Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
m (Reverse emperor boss selection)
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| id = 60
 
| id = 60
 
| quote = May you find a worthy opponent
 
| quote = May you find a worthy opponent
| description = Teleports Isaac into an extra [[Boss Room]]. The boss will drop a reward, but the room has no trapdoor so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
+
| description = Teleports Isaac into an extra [[Boss Room]] from the boss pool two floors deeper than the current floor. The boss will drop a reward, but the room has no trapdoor so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
 
| unlocked by = The Emperor
 
| unlocked by = The Emperor
 
}}{{infobox pickup | hidden = yes
 
}}{{infobox pickup | hidden = yes
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{{Bug|Entering a trapdoor created by {{p|Rune of Ehwaz}} on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.||dlc=r}}
 
{{Bug|Entering a trapdoor created by {{p|Rune of Ehwaz}} on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.||dlc=r}}
 
{{Bug|Using {{p|IV - The Emperor?}} on [[??? (floor)]] and defeating the extra boss will validate the completion mark for Hush.||dlc=r}}
 
{{Bug|Using {{p|IV - The Emperor?}} on [[??? (floor)]] and defeating the extra boss will validate the completion mark for Hush.||dlc=r}}
{{Bug|Using {{p|IV - The Emperor?}} on the 2nd chapter may bring you to the Mom fight which will not spawn an exit door, resulting in a softlock.||dlc=r}}
+
{{Bug|Using {{p|IV - The Emperor?}} on Caves 2 will teleport Isaac to the Mom fight, which will not spawn an exit door, resulting in a softlock.||dlc=r}}
 
{{Bug|If the Esau spawned by {{p|Soul of Jacob and Esau}} spawns with {{I|Birthright}}, the game will instantly crash.||dlc=r}}
 
{{Bug|If the Esau spawned by {{p|Soul of Jacob and Esau}} spawns with {{I|Birthright}}, the game will instantly crash.||dlc=r}}
 
{{Bug|Using {{p|III - The Empress?}} as [[Keeper]] will not grant extra heart containers, but will permanently remove two when the effect wears off.||dlc=r}}
 
{{Bug|Using {{p|III - The Empress?}} as [[Keeper]] will not grant extra heart containers, but will permanently remove two when the effect wears off.||dlc=r}}

Revision as of 11:15, 5 May 2021

Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.

Runes and special cards are unlocked by completing challenges.

