full Red Hearts on the ground.

Magic: The Gathering Card Backs

When on the ground, these cards look like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † / Removed in Repentance MagicCard.png Added in Repentance MagicCardRepentance.png

Name ID Icon Unlock method Message Description
Chaos Card 5.300.42 Chaos Card Chaos Card Complete Demo Man (challenge #9) ??? Throws the card to kill nearly anything in its path. Opens doors as if a Bomb exploded.
Added in Afterbirth † Huge Growth 5.300.52 Huge Growth Huge Growth Increase in size 5 times in a single run via Magic Mushroom Magic Mushroom, "One Makes you Larger" pills, XI - Strength XI - Strength, etc. Become immense! Makes Isaac large for the current room, increases damage by 7, increases range by Removed in Repentance 30 Added in Repentance 3, and allows Isaac to walk over obstacles to destroy them.
Added in Afterbirth † Ancient Recall 5.300.53 Ancient Recall Ancient Recall Use Cards and Runes 20 times Draw 3 cards Spawns 3 random cards.
Added in Afterbirth † Era Walk 5.300.54 Era Walk Era Walk Have both the Broken Watch Broken Watch and the Stop Watch Stop Watch unlocked Savor the moment For the current room, enemies are slowed, Isaac's speed is increased by 0.50, and his shot speed is decreased by 1.00.

Credit Card Back

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † CreditCard.png

Name ID Icon Unlock method Message Description
Credit Card 5.300.43 Credit Card Credit Card Complete Cursed! (challenge #10) Charge it! Converts all items in the Shop Shop, Devil Room Devil Room, or Black Market Black Market into pickups or items on pedestals, allowing them to be picked up for free.

Other Playing Card Backs

When on the ground, these cards look like: FaceCard.png

Name ID Icon Unlock method Message Description
Rules Card 5.300.44 Rules Card Rules Card Complete Glass Cannon (challenge #11) ??? Displays a cryptic statement on the screen, similar to a Fortune Teller. These messages (often) provide hints on bosses, bonus areas, etc.
Added in Afterbirth ? Card 5.300.48 ? Card Always available Double active When used, copies the effect of Isaac's currently held activated collectible.

Card Against Humanity Back

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † HumanityCard.png

Name ID Icon Unlock method Message Description
A Card Against Humanity 5.300.45 A Card Against Humanity Card Against Humanity Complete When Life Gives You Lemons (challenge #12) Something stinks... Covers the entire room with Poop. The process is not instant, and the room will not get filled if Isaac leaves before it's done filling.

Added in Afterbirth Chance Card Back

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † ChanceCard.png

Name ID Icon Unlock method Message Description
Get out of Jail Free Card 5.300.47 Get out of Jail Free Card Get out of Jail Free Card Complete SPEED! (challenge #22) Open Sesame Upon use, opens all doors in the current room, exactly like 15►Dad's Key Dad's Key.

Added in Afterbirth † Holy Card Back

When on the ground, this card looks like: HolyCard.png

Name ID Icon Unlock method Message Description
Holy Card 5.300.51 Holy Card Holy Card Defeat Delirium as The Lost The Lost You feel protected Grants a one-time Holy Mantle Holy Mantle effect. Removed in Repentance It lasts for the current room.

Added in Repentance Uno Card Back

When on the ground, this card looks like: WildCardBack.png

Name ID Icon Unlock method Message Description
Wild Card 5.300.80 Wild Card Wild Card Defeat Mega Satan as Tainted Eden Tainted Eden Again When used, copies the effect of the most recently used Pill, Card, Rune, Soul Stone or activated item.

Runes

Left Pointing Runes

When on the ground, these runes look like: Rune2.png

Name ID Icon Unlock method Message Description
Rune of Hagalaz 5.300.32 Rune of Hagalaz Rune of Hagalaz Complete Pitch Black (challenge #1) Destruction Destroys all breakable objects in the room. Does not affect Key Blocks.
Rune of Jera 5.300.33 Rune of Jera Rune of Jera Complete High Brow (challenge #2) Abundance Clones all pickups and Chests in the room (including Shop Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
Rune of Ehwaz 5.300.34 Rune of Ehwaz Rune of Ehwaz Complete Head Trauma (challenge #3) Passage Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to create a trapdoor leading to a Crawl Space Crawl Space instead.
Rune of Dagaz 5.300.35 Rune of Dagaz Rune of Dagaz Complete Darkness Falls (challenge #4) Purity Removes any Curses from the current floor and grants a Soul Heart Soul Heart. (This will not remove Curse of the Labyrinth.png Curse of the Labyrinth.)

