Binding of Isaac: Rebirth Wiki
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Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.

Runes and special cards are unlocked by completing challenges.

Cards

Major Arcana Cards

When on the ground, these cards look like: TarotCard

Name ID Icon Message Description
0 - The Fool 5.300.1 0 - The Fool Where journey begins Teleports Isaac back to the starting room of the floor that he is currently on.
I - The Magician 5.300.2 I - The Magician May you never miss your goal (except in Repentance) Grants homing tears for the current room.
(in Repentance) Grants homing tears and +3 Range for the current room.
II - The High Priestess 5.300.3 II - The High Priestess Mother is watching you Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. Shopkeepers count as enemies. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress 5.300.4 III - The Empress May your rage bring power Triggers the Collectible Whore of Babylon iconWhore of Babylon effect (+1.5 Damage, +0.3 Speed) for the current room, regardless of Isaac's health total.
IV - The Emperor 5.300.5 IV - The Emperor Challenge me! Teleports Isaac into the Boss RoomBoss Room of a floor.
V - The Hierophant 5.300.6 V - The Hierophant Two prayers for the lost Drops 2 full Soul HeartSoul Hearts on the ground.
VI - The Lovers 5.300.7 VI - The Lovers May you prosper and be in good health Drops 2 full Red HeartRed Hearts on the ground.
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies (same effect as Collectible My Little Unicorn iconMy Little Unicorn).
VIII - Justice 5.300.9 VIII - Justice May your future become balanced Drops a random type of Heart, KeyKey, BombBomb and Coin pickup on the ground.
IX - The Hermit 5.300.10 IX - The Hermit May you see what life has to offer Teleports Isaac to the ShopShop.
X - Wheel of Fortune 5.300.11 X - Wheel of Fortune Spin the wheel of destiny Creates a Slot MachineSlot Machine or Fortune Telling MachineFortune Telling Machine near Isaac.
XI - Strength 5.300.12 XI - Strength May your power bring rage Grants the effects of Collectible Magic Mushroom iconMagic Mushroom (minus the health restoration) for one room. The added Red Heart container is not removed if doing so would kill Isaac.
XII - The Hanged Man 5.300.13 XII - The Hanged Man May you find enlightenment Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as Collectible Transcendence iconTranscendence).
XIII - Death 5.300.14 XIII - Death Lay waste to all that oppose you Deals 40 damage to all enemies in the room (same effect as Collectible The Necronomicon iconThe Necronomicon).
XIV - Temperance 5.300.15 XIV - Temperance May you be pure in heart Creates a Blood Donation MachineBlood Donation Machine near Isaac. (except in Rebirth) Spawns a Devil BeggarDevil Beggar instead in Greed mode.
XV - The Devil 5.300.16 XV - The Devil Revel in the power of darkness Grants Isaac a temporary +2 increase to Damage for the current room (same effect as Collectible The Book of Belial iconThe Book of Belial).
XVI - The Tower 5.300.17 XVI - The Tower Destruction brings creation Drops 6 Troll BombTroll Bombs randomly around the room (same effect as the Collectible Anarchist Cookbook iconAnarchist Cookbook).
XVII - The Stars 5.300.18 XVII - The Stars May you find what you desire Teleports Isaac to the Treasure RoomTreasure Room. Randomly chooses a Treasure Room if there is an active Curse of the LabyrinthCurse of the Labyrinth. (in Repentance) If there is a PlanetariumPlanetarium, teleports Isaac there instead.
XVIII - The Moon 5.300.19 XVIII - The Moon May you find all you have lost Teleports Isaac to the Secret RoomSecret Room. This card will open one random wall once inside the Secret Room, so Isaac can leave even if he doesn't have any BombBombs available. Randomly chooses a Secret Room if there are multiple (via (in Afterbirth † and Repentance)Fragmented CardFragmented Card or (in Repentance)Collectible Luna iconLuna).
XIX - The Sun 5.300.20 XIX - The Sun May the light heal and enlighten you Restores Isaac to full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except for the Super Secret RoomSuper Secret Room (in Repentance) and Ultra Secret RoomUltra Secret Room. (in Repentance) Removes Curse of DarknessCurse of Darkness for the current floor.
XX - Judgement 5.300.21 XX - Judgement Judge lest ye be judged Spawns a BeggarBeggar or, more rarely, a Devil BeggarDevil Beggar, (in Repentance) Battery BumBattery Bum, (in Repentance) Rotten BeggarRotten Beggar, Key MasterKey Master, or (except in Rebirth) Bomb BumBomb Bum near Isaac.
XXI - The World 5.300.22 XXI - The World Open your eyes and see Reveals the entire floor, except for the Super Secret RoomSuper Secret Room (in Repentance) and Ultra Secret RoomUltra Secret Room.