Cards

Major Arcana Cards

When on the ground, these cards look like: TarotCard.png

Name ID Icon Message Description
0 - The Fool 5.300.1 0 - The Fool Where journey begins Teleports Isaac back to the starting room of a floor.
I - The Magician 5.300.2 I - The Magician May you never miss your goal Grants homing tears and Added in Repentance +3 range for the current room (same effect as 15►Telepathy for Dummies Telepathy for Dummies).
II - The High Priestess 5.300.3 II - The High Priestess Mother is watching you Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress 5.300.4 III - The Empress May your rage bring power Triggers the 15►Whore of Babylon Whore of Babylon effect (+1.5 damage, +0.3 speed) for the current room, but without the need for Isaac to have a half a red heart or less of health.
IV - The Emperor 5.300.5 IV - The Emperor Challenge me! Teleports Isaac into the Boss Room of a floor. In Added in Repentance Home Home, this will act as a random teleport.
V - The Hierophant 5.300.6 V - The Hierophant Two prayers for the lost Spawns 2 Soul Hearts.
VI - The Lovers 5.300.7 VI - The Lovers May you prosper and be in good health Spawns 2 Red Hearts. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Grants the temporary invulnerability effect of 15►My Little Unicorn My Little Unicorn.
VIII - Justice 5.300.9 VIII - Justice May your future become balanced Spawns one of each consumable drop (a Red Heart, a Key, a Bomb, and a Penny). Hearts have a chance to spawn as either a Half Red Heart or a Double Heart. Bombs have a chance to spawn as a Troll Bomb.
IX - The Hermit 5.300.10 IX - The Hermit May you see what life has to offer Teleports Isaac to the Shop. If there is no Shop, this will act as a random teleport. If the Shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
X - Wheel of Fortune 5.300.11 X - Wheel of Fortune Spin the wheel of destiny Spawns an Arcade machine (Slot Machine or Fortune Telling Machine).
XI - Strength 5.300.12 XI - Strength May your power bring rage Grants the effects of 15►Magic Mushroom Magic Mushroom (minus the health restoration) for one room. The added Red Heart container is removed upon leaving the room.
XII - The Hanged Man 5.300.13 XII - The Hanged Man May you find enlightenment Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as 15►Transcendence Transcendence).
XIII - Death 5.300.14 XIII - Death Lay waste to all that oppose you Deals 40 damage to all enemies in the room (same effect as 15►The Necronomicon The Necronomicon).
XIV - Temperance 5.300.15 XIV - Temperance May you be pure in heart Spawns a Blood Donation Machine.
Added in Afterbirth Spawns a Devil Beggar in Greed mode.
XV - The Devil 5.300.16 XV - The Devil Revel in the power of darkness Grants Isaac a temporary +2 increase to damage for the current room (same effect as 15►The Book of Belial The Book of Belial).
XVI - The Tower 5.300.17 XVI - The Tower Destruction brings creation Spawns 6 Troll Bombs randomly around the room (same effect as the 15►Anarchist Cookbook Anarchist Cookbook).
XVII - The Stars 5.300.18 XVII - The Stars May you find what you desire Teleports Isaac to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance). Added in Repentance If there is a Planetarium, teleports Isaac there instead.
XVIII - The Moon 5.300.19 XVIII - The Moon May you find all you have lost Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available. Added in Afterbirth Does not work in Greed and Greedier mode.
XIX - The Sun 5.300.20 XIX - The Sun May the light heal and enlighten you Restores Isaac's full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room. Added in Repentance Removes Curse of Darkness for the current floor.
XX - Judgement 5.300.21 XX - Judgement Judge lest ye be judged Spawns a Beggar.
XXI - The World 5.300.22 XXI - The World Open your eyes and see Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.

Added in Repentance Reversed Major Arcana Cards

These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, the narrator sound clip reversed, and give different effects.

