PLEASE NOTE:
This wiki contains The Binding of Isaac: Repentance content, including potentially heavy spoilers.
All information is welcome to be added and is not hidden, but if you still wish to browse, you can activate the DLC filter (at the top right of any article) according to your game version to minimize your exposure to Repentance additions and changes.

Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.

Runes and special cards are unlocked by completing challenges.

Cards

Major Arcana Cards

When on the ground, these cards look like: TarotCard.png

Name ID Icon Message Desciption
0 - The Fool 5.300.1 Pickup 0 - The Fool icon.png Where journey begins Teleports Isaac back to the starting room of a floor.
I - The Magician 5.300.2 Pickup I - The Magician icon.png May you never miss your goal Grants homing tears and Dlc r indicator.png +3 range for the current room (same effect as Collectible Telepathy for Dummies icon.png Telepathy for Dummies).
II - The High Priestess 5.300.3 Pickup II - The High Priestess icon.png Mother is watching you Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress 5.300.4 Pickup III - The Empress icon.png May your rage bring power Triggers the Collectible Whore of Babylon icon.png Whore of Babylon effect (+1.5 damage, +0.3 speed) for the current room, but without the need for Isaac to have a red heart or less of health.
IV - The Emperor 5.300.5 Pickup IV - The Emperor icon.png Challenge me! Teleports Isaac into the Boss Room of a floor.
V - The Hierophant 5.300.6 Pickup V - The Hierophant icon.png Two prayers for the lost Spawns 2 Soul Hearts.
VI - The Lovers 5.300.7 Pickup VI - The Lovers icon.png May you prosper and be in good health Spawns 2 Red Hearts. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.
VII - The Chariot 5.300.8 Pickup VII - The Chariot icon.png May nothing stand before you Grants the temporary invulnerability effect of Collectible My Little Unicorn icon.png My Little Unicorn.
VIII - Justice 5.300.9 Pickup VIII - Justice icon.png May your future become balanced Spawns one of each consumable drop (a Red Heart, a Key, a Bomb, and a Penny). Hearts have a chance to spawn as either a Half Red Heart or a Double Heart.
IX - The Hermit 5.300.10 Pickup IX - The Hermit icon.png May you see what life has to offer Teleports Isaac to the Shop. If there is no Shop, this will act as a random teleport. If the Shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
X - Wheel of Fortune 5.300.11 Pickup X - Wheel of Fortune icon.png Spin the wheel of destiny Spawns an Arcade machine (Slot Machine or Fortune Telling Machine).
XI - Strength 5.300.12 Pickup XI - Strength icon.png May your power bring rage Grants the effect of Collectible Magic Mushroom icon.png Magic Mushroom (increases all of Isaac's stats except tears), but adds one (temporary) Red Heart container for the current room as opposed to a permanent one.
XII - The Hanged Man 5.300.13 Pickup XII - The Hanged Man icon.png May you find enlightenment Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as Collectible Transcendence icon.png Transcendence).
XIII - Death 5.300.14 Pickup XIII - Death icon.png Lay waste to all that oppose you Deals 40 damage to all enemies in the room (same effect as Collectible The Necronomicon icon.png The Necronomicon).
XIV - Temperance 5.300.15 Pickup XIV - Temperance icon.png May you be pure in heart Spawns a Blood Donation Machine.
Dlc a indicator.png Spawns a Devil Beggar in Greed mode.
XV - The Devil 5.300.16 Pickup XV - The Devil icon.png Revel in the power of darkness Grants Isaac a temporary +2 increase to damage for the current room (same effect as Collectible The Book of Belial icon.png The Book of Belial).
XVI - The Tower 5.300.17 Pickup XVI - The Tower icon.png Destruction brings creation Spawns 6 Troll Bombs randomly around the room (same effect as the Collectible Anarchist Cookbook icon.png Anarchist Cookbook).
XVII - The Stars 5.300.18 Pickup XVII - The Stars icon.png May you find what you desire Teleports Isaac to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance). Dlc r indicator.pngCan also teleport you to the Planetarium
XVIII - The Moon 5.300.19 Pickup XVIII - The Moon icon.png May you find all you have lost Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available.
XIX - The Sun 5.300.20 Pickup XIX - The Sun icon.png May the light heal and enlighten you Restores Isaac's full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room. Dlc r indicator.png Removes Curse of Darkness for the current floor.
XX - Judgement 5.300.21 Pickup XX - Judgement icon.png Judge lest ye be judged Spawns a Beggar.
XXI - The World 5.300.22 Pickup XXI - The World icon.png Open your eyes and see Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.

