| Pickups |
| Hearts | Coins | Bombs | Keys | Batteries | Pills | Cards/Runes | Chests |  Sacks
|
Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.
Runes and special cards are unlocked by completing challenges.
Cards
Major Arcana Cards
When on the ground, these cards look like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| 0 - The Fool | 5.300.1 | 
|
Where journey begins | Teleports Isaac back to the starting room of the floor that he is currently on. |
| I - The Magician | 5.300.2 | 
|
May you never miss your goal |  Grants homing tears for the current room. Grants homing tears and +3 Range for the current room.
|
| II - The High Priestess | 5.300.3 | 
|
Mother is watching you | Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. Shopkeepers count as enemies. If used in an empty room or during the fight with Mom, it will stomp Isaac instead. |
| III - The Empress | 5.300.4 | 
|
May your rage bring power | Triggers the  Whore of Babylon effect (+1.5 Damage, +0.3 Speed) for the current room, regardless of Isaac's health total.
|
| IV - The Emperor | 5.300.5 | 
|
Challenge me! | Teleports Isaac into the  Boss Room of a floor.
|
| V - The Hierophant | 5.300.6 | 
|
Two prayers for the lost | Drops 2 full  Soul Hearts on the ground.
|
| VI - The Lovers | 5.300.7 | 
|
May you prosper and be in good health | Drops 2 full  Red Hearts on the ground.
|
| VII - The Chariot | 5.300.8 | 
|
May nothing stand before you | Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies (same effect as  My Little Unicorn).
|
| VIII - Justice | 5.300.9 | 
|
May your future become balanced | Drops a random type of Heart,  Key,  Bomb and Coin pickup on the ground.
|
| IX - The Hermit | 5.300.10 | 
|
May you see what life has to offer | Teleports Isaac to the  Shop.
|
| X - Wheel of Fortune | 5.300.11 | 
|
Spin the wheel of destiny | Creates a  Slot Machine or  Fortune Telling Machine near Isaac.
|
| XI - Strength | 5.300.12 | 
|
May your power bring rage | Grants the effects of  Magic Mushroom (minus the health restoration) for one room. The added Red Heart container is not removed if doing so would kill Isaac.
|
| XII - The Hanged Man | 5.300.13 | 
|
May you find enlightenment | Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as  Transcendence).
|
| XIII - Death | 5.300.14 | 
|
Lay waste to all that oppose you | Deals 40 damage to all enemies in the room (same effect as  The Necronomicon).
|
| XIV - Temperance | 5.300.15 | 
|
May you be pure in heart | Creates a  Blood Donation Machine near Isaac. Spawns a  Devil Beggar instead in Greed mode.
|
| XV - The Devil | 5.300.16 | 
|
Revel in the power of darkness | Grants Isaac a temporary +2 increase to Damage for the current room (same effect as  The Book of Belial).
|
| XVI - The Tower | 5.300.17 | 
|
Destruction brings creation | Drops 6  Troll Bombs randomly around the room (same effect as the  Anarchist Cookbook).
|
| XVII - The Stars | 5.300.18 | 
|
May you find what you desire | Teleports Isaac to the  Treasure Room. Randomly chooses a Treasure Room if there is an active  Curse of the Labyrinth. If there is a  Planetarium, teleports Isaac there instead.
|
| XVIII - The Moon | 5.300.19 | 
|
May you find all you have lost | Teleports Isaac to the  Secret Room. This card will open one random wall once inside the Secret Room, so Isaac can leave even if he doesn't have any Bombs available. Randomly chooses a Secret Room if there are multiple (via   Fragmented Card or  Luna).
|
| XIX - The Sun | 5.300.20 | 
|
May the light heal and enlighten you | Restores Isaac to full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except for the  Super Secret Room and  Ultra Secret Room. Removes  Curse of Darkness for the current floor.
|
| XX - Judgement | 5.300.21 | 
|
Judge lest ye be judged | Spawns a  Beggar or, more rarely, a Devil Beggar,  Battery Bum,  Rotten Beggar,  Key Master, or  Bomb Bum near Isaac.
|
| XXI - The World | 5.300.22 | 
|
Open your eyes and see | Reveals the entire floor, except for the Super Secret Room and Ultra Secret Room.
|
Reversed Major Arcana Cards
These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, the narrator sound clip reversed, and give different effects.