When on the ground, these cards look like: ReverseTarotCard.png

Name ID Icon Unlock method Message Description
0 - The Fool? 5.300.56 0 - The Fool? The Fool Defeat Ultra Greedier as Tainted Lost Tainted Lost Let go and move on Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Pickups may be spawned as items such as 15►A Quarter A Quarter and 15►Boom! Boom!.
I - The Magician? 5.300.57 I - The Magician? The Magician Defeat Ultra Greedier as Tainted Judas Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like 15►The Soul The Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 II - The High Priestess? The High Priestess Defeat Ultra Greedier as Tainted Lilith Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding 15►Broken Shovel Broken Shovel.
III - The Empress? 5.300.59 III - The Empress? The Empress Defeat Ultra Greedier as Tainted Eve Tainted Eve May your love bring protection Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene Magdalene's hairstyle. Does not stack.
IV - The Emperor? 5.300.60 IV - The Emperor? The Emperor Defeat Ultra Greedier as Tainted ??? Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor. The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
V - The Hierophant? 5.300.61 V - The Hierophant? The Hierophant Defeat Ultra Greedier as Tainted Bethany Tainted Bethany Two prayers for the forgotten Spawns 2 Bone Hearts.
VI - The Lovers? 5.300.62 VI - The Lovers? The Lovers Defeat Ultra Greedier as Tainted Magdalene Tainted Magdalene May your heart shatter to pieces Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally; no downside for any character who has no health bar; Tainted Keeper Tainted Keeper locked to 1 HP.
VII - The Chariot? 5.300.63 VII - The Chariot? The Chariot Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
VIII - Justice? 5.300.64 VIII - Justice? Justice Complete Cantripped (challenge #43) May your sins come back to torment you Spawns 2 to 4 Golden Chests.
IX - The Hermit? 5.300.65 IX - The Hermit? The Hermit Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
X - Wheel of Fortune? 5.300.66 X - Wheel of Fortune? Wheel of Fortune Defeat Ultra Greedier as Tainted Cain Tainted Cain Throw the dice of fate Invokes a random dice room effect.
XI - Strength? 5.300.67 XI - Strength? Strength Defeat Ultra Greedier as Tainted Samson Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.
XII - The Hanged Man? 5.300.68 XII - The Hanged Man? The Hanged Man Defeat Ultra Greedier as Tainted Keeper Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus, and -0.1 speed. Killed enemies drop random coins.
XIII - Death? 5.300.69 XIII - Death? Death Defeat Ultra Greedier as Tainted Forgotten Tainted Forgotten May life spring forth from the fallen Invokes a 15►Book of the Dead Book of the Dead effect.
XIV - Temperance? 5.300.70 XIV - Temperance? Temperance Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random pills in quick succession.
XV - The Devil? 5.300.71 XV - The Devil? The Devil Defeat Ultra Greedier as Tainted Azazel Tainted Azazel Bask in the light of your mercy Invokes 15►The Bible The Bible (which can kill Mom), and grants Isaac flight and a 15►Seraphim Seraphim familiar for 30 seconds.
XVI - The Tower? 5.300.72 XVI - The Tower? The Tower Defeat Ultra Greedier as Tainted Apollyon Tainted Apollyon Creation brings destruction Spawns 6 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 XVII - The Stars? The Stars Defeat Ultra Greedier as Tainted Isaac Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item, including starting items, and spawns 2 random items from the current room's item pool. Doesn't spawn anything if Isaac has no items.
XVIII - The Moon? 5.300.74 XVIII - The Moon? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May you remember lost memories Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.
XIX - The Sun? 5.300.75 XIX - The Sun? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May the darkness swallow all around you Gain 15►Spirit of the Night Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 XX - Judgement? Judgement Defeat Ultra Greedier as Tainted Lazarus Tainted Lazarus May you redeem those found wanting Spawns a Restock Machine.
XXI - The World? 5.300.77 XXI - The World? The World Defeat Ultra Greedier as Tainted Eden Tainted Eden Step into the abyss Spawns a trap door to a crawl space.

Playing Cards

When on the ground, these cards look like: FaceCard.png

Name ID Icon Unlock method Message Description
2 of Clubs 5.300.23 2 of Clubs Always available Item multiplier Doubles your bombs. If you have no bombs, gives you 2 instead.
2 of Diamonds 5.300.24 2 of Diamonds Always available Item multiplier Doubles your coins. If you have no coins, gives you 2 instead.
2 of Spades 5.300.25 2 of Spades Always available Item multiplier Doubles your keys. If you have no keys, gives you 2 instead.
2 of Hearts 5.300.26 2 of Hearts Always available Item multiplier Doubles Isaac's current number of Red Hearts. Does not affect Eternal Hearts, Soul Hearts, or Black Hearts. Doesn't add new Red Heart containers, just fills empty ones.
Added in Afterbirth † Ace of Clubs 5.300.27 Ace of Clubs Hat trick! Get a 3-win streak Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into Bombs.
Added in Afterbirth † Ace of Diamonds 5.300.28 Ace of Diamonds ZIP! Defeat The Lamb in under 20 minutes Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into Pennies.
Added in Afterbirth † Ace of Spades 5.300.29 Ace of Spades It's the Key Defeat The Lamb without taking hearts, coins, and bombs through an entire run Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into Keys.
Added in Afterbirth † Ace of Hearts 5.300.30 Ace of Hearts Living on the edge Complete a Chapter (floors I and II) after The Basement, start-to-finish, with only half a heart of health (can use The Lost The Lost) Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into random heart pickups.
Joker 5.300.31 Joker Always available ??? Teleports Isaac to the Devil Room or Angel Room.
Suicide King 5.300.46 Suicide King Suicide King Complete Suicide King (challenge #7) A true ending? Kills Isaac and spawns lots of pickups, items, and/or chests in the same room.
Added in Repentance Queen of Hearts 5.300.79 Queen of Hearts Queen of Hearts Defeat Mega Satan as Tainted Magdalene Tainted Magdalene <3 Spawns 1-16 full red hearts.