Right Pointing Runes

When on the ground, these runes look like: Rune1.png

Name ID Icon Unlock method Message Description
Rune of Ansuz 5.300.36 Rune of Ansuz Rune of Ansuz Complete The Tank (challenge #5) Vision Reveals the whole map, including the Secret Room Secret Room and the Super Secret Room Super Secret Room. (This will not remove Curse of the Lost.png Curse of the Lost.) Added in Repentance Does not reveal the Ultra Secret Room Ultra Secret Room
Rune of Perthro 5.300.37 Rune of Perthro Rune of Perthro Complete Solar System (challenge #6) Change Re-rolls all item pedestals in the room (the same effect as The D6 The D6).
Rune of Berkano 5.300.38 Rune of Berkano Rune of Berkano Complete Purist (challenge #20) Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
Rune of Algiz 5.300.39 Rune of Algiz Rune of Algiz Complete Cat Got Your Tongue (challenge #8) Resistance Grants a shield which lasts for Removed in Repentance 30 Added in Repentance 20 seconds.
Added in Afterbirth Blank Rune 5.300.40 Blank Rune Blank Rune Removed in Afterbirth † Complete Onan's Streak (challenge #29)
Added in Afterbirth † Complete The Guardian (challenge #30)
??? Grants a random rune effect Removed in Repentance excluding Black Rune. Has a 25% chance to drop another Blank Rune on the ground upon use.

Other Runes

Added in Repentance Rune Shards can be encountered only as replacements for runes that have not been unlocked. Once all runes are available, Rune Shards cease to spawn.

Name ID Icon Unlock method Message Description
Added in Afterbirth † Black Rune 5.300.41 Black Rune Black Rune Defeat Ultra Greedier as Apollyon Apollyon Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on Shop Shop items.
Added in Repentance Rune Shard 5.300.55 Rune Shard Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a Soul Heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup, and Perthro re-rolls one item.

Added in Repentance Soul Stones

Soul Stones are all unlocked by beating both Hush Hush and Boss Rush Boss Rush as their respective Tainted character. They count as runes for the purposes of Clear Rune Clear Rune and Rune Bag Rune Bag.