(in Repentance) Reversed Major Arcana Cards

These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, a different message, the narrator sound clip reversed, and give different effects.

When on the ground, these cards look like: ReverseTarotCard

Name ID Icon Unlock method Message Description
0 - The Fool? 5.300.56 0 - The Fool? The Fool Defeat Ultra Greedier as Character Tainted Lost iconTainted Lost Let go and move on Drops all Hearts and pickups Isaac currently possesses on the floor, leaving Isaac at half a heart. Pickups may be dropped as items such as Collectible A Quarter iconA Quarter and Collectible Boom! iconBoom!.
I - The Magician? 5.300.57 I - The Magician? The Magician Defeat Ultra Greedier as Character Tainted Judas iconTainted Judas May no harm come to you Grants a repelling blue aura for one minute, like Collectible The Soul iconThe Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 II - The High Priestess? The High Priestess Defeat Ultra Greedier as Character Tainted Lilith iconTainted Lilith Run Boss Mom ingameMom's leg starts stomping down repeatedly (targeting Isaac, not the enemies) for one minute, like holding Collectible Broken Shovel 1 iconBroken Shovel.
III - The Empress? 5.300.59 III - The Empress? The Empress Defeat Ultra Greedier as Character Tainted Eve iconTainted Eve May your love bring protection Grants 2 temporary Red Heart Containers, +1.5 Fire Rate and -0.1 Speed for one minute, along with Character Magdalene iconMagdalene's hairstyle. The effect does not stack with itself. On characters that can't have Red Heart Containers, they will get Soul HeartSoul Hearts / Black HeartBlack Hearts / Bone HeartBone Hearts accordingly. When the effect ends, if the removal of the Heart Containers would kill Isaac, he gets left with one instead.
IV - The Emperor? 5.300.60 IV - The Emperor? The Emperor Defeat Ultra Greedier as Character Tainted ??? iconTainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss RoomBoss Room from the boss pool two floors deeper than the current floor (but never a final boss). The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used it.
V - The Hierophant? 5.300.61 V - The Hierophant? The Hierophant Defeat Ultra Greedier as Character Tainted Bethany iconTainted Bethany Two prayers for the forgotten Drops 2 Bone HeartBone Hearts on the ground.
VI - The Lovers? 5.300.62 VI - The Lovers? The Lovers Defeat Ultra Greedier as Character Tainted Magdalene iconTainted Magdalene May your heart shatter to pieces Creates a random item from the current room's item pool. Turns one Red Heart Container or two Soul HeartSoul Hearts into a Broken Heart.
VII - The Chariot? 5.300.63 VII - The Chariot? The Chariot Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible statue with 4x fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
VIII - Justice? 5.300.64 VIII - Justice? Justice Complete Cantripped (challenge #43) May your sins come back to torment you Creates 2 to 4 Locked ChestLocked Chests near Isaac.
IX - The Hermit? 5.300.65 IX - The Hermit? The Hermit Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room. Items are sold for 15 cents, pickups for their usual ShopShop price, spawning a matching amount of Coins. If there is nothing to sell, drops a PennyPenny.
X - Wheel of Fortune? 5.300.66 X - Wheel of Fortune? Wheel of Fortune Defeat Ultra Greedier as Character Tainted Cain iconTainted Cain Throw the dice of fate Invokes a random Dice RoomDice Room effect.
XI - Strength? 5.300.67 XI - Strength? Strength Defeat Ultra Greedier as Character Tainted Samson iconTainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.
XII - The Hanged Man? 5.300.68 XII - The Hanged Man? The Hanged Man Defeat Ultra Greedier as Character Tainted Keeper iconTainted Keeper May your greed know no bounds Isaac turns visually into Character Keeper iconKeeper for 30 seconds, with triple shot, no damage bonus, and -0.1 Speed. Killed enemies drop random Coins.
XIII - Death? 5.300.69 XIII - Death? Death Defeat Ultra Greedier as Character Tainted Forgotten iconTainted Forgotten May life spring forth from the fallen Invokes the Collectible Book of the Dead iconBook of the Dead effect.
XIV - Temperance? 5.300.70 XIV - Temperance? Temperance Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random Pills in quick succession.
XV - The Devil? 5.300.71 XV - The Devil? The Devil Defeat Ultra Greedier as Character Tainted Azazel iconTainted Azazel Bask in the light of your mercy Invokes Collectible The Bible iconThe Bible (which can kill Boss Mom ingameMom and grants Isaac flight) and spawns a Collectible Seraphim iconSeraphim familiar for 30 seconds.
XVI - The Tower? 5.300.72 XVI - The Tower? The Tower Defeat Ultra Greedier as Character Tainted Apollyon iconTainted Apollyon Creation brings destruction Creates 7 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of finding more than one in the same room. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 XVII - The Stars? The Stars Defeat Ultra Greedier as Character Tainted Isaac iconTainted Isaac May your loss bring fortune Removes Isaac's oldest passive item (ignoring starting items) and creates 2 random items from the current room's item pool. Does nothing if Isaac has no items.
XVIII - The Moon? 5.300.74 XVIII - The Moon? The Sun and the Moon Defeat Ultra Greedier as Character Tainted Jacob iconTainted Jacob May you remember lost memories Teleports Isaac to the Ultra Secret RoomUltra Secret Room. The pathway back to the normal rooms will be made of Red RoomRed Rooms.
XIX - The Sun? 5.300.75 XIX - The Sun? The Sun and the Moon Defeat Ultra Greedier as Character Tainted Jacob iconTainted Jacob May the darkness swallow all around you Gain Collectible Spirit of the Night iconSpirit of the Night and +1.5 Damage for the current floor. Turns Isaac's Red Hearts into Bone Hearts, but they revert once the effect ends. Also causes Curse of DarknessCurse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 XX - Judgement? Judgement Defeat Ultra Greedier as Character Tainted Lazarus iconTainted Lazarus May you redeem those found wanting Creates a Shop Restock MachineShop Restock Machine near Isaac.
XXI - The World? 5.300.77 XXI - The World? The World Defeat Ultra Greedier as Character Tainted Eden iconTainted Eden Step into the abyss Creates a trap door which always leads to a Crawl SpaceCrawl Space.