| Name | ID | Icon | Unlock method | Message | Description |
|---|---|---|---|---|---|
| 0 - The Fool? | 5.300.56 | 
|
 Defeat Ultra Greedier as  Tainted Lost
|
Let go and move on | Drops all Hearts and pickups Isaac currently possesses on the floor, leaving Isaac at half a heart. Pickups may be dropped as items such as  A Quarter and  Boom!.
|
| I - The Magician? | 5.300.57 | 
|
 Defeat Ultra Greedier as  Tainted Judas
|
May no harm come to you | Grants a repelling blue aura for one minute, like  The Soul but stronger and with a wider area of effect.
|
| II - The High Priestess? | 5.300.58 | 
|
 Defeat Ultra Greedier as  Tainted Lilith
|
Run |  Mom's leg starts stomping down repeatedly (targeting Isaac, not the enemies) for one minute, like holding  Broken Shovel.
|
| III - The Empress? | 5.300.59 | 
|
 Defeat Ultra Greedier as  Tainted Eve
|
May your love bring protection | Grants 2 temporary Red Heart Containers, +1.5 Fire Rate and -0.1 Speed for one minute, along with  Magdalene's hairstyle. The effect does not stack with itself. On characters that can't have Red Heart Containers, they will get Soul Hearts /  Black Hearts /  Bone Hearts accordingly. When the effect ends, if the removal of the Heart Containers would kill Isaac, he gets left with one instead.
|
| IV - The Emperor? | 5.300.60 | 
|
 Defeat Ultra Greedier as  Tainted ???
|
May you find a worthy opponent | Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor (but never a final boss). The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used it.
|
| V - The Hierophant? | 5.300.61 | 
|
 Defeat Ultra Greedier as  Tainted Bethany
|
Two prayers for the forgotten | Drops 2 Bone Hearts on the ground.
|
| VI - The Lovers? | 5.300.62 | 
|
 Defeat Ultra Greedier as  Tainted Magdalene
|
May your heart shatter to pieces | Creates a random item from the current room's item pool. Turns one Red Heart Container or two Soul Hearts into a Broken Heart.
|
| VII - The Chariot? | 5.300.63 | 
|
 Complete Hot Potato (challenge #42)
|
May nothing walk past you | Isaac becomes an invincible statue with 4x fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback. |
| VIII - Justice? | 5.300.64 | 
|
 Complete Cantripped (challenge #43)
|
May your sins come back to torment you | Creates 2 to 4  Locked Chests near Isaac.
|
| IX - The Hermit? | 5.300.65 | 
|
 Complete Red Redemption (challenge #44)
|
May you see the value of all things in life | "Sells" items and pickups in the room. Items are sold for 15 cents, pickups for their usual Shop price, spawning a matching amount of Coins. If there is nothing to sell, drops a  Penny.
|
| X - Wheel of Fortune? | 5.300.66 | 
|
 Defeat Ultra Greedier as  Tainted Cain
|
Throw the dice of fate | Invokes a random  Dice Room effect.
|
| XI - Strength? | 5.300.67 | 
|
 Defeat Ultra Greedier as  Tainted Samson
|
May you break their resolve | All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left. |
| XII - The Hanged Man? | 5.300.68 | 
|
 Defeat Ultra Greedier as  Tainted Keeper
|
May your greed know no bounds | Isaac turns visually into  Keeper for 30 seconds, with triple shot, no damage bonus, and -0.1 Speed. Killed enemies drop random Coins.
|
| XIII - Death? | 5.300.69 | 
|
 Defeat Ultra Greedier as  Tainted Forgotten
|
May life spring forth from the fallen | Invokes the  Book of the Dead effect.
|
| XIV - Temperance? | 5.300.70 | 
|
 Complete DELETE THIS (challenge #45)
|
May your hunger be satiated | Forces Isaac to eat 5 random Pills in quick succession. |
| XV - The Devil? | 5.300.71 | 
|
 Defeat Ultra Greedier as  Tainted Azazel
|
Bask in the light of your mercy | Invokes  The Bible (which can kill Mom and grants Isaac flight) and spawns a  Seraphim familiar for 30 seconds.
|
| XVI - The Tower? | 5.300.72 | 
|
 Defeat Ultra Greedier as  Tainted Apollyon
|
Creation brings destruction | Creates 7 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of finding more than one in the same room. The pathways between exits can't be blocked. |
| XVII - The Stars? | 5.300.73 | 
|
 Defeat Ultra Greedier as  Tainted Isaac
|
May your loss bring fortune | Removes Isaac's oldest passive item (ignoring starting items) and creates 2 random items from the current room's item pool. Does nothing if Isaac has no items. |
| XVIII - The Moon? | 5.300.74 | 
|
 Defeat Ultra Greedier as  Tainted Jacob
|
May you remember lost memories | Teleports Isaac to the Ultra Secret Room. The pathway back to the normal rooms will be made of  Red Rooms.