Dlc r indicator.png Reversed Major Arcana Cards

These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, the narrator sound clip reversed, and give different effects.

When on the ground, these cards look like: ReverseTarotCard.png

Name ID Icon Unlock method Message Desciption
0 - The Fool? 5.300.56 Pickup 0 - The Fool? icon.png Achievement The Fool icon.png Defeat Ultra Greedier as Character Tainted Lost icon.png Tainted Lost Let go and move on Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Pickups may be spawned as items such as Collectible A Quarter icon.png A Quarter and Collectible Boom! icon.png Boom!.
I - The Magician? 5.300.57 Pickup I - The Magician? icon.png Achievement The Magician icon.png Defeat Ultra Greedier as Character Tainted Judas icon.png Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like Collectible The Soul icon.png The Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 Pickup II - The High Priestess? icon.png Achievement The High Priestess icon.png Defeat Ultra Greedier as Character Tainted Lilith icon.png Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding Collectible Broken Shovel 1 icon.png Broken Shovel.
III - The Empress? 5.300.59 Pickup III - The Empress? icon.png Achievement The Empress icon.png Defeat Ultra Greedier as Character Tainted Eve icon.png Tainted Eve May your love bring protection Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene's hairstyle. Does not stack.
IV - The Emperor? 5.300.60 Pickup IV - The Emperor? icon.png Achievement The Emperor icon.png Defeat Ultra Greedier as Character Tainted ??? icon.png Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room. The boss will drop a reward, but the room has no trapdoor and can be returned to only with another card.
V - The Hierophant? 5.300.61 Pickup V - The Hierophant? icon.png Achievement The Hierophant icon.png Defeat Ultra Greedier as Character Tainted Bethany icon.png Tainted Bethany Two prayers for the forgotten Spawns 2 Bone Hearts.
VI - The Lovers? 5.300.62 Pickup VI - The Lovers? icon.png Achievement The Lovers icon.png Defeat Ultra Greedier as Character Tainted Magdalene icon.png Tainted Magdalene May your heart shatter to pieces Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally.
VII - The Chariot? 5.300.63 Pickup VII - The Chariot? icon.png Achievement The Chariot icon.png Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible, immobile statue with extreme fire rate for 10 seconds. Sometimes the statue looks like Edith.
VIII - Justice? 5.300.64 Pickup VIII - Justice? icon.png Achievement Justice icon.png Complete Cantripped (challenge #43) May your sins come back to torment you Spawns 2 to 4 Golden Chests.
IX - The Hermit? 5.300.65 Pickup IX - The Hermit? icon.png Achievement The Hermit icon.png Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
X - Wheel of Fortune? 5.300.66 Pickup X - Wheel of Fortune? icon.png Achievement Wheel of Fortune icon.png Defeat Ultra Greedier as Character Tainted Cain icon.png Tainted Cain Throw the dice of fate Invokes a random dice room effect.
XI - Strength? 5.300.67 Pickup XI - Strength? icon.png Achievement Strength icon.png Defeat Ultra Greedier as Character Tainted Samson icon.png Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage.
XII - The Hanged Man? 5.300.68 Pickup XII - The Hanged Man? icon.png Achievement The Hanged Man icon.png Defeat Ultra Greedier as Character Tainted Keeper icon.png Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus and -0.1 speed. Killed enemies drop random coins.
XIII - Death? 5.300.69 Pickup XIII - Death? icon.png Achievement Death icon.png Defeat Ultra Greedier as Character Tainted Forgotten icon.png Tainted Forgotten May life spring forth from the fallen Invokes a Collectible Book of the Dead icon.png Book of the Dead effect.
XIV - Temperance? 5.300.70 Pickup XIV - Temperance? icon.png Achievement Temperance icon.png Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random pills in quick succession.
XV - The Devil? 5.300.71 Pickup XV - The Devil? icon.png Achievement The Devil icon.png Defeat Ultra Greedier as Character Tainted Azazel icon.png Tainted Azazel Bask in the light of your mercy Invokes Collectible The Bible icon.png The Bible and grants a Collectible Seraphim icon.png Seraphim familiar and flight for 30 seconds.
XVI - The Tower? 5.300.72 Pickup XVI - The Tower? icon.png Achievement The Tower icon.png Defeat Ultra Greedier as Character Tainted Apollyon icon.png Tainted Apollyon Creation brings destruction Spawns 6 clusters of random rocks and other obstacles. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 Pickup XVII - The Stars? icon.png Achievement The Stars icon.png Defeat Ultra Greedier as Character Tainted Isaac icon.png Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item and spawns 2 random items from the current room's item pool.
XVIII - The Moon? 5.300.74 Pickup XVIII - The Moon? icon.png Achievement The Sun and the Moon icon.png Defeat Ultra Greedier as Character Tainted Jacob icon.png Tainted Jacob May you remember lost memories Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.
XIX - The Sun? 5.300.75 Pickup XIX - The Sun? icon.png Achievement The Sun and the Moon icon.png Defeat Ultra Greedier as Character Tainted Jacob icon.png Tainted Jacob May the darkness swallow all around you Gain Collectible Spirit of the Night icon.png Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 Pickup XX - Judgement? icon.png Achievement Judgement icon.png Defeat Ultra Greedier as Character Tainted Lazarus icon.png Tainted Lazarus May you redeem those found wanting Spawns a Restock Machine.
XXI - The World? 5.300.77 Pickup XXI - The World? icon.png Achievement The World icon.png Defeat Ultra Greedier as Character Tainted Eden icon.png Tainted Eden Step into the abyss Spawns a trap door to a crawl space.