Playing Cards

When on the ground, these cards look like: FaceCard

Name ID Icon Unlock method Message Description
2 of Clubs 5.300.23 2 of Clubs Always available Item multiplier Doubles Isaac's BombBombs. If he has no bombs, gives him 2 instead.
2 of Diamonds 5.300.24 2 of Diamonds Always available Item multiplier Doubles Isaac's PennyPenny. If he has no coins, gives him 2 instead.
2 of Spades 5.300.25 2 of Spades Always available Item multiplier Doubles Isaac's KeyKeys. If he has no keys, gives him 2 instead.
2 of Hearts 5.300.26 2 of Hearts Always available Item multiplier Doubles Isaac's current number of Red HeartRed Hearts. Doesn't add new Red Heart containers, just fills empty ones. If Isaac has only empty Red Heart containers, he is healed for 1 Red Heart. (in Repentance) Doubles Character Tainted Bethany iconTainted Bethany's Blood Charges.
Ace of Clubs 5.300.27 Ace of Clubs Hat trick! Get a 3-win streak Convert all Turns all Pickups, Chests, and (in Repentance) non-boss enemies in the room into random Bomb pickups, including Troll BombTroll Bombs.
Ace of Diamonds 5.300.28 Ace of Diamonds ZIP! Defeat The Lamb in under 20 minutes Convert all Turns all Pickups, Chests, and (in Repentance) non-boss enemies in the room into random Coin pickups.
Ace of Spades 5.300.29 Ace of Spades It's the Key Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run Convert all Turns all Pickups, Chests, and (in Repentance) non-boss enemies in the room into random Key pickups.
Ace of Hearts 5.300.30 Ace of Hearts Living on the edge Complete a Chapter (floors I and II) after BasementBasement, start-to-finish, with only half a Heart total (can use Character The Lost iconThe Lost) Convert all Turns all Pickups, Chests, and (in Repentance) non-boss enemies in the room into random Hearts.
Joker 5.300.31 Joker Always available ??? Teleports Isaac to the Devil RoomDevil Room or Angel RoomAngel Room.
Suicide King 5.300.46 Suicide King Suicide King Complete Suicide King (challenge #7) A true ending? Kills Isaac and spawns lots of Pickups, items, and/or Chests in the same room.
Queen of Hearts 5.300.79 Queen of Hearts Queen of Hearts Defeat Mega Satan as Character Tainted Magdalene iconTainted Magdalene <3 Drops 1-20 full Red HeartRed Hearts on the ground.