|
| XIX - The Sun? | 5.300.75 | 
|
Defeat Ultra Greedier as Tainted Jacob
|
May the darkness swallow all around you | Gain  Spirit of the Night and +1.5 Damage for the current floor. Turns Isaac's Red Hearts into Bone Hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
|
| XX - Judgement? | 5.300.76 | 
|
 Defeat Ultra Greedier as  Tainted Lazarus
|
May you redeem those found wanting | Creates a  Shop Restock Machine near Isaac.
|
| XXI - The World? | 5.300.77 | 
|
 Defeat Ultra Greedier as  Tainted Eden
|
Step into the abyss | Creates a trap door which always leads to a  Crawl Space.
|
Playing Cards
When on the ground, these cards look like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| 2 of Clubs | 5.300.23 | 
|
Item multiplier | Doubles Isaac's Bombs. If he has no bombs, gives him 2 instead.
|
| 2 of Diamonds | 5.300.24 | 
|
Item multiplier | Doubles Isaac's Penny. If he has no coins, gives him 2 instead.
|
| 2 of Spades | 5.300.25 | 
|
Item multiplier | Doubles Isaac's Keys. If he has no keys, gives him 2 instead.
|
| 2 of Hearts | 5.300.26 | 
|
Item multiplier | Doubles Isaac's current number of Red Hearts. Doesn't add new Red Heart containers, just fills empty ones. If Isaac has only empty Red Heart containers, he is healed for 1 Red Heart. Doubles Tainted Bethany's Blood Charges.
|
| Ace of Clubs | 5.300.27 | 
|
Convert all | Turns all Pickups, Chests, and non-boss enemies in the room into random Bomb pickups, including Troll Bombs.
|
| Ace of Diamonds | 5.300.28 | 
|
Convert all | Turns all Pickups, Chests, and non-boss enemies in the room into random Coin pickups.
|
| Ace of Spades | 5.300.29 | 
|
Convert all | Turns all Pickups, Chests, and non-boss enemies in the room into random Key pickups.
|
| Ace of Hearts | 5.300.30 | 
|
Convert all | Turns all Pickups, Chests, and non-boss enemies in the room into random Hearts.
|
| Joker | 5.300.31 | 
|
??? | Teleports Isaac to the  Devil Room or  Angel Room.
|
| Queen of Hearts | 5.300.79 | 
|
<3 | Drops 1-20 full Red Hearts on the ground.
|
Special Cards
Magic: The Gathering Card Backs
When on the ground, these cards look like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Chaos Card | 5.300.42 | 
|
??? | Throws the card to kill nearly anything in its path. Opens doors as if a Bomb exploded.
|
| Huge Growth | 5.300.52 | 
|
Become immense! | For the current room, makes Isaac larger, allows him to crush obstacles he walks on, and grants +7 flat Damage and +30 Range. For the current room, makes Isaac larger, allows him to crush obstacles he walks on, and grants +7 flat Damage and +3 Range.
|
| Ancient Recall | 5.300.53 | 
|
Draw 3 cards | Spawns 3 random cards. |
| Era Walk | 5.300.54 | 
|
Savor the moment | For the current room, enemies are slowed, Isaac's speed is increased by 0.50, and his shot speed is decreased by 1.00. |
Credit Card Backs
When on the ground, this card looks like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Credit Card | 5.300.43 | 
|
Charge it! | Makes all pickups and items that cost money or health in the room free. |
Playing Card Backs
When on the ground, these cards look like:
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Rules Card | 5.300.44 | 
|
??? | Displays a cryptic statement on the screen, similar to a Fortune Telling Machine. These messages (often) provide hints on bosses, bonus areas, etc.
|
| Suicide King | 5.300.46 | 
|
A true ending? | Kills Isaac and spawns lots of Pickups, items, and/or Chests in the same room. |
| ? Card | 5.300.48 | 
|
Double active | When used, copies the effect of Isaac's currently held activated collectible. |
Card Against Humanity Back
When on the ground, this card looks like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| A Card Against Humanity | 5.300.45 | 
|
Something stinks... | Covers the entire room with  Poop. The process is not instant, and the room will not get filled if Isaac leaves before it's done filling.