Magic: The Gathering Card Backs

When on the ground, these cards look like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † MagicCard.png

Name ID Icon Unlock method Message Description
Chaos Card 5.300.42 Chaos Card Chaos Card Complete Demo Man (challenge #9) ??? Throws the card to kill anything in its path. Opens normal doors.
Added in Afterbirth † Huge Growth 5.300.52 Huge Growth Huge Growth Increase in size 5 times in a single run. Sources of increased size include "One Makes you Larger" pills, XI - Strength, and Magic Mushroom Become immense! Makes Isaac large for the current room, increasing his range and damage.
Added in Afterbirth † Ancient Recall 5.300.53 Ancient Recall Ancient Recall Use cards and runes 20 times Draw 3 cards Spawns 3 random cards.
Added in Afterbirth † Era Walk 5.300.54 Era Walk Era Walk Have both the 15►Broken Watch Broken Watch and the 15►Stop Watch Stop Watch in your collection Savor the moment For the current room, enemies are slowed, Isaac's speed is increased, and his shot speed is decreased.

Credit Card Back

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † CreditCard.png

Name ID Icon Unlock method Message Description
Credit Card 5.300.43 Credit Card Credit Card Complete Cursed (challenge #10) Charge it! Converts all items in the Shop or Devil Room into pickups or items on pedestals, allowing them to be picked up for free.

Other Playing Card Backs

When on the ground, these cards look like: FaceCard.png

Name ID Icon Unlock method Message Description
Rules Card 5.300.44 Rules Card Rules Card Complete Glass Cannon (challenge #11) ??? Displays a cryptic statement on the screen, similar to a Fortune Teller. These messages (often) provide hints on bosses, bonus areas, etc.
Added in Afterbirth ? Card 5.300.48 ? Card Always available Double active When used, copies the effect of Isaac's currently held activated collectible.

Card Against Humanity Back

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † HumanityCard.png

Name ID Icon Unlock method Message Description
A Card Against Humanity 5.300.45 A Card Against Humanity Card Against Humanity Complete When Life Gives You Lemons (challenge #12) Something stinks... Covers the entire room with poop. The process is not instant, and the room will not get filled if Isaac leaves before it's done filling.

Added in Afterbirth Chance Card Back

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † ChanceCard.png

Name ID Icon Unlock method Message Description
Get out of Jail Free Card 5.300.47 Get out of Jail Free Card Get out of Jail Free Card Complete SPEED! (challenge #22) Open Sesame Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.

Added in Afterbirth † Holy Card Back

When on the ground, this card looks like: HolyCard.png

Name ID Icon Unlock method Message Description
Holy Card 5.300.51 Holy Card Holy Card Defeat Delirium as The Lost The Lost You feel protected Grants the 15►Holy Mantle Holy Mantle effect. Removed in Repentance It lasts for the current room. Added in Repentance It lasts until taking damage.

Added in Repentance Uno Card Back

When on the ground, this card looks like: WildCardBack.png

Name ID Icon Unlock method Message Description
Wild Card 5.300.80 Wild Card Wild Card Defeat Mega Satan as Tainted Eden Tainted Eden Again When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Runes

Left Pointing Runes

When on the ground, these runes look like: Rune2.png

Name ID Icon Unlock method Message Description
Rune of Hagalaz 5.300.32 Rune of Hagalaz Rune of Hagalaz Complete Pitch Black (challenge #1) Destruction Destroys all breakable objects in the room. Removed in Repentance Does not affect Key Blocks.
Rune of Jera 5.300.33 Rune of Jera Rune of Jera Complete High Brow (challenge #2) Abundance Clones all pickups and chests in a room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
Rune of Ehwaz 5.300.34 Rune of Ehwaz Rune of Ehwaz Complete Head Trauma (challenge #3) Passage Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.
Rune of Dagaz 5.300.35 Rune of Dagaz Rune of Dagaz Complete Darkness Falls (challenge #4) Purity Removes any curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)