Magic: The Gathering Card Backs

When on the ground, these cards look like: FaceCard    MagicCard MagicCardRepentance

Name ID Icon Unlock method Message Description
Chaos Card 5.300.42 Chaos Card Chaos Card Complete Demo Man (challenge #9) ??? Throws the card to kill nearly anything in its path. Opens doors as if a BombBomb exploded.
Huge Growth 5.300.52 Huge Growth Huge Growth Increase in size 5 times in a single run via Collectible Magic Mushroom iconMagic Mushroom, "One makes you larger" pills, XI - StrengthXI - Strength, etc. Become immense! (except in Repentance) For the current room, makes Isaac larger, allows him to crush obstacles he walks on, and grants +7 flat Damage and +30 Range.
(in Repentance) For the current room, makes Isaac larger, allows him to crush obstacles he walks on, and grants +7 flat Damage and +3 Range.
Ancient Recall 5.300.53 Ancient Recall Ancient Recall Use Cards and Runes 20 times Draw 3 cards Spawns 3 random cards.
Era Walk 5.300.54 Era Walk Era Walk Add both the Collectible Broken Watch iconBroken Watch and the Collectible Stop Watch iconStop Watch to your collection Savor the moment For the current room, enemies are slowed, Isaac's speed is increased by 0.50, and his shot speed is decreased by 1.00.

Credit Card Back

When on the ground, this card looks like: FaceCard    CreditCard

Name ID Icon Unlock method Message Description
Credit Card 5.300.43 Credit Card Credit Card Complete Cursed! (challenge #10) Charge it! Makes all pickups and items that cost money or health in the room free.

Other Playing Card Backs

When on the ground, these cards look like: FaceCard

Name ID Icon Unlock method Message Description
Rules Card 5.300.44 Rules Card Rules Card Complete Glass Cannon (challenge #11) ??? Displays a cryptic statement on the screen, similar to a Fortune Telling MachineFortune Telling Machine. These messages (often) provide hints on bosses, bonus areas, etc.
? Card 5.300.48 ? Card Always available Double active When used, copies the effect of Isaac's currently held activated collectible.

Card Against Humanity Back

When on the ground, this card looks like: FaceCard    HumanityCard

Name ID Icon Unlock method Message Description
A Card Against Humanity 5.300.45 A Card Against Humanity Card Against Humanity Complete When Life Gives You Lemons (challenge #12) Something stinks... Covers the entire room with PoopPoop. The process is not instant, and the room will not get filled if Isaac leaves before it's done filling.

Chance Card Back

When on the ground, this card looks like: FaceCard    ChanceCard

Name ID Icon Unlock method Message Description
Get out of Jail Free Card 5.300.47 Get out of Jail Free Card Get out of Jail Free Card Complete SPEED! (challenge #22) Open Sesame Upon use, opens all doors in the current room, exactly like Collectible Dad's Key iconDad's Key.

Holy Card Back

When on the ground, this card looks like: HolyCard

Name ID Icon Unlock method Message Description
Holy Card 5.300.51 Holy Card Holy Card Defeat Delirium as Character The Lost iconThe Lost You feel protected Grants a one-time Collectible Holy Mantle iconHoly Mantle effect. (except in Repentance) It lasts for the current room.

Uno Card Back

When on the ground, this card looks like: WildCardBack

Name ID Icon Unlock method Message Description
Wild Card 5.300.80 Wild Card Wild Card Defeat Mega Satan as Character Tainted Eden iconTainted Eden Again When used, copies the effect of the most recently used Pill, Card, Rune, Soul Stone or activated item.

Runes

Left Pointing Runes

When on the ground, these runes look like: Rune2

Name ID Icon Unlock method Message Description
Rune of Hagalaz 5.300.32 Rune of Hagalaz Rune of Hagalaz Complete Pitch Black (challenge #1) Destruction Destroys all breakable objects in the room. Does not affect Key Blocks.
Rune of Jera 5.300.33 Rune of Jera Rune of Jera Complete High Brow (challenge #2) Abundance Clones all pickups and Chests in the room (including ShopShop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
Rune of Ehwaz 5.300.34 Rune of Ehwaz Rune of Ehwaz Complete Head Trauma (challenge #3) Passage Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to create a trapdoor leading to a Crawl SpaceCrawl Space instead. (in Repentance) Guaranteed to create a trap door to a Crawl SpaceCrawl Space if used on floor tiles containing certain patterns. Will not create trapdoors if used on the end floor of a challenge.
Rune of Dagaz 5.300.35 Rune of Dagaz Rune of Dagaz Complete Darkness Falls (challenge #4) Purity Removes any Curses from the current floor and grants a Soul HeartSoul Heart. (This will not remove Curse of the LabyrinthCurse of the Labyrinth.)