|
Chance Card Back
When on the ground, this card looks like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Get out of Jail Free Card | 5.300.47 | 
|
Open Sesame | Upon use, opens all doors in the current room, exactly like  Dad's Key.
|
Holy Card Back
When on the ground, this card looks like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Holy Card | 5.300.51 | 
|
You feel protected | Grants a one-time  Holy Mantle effect. It lasts for the current room.
|
Uno Card Back
When on the ground, this card looks like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Wild Card | 5.300.80 | 
|
Again | When used, copies the effect of the most recently used Pill, Card, Rune, Soul Stone or activated item. |
Runes
Left Pointing Runes
When on the ground, these runes look like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Rune of Hagalaz | 5.300.32 | 
|
Destruction | Destroys all breakable objects in the room. Does not affect Key Blocks. |
| Rune of Jera | 5.300.33 | 
|
Abundance | Clones all pickups and Chests in the room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
|
| Rune of Ehwaz | 5.300.34 | 
|
Passage | Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to create a trapdoor leading to a Crawl Space instead. Guaranteed to create a trap door to a Crawl Space if used on floor tiles containing certain patterns. Will not create trapdoors if used on the end floor of a challenge.
|
| Rune of Dagaz | 5.300.35 | 
|
Purity | Removes any Curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)
|
Right Pointing Runes
When on the ground, these runes look like: 
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Rune of Ansuz | 5.300.36 | 
|
Vision | Reveals the whole map, including the Secret Room and the Super Secret Room. (This will not remove  Curse of the Lost.) Does not reveal the Ultra Secret Room
|
| Rune of Perthro | 5.300.37 | 
|
Change | Rerolls all item pedestals in the room (the same effect as  The D6).
|
| Rune of Berkano | 5.300.38 | 
|
Companionship | Summons 3 friendly Blue Flies and 3 friendly Blue Spiders. |
| Rune of Algiz | 5.300.39 | 
|
Resistance | Grants a shield which lasts for 30 seconds. Grants a shield which lasts for 20 seconds.
|
| Blank Rune | 5.300.40 | 
|
??? | Grants a random rune effect excluding Black Rune. Has a 25% chance to drop another Blank Rune on the ground upon use.
|
Other Runes
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Black Rune | 5.300.41 | 
|
Void | Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on Shop or Devil Room items. (Essentially, activates The Necronomicon,  Compost, and  Void).
|
| Rune Shard | 5.300.55 | 
|
It still glows faintly | Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a Soul Heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup, and Perthro rerolls one item. |
Soul Stones
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Soul of Isaac | 5.300.81 | 
|
Reroll... or not | Rerolls the items in the room like The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
|
| Soul of Magdalene | 5.300.82 | 
|
Give me your love! | Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop  Half Red Hearts that disappear in 2 seconds.
|
| Soul of Cain | 5.300.83 | 
|
Opens the unopenable | Opens all doors in the room. Additionally, creates a Red Room like the  Red Key on all valid walls. This also destroys the mirror located in  Downpour /  Dross II.
|
| Soul of Judas | 5.300.84 | 
|
Right behind you | Stops time for 3 seconds and invokes  Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
|
| Soul of ??? | 5.300.85 | 
|
Chemical warfare | Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7  Butt Bombs in quick succession. Standing on the creep gives +1.5 Fire Rate and +1 Damage.
|
| Soul of Eve | 5.300.86 | 
|
Your very own murder | 14  Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
|
| Soul of Samson | 5.300.87 | 
|
Slay a thousand | Isaac turns berserk (similar to using  Berserk!) for 10 seconds, gaining +0.4 Speed, some Tears and +3 flat Damage along with his melee attack.
|
| Soul of Azazel | 5.300.88 | 
|
Demon rage! | Activates  Mega Blast for 7.5 seconds.
|
| Soul of Lazarus | 5.300.89 | 
|
Life after death | Isaac dies, and is immediately revived at half a Heart in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage. Has the highest priority of all Revival items. |
| Soul of Eden | 5.300.90 | 
|
Embrace chaos | Uses The D6 and  D20. The rerolled items use random pools, as if  Chaos were active.
|
| Soul of the Lost | 5.300.91 | 
|
Leave your body behind | Isaac "dies" and turns into a ghost (similar to  The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Allows him to take 1 Devil Room items for free, after which the other items vanish. Also allows him to enter the  Mausoleum /  Gehenna door for free. The Holy Mantle effect gained from this can be stacked with multiple uses.