Playing Cards

When on the ground, these cards look like: FaceCard.png

Name ID Icon Unlock method Message Desciption
2 of Clubs 5.300.23 Pickup 2 of Clubs icon.png Always available Item multiplier Doubles your bombs. If you have no bombs, gives you 2 instead.
2 of Diamonds 5.300.24 Pickup 2 of Diamonds icon.png Always available Item multiplier Doubles your coins. If you have no coins, gives you 2 instead.
2 of Spades 5.300.25 Pickup 2 of Spades icon.png Always available Item multiplier Doubles your keys. If you have no keys, gives you 2 instead.
2 of Hearts 5.300.26 Pickup 2 of Hearts icon.png Always available Item multiplier Doubles Isaac's current number of Red Hearts. Does not affect Eternal Hearts, Soul Hearts, or Black Hearts. Doesn't add new Red Heart containers, just fills empty ones.
Dlc a† indicator.png Ace of Clubs 5.300.27 Pickup Ace of Clubs icon.png Achievement Hat trick! icon.png Get a 3-win streak Convert all Turns all pickups, chests, and Dlc r indicator.png non-boss enemies in the room into Bombs.
Dlc a† indicator.png Ace of Diamonds 5.300.28 Pickup Ace of Diamonds icon.png Achievement ZIP! icon.png Defeat The Lamb in under 20 minutes Convert all Turns all pickups, chests, and Dlc r indicator.png non-boss enemies in the room into Pennies.
Dlc a† indicator.png Ace of Spades 5.300.29 Ace of Spades (Card) Icon.png Achievement It's the Key icon.png Defeat The Lamb without taking hearts, coins, and bombs through an entire run Convert all Turns all pickups, chests, and Dlc r indicator.png non-boss enemies in the room into Keys.
Dlc a† indicator.png Ace of Hearts 5.300.30 Pickup Ace of Hearts icon.png Achievement Living on the edge icon.png Complete a Chapter (floors I and II) after The Basement, start-to-finish, with only half a heart of health (can use Character The Lost icon.png The Lost) Convert all Turns all pickups, chests, and Dlc r indicator.png non-boss enemies in the room into random heart pickups.
Joker 5.300.31 Pickup Joker icon.png Always available ??? Teleports Isaac to the Devil Room or Angel Room.
Suicide King 5.300.46 Pickup Suicide King icon.png Achievement Suicide King icon.png Complete Suicide King (challenge #7) A true ending? Kills Isaac and spawns lots of pickups, items, and/or chests in the same room.
Dlc r indicator.png Queen of Hearts 5.300.79 Pickup Queen of Hearts icon.png Achievement Queen of Hearts icon.png Defeat Mega Satan as Character Tainted Magdalene icon.png Tainted Magdalene <3 Spawns 1-21 full red hearts.

