Page values for "Cards and Runes"

Teleports Isaac back to the starting room of a floor.

Grants homing tears and +3 range for the current room (same effect as Telepathy for Dummies).

Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.

Triggers the Whore of Babylon effect (+1.5 damage, +0.3 speed) for the current room, but without the need for Isaac to have a red heart or less of health.

Teleports Isaac into the Boss Room of a floor.

Spawns 2 Soul Hearts.

Spawns 2 Red Hearts. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.

Grants the temporary invulnerability effect of My Little Unicorn.

Spawns one of each consumable drop (a Red Heart, a Key, a Bomb, and a Penny). Hearts have a chance to spawn as either a Half Red Heart or a Double Heart.

Teleports Isaac to the Shop. If there is no Shop, this will act as a random teleport. If the Shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).

Spawns an Arcade machine (Slot Machine or Fortune Telling Machine).

Grants the effect of Magic Mushroom (increases all of Isaac's stats except tears), but adds one (temporary) Red Heart container for the current room as opposed to a permanent one.

Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as Transcendence).

Deals 40 damage to all enemies in the room (same effect as The Necronomicon).

Spawns a Blood Donation Machine.
Spawns a Devil Beggar in Greed mode.

Grants Isaac a temporary +2 increase to damage for the current room (same effect as The Book of Belial).

Spawns 6 Troll Bombs randomly around the room (same effect as the Anarchist Cookbook).

Teleports Isaac to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance). Can also teleport you to the Planetarium

Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available.

Restores Isaac's full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room. Removes Curse of Darkness for the current floor.

Spawns a Beggar.

Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.

Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Pickups may be spawned as items such as A Quarter and Boom!.

Grants a repelling blue aura for one minute, like The Soul but stronger and with a wider area of effect.

Mom's leg starts stomping down repeatedly for one minute, like holding Broken Shovel.

Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene's hairstyle. Does not stack.

Teleports Isaac into an extra Boss Room. The boss will drop a reward, but the room has no trapdoor and can be returned to only with another card.

Spawns 2 Bone Hearts.

Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally.

Isaac becomes an invincible, immobile statue with extreme fire rate for 10 seconds. Sometimes the statue looks like Edith.

Spawns 2 to 4 Golden Chests.

"Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.

Invokes a random dice room effect.

All enemies in the room are weakened, becoming slow and take double damage.

Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus and -0.1 speed. Killed enemies drop random coins.

Invokes a Book of the Dead effect.

Forces Isaac to eat 5 random pills in quick succession.

Invokes The Bible and grants a Seraphim familiar and flight for 30 seconds.

Spawns 6 clusters of random rocks and other obstacles. The pathways between exits can't be blocked.

Removes Isaac's oldest passive item and spawns 2 random items from the current room's item pool.

Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.

Gain Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.

Spawns a Restock Machine.

Spawns a trap door to a crawl space.

Doubles your bombs. If you have no bombs, gives you 2 instead.

Doubles your coins. If you have no coins, gives you 2 instead.

Doubles your keys. If you have no keys, gives you 2 instead.

Doubles Isaac's current number of Red Hearts. Does not affect Eternal Hearts, Soul Hearts, or Black Hearts. Doesn't add new Red Heart containers, just fills empty ones.

Turns all pickups, chests, and non-boss enemies in the room into Bombs.

Turns all pickups, chests, and non-boss enemies in the room into Pennies.

Turns all pickups, chests, and non-boss enemies in the room into Keys.

Turns all pickups, chests, and non-boss enemies in the room into random heart pickups.

Teleports you to the Devil Room or Angel Room.

Spawns 1-16 full red hearts.

When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Destroys all breakable objects in the room. Does not affect Key Blocks. Does affect Key Blocks

Clones all pickups and chests in a room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.

Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.

Removes any curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)

Reveals the whole map, including the Secret Room and the Super Secret Room.

Rerolls all pedestal items in the room. (This is the same effect as The D6.)

Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.

Grants a shield which lasts for 30 seconds. Grants a shield which lasts for 20 seconds.

Grants a random rune effect (excluding the Black Rune). Has a 25% chance to spawn another Blank Rune upon use. Now has a chance to activate Black Rune upon use.

Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on shop items.

Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Rerolls the items in the room like The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, all the rerolls are cycled through.

Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.

Creates a red room like Red Key, for every possible exit.

Invokes Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them. After a few seconds, he will attack them all, gaining damage bonuses for each target.

Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.

14 Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.

Isaac turns into a berserk Tainted Samson for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.

Activates Mega Blast for 7.5 seconds.

Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, as well, functioning as a minimal extra life.

Uses The D6 and D20. The rerolled items use random pools, like Chaos was active.

Isaac "dies" and turns into The Lost for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room.

Adds one random familiar item permanently.

Spawns ~3-25 random coins.

Spawns 15 random locusts.

Spawns The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his two bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.

Spawns 6 Book of Virtues wisps with random properties.

Spawns Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room.