Right Pointing Runes

When on the ground, these runes look like: Rune1

Name ID Icon Unlock method Message Description
Rune of Ansuz 5.300.36 Rune of Ansuz Rune of Ansuz Complete The Tank (challenge #5) Vision Reveals the whole map, including the Secret RoomSecret Room and the Super Secret RoomSuper Secret Room. (This will not remove Curse of the LostCurse of the Lost.) (in Repentance) Does not reveal the Ultra Secret RoomUltra Secret Room
Rune of Perthro 5.300.37 Rune of Perthro Rune of Perthro Complete Solar System (challenge #6) Change Rerolls all item pedestals in the room (the same effect as Collectible The D6 iconThe D6).
Rune of Berkano 5.300.38 Rune of Berkano Rune of Berkano Complete Purist (challenge #20) Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
Rune of Algiz 5.300.39 Rune of Algiz Rune of Algiz Complete Cat Got Your Tongue (challenge #8) Resistance (except in Repentance) Grants a shield which lasts for 30 seconds.
(in Repentance) Grants a shield which lasts for 20 seconds.
Blank Rune 5.300.40 Blank Rune Blank Rune (in Rebirth and Afterbirth) Complete Onan's Streak (challenge #29)
(in Afterbirth † and Repentance) Complete The Guardian (challenge #30)
??? Grants a random rune effect (except in Repentance) excluding Black Rune. Has a 25% chance to drop another Blank Rune on the ground upon use.

Other Runes

(in Repentance) Rune Shards can be encountered only as replacements for runes that have not been unlocked. Once all runes are available, Rune Shards cease to spawn.

Name ID Icon Unlock method Message Description
Black Rune 5.300.41 Black Rune Black Rune Defeat Ultra Greedier as Character Apollyon iconApollyon Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on ShopShop or Devil RoomDevil Room items. (Essentially, activates Collectible The Necronomicon iconThe Necronomicon, Collectible Compost iconCompost, and Collectible Void iconVoid).
Rune Shard 5.300.55 Rune Shard Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a Soul Heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup, and Perthro rerolls one item.

(in Repentance) Soul Stones

Soul Stones are all unlocked by beating both Hush and Boss Rush as their respective Tainted character. They count as runes for the purposes of duplication with Collectible Clear Rune iconClear Rune, and Collectible Rune Bag iconRune Bag and other sources for generation.

Name ID Icon Unlock method Message Description
Soul of Isaac 5.300.81 Soul of Isaac Soul of Isaac Defeat Hush and Boss RushBoss Rush as Character Tainted Isaac iconTainted Isaac Reroll... or not Rerolls the items in the room like Collectible The D6 iconThe D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
Soul of Magdalene 5.300.82 Soul of Magdalene Soul of Magdalene Defeat Hush and Boss RushBoss Rush as Character Tainted Magdalene iconTainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop Half Red HeartHalf Red Hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Soul of Cain Soul of Cain Defeat Hush and Boss RushBoss Rush as Character Tainted Cain iconTainted Cain Opens the unopenable Opens all doors in the room. Additionally, creates a Red RoomRed Room like the Collectible Red Key iconRed Key on all valid walls. This also destroys the mirror located in DownpourDownpour / DrossDross II.
Soul of Judas 5.300.84 Soul of Judas Soul of Judas Defeat Hush and Boss RushBoss Rush as Character Tainted Judas iconTainted Judas Right behind you Stops time for 3 seconds and invokes Collectible Dark Arts iconDark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
Soul of ??? 5.300.85 Soul of ??? Soul of ??? Defeat Hush and Boss RushBoss Rush as Character Tainted ??? iconTainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Collectible Butt Bombs iconButt Bombs in quick succession. Standing on the creep gives +1.5 Fire Rate and +1 Damage.