Right Pointing Runes

When on the ground, these runes look like: Rune1.png

Name ID Icon Unlock method Message Description
Rune of Ansuz 5.300.36 Rune of Ansuz Rune of Ansuz Complete The Tank (challenge #5) Vision Reveals the whole map, including the Secret Room and the Super Secret Room. (This will not remove Curse of the Lost.)
Rune of Perthro 5.300.37 Rune of Perthro Rune of Perthro Complete Solar System (challenge #6) Change Rerolls all pedestal items in the room. (This is the same effect as 15►The D6 The D6.)
Rune of Berkano 5.300.38 Rune of Berkano Rune of Berkano Complete Purist (challenge #20) Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
Rune of Algiz 5.300.39 Rune of Algiz Rune of Algiz Complete Cat Got Your Tongue (challenge #8) Resistance Removed in RepentanceGrants a shield which lasts for 30 seconds. Added in RepentanceGrants a shield which lasts for 20 seconds.
Added in Afterbirth Blank Rune 5.300.40 Blank Rune Blank Rune Removed in Afterbirth † Complete Onan's Streak (challenge #29)
Added in Afterbirth † Complete The Guardian (challenge #30)
??? Grants a random rune effect Removed in Repentance excluding the Black Rune. Has a 25% chance to spawn another Blank Rune upon use.

Other Runes

Added in Repentance Rune Shards can be encountered only as replacements for runes that have not been unlocked. Once all runes are available, Rune Shards cease to spawn.

Name ID Icon Unlock method Message Description
Added in Afterbirth † Black Rune 5.300.41 Black Rune Black Rune Defeat Ultra Greedier as Apollyon Apollyon Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on shop items.
Added in Repentance Rune Shard 5.300.55 Rune Shard Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Added in Repentance Soul Stones

Soul Stones are all unlocked by beating both Hush and Boss Rush as their respective Tainted character. They count as runes for the purposes of duplication with 15►Clear Rune Clear Rune, and 15►Rune Bag Rune Bag and other sources for generation.

Name ID Icon Unlock method Message Description
Soul of Isaac 5.300.81 Soul of Isaac Soul of Isaac Defeat Hush and Boss Rush as Tainted Isaac Tainted Isaac Reroll... or not Rerolls the items in the room like 15►The D6 The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
Soul of Magdalene 5.300.82 Soul of Magdalene Soul of Magdalene Defeat Hush and Boss Rush as Tainted Magdalene Tainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Soul of Cain Soul of Cain Defeat Hush and Boss Rush as Tainted Cain Tainted Cain Opens the unopenable Opens all doors in the room. Additionally, creates a red room like the 15►Red Key Red Key for every possible red exit. This also destroys the mirror located in Downpour Downpour/Dross Dross II.
Soul of Judas 5.300.84 Soul of Judas Soul of Judas Defeat Hush and Boss Rush as Tainted Judas Tainted Judas Right behind you Stops time for 3 seconds and invokes 15►Dark Arts Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
Soul of ??? 5.300.85 Soul of ??? Soul of ??? Defeat Hush and Boss Rush as Tainted ??? Tainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 15►Butt Bombs Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.
Soul of Eve 5.300.86 Soul of Eve Soul of Eve Defeat Hush and Boss Rush as Tainted Eve Tainted Eve Your very own murder 14 15►Dead Bird Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Soul of Samson Soul of Samson Defeat Hush and Boss Rush as Tainted Samson Tainted Samson Slay a thousand Isaac turns berserk (similar to Tainted Samson) for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.
Soul of Azazel 5.300.88 Soul of Azazel Soul of Azazel Defeat Hush and Boss Rush as Tainted Azazel Tainted Azazel Demon rage! Activates 15►Mega Blast Mega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Soul of Lazarus Soul of Lazarus Defeat Hush and Boss Rush as Tainted Lazarus Tainted Lazarus Life after death Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, functioning as a minimal extra life.
Soul of Eden 5.300.90 Soul of Eden Soul of Eden Defeat Hush and Boss Rush as Tainted Eden Tainted Eden Embrace chaos Uses 15►The D6 The D6 and 15►D20 D20. The rerolled items use random pools, as if 15►Chaos Chaos were active.
Soul of the Lost 5.300.91 Soul of the Lost Soul of the Lost Defeat Hush and Boss Rush as Tainted Lost Tainted Lost Leave your body behind Isaac "dies" and turns into a ghost (similar to The Lost The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Does not allow you to take devil deals for free. Does not allow you to open the door to Mausoleum for free. The Holy Mantle effect gained from this can be stacked with multiple uses.
Soul of Lilith 5.300.92 Soul of Lilith Soul of Lilith Defeat Hush and Boss Rush as Tainted Lilith Tainted Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except 15►Stitches Stitches. Unique familiars can be received only once.
Soul of the Keeper 5.300.93 Soul of the Keeper Soul of the Keeper Defeat Hush and Boss Rush as Tainted Keeper Tainted Keeper $$$ Spawns ~2-25 random coins.
Soul of Apollyon 5.300.94 Soul of Apollyon Soul of Apollyon Defeat Hush and Boss Rush as Tainted Apollyon Tainted Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Soul of the Forgotten Soul of the Forgotten Defeat Hush and Boss Rush as Tainted Forgotten Tainted Forgotten Skeletal protector Spawns The Forgotten The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his three bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Soul of Bethany 5.300.96 Soul of Bethany Soul of Bethany Defeat Hush and Boss Rush as Tainted Bethany Tainted Bethany Friends from beyond Spawns 6 15►Book of Virtues Book of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Soul of Jacob and Esau Soul of Jacob and Esau Defeat Hush and Boss Rush as Tainted Jacob Tainted Jacob Bound by blood Spawns Esau Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items the player who spawned him has.