|
| Soul of Lilith | 5.300.92 | 
|
Motherhood | Adds one permanent familiar from the Baby Shop pool, except  Stitches. Can give familiars that the player already has. Unique familiars can be received only once.
|
| Soul of the Keeper | 5.300.93 | 
|
$$$ | Drops 1-25 random Coins on the ground. |
| Soul of Apollyon | 5.300.94 | 
|
Bringer of calamity | Spawns 15 random locusts. |
| Soul of the Forgotten | 5.300.95 | 
|
Skeletal protector | Spawns  The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his 3 Bone Hearts run out, with no further consequence, and disappears when Isaac leaves the room. The bone swing deals high damage, and reflects tears.
|
| Soul of Bethany | 5.300.96 | 
|
Friends from beyond | Spawns 6  Book of Virtues wisps with random properties.
|
| Soul of Jacob and Esau | 5.300.97 | 
|
Bound by blood | Spawns  Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items Isaac has, each based on the pools of the items Isaac's were obtained from.
|
Other
These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. These consumables cannot be replicated by either 
Blank Card or 
Clear Rune, and 
Tarot Cloth has no effect on them.
| Name | ID | Icon | Message | Description |
|---|---|---|---|---|
| Dice Shard | 5.300.49 | 
|
D6 + D20 | Upon use, invokes the effects of The D6 and the D20 at the same time, re-rolling all item pedestals and pickups in the room.
|
| Emergency Contact | 5.300.50 | 
|
Help from above | When used, will cause two  Mom's Hands to come down and grab two random enemies, dealing damage and, if they have 40 or more HP, pinning them to the ground temporarily.
|
| Cracked Key
|
5.300.78 | 
|
??? | Creates a room adjacent to a viable wall, like Red Key.
|
Notes
- The game counts runes as cards for the purposes of Starter Deck, Blank Card, and Tarot Cloth.
- Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
- The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the Whore of Babylon.
- The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
- The Devil card's effect does not stack with multiple uses, nor does it stack with The Book of Belial. It also does not increase the chance of a Devil or Angel Room appearing when used like with the Book of Belial.
- Blood of the Martyr grants its additional 1.5x damage multiplier with The Devil card.
- Using the Joker card in Error: The given stage ("The Womb") does not exist. II or Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Sheol or to the Cathedral. This can be used to skip Mom's Heart and will not count as a kill.
- After unlocking It Lives, Devil or Angel Rooms in The Womb II, Utero II, and Scarred Womb II no longer contain trapdoors and instead have their normal contents.
- Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
- If you use the Strength card with only Soul, Black, or Bone Hearts left, and lose the non-Red Hearts while in the same room, you retain the full Red Heart container that Strength grants after you leave.
- The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Rooms.
- The damage dealt by The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing Host Hat or Pyromaniac.
- Using the Strength card as ??? will give you a permanent Soul Heart instead of a temporary one. When Keeper has only one Coin Heart, he can use the Strength card to gain a second one which is also permanent.
- While Curse of the Maze is active, The Fool, Moon, Hermit, and Stars cards may fail and leave the player in a different room than intended. The Joker card still works normally.
- Using the Temperance card can, in rare cases, spawn the Blood Donation Machine directly on the player, forcing them to use it once. Caution should be taken when using Temperance as The Lost (or when on half a heart of health), as this will instantly kill the player regardless of the Holy Mantle.
- All teleportation cards except The Fool are unavailable in Greed Mode.
- Rune Shards spawn in place of a Rune that hasn't been unlocked yet. Once all Runes are unlocked, Rune Shards no longer appear.
- Leaving Trinkets in a Boss Room or a Treasure Room will transform them into a Cracked Key when on the Ascent back Home.
Unlockable Achievements
- The Necronomicon - UseXIII - Death 4 times.
- Ancient Recall - Use Cards and Runes 20 times.
- Huge Growth - Increase in size 5 times in a single run via Magic Mushroom, "One makes you larger" pills, XI - Strength, etc..
Trivia
- The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
- The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
- The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
- The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
- Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
- The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
- The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
- The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
- The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game.
- Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
- The "Soul of Judas" description and ability are a reference to the Spy from Team Fortress 2.
- The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.
Gallery
Bugs
 Bug!
|
 Hagalaz will open Secret Room doors in L-shaped rooms.
|
|---|
| Bug!
|
Entering a trapdoor created by Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.
|
|---|
 The Binding of Isaac: Rebirth
|
|---|