Soul of Eve 5.300.86 Soul of Eve Soul of Eve Defeat Hush and Boss RushBoss Rush as Character Tainted Eve iconTainted Eve Your very own murder 14 Collectible Dead Bird iconDead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Soul of Samson Soul of Samson Defeat Hush and Boss RushBoss Rush as Character Tainted Samson iconTainted Samson Slay a thousand Isaac turns berserk (similar to using Collectible Berserk! iconBerserk!) for 10 seconds, gaining +0.4 Speed, some Tears and +3 flat Damage along with his melee attack.
Soul of Azazel 5.300.88 Soul of Azazel Soul of Azazel Defeat Hush and Boss RushBoss Rush as Character Tainted Azazel iconTainted Azazel Demon rage! Activates Collectible Mega Blast iconMega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Soul of Lazarus Soul of Lazarus Defeat Hush and Boss RushBoss Rush as Character Tainted Lazarus iconTainted Lazarus Life after death Isaac dies, and is immediately revived at half a Heart in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage. Has the highest priority of all Revival items.
Soul of Eden 5.300.90 Soul of Eden Soul of Eden Defeat Hush and Boss RushBoss Rush as Character Tainted Eden iconTainted Eden Embrace chaos Uses Collectible The D6 iconThe D6 and Collectible D20 iconD20. The rerolled items use random pools, as if Collectible Chaos iconChaos were active.
Soul of the Lost 5.300.91 Soul of the Lost Soul of the Lost Defeat Hush and Boss RushBoss Rush as Character Tainted Lost iconTainted Lost Leave your body behind Isaac "dies" and turns into a ghost (similar to Character The Lost iconThe Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Allows him to take 1 Devil RoomDevil Room items for free, after which the other items vanish. Also allows him to enter the MausoleumMausoleum / GehennaGehenna door for free. The Collectible Holy Mantle iconHoly Mantle effect gained from this can be stacked with multiple uses.
Soul of Lilith 5.300.92 Soul of Lilith Soul of Lilith Defeat Hush and Boss RushBoss Rush as Character Tainted Lilith iconTainted Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except Collectible Stitches iconStitches. Can give familiars that the player already has. Unique familiars can be received only once.
Soul of the Keeper 5.300.93 Soul of the Keeper Soul of the Keeper Defeat Hush and Boss RushBoss Rush as Character Tainted Keeper iconTainted Keeper $$$ Drops 1-25 random Coins on the ground.
Soul of Apollyon 5.300.94 Soul of Apollyon Soul of Apollyon Defeat Hush and Boss RushBoss Rush as Character Tainted Apollyon iconTainted Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Soul of the Forgotten Soul of the Forgotten Defeat Hush and Boss RushBoss Rush as Character Tainted Forgotten iconTainted Forgotten Skeletal protector Spawns Character The Forgotten iconThe Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his 3 Bone HeartBone Hearts run out, with no further consequence, and disappears when Isaac leaves the room. The bone swing deals high damage, and reflects tears.
Soul of Bethany 5.300.96 Soul of Bethany Soul of Bethany Defeat Hush and Boss RushBoss Rush as Character Tainted Bethany iconTainted Bethany Friends from beyond Spawns 6 Collectible Book of Virtues iconBook of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Soul of Jacob and Esau Soul of Jacob and Esau Defeat Hush and Boss RushBoss Rush as Character Tainted Jacob iconTainted Jacob Bound by blood Spawns Character Esau iconEsau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items Isaac has, each based on the pools of the items Isaac's were obtained from.