Magic: The Gathering Card Backs

When on the ground, these cards look like: Dlc na† indicator.png FaceCard.png    Dlc a† indicator.png MagicCard.png

Name ID Icon Unlock method Message Desciption
Chaos Card 5.300.42 Pickup Chaos Card icon.png Achievement Chaos Card icon.png Complete Demo Man (challenge #9) ??? Throws the card to kill anything in its path. Opens normal doors.
Dlc a† indicator.png Huge Growth 5.300.52 Pickup Huge Growth icon.png Achievement Huge Growth icon.png Increase in size 5 times in a single run. Sources of increased size include "One Makes you Larger" pills, XI - Strength, and Magic Mushroom Become immense! Makes Isaac large for the current room, increasing his range and damage.
Dlc a† indicator.png Ancient Recall 5.300.53 Pickup Ancient Recall icon.png Achievement Ancient Recall icon.png Use cards and runes 20 times Draw 3 cards Spawns 3 random cards.
Dlc a† indicator.png Era Walk 5.300.54 Pickup Era Walk icon.png Achievement Era Walk icon.png Have both the Collectible Broken Watch icon.png Broken Watch and the Collectible Stop Watch icon.png Stop Watch in your collection Savor the moment For the current room, enemies are slowed, Isaac's speed is increased, and his shot speed is decreased.

Credit Card Back

When on the ground, this card looks like: Dlc na† indicator.png FaceCard.png    Dlc a† indicator.png CreditCard.png

Name ID Icon Unlock method Message Desciption
Credit Card 5.300.43 Pickup Credit Card icon.png Achievement Credit Card icon.png Complete Cursed (challenge #10) Charge it! Converts all items in the Shop or Devil Room into pickups or items on pedestals, allowing them to be picked up for free.

Other Playing Card Backs

When on the ground, these cards look like: FaceCard.png

Name ID Icon Unlock method Message Desciption
Rules Card 5.300.44 Pickup Rules Card icon.png Achievement Rules Card icon.png Complete Glass Cannon (challenge #11) ??? Displays a cryptic statement on the screen, similar to a Fortune Teller. These messages (often) provide hints on bosses, bonus areas, etc.
Dlc a indicator.png ? Card 5.300.48 Pickup Q Card icon.png Always available Double active When used, copies the effect of Isaac's currently held activated collectible.

Card Against Humanity Back

When on the ground, this card looks like: Dlc na† indicator.png FaceCard.png    Dlc a† indicator.png HumanityCard.png

Name ID Icon Unlock method Message Desciption
A Card Against Humanity 5.300.45 Pickup A Card Against Humanity icon.png Achievement Card Against Humanity icon.png Complete When Life Gives You Lemons (challenge #12) Something stinks... Covers the entire room with poop. The process is not instant, and the room will not get filled if you leave it before it's done filling.

Dlc a indicator.png Chance Card Back

When on the ground, this card looks like: Dlc na† indicator.png FaceCard.png    Dlc a† indicator.png ChanceCard.png

Name ID Icon Unlock method Message Desciption
Get out of Jail Free Card 5.300.47 Pickup Get out of Jail Free Card icon.png Achievement Get out of Jail Free Card icon.png Complete SPEED! (challenge #22) Open Sesame Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.

Dlc a† indicator.png Holy Card Back

When on the ground, this card looks like: HolyCard.png

Name ID Icon Unlock method Message Desciption
Holy Card 5.300.51 Pickup Holy Card icon.png Achievement Holy Card icon.png Defeat Delirium as Character The Lost icon.png The Lost You feel protected Grants the Collectible Holy Mantle icon.png Holy Mantle effect. Dlc nr indicator.png It lasts for the current room. Dlc r indicator.png It lasts until taking damage.