Name ID Icon Unlock method Message Description
Soul of Isaac 5.300.81 Soul of Isaac Soul of Isaac Defeat Hush and Boss Rush Boss Rush as Tainted Isaac Tainted Isaac Reroll... or not Rerolls the items in the room like The D6 The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
Soul of Magdalene 5.300.82 Soul of Magdalene Soul of Magdalene Defeat Hush and Boss Rush Boss Rush as Tainted Magdalene Tainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop Half Red Heart Half Red Hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Soul of Cain Soul of Cain Defeat Hush and Boss Rush Boss Rush as Tainted Cain Tainted Cain Opens the unopenable Opens all doors in the room. Additionally, creates a Red Room Red Room like the Red Key Red Key on all valid walls. This also destroys the mirror located in Downpour Downpour / Dross Dross II.
Soul of Judas 5.300.84 Soul of Judas Soul of Judas Defeat Hush and Boss Rush Boss Rush as Tainted Judas Tainted Judas Right behind you Stops time for 3 seconds and invokes Dark Arts Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
Soul of ??? 5.300.85 Soul of ??? Soul of ??? Defeat Hush and Boss Rush Boss Rush as Tainted ??? Tainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Butt Bombs Butt Bombs in quick succession. Standing on the creep gives +1.35 Tears and +1 Damage.
Soul of Eve 5.300.86 Soul of Eve Soul of Eve Defeat Hush and Boss Rush Boss Rush as Tainted Eve Tainted Eve Your very own murder 14 Dead Bird Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Soul of Samson Soul of Samson Defeat Hush and Boss Rush Boss Rush as Tainted Samson Tainted Samson Slay a thousand Isaac turns berserk (similar to using Berserk! Berserk!) for 10 seconds, gaining +0.4 Speed, some Tears and +3 flat Damage along with his melee attack.
Soul of Azazel 5.300.88 Soul of Azazel Soul of Azazel Defeat Hush and Boss Rush Boss Rush as Tainted Azazel Tainted Azazel Demon rage! Activates Mega Blast Mega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Soul of Lazarus Soul of Lazarus Defeat Hush and Boss Rush Boss Rush as Tainted Lazarus Tainted Lazarus Life after death Isaac dies, and is immediately revived at half a Heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, functioning as a minimal extra life.
Soul of Eden 5.300.90 Soul of Eden Soul of Eden Defeat Hush and Boss Rush Boss Rush as Tainted Eden Tainted Eden Embrace chaos Uses The D6 The D6 and D20 D20. The rerolled items use random pools, as if Chaos Chaos were active.
Soul of the Lost 5.300.91 Soul of the Lost Soul of the Lost Defeat Hush and Boss Rush Boss Rush as Tainted Lost Tainted Lost Leave your body behind Isaac "dies" and turns into a ghost (similar to The Lost The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Allows him to take 1 Devil Room Devil Room items for free, after which the other items vanish. Also allows him to enter the Mausoleum Mausoleum / Gehenna Gehenna door for free. The Holy Mantle Holy Mantle effect gained from this can be stacked with multiple uses.
Soul of Lilith 5.300.92 Soul of Lilith Soul of Lilith Defeat Hush and Boss Rush Boss Rush as Tainted Lilith Tainted Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except Stitches Stitches. Unique familiars can be received only once.
Soul of the Keeper 5.300.93 Soul of the Keeper Soul of the Keeper Defeat Hush and Boss Rush Boss Rush as Tainted Keeper Tainted Keeper $$$ Drops 1-25 random Coins on the ground.
Soul of Apollyon 5.300.94 Soul of Apollyon Soul of Apollyon Defeat Hush and Boss Rush Boss Rush as Tainted Apollyon Tainted Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Soul of the Forgotten Soul of the Forgotten Defeat Hush and Boss Rush Boss Rush as Tainted Forgotten Tainted Forgotten Skeletal protector Spawns The Forgotten The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his 3 Bone Heart Bone Hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Soul of Bethany 5.300.96 Soul of Bethany Soul of Bethany Defeat Hush and Boss Rush Boss Rush as Tainted Bethany Tainted Bethany Friends from beyond Spawns 6 Book of Virtues Book of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Soul of Jacob and Esau Soul of Jacob and Esau Defeat Hush and Boss Rush Boss Rush as Tainted Jacob Tainted Jacob Bound by blood Spawns Esau Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items Isaac has, each based on the pools of the items Isaac's were obtained from.

Other

These are items other than cards and runes (and Pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. Added in Repentance These consumables cannot be replicated by either Blank Card Blank Card or Clear Rune Clear Rune, and Tarot Cloth Tarot Cloth has no effect on them.

Name ID Icon Unlock method Message Description
Added in Afterbirth Dice Shard 5.300.49 Dice Shard Always available D6 + D20 Upon use, invokes the effects of The D6 The D6 and the D20 D20 at the same time, re-rolling all item pedestals and pickups in the room.
Added in Afterbirth Emergency Contact 5.300.50 Emergency Contact Always available Help from above When used, will cause two Mom's Hands to come down and grab two random enemies, dealing damage and, if they have 40 or more HP, pinning them to the ground temporarily.
Added in Repentance Cracked Key 5.300.78 Cracked Key Red Key Open Mom's Chest in Home Home ??? Creates a room adjacent to a viable wall, like Red Key Red Key.