Other

These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. (in Repentance) These consumables cannot be replicated by either Collectible Blank Card iconBlank Card or Collectible Clear Rune iconClear Rune, and Collectible Tarot Cloth iconTarot Cloth has no effect on them.

Name ID Icon Unlock method Message Description
(except in Rebirth) Dice Shard 5.300.49 Dice Shard Always available D6 + D20 Upon use, invokes the effects of Collectible The D6 iconThe D6 and the Collectible D20 iconD20 at the same time, re-rolling all item pedestals and pickups in the room.
(except in Rebirth) Emergency Contact 5.300.50 Emergency Contact Always available Help from above When used, will cause two Mom's HandMom's Hands to come down and grab two random enemies, dealing damage and, if they have 40 or more HP, pinning them to the ground temporarily.
(in Repentance) Cracked Key 5.300.78 Cracked Key Red Key Open Mom's Chest in (in Repentance)HomeHome ??? Creates a room adjacent to a viable wall, like Collectible Red Key iconRed Key.

Notes

  • (except in Repentance) The game counts runes as cards for the purposes of Collectible Starter Deck iconStarter Deck, Collectible Blank Card iconBlank Card, and (in Afterbirth † and Repentance)Collectible Tarot Cloth iconTarot Cloth.
  • (except in Rebirth) Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
  • The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the Collectible Whore of Babylon iconWhore of Babylon.
    • The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
  • (except in Repentance) The Devil card's effect does not stack with multiple uses, nor does it stack with Collectible The Book of Belial iconThe Book of Belial. It also does not increase the chance of a Devil or Angel Room appearing when used like with the Book of Belial.
  • Using the Joker card in WombWomb II or UteroUtero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to SheolSheol or to the CathedralCathedral. This can be used to skip Mom's Heart and will not count as a kill.
    • (except in Rebirth) After unlocking It Lives, Devil or Angel Rooms in Template:Stage II, Template:Stage II, and (except in Rebirth)Scarred WombScarred Womb II no longer contain trapdoors and instead have their normal contents.
  • Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
  • If you use the Strength card with only Soul, Black, or Bone Hearts left, and lose the non-Red Hearts while in the same room, you retain the full Red Heart container that Strength grants after you leave.
  • The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Rooms.
  • (except in Repentance) The damage dealt by The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing (except in Rebirth)Collectible Host Hat iconHost Hat or Collectible Pyromaniac iconPyromaniac.
  • Using the sun card as Character ??? (Character) icon??? or characters with only soul hearts will not grant additional health.
  • Using the Strength card as Character ??? (Character) icon??? will give you a permanent Soul Heart instead of a temporary one. (except in Rebirth) When Character Keeper iconKeeper has only one Coin Heart, he can use the Strength card to gain a second one which is also permanent.
  • While Curse of the Maze is active, The Fool, Moon, Hermit, and Stars cards may fail and leave the player in a different room than intended. The Joker card still works normally.
  • Using the Temperance card can, in rare cases, spawn the Blood Donation Machine directly on the player, forcing them to use it once. Caution should be taken when using Temperance as Character The Lost iconThe Lost (or when on half a heart of health), as this will instantly kill the player regardless of the Collectible Holy Mantle iconHoly Mantle.
  • All teleportation cards except The Fool are unavailable in Greed Mode.
  • (in Repentance) Rune Shards spawn in place of a Rune that hasn't been unlocked yet. Once all Runes are unlocked, Rune Shards no longer appear.
  • (in Repentance) Leaving Trinkets in a Boss Room or a Treasure Room will transform them into a Cracked Key when on the Ascent to Template:Stage, if the Red Key is unlocked.
  • (in Repentance) Once Mother is defeated, a unique marked skull will spawn on Template:Stage II or XL. When destroyed, it will always drop The Fool card (Or an identified Telepills if Collectible Little Baggy iconLittle Baggy has been picked up).
  • (in Repentance) Soul of Cain's effect can open any door that Collectible Cracked Orb iconCracked Orb can, including the Strange Door and door to Mega Satan.
  • (in Repentance) Using Soul of The Lost and then beating a boss for a completion mark within the same room will not count as a completion mark for The Lost. Instead, the completion mark and achievement will go to the character who used the soul stone.
  • (in Repentance) Esau spawned using Soul of Jacob and Esau spawns with random items based on the pools of the items that Isaac currently holds.
  • (in Repentance) Using The Fool? while having all empty heart containers with soul hearts will cause the soul hearts to all be dropped on the ground, killing the player.
  • (in Repentance) If (in Afterbirth † and Repentance)Collectible Tarot Cloth iconTarot Cloth is held, the currently held card will flash, indicating that it is being affected by Tarot Cloth.
  • (in Repentance) If Mega Chests have been unlocked. each Golden Chest spawned by Justice? has a chance of being replaced with a Mega Chest.
  • (in Repentance) Using The Emperor? in WombWomb I or (in Repentance)CorpseCorpse I will spawn a boss from the current boss pool.
    • Using it in WombWomb II will spawn an extra Mom's Heart or It Lives fight.
    • Using it in (in Repentance) (in Repentance)CorpseCorpse II will lead you to an extra (in Repentance) Mother boss fight.
    • Using it in SheolSheol, CathedralCathedral, Dark RoomDark Room, ChestChest, (in Afterbirth † and Repentance) (in Afterbirth † and Repentance)The VoidThe Void or (in Repentance) (in Repentance)HomeHome will teleport you to a random room.
    • Using it in (except in Rebirth) (except in Rebirth)?????? will teleport you to a extra Monstro boss fight.
    • Using it in the Ascent version of (in Repentance) (in Repentance)MausoleumMausoleum II will spawn a beam of light leading to DepthsDepths II.
    • Using it in the Ascent version of (in Repentance) (in Repentance)MinesMines II will spawn a room having Dad's Note.
    • Using it in the Ascent version of CavesCaves II will teleport you to a extra Mom boss fight. Unlike the normal version, you can exit this fight normally.
    • It can be used to skip the Boss Rush after touching a pedestal item. After defeating the extra Mom's Heart, leaving the room will lead you to the regular, locked Mom boss room. The door to the Boss Rush will remain open if the timer allows it, but it cannot be restarted.
  • (in Repentance) XIX - The Sun? effect, particularly flight, will persist even through the Knife Piece 2 sequence.
  • (in Repentance) Using The Moon? in (except in Rebirth)?????? will teleport you to the current room.
    • Using it in Ascent or (in Repentance)HomeHome will teleport you to a random room.