Dlc r indicator.png Uno Card Back

When on the ground, this card looks like: WildCardBack.png

Name ID Icon Unlock method Message Desciption
Wild Card 5.300.80 Pickup Wild Card icon.png Achievement Wild Card icon.png Defeat Mega Satan as Character Tainted Eden icon.png Tainted Eden Again When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Runes

Left Pointing Runes

When on the ground, these runes look like: Rune2.png

Name ID Icon Unlock method Message Desciption
Rune of Hagalaz 5.300.32 Hagalaz Icon.png Achievement Rune of Hagalaz icon.png Complete Pitch Black (challenge #1) Destruction Destroys all breakable objects in the room. Does not affect Key Blocks. Dlc r indicator.png Does affect Key Blocks
Rune of Jera 5.300.33 Jera Icon.png Achievement Rune of Jera icon.png Complete High Brow (challenge #2) Abundance Clones all pickups and chests in a room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
Rune of Ehwaz 5.300.34 Ehwaz Icon.png Achievement Rune of Ehwaz icon.png Complete Head Trauma (challenge #3) Passage Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.
Rune of Dagaz 5.300.35 Dagaz Icon.png Achievement Rune of Dagaz icon.png Complete Darkness Falls (challenge #4) Purity Removes any curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)

Right Pointing Runes

When on the ground, these runes look like: Rune1.png

Name ID Icon Unlock method Message Desciption
Rune of Ansuz 5.300.36 Ansuz Icon.png Achievement Rune of Ansuz icon.png Complete The Tank (challenge #5) Vision Reveals the whole map, including the Secret Room and the Super Secret Room.
Rune of Perthro 5.300.37 Perthro Icon.png Achievement Rune of Perthro icon.png Complete Solar System (challenge #6) Change Rerolls all pedestal items in the room. (This is the same effect as The D6.)
Rune of Berkano 5.300.38 Berkano Icon.png Achievement Rune of Berkano icon.png Complete Purist (challenge #20) Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
Rune of Algiz 5.300.39 Algiz Icon.png Achievement Rune of Algiz icon.png Complete Cat Got Your Tongue (challenge #8) Resistance Dlc nr indicator.pngGrants a shield which lasts for 30 seconds. Dlc r indicator.pngGrants a shield which lasts for 20 seconds.
Dlc a indicator.png Blank Rune 5.300.40 Pickup Blank Rune icon.png Achievement Blank Rune icon.png Dlc na† indicator.png Complete Onan's Streak (challenge #29)
Dlc a† indicator.png Complete The Guardian (challenge #30)
??? Grants a random rune effect Dlc nr indicator.png excluding the Black Rune. Has a 25% chance to spawn another Blank Rune upon use.

Dlc a† indicator.png Other Runes

Name ID Icon Unlock method Message Desciption
Black Rune 5.300.41 Pickup Black Rune icon.png Achievement Black Rune icon.png Defeat Ultra Greedier as Character Apollyon icon.png Apollyon Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on shop items.
Dlc r indicator.png Rune Shard 5.300.55 Pickup Rune Shard icon.png Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Dlc r indicator.png Soul Stones

Soul Stones are all unlocked by beating both Hush and Boss Rush as their respective Tainted character. These are counted in-game as runes and will, as such, drop from items like Rune Bag.

