Page values for "Cards and Runes"

Teleports Isaac back to the starting room of a floor.

Grants homing tears and +3 Range for the current room (same effect as Telepathy for Dummies).

Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.

Triggers the Whore of Babylon effect (+1.5 Damage, +0.3 Speed) for the current room, regardless of Isaac's health total.

Teleports Isaac into the Boss Room of a floor. In Home, this will act as a random teleport.

Drops 2 full Soul Hearts on the ground.

Drops 2 full Red Hearts on the ground.

Grants the temporary invulnerability effect of My Little Unicorn.

Drops a random Red Heart, Key (except Key Ring), Bomb, and Coin pickup on the ground. Sometimes drops an Eternal-, Gold- Soul-, or Rotten Heart in place of the Red Heart. Sometimes drops a Troll Bomb or Mega Troll Bomb in place of the Bomb.

Teleports Isaac to the Shop. If there is no Shop, this will act as a random teleport.

Creates a Slot Machine or Fortune Telling Machine near Isaac.

Grants the effects of Magic Mushroom (minus the health restoration) for one room. The added Red Heart container is not removed if doing so would kill Isaac.

Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as Transcendence).

Deals 40 damage to all enemies in the room (same effect as The Necronomicon).

Creates a Blood Donation Machine near Isaac. Spawns a Devil Beggar instead in Greed mode.

Grants Isaac a temporary +2 increase to Damage for the current room (same effect as The Book of Belial).

Drops 6 Troll Bombs randomly around the room (same effect as the Anarchist Cookbook).

Teleports Isaac to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room if there is an active Curse of the Labyrinth. If there is a Planetarium, teleports Isaac there instead.

Teleports Isaac to the Secret Room. This card will open one random wall once inside the Secret Room, so Isaac can leave even if he doesn't have any Bombs available. Does nothing in Greed Mode.

Restores Isaac to full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except for the Super Secret Room. Removes Curse of Darkness for the current floor and does not reveal the Ultra Secret Room.

Spawns a Beggar or, more rarely, a Devil Beggar near Isaac.

Reveals the entire floor, except for the Super Secret Room. Does not reveal the Ultra Secret Room.

Drops all Hearts and pickups Isaac currently possesses on the floor, leaving Isaac at half a heart. Pickups may be dropped as items such as A Quarter and Boom!.

Grants a repelling blue aura for one minute, like The Soul but stronger and with a wider area of effect.

Mom's leg starts stomping down repeatedly for one minute, like holding Broken Shovel.

Grants 2 temporary Red Heart Containers and +1.35 Tears for one minute, along with Magdalene's hairstyle. The effect does not stack with itself. On characters that can't have Red Heart Containers, they will get Soul Hearts / Black Hearts / Bone Hearts accordingly. When the effect ends, if the removal of the Heart Containers would kill Isaac, he gets left with one instead.

Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor (but never a final boss). The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used it.

Drops 2 Bone Hearts on the ground.

Creates a random item from the current room's item pool. Turns one Red Heart Container or two Soul Hearts into a Broken Heart, potentially fatally; no downside for any character who has no health bar. Keeper and Tainted Keeper lose a Coin Heart and gain a Broken Coin Heart; that lost Coin Heart can't be replaced while the Broken Coin Heart remains.

Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.

Creates 2 to 4 Locked Chests near Isaac.

"Sells" items and pickups in the room for their usual Shop price, spawning a matching amount of Coins. If there is nothing to sell, drops a Penny.

Invokes a random Dice Room effect.

All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.

Isaac turns visually into Keeper for 30 seconds, with triple shot, no damage bonus, and -0.1 Speed. Killed enemies drop random Coins.

Invokes the Book of the Dead effect.

Forces Isaac to eat 5 random Pills in quick succession.

Invokes The Bible (which can kill Mom), and grants Isaac flight and a Seraphim familiar for 30 seconds.

Creates 6 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of finding more than one in the same room. The pathways between exits can't be blocked.

Removes Isaac's oldest passive item (ignoring starting items) and creates 2 random items from the current room's item pool. Does nothing if Isaac has no items.

Teleports Isaac to the Ultra Secret Room. The pathway back to the normal rooms will be made of Red Rooms.

Gain Spirit of the Night and +1.5 Damage for the current floor. Turns Isaac's Red Hearts into Bone Hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.

Creates a Shop Restock Machine near Isaac.

Creates a trap door which always leads to a Crawl Space.

Doubles Isaac's Bombs. If he has no bombs, gives him 2 instead.

Doubles Isaac's Coins. If he has no coins, gives him 2 instead.

Doubles Isaac's Keys. If he has no keys, gives him 2 instead.

Doubles Isaac's current number of Red Hearts. Doesn't add new Red Heart containers, just fills empty ones. If Isaac has only empty Red Heart containers, he is healed for 1 Red Heart.

Turns all Pickups, Chests, and non-boss enemies in the room into random Bomb pickups, including Troll Bombs.

Turns all Pickups, Chests, and non-boss enemies in the room into random Coin pickups.

Turns all Pickups, Chests, and non-boss enemies in the room into random Key pickups (except Key Rings).

Turns all Pickups, Chests, and non-boss enemies in the room into random Hearts.

Teleports Isaac to the Devil Room or Angel Room.

Drops 1-20 full Red Hearts on the ground.

When used, copies the effect of the most recently used Pill, Card, Rune, Soul Stone or activated item.

Destroys all breakable objects in the room. Does not affect Key Blocks.

Clones all pickups and Chests in the room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.

Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to create a trapdoor leading to a Crawl Space instead.

Removes any Curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)

Reveals the whole map, including the Secret Room and the Super Secret Room. (This will not remove Curse of the Lost.) Does not reveal the Ultra Secret Room

Re-rolls all item pedestals in the room (the same effect as The D6).

Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.

Grants a shield which lasts for 30 20 seconds.

Grants a random rune effect excluding Black Rune. Has a 25% chance to drop another Blank Rune on the ground upon use.

Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on Shop items.

Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a Soul Heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup, and Perthro re-rolls one item.

Rerolls the items in the room like The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.

Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop Half Red Hearts that disappear in 2 seconds.

Opens all doors in the room. Additionally, creates a Red Room like the Red Key on all valid walls. This also destroys the mirror located in Downpour / Dross II.

Stops time for 3 seconds and invokes Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.

Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Butt Bombs in quick succession. Standing on the creep gives +1.35 Tears and +1 Damage.

14 Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.

Isaac turns berserk (similar to using Berserk!) for 10 seconds, gaining +0.4 Speed, some Tears and +3 flat Damage along with his melee attack.

Activates Mega Blast for 7.5 seconds.

Isaac dies, and is immediately revived at half a Heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, functioning as a minimal extra life.

Uses The D6 and D20. The rerolled items use random pools, as if Chaos were active.

Isaac "dies" and turns into a ghost (similar to The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Allows him to take 1 Devil Room items for free, after which the other items vanish. Also allows him to enter the Mausoleum / Gehenna door for free. The Holy Mantle effect gained from this can be stacked with multiple uses.

Adds one permanent familiar from the Baby Shop pool, except Stitches. Unique familiars can be received only once.

Drops 1-25 random Coins on the ground.

Spawns 15 random locusts.

Spawns The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his 3 Bone Hearts run out, with no further consequence, and disappears when Isaac leaves the room.

Spawns 6 Book of Virtues wisps with random properties.

Spawns Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items Isaac has, each based on the pools of the items Isaac's were obtained from.