Unlockable Achievements

Trivia

  • The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
    • (in Repentance) IX - The Hermit?'s effect was based directly on the Rune of Fehu from Antibirth. No other Antibirth rune was adapted into Repentance.
  • The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
  • (except in Rebirth) The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
  • Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
    • The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
    • (in Afterbirth † and Repentance) The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
    • (in Afterbirth † and Repentance) The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
    • (in Afterbirth † and Repentance) The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
  • A NULL card with ID 0 exists, revealed by the "giveitem k0" Debug Console command. It can't be acquired or used in any way.
  • (in Afterbirth † and Repentance) Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
  • (in Repentance) Soul of Cain's ability is likely a reference to (in Repentance)Collectible Red Key iconRed Key being an unlock for Character Cain iconCain in the original Antibirth mod.
  • (in Repentance) Soul of Judas' description and ability are a reference to the Spy from Team Fortress 2.
  • (in Repentance) Soul of Samson's description is a reference to Judges: it is said that Samson killed an army of 1,000 Philistines using a donkey's jawbone.
  • (in Repentance) Soul of Eve's description is a reference to the original description (in Repentance)Collectible Birthright iconBirthright had when taken as Character Eve iconEve in the original Antibirth mod.
    • Its effect was also probably inspired by the old original (in Repentance)Collectible Birthright iconBirthright effect, which caused Character Eve iconEve to sometimes generate extra Collectible Dead Bird iconDead Birds upon being hit that would persist between rooms.
  • (in Repentance)III - The Empress? will display a pop up saying "The morning sun has vanquished the horrible night" a reference to Castlevania II: Simon's Quest when night turns to day.
    • This is also a reference to Collectible Whore of Babylon iconWhore of Babylon's (and by extension III - The Empress) pop up being the day to night message in said game.
  • (in Repentance) When VII - The Chariot? is activated, the statue will sometimes look like Edith, a character from Antibirth that wasn't adapted into Repentance.
  • (in Repentance) The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.


Gallery

Bugs

Bug Bug! (in Afterbirth †) Rune of HagalazRune of Hagalaz will open Secret Room doors in L-shaped rooms.
Bug Bug! (in Repentance) Entering a trapdoor created by Rune of EhwazRune of Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.
Bug Bug! (in Repentance) Using IV - The Emperor?IV - The Emperor? on ??? (floor) and defeating Monstro will validate the completion mark for Hush.
Bug Bug! Using (in Repentance)IV - The Emperor?IV - The Emperor? on Mausoleum/Gehenna II will teleport Isaac to the floor's Mom fight, however, when this boss is killed, no exit will spawn, likely softlocking Isaac.
Bug Bug! (in Repentance) Using IV - The Emperor?IV - The Emperor? on Caves 2 will teleport Isaac to the Mom fight, which will not spawn an exit door, resulting in a softlock. This does not happen in the Ascent.
Bug Bug! (in Repentance) Using IV - The Emperor?IV - The Emperor? on Mausoleum I has a chance to teleport you to the Rotgut fight. Defeat it and the door will lead you to the 3rd phase of the fight.
Bug Bug! (in Repentance) Using IV - The Emperor?IV - The Emperor? on Gehenna I, due to the lack of a alternative variant for Corpse, will teleport Isaac to a green looking Gehenna room without walls where you fight Monstro.
Bug Bug! (in Repentance) Using IV - The Emperor?IV - The Emperor? on Mausoleum/Gehenna II will teleport Isaac to the Mother's fight access room, entering it will crash the game
Bug Bug! (in Repentance) If the Esau spawned by Soul of Jacob and EsauSoul of Jacob and Esau spawns with Collectible Birthright iconBirthright, the game will instantly crash.
Bug Bug! (in Repentance) If the Esau spawned with Soul of Jacob and EsauSoul of Jacob and Esau touches the end chest, the game will crash.
Bug Bug! (in Repentance) Using III - The Empress?III - The Empress? as Keeper will not grant extra heart containers, but will permanently remove two when the effect wears off.
Bug Bug! (in Repentance) Using III - The Empress?III - The Empress? as ??? and Tainted ??? will leave him at one half soul heart when the effect wears off.
Bug Bug! (in Repentance) Using JokerJoker in the Mirrored World causes the game to crash
Bug Bug! (in Repentance) If Isaac has heart containers and they are all empty, using (in Repentance)0 - The Fool?0 - The Fool? will remove all of Isaac's soul hearts and kill him.
Bug Bug! (in Repentance) Using (in Repentance)XVIII - The Moon?XVIII - The Moon? can generate a red room attached to a Secret Room. Isaac will need a bomb to exit, potentially softlocking him
Bug Bug! (in Repentance) Using (in Repentance)XVIII - The Moon?XVIII - The Moon? has a chance to softlock the player if it tries to generate a red room on the space that cannot have one
Bug Bug! Using (in Repentance)XVII - The Stars?XVII - The Stars? can remove starting items in challenges.


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