Name ID Icon Unlock method Message Desciption
Soul of Isaac 5.300.81 Pickup Soul of Isaac icon.png Achievement Soul of Isaac icon.png Defeat Hush and Boss Rush as Character Tainted Isaac icon.png Tainted Isaac Reroll... or not Rerolls the items in the room like Collectible The D6 icon.png The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, all the rerolls are cycled through.
Soul of Magdalene 5.300.82 Pickup Soul of Magdalene icon.png Achievement Soul of Magdalene icon.png Defeat Hush and Boss Rush as Character Tainted Magdalene icon.png Tainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Pickup Soul of Cain icon.png Achievement Soul of Cain icon.png Defeat Hush and Boss Rush as Character Tainted Cain icon.png Tainted Cain Opens the unopenable Creates a red room like the Collectible Red Key icon.png Red Key, for every possible red exit in the current room.
Soul of Judas 5.300.84 Pickup Soul of Judas icon.png Achievement Soul of Judas icon.png Defeat Hush and Boss Rush as Character Tainted Judas icon.png Tainted Judas Right behind you Invokes Collectible Dark Arts icon.png Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them. After a few seconds, it will attack every paralyzed enemy, gaining damage bonuses for each target.
Soul of ??? 5.300.85 Pickup Soul of ??? icon.png Achievement Soul of ??? icon.png Defeat Hush and Boss Rush as Character Tainted ??? icon.png Tainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Collectible Butt Bombs icon.png Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.
Soul of Eve 5.300.86 Pickup Soul of Eve icon.png Achievement Soul of Eve icon.png Defeat Hush and Boss Rush as Character Tainted Eve icon.png Tainted Eve Your very own murder 14 Collectible Dead Bird icon.png Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Pickup Soul of Samson icon.png Achievement Soul of Samson icon.png Defeat Hush and Boss Rush as Character Tainted Samson icon.png Tainted Samson Slay a thousand Isaac turns into a berserk Tainted Samson for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.
Soul of Azazel 5.300.88 Pickup Soul of Azazel icon.png Achievement Soul of Azazel icon.png Defeat Hush and Boss Rush as Character Tainted Azazel icon.png Tainted Azazel Demon rage! Activates Collectible Mega Blast icon.png Mega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Pickup Soul of Lazarus icon.png Achievement Soul of Lazarus icon.png Defeat Hush and Boss Rush as Character Tainted Lazarus icon.png Tainted Lazarus Life after death Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, as well, functioning as a minimal extra life.
Soul of Eden 5.300.90 Pickup Soul of Eden icon.png Achievement Soul of Eden icon.png Defeat Hush and Boss Rush as Character Tainted Eden icon.png Tainted Eden Embrace chaos Uses Collectible The D6 icon.png The D6 and Collectible D20 icon.png D20. The rerolled items use random pools, like Collectible Chaos icon.png Chaos was active.
Soul of the Lost 5.300.91 Pickup Soul of the Lost icon.png Achievement Soul of the Lost icon.png Defeat Hush and Boss Rush as Character Tainted Lost icon.png Tainted Lost Leave your body behind Isaac "dies" and turns into The Lost for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room.
Soul of Lilith 5.300.92 Pickup Soul of Lilith icon.png Achievement Soul of Lilith icon.png Defeat Hush and Boss Rush as Character Tainted Lilith icon.png Tainted Lilith Motherhood Adds one random familiar item permanently.
Soul of the Keeper 5.300.93 Pickup Soul of the Keeper icon.png Achievement Soul of the Keeper icon.png Defeat Hush and Boss Rush as Character Tainted Keeper icon.png Tainted Keeper $$$ Spawns ~2-25 random coins.
Soul of Apollyon 5.300.94 Pickup Soul of Apollyon icon.png Achievement Soul of Apollyon icon.png Defeat Hush and Boss Rush as Character Tainted Apollyon icon.png Tainted Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Pickup Soul of the Forgotten icon.png Achievement Soul of the Forgotten icon.png Defeat Hush and Boss Rush as Character Tainted Forgotten icon.png Tainted Forgotten Skeletal protector Spawns The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his two bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Soul of Bethany 5.300.96 Pickup Soul of Bethany icon.png Achievement Soul of Bethany icon.png Defeat Hush and Boss Rush as Character Tainted Bethany icon.png Tainted Bethany Friends from beyond Spawns 6 Collectible Book of Virtues icon.png Book of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Pickup Soul of Jacob and Esau icon.png Achievement Soul of Jacob and Esau icon.png Defeat Hush and Boss Rush as Character Tainted Jacob icon.png Tainted Jacob Bound by blood Spawns Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room.

Dlc a indicator.png Other

These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. Dlc r indicator.png These consumables cannot be replicated by either Collectible Blank Card icon.png Blank Card or Collectible Clear Rune icon.png Clear Rune, and Collectible Tarot Cloth icon.png Tarot Cloth has no effect on them.

Name ID Icon Unlock method Message Desciption
Dice Shard 5.300.49 Pickup Dice Shard icon.png Always available D6 + D20 Upon use, activates the effects of The D6 and the D20 at the same time.
Emergency Contact 5.300.50 Pickup Emergency Contact icon.png Always available Help from above When used, will cause two Mom's Hands to come down and grab two random enemies.
Dlc r indicator.png Cracked Key 5.300.78 Pickup Cracked Key icon.png Achievement Red Key icon.png Open the large version of Mom's Box in Home ??? Creates a room adjacent to a viable wall, like Dlc r indicator.png Collectible Red Key icon.png Red Key.