Other

These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. Added in Repentance These consumables cannot be replicated by either 15►Blank Card Blank Card or 15►Clear Rune Clear Rune, and 15►Tarot Cloth Tarot Cloth has no effect on them.

Name ID Icon Unlock method Message Description
Added in Afterbirth Dice Shard 5.300.49 Dice Shard Always available D6 + D20 Upon use, activates the effects of The D6 and the D20 at the same time.
Added in Afterbirth Emergency Contact 5.300.50 Emergency Contact Always available Help from above When used, will cause two Mom's Hands to come down and grab two random enemies.
Added in Repentance Cracked Key 5.300.78 Cracked Key Red Key Open the large version of Mom's Box in Home ??? Creates a room adjacent to a viable wall, like 15►Red Key Red Key.

Notes

  • Removed in Repentance The game counts runes as cards for the purposes of 15►Starter Deck Starter Deck, 15►Blank Card Blank Card, and Added in Afterbirth †15►Tarot Cloth Tarot Cloth.
  • Added in Afterbirth Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
  • The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the 15►Whore of Babylon Whore of Babylon.
    • The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
  • Removed in Repentance The Devil card's effect does not stack with multiple uses, nor does it stack with 15►The Book of Belial The Book of Belial. It also does not increase the chance of a Devil or Angel Room appearing when used like with the Book of Belial.
  • Using the Joker card in II or Utero Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Sheol Sheol or to the Cathedral Cathedral. This can be used to skip Mom's Heart and will not count as a kill.
    • Added in Afterbirth After unlocking It Lives, Devil or Angel Rooms in II, Utero Utero II, and Scarred Womb Scarred Womb II no longer contain trapdoors and instead have their normal contents.
  • Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
  • If you use the Strength card with only Soul, Black, or Bone Hearts left, and lose the non-Red Hearts while in the same room, you retain the full Red Heart container that Strength grants after you leave.
  • The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Rooms.
  • Removed in Repentance The damage dealt by The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing Added in Afterbirth15►Host Hat Host Hat or 15►Pyromaniac Pyromaniac.
  • Using the Strength card as ??? ??? will give you a permanent Soul Heart instead of a temporary one. Added in Afterbirth When Keeper Keeper has only one Coin Heart, he can use the Strength card to gain a second one which is also permanent.
  • While Curse of the Maze is active, The Fool, Moon, Hermit, and Stars cards may fail and leave the player in a different room than intended. The Joker card still works normally.
  • Using the Temperance card can, in rare cases, spawn the Blood Donation Machine directly on the player, forcing them to use it once. Caution should be taken when using Temperance as The Lost The Lost (or when on half a heart of health), as this will instantly kill the player regardless of the 15►Holy Mantle Holy Mantle.
  • All teleportation cards except The Fool are unavailable in Greed Mode.
  • Added in Repentance Rune Shards spawn in place of a Rune that hasn't been unlocked yet. Once all Runes are unlocked, Rune Shards no longer appear.
  • Added in Repentance Leaving Trinkets in a Boss Room or a Treasure Room will transform them into a Cracked Key when on the Ascent to Home Home, if the Red Key is unlocked.
  • Added in RepentanceOnce Mother is defeated, a unique marked skull that will spawn on II or XL. When destroyed, it will always drop The Fool card (Or an identified Telepills if 15►Little Baggy Little Baggy has been picked up).
  • Added in Repentance Using Soul of The Lost and then beating a boss for a completion mark within the same room will not count as a completion mark for The Lost. Instead, the completion mark and achievement will go to the character who used the soul stone.
  • Added in Repentance Esau spawned using Soul of Jacob and Esau spawns with random items based on the pools of the items that Isaac currently holds.
  • Added in Repentance Using The Fool? while having all empty heart containers with soul hearts will cause the soul hearts to all be dropped on the ground, killing the player.