Notes

  • Removed in Repentance The game counts runes as cards for the purposes of Blank Card Blank Card, and Added in Afterbirth †Tarot Cloth Tarot Cloth.
  • Starter Deck Starter Deck does not prevent runes from generating, and allows holding two of them.
  • Added in Afterbirth Using the Blank Card with the ? Card teleports Isaac to the I AM ERROR I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
  • III - The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the Whore of Babylon Whore of Babylon.
    • The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
  • Removed in Repentance XV - The Devil card's effect does not stack with multiple uses, nor does it stack with The Book of Belial The Book of Belial. It also does not increase the chance of a Devil Room Devil Room or Angel Room Angel Room appearing when used like with the Book of Belial.
  • Using the Joker card in Womb Womb / Utero Utero II will instantly teleport Isaac to the Devil Room or Angel Room with a trapdoor leading to Sheol Sheol or to the Cathedral Cathedral. This can be used to skip Mom's Heart and will not count as a kill.
    • Added in Afterbirth After unlocking It Lives, Devil or Angel Rooms in Womb Womb / Utero Utero / Scarred Womb Scarred Womb II no longer contain trapdoors and instead have their normal contents.
  • Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
  • If Isaac uses XI - Strength card with only Soul, Black, or Bone Hearts left, and loses the non-Red Hearts while in the same room, he retains the full Red Heart Container that XI - Strength grants.
  • The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Room Secret Rooms.
  • Removed in Repentance The damage dealt by II - The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing Added in AfterbirthHost Hat Host Hat or Pyromaniac Pyromaniac.
  • Using XI - Strength as ??? ??? will give him a permanent Soul Heart instead of a temporary one. Added in Afterbirth When Keeper Keeper has only one Coin Heart, he can use XI - Strength to gain a second one which is also permanent.
  • While Curse of the Maze.png Curse of the Maze is active, 0 - The Fool, IX - Hermit, XVII - The Stars, and XVIII - The Moon may fail and leave Isaac in a different room than intended. The Joker card still works normally.
  • Using the XIV - Temperance can, in rare cases, spawn the Blood Donation Machine.png Blood Donation Machine directly on Isaac, forcing him to use it once.
  • All teleportation cards except 0 - The Fool are unavailable in Greed Mode.
  • Added in Repentance Leaving Trinkets in a Boss Room Boss Room or Treasure Room Treasure Room will transform them into a Cracked Key when on the Ascent to Home Home, if the Red Key is unlocked.
  • Added in Repentance Once Mother is defeated, a unique marked skull will spawn on Depths Depths / Necropolis Necropolis / Dank Depths Dank Depths II or XL. When destroyed, it will always drop 0 - The Fool card (Or an identified Telepills if Little Baggy Little Baggy has been picked up).
  • Added in Repentance Soul of Cain's effect can open any door that Cracked Orb Cracked Orb can, including the Strange Door and door to Mega Satan.
  • Added in Repentance Using Soul of The Lost and then beating a boss for a completion mark within the same room will not count as a completion mark for The Lost The Lost. Instead, the completion mark and achievement will go to the character who used the soul stone.
  • Added in Repentance Using 0 - The Fool? while having all empty Heart Containers with Soul Hearts will cause the Soul Hearts to all be dropped on the ground, killing Isaac.
  • Added in Repentance If Tarot Cloth Tarot Cloth is held, the currently held card will flash, indicating that it is being affected by Tarot Cloth.
  • Added in Repentance If Mega Chests have been unlocked, each Golden Chest spawned by VIII - Justice? has a chance of being replaced with a Mega Chest.
  • Added in Repentance Using any teleport cards while inside of The Beast fight will simply move Isaac instantly to different spot in the same room. This also ncludes the Joker card.
  • Added in Repentance Using IV - The Emperor? in Womb Womb / Utero Utero/ Scarred Womb Scarred Womb / Corpse Corpse I will spawn a boss from the current boss pool.
    • Using it in Womb Womb II will spawn an extra Mom's Heart or It Lives fight.
    • Using it in Corpse Corpse II will lead Isaac to an extra Mother boss fight.
    • Using it in Sheol Sheol / Cathedral Cathedral / Dark Room Dark Room / Chest Chest / The Void The Void / Home Home will teleport Isaac to a random room.
    • Using it in ??? ??? will teleport Isaac to an extra Monstro boss fight.
    • Using it in the Ascent version of Mausoleum Mausoleum II will spawn a beam of light leading to Depths Depths II.
    • Using it in the Ascent version of Mines Mines II will teleport Isaac a room containing Dad's Note Dad's Note.
    • Using it in the Ascent version of Caves Caves II will teleport Isaac to an extra Mom boss fight. Unlike the normal version, he can exit this fight normally.
    • It can be used to skip Boss Rush Boss Rush after touching a pedestal item. After defeating the extra Mom's Heart, leaving the room will lead Isaac to the regular, locked Mom boss room.
  • Added in Repentance Using IV - The Emperor? again on the same floor after defeating the boss it spawns takes Isaac back to the same cleared boss room.
  • Added in Repentance The effect of XIX - The Sun?, particularly flight, will persist even through the Knife Piece 2 Knife Piece 2 sequence.
  • Added in Repentance Familiars gained from Soul of Lilith do not count as collected, and can still spawn in their appropriate pools.
  • Added in Repentance Esau from the Soul of Jacob and Esau can use Devil Beggar.png Devil Beggar and Added in Repentance Hell Game.png Hell Game allowing The Lost The Lost and the Tainted Lost Tainted Lost to use them without dying, or a form of invulnerability.

Unlockable Achievements

Trivia

  • The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
    • Added in Repentance IX - The Hermit?'s effect was based directly on the Rune of Fehu from Antibirth. No other Antibirth rune was adapted into Repentance.
  • The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
  • Added in Afterbirth The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
  • Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
    • The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
    • Added in Afterbirth † The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
    • Added in Afterbirth † The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
    • Added in Afterbirth † The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
  • A NULL card with ID 0 exists, revealed by the "giveitem k0" Debug Console command. It can't be acquired or used in any way.
  • Added in Afterbirth † Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
  • Added in Repentance Soul of Cain's ability is likely a reference to Red Key Red Key being an unlock for Cain Cain in the original Antibirth mod.
  • Added in Repentance Soul of Judas' description and ability are a reference to the Spy from Team Fortress 2.
  • Added in Repentance Soul of Samson's description is a reference to Judges: it is said that Samson killed an army of 1,000 Philistines using a donkey's jawbone.
  • Added in Repentance Soul of Eve's description is a reference to the original description Birthright Birthright had when taken as Eve Eve in the original Antibirth mod.
    • Its effect was also probably inspired by the old original Birthright Birthright effect, which caused Eve Eve to sometimes generate extra Dead Bird Dead Birds upon being hit that would persist between rooms.
  • Added in RepentanceIII - The Empress? will display a pop up saying "The morning sun has vanquished the horrible night" a reference to Castlevania II: Simon's Quest when night turns to day.
    • This is also a reference to Whore of Babylon Whore of Babylon's (and by extension III - The Empress) pop up being the day to night message in said game.
  • Added in Repentance When VII - The Chariot? is activated, the statue will sometimes look like Edith, a character from Antibirth that wasn't adapted into Repentance.
  • Added in Repentance The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.

Voiceovers

Major Arcana Cards

Tarot Card Voiceover Voiceover (Reverse)
0 - The Fool
I - The Magician
II - The High Priestess
III - The Empress
IV - The Emperor
V - The Hierophant
VI - The Lovers
VII - The Chariot
VIII - Justice
IX - The Hermit
X - Wheel of Fortune
XI - Strength
XII - The Hanged Man
XIII - Death
XIV - Temperance
XV - The Devil
XVI - The Tower
XVII - The Stars
XVIII - The Moon
XIX - The Sun
XX - Judgement
XXI - The World

Playing Cards

Card Voiceover
2 of Clubs
2 of Diamonds
2 of Spades
2 of Hearts
Ace of Clubs
Ace of Diamonds
Ace of Spades
Ace of Hearts
Joker
Suicide King
Queen of Hearts

Runes and Soul Stones

Rune or Soul Stone Voiceover
Hagalaz
Jera
Ehwaz
Dagaz
Ansuz
Perthro
Berkano
Algiz
Black Rune
Rune Shard
Soul of Isaac
Soul of Magdalene
Soul of Cain
Soul of Judas
Soul of ???
Soul of Eve
Soul of Samson
Soul of Azazel
Soul of Lazarus
Soul of Eden
Soul of the Lost
Soul of Lilith
Soul of the Keeper
Soul of Apollyon
Soul of the Forgotten
Soul of Bethany
Soul of Jacob and Esau

Other cards and consumables

Consumable Voiceover
Chaos Card
Huge Growth
Ancient Recall
Era Walk
Credit Card
Rules Card
A Card Against Humanity
Get out of Jail Free Card
? Card
Dice Shard
Emergency Contact
Holy Card
Wild Card
Cracked Key

Gallery

Bugs

Bug Bug! Added in Afterbirth † / Removed in Repentance Rune of Hagalaz Rune of Hagalaz will open Secret Room Secret Room doors in L-shaped rooms.
Bug Bug! Added in Repentance Using XVI - The Tower? XVI - The Tower? in a Boss Room Boss Room may block all paths to the trap door, resulting in a softlock if no bombs or flight are available.
Bug Bug! Added in Repentance As Tainted Lazarus Tainted Lazarus , all effects of XIX - The Sun? XIX - The Sun? except bone heart conversion and sprite change will disappear when flipping.
Bug Bug! Added in Repentance If Esau Esau is holding Soul of Lazarus Soul of Lazarus when either Jacob Jacob or Esau dies, they will respawn without consuming the Soul of Lazarus. This effect will continue as long as Esau is the one holding it.


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