Notes

  • Dlc nr indicator.png The game counts runes as cards for the purposes of Collectible Starter Deck icon.png Starter Deck, Collectible Blank Card icon.png Blank Card, and Dlc a† indicator.png Collectible Tarot Cloth icon.png Tarot Cloth.
  • Dlc a indicator.png Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
  • The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the Collectible Whore of Babylon icon.png Whore of Babylon.
    • The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
  • The Devil card's effect does not stack with multiple uses, nor does it stack with Collectible The Book of Belial icon.png The Book of Belial. It also does not increase the chance of a Devil or Angel Room appearing when used like with the Book of Belial.
  • Using the Joker card in Stage The Womb icon.png The Womb II or Stage Utero icon.png Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Stage Sheol icon.png Sheol or to the Stage Cathedral icon.png Cathedral. This can be used to skip Mom's Heart and will not count as a kill.
    • Dlc a indicator.png After unlocking It Lives, Devil or Angel Rooms in The Womb II, Utero II, and Stage Scarred Womb icon.png Scarred Womb II no longer contain trapdoors and instead have their normal contents.
  • Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
  • If you use the Strength card with only Soul, Black, or Bone Hearts left, and lose the non-Red Hearts while in the same room, you retain the full Red Heart container that Strength grants after you leave.
  • The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Rooms.
  • Dlc nr indicator.png The damage dealt by The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing Dlc a indicator.png Collectible Host Hat icon.png Host Hat or Collectible Pyromaniac icon.png Pyromaniac.
  • Using the Strength card as ??? will give you a permanent Soul Heart instead of a temporary one. Dlc a indicator.png When Keeper has only one Coin Heart, he can use the Strength card to gain a second one which is also permanent.
  • While Curse of the Maze is active, The Fool, Moon, Hermit, and Stars cards may fail and leave the player in a different room than intended. The Joker card still works normally.
  • Using the Temperance card can, in rare cases, spawn the Blood Donation Machine directly on the player, forcing them to use it once. Caution should be taken when using Temperance as The Lost (or when on half a heart of health), as this will instantly kill the player regardless of the Collectible Holy Mantle icon.png Holy Mantle.
  • All teleportation cards except The Fool are unavailable in Greed Mode.
  • Dlc r indicator.png Rune Shards spawn in place of a Rune that hasn't been unlocked yet. Once all Runes are unlocked, Rune Shards no longer appear.
  • Dlc r indicator.png Leaving Trinkets in a Boss Room or a Treasure Room will transform them into a Cracked Key when on the Ascent back Home.
  • Dlc r indicator.png There is a unique marked skull that will spawn on Depths II or XL. It is marked by a tiny black cross, and when blown up will always drop The Fool card (Or an identified Telepills if Little Baggy has been picked up).
  • Dlc r indicator.png Using Soul of The Lost and then beating a boss for a completion mark within the same room will not count as a completion mark for The Lost. Instead, the completion mark and achievement will go to the character who used the soul stone.

Unlockable Achievements

Trivia

  • The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
  • The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
  • Dlc a indicator.png The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
  • Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
    • The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
    • Dlc a† indicator.png The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
    • Dlc a† indicator.png The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
    • Dlc a† indicator.png The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
  • Dlc a† indicator.png Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
  • Dlc r indicator.png The "Soul of Cain"'s ability is likely a reference to Dlc r indicator.png Collectible Red Key icon.png Red Key being an unlock for Cain in the original Antibirth mod.
  • Dlc r indicator.png The "Soul of Judas" description and ability are a reference to the Spy from Team Fortress 2.
  • Dlc r indicator.png The "Soul of Eve" description and ability refer to how a group of crows is called a murder.
  • Dlc r indicator.png The "Soul of Samson" description is a reference to Judges: it is said that Samson killed an army of 1,000 Philistines using a donkey's jawbone.
  • Dlc r indicator.png The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.
  • Typing the command "giveitem k0" into the Debug Console will reveal a secret usable item called "NULL". Executing the command, however, does not give anything.

Bugs

Collectible Undefined icon.png Bug! Dlc a†nr indicator.png Hagalaz will open Secret Room doors in L-shaped rooms.
Collectible Undefined icon.png Bug! Dlc r indicator.png Entering a trapdoor created by Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.

SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Character Isaac appearance.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Collectible Isaac's Tears icon.png Item pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red Heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Guppy App.png Transformations Trinket The Left Hand icon.png Trinkets
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