Unlockable Achievements

Trivia

  • The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
    • Added in Repentance IX - The Hermit?'s effect was based directly on the Rune of Fehu from Antibirth. No other Antibirth rune was adapted into Repentance.
  • The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
  • Added in Afterbirth The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
  • Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
    • The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
    • Added in Afterbirth † The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
    • Added in Afterbirth † The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
    • Added in Afterbirth † The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
  • Added in Afterbirth † Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
  • Added in Repentance Soul of Cain's ability is likely a reference to Added in Repentance15►Red Key Red Key being an unlock for Cain Cain in the original Antibirth mod.
  • Added in Repentance Soul of Judas' description and ability are a reference to the Spy from Team Fortress 2.
  • Added in Repentance Soul of Samson's description is a reference to Judges: it is said that Samson killed an army of 1,000 Philistines using a donkey's jawbone.
  • Added in Repentance Soul of Eve's description is a reference to original description Added in Repentance15►Birthright Birthright had when taken as Eve Eve in the original Antibirth mod.
    • Its effect was also probably inspired by the old original Added in Repentance15►Birthright Birthright effect, which caused Eve Eve to sometimes generate extra 15►Dead Bird Dead Birds that would persist between rooms.
  • Added in Repentance The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.
  • Typing the command "giveitem k0" into the Debug Console will reveal a secret usable item called "NULL". Executing the command, however, does not give anything.

Gallery

Bugs

Bug Bug! Added in Afterbirth † / Removed in Repentance Rune of Hagalaz Rune of Hagalaz will open Secret Room doors in L-shaped rooms.
Bug Bug! Added in Repentance Entering a trapdoor created by Rune of Ehwaz Rune of Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.
Bug Bug! Added in Repentance Using IV - The Emperor? IV - The Emperor? on ??? (floor) and defeating the extra boss will validate the completion mark for Hush.
Bug Bug! Added in Repentance Using IV - The Emperor? IV - The Emperor? on Caves 2 will teleport Isaac to the Mom fight, which will not spawn an exit door, resulting in a softlock.
Bug Bug! Added in Repentance If the Esau spawned by Soul of Jacob and Esau Soul of Jacob and Esau spawns with 15►Birthright Birthright, the game will instantly crash.
Bug Bug! Added in Repentance Using III - The Empress? III - The Empress? as Keeper will not grant extra heart containers, but will permanently remove two when the effect wears off.
Bug Bug! Added in Repentance Using III - The Empress? III - The Empress? as ??? will leave him at one half soul heart when the effect wears off.
Bug Bug! Added in Repentance Using Joker Joker in the Mirrored World causes the game to crash


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets