Cards and runes are usable items with a wide variety of effects. They take up the same slot as Pills.
Runes and special cards are unlocked by completing challenges.
Cards[]
Major Arcana Cards[]
When on the ground, these cards look like:
Name
|
ID
|
Icon
|
Message
|
Description
|
0 - The Fool
|
5.300.1
|
|
Where journey begins
|
Teleports Isaac back to the starting room of the floor that he is currently on.
|
I - The Magician
|
5.300.2
|
|
May you never miss your goal
|
Grants homing tears for the current room.
Grants homing tears and +3 Range for the current room.
|
II - The High Priestess
|
5.300.3
|
|
Mother is watching you
|
Mom's dismembered leg stomps on the enemy with the most health, dealing 300 damage and destroying obstacles in the area. If used in an empty room or during the Mom fight, stomps Isaac instead. Isaac can move to avoid the stomp.
|
III - The Empress
|
5.300.4
|
|
May your rage bring power
|
Triggers the Whore of Babylon effect (+1.5 Damage, +0.3 Speed) for the current room, regardless of Isaac's health total.
|
IV - The Emperor
|
5.300.5
|
|
Challenge me!
|
Teleports Isaac into the Boss Room.
|
V - The Hierophant
|
5.300.6
|
|
Two prayers for the lost
|
Drops 2 full Soul Hearts on the ground.
|
VI - The Lovers
|
5.300.7
|
|
May you prosper and be in good health
|
Drops 2 full Red Hearts on the ground.
|
VII - The Chariot
|
5.300.8
|
|
May nothing stand before you
|
Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
|
VIII - Justice
|
5.300.9
|
|
May your future become balanced
|
Drops a random type of Heart, Key, Bomb, and Coin pickup on the ground.
|
IX - The Hermit
|
5.300.10
|
|
May you see what life has to offer
|
Teleports Isaac to the Shop.
|
X - Wheel of Fortune
|
5.300.11
|
|
Spin the wheel of destiny
|
Creates a Slot Machine or Fortune Telling Machine near Isaac.
|
XI - Strength
|
5.300.12
|
|
May your power bring rage
|
Grants the effects of Magic Mushroom (minus the health restoration) for one room. The added Red Heart container is not removed if doing so would kill Isaac.
|
XII - The Hanged Man
|
5.300.13
|
|
May you find enlightenment
|
Grants flight for the duration of the room.
|
XIII - Death
|
5.300.14
|
|
Lay waste to all that oppose you
|
Deals 40 damage to all enemies in the room.
|
XIV - Temperance
|
5.300.15
|
|
May you be pure in heart
|
Creates a Blood Donation Machine near Isaac. Spawns a Devil Beggar instead in Greed mode.
|
XV - The Devil
|
5.300.16
|
|
Revel in the power of darkness
|
Grants +2 Damage for the current room.
|
XVI - The Tower
|
5.300.17
|
|
Destruction brings creation
|
Drops 6 Troll Bombs randomly around the room.
|
XVII - The Stars
|
5.300.18
|
|
May you find what you desire
|
Teleports Isaac to the Treasure Room. Randomly chooses a Treasure Room if there is an active Curse of the Labyrinth. If there is a Planetarium, teleports Isaac there instead.
|
XVIII - The Moon
|
5.300.19
|
|
May you find all you have lost
|
Teleports Isaac to the Secret Room. Opens one random wall inside the Secret Room, so Isaac can leave even if he doesn't have any Bombs. Randomly chooses a Secret Room if there are multiple (via Fragmented Card and/or Luna).
|
XIX - The Sun
|
5.300.20
|
|
May the light heal and enlighten you
|
Restores Isaac to full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except for the Super Secret Room and Ultra Secret Room. Removes Curse of Darkness for the current floor.
|
XX - Judgement
|
5.300.21
|
|
Judge lest ye be judged
|
Spawns a Beggar or a Devil Beggar near Isaac. Has a 2% chance to spawn a Battery Bum, Rotten Beggar, Key Master, or Bomb Bum instead.
|
XXI - The World
|
5.300.22
|
|
Open your eyes and see
|
Reveals the entire floor, except for the Super Secret Room and Ultra Secret Room.
|
Reversed Major Arcana Cards[]
These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, a different message, the narrator sound clip reversed, and give different effects.
When on the ground, these cards look like:
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
0 - The Fool?
|
5.300.56
|
|
Defeat Ultra Greedier as Tainted Lost
|
Let go and move on
|
Drops all Hearts and pickups Isaac currently possesses on the floor, leaving Isaac at half a heart. Pickups may be dropped as items such as A Quarter and Boom!.
|
I - The Magician?
|
5.300.57
|
|
Defeat Ultra Greedier as Tainted Judas
|
May no harm come to you
|
Grants a repelling blue aura for one minute, like The Soul but stronger and with a wider area of effect.
|
II - The High Priestess?
|
5.300.58
|
|
Defeat Ultra Greedier as Tainted Lilith
|
Run
|
Mom's leg starts stomping down repeatedly (targeting Isaac, not the enemies) for one minute, like holding Broken Shovel.
|
III - The Empress?
|
5.300.59
|
|
Defeat Ultra Greedier as Tainted Eve
|
May your love bring protection
|
Grants 2 temporary Red Heart Containers, +1.5 Fire Rate, and -0.1 Speed for one minute, along with Magdalene's hairstyle. The effect does not stack with itself. When the effect ends, if the removal of the Heart Containers would kill Isaac, he is left with one instead.
|
IV - The Emperor?
|
5.300.60
|
|
Defeat Ultra Greedier as Tainted ???
|
May you find a worthy opponent
|
Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor (but never a final boss). The boss will drop a reward. Exiting the room returns Isaac to where he used the card.
|
V - The Hierophant?
|
5.300.61
|
|
Defeat Ultra Greedier as Tainted Bethany
|
Two prayers for the forgotten
|
Drops 2 Bone Hearts on the ground.
|
VI - The Lovers?
|
5.300.62
|
|
Defeat Ultra Greedier as Tainted Magdalene
|
May your heart shatter to pieces
|
Creates a random item from the current room's item pool. Turns one Red Heart Container or two Soul Hearts into a Broken Heart.
|
VII - The Chariot?
|
5.300.63
|
|
Complete Hot Potato (challenge #42)
|
May nothing walk past you
|
Isaac becomes an invincible statue with 4× fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
|
VIII - Justice?
|
5.300.64
|
|
Complete Cantripped (challenge #43)
|
May your sins come back to torment you
|
Creates 2 to 4 Locked Chests near Isaac.
|
IX - The Hermit?
|
5.300.65
|
|
Complete Red Redemption (challenge #44)
|
May you see the value of all things in life
|
Turns items and pickups in the room into Coins, matching their normal shop price. If there is nothing to sell, drops a Penny.
|
X - Wheel of Fortune?
|
5.300.66
|
|
Defeat Ultra Greedier as Tainted Cain
|
Throw the dice of fate
|
Invokes a random Dice Room effect.
|
XI - Strength?
|
5.300.67
|
|
Defeat Ultra Greedier as Tainted Samson
|
May you break their resolve
|
All enemies in the room are weakened, becoming slow and taking double damage. The effect lasts up to one minute or until the room is left.
|
XII - The Hanged Man?
|
5.300.68
|
|
Defeat Ultra Greedier as Tainted Keeper
|
May your greed know no bounds
|
Isaac turns visually into Keeper for 30 seconds, with triple shot and -0.1 Speed. Killed enemies drop random Coins.
|
XIII - Death?
|
5.300.69
|
|
Defeat Ultra Greedier as Tainted Forgotten
|
May life spring forth from the fallen
|
Creates a friendly Bony or temporary bone orbital for each enemy killed in the current room.
|
XIV - Temperance?
|
5.300.70
|
|
Complete DELETE THIS (challenge #45)
|
May your hunger be satiated
|
Forces Isaac to eat 5 random Pills in quick succession.
|
XV - The Devil?
|
5.300.71
|
|
Defeat Ultra Greedier as Tainted Azazel
|
Bask in the light of your mercy
|
Invokes The Bible (which can kill Mom). Grants Flight and spawns a Seraphim familiar for 30 seconds.
|
XVI - The Tower?
|
5.300.72
|
|
Defeat Ultra Greedier as Tainted Apollyon
|
Creation brings destruction
|
Creates 7 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of finding more than one in the same room. The pathways between exits can't be blocked.
|
XVII - The Stars?
|
5.300.73
|
|
Defeat Ultra Greedier as Tainted Isaac
|
May your loss bring fortune
|
Removes Isaac's oldest passive item (ignoring starting items) and creates 2 random items from the current room's item pool. Does nothing if Isaac has no items.
|
XVIII - The Moon?
|
5.300.74
|
|
Defeat Ultra Greedier as Tainted Jacob
|
May you remember lost memories
|
Teleports Isaac to the Ultra Secret Room. The pathway back to the normal rooms will be made of Red Rooms.
|
XIX - The Sun?
|
5.300.75
|
|
Defeat Ultra Greedier as Tainted Jacob
|
May the darkness swallow all around you
|
Gain Spirit of the Night and +1.5 Damage for the current floor. Turns Isaac's Red Hearts into Bone Hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
|
XX - Judgement?
|
5.300.76
|
|
Defeat Ultra Greedier as Tainted Lazarus
|
May you redeem those found wanting
|
Creates a Shop Restock Machine near Isaac.
|
XXI - The World?
|
5.300.77
|
|
Defeat Ultra Greedier as Tainted Eden
|
Step into the abyss
|
Creates a trap door which always leads to a Crawl Space.
|
Playing Cards[]
When on the ground, these cards look like:
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
2 of Clubs
|
5.300.23
|
|
Always available
|
Item multiplier
|
Doubles Isaac's Bombs. If he has no bombs, gives him 2 instead.
|
2 of Diamonds
|
5.300.24
|
|
Always available
|
Item multiplier
|
Doubles Isaac's Penny. If he has no coins, gives him 2 instead.
|
2 of Spades
|
5.300.25
|
|
Always available
|
Item multiplier
|
Doubles Isaac's Keys. If he has no keys, gives him 2 instead.
|
2 of Hearts
|
5.300.26
|
|
Always available
|
Item multiplier
|
Doubles Isaac's current number of Red Hearts. Doesn't add new Red Heart containers, just fills empty ones. If Isaac has only empty Red Heart containers, he is healed for 1 Red Heart. Doubles Tainted Bethany's Blood Charges.
|
Ace of Clubs
|
5.300.27
|
|
Get a 3-win streak
|
Convert all
|
Turns all Pickups, Chests, and non-boss enemies in the room into random Bomb pickups, including Troll Bombs.
|
Ace of Diamonds
|
5.300.28
|
|
Defeat The Lamb in under 20 minutes
|
Convert all
|
Turns all Pickups, Chests, and non-boss enemies in the room into random Coin pickups.
|
Ace of Spades
|
5.300.29
|
|
Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run. Letting certain familiars (e.g. Bum Friend, Dark Bum, Bumbo or Lil Portal) or bosses (e.g. Bumbino) pick up the consumables fails this condition as well.
|
Convert all
|
Turns all Pickups, Chests, and non-boss enemies in the room into random Key pickups.
|
Ace of Hearts
|
5.300.30
|
|
Complete a Chapter (floors I and II) after Basement, start-to-finish, with only half a Heart total (can use The Lost)
|
Convert all
|
Turns all Pickups, Chests, and non-boss enemies in the room into random Hearts.
|
Joker
|
5.300.31
|
|
Always available
|
???
|
Teleports Isaac to the Devil Room or Angel Room.
|
Suicide King
|
5.300.46
|
|
Complete Suicide King (challenge #7)
|
A true ending?
|
Kills Isaac and spawns lots of Pickups, items, and/or Chests in the same room.
|
Queen of Hearts
|
5.300.79
|
|
Defeat Mega Satan as Tainted Magdalene
|
<3
|
Drops 1-20 full Red Hearts on the ground.
|
Magic: The Gathering Cards[]
When on the ground, these cards look like:
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
Chaos Card
|
5.300.42
|
|
Complete Demo Man (challenge #9)
|
???
|
Throws the card in the direction Isaac is moving, which opens doors, breaks obstacles, and instantly kills any enemy in its path.
|
Huge Growth
|
5.300.52
|
|
Increase in size 5 times in a single run via Magic Mushroom, "One makes you larger" pills, XI - Strength, etc.
|
Become immense!
|
For the current room, makes Isaac larger, allows him to crush obstacles he walks on, and grants +7 flat Damage and +30 Range.
For the current room, makes Isaac larger, allows him to crush obstacles he walks on, and grants +7 flat Damage and +3 Range.
|
Ancient Recall
|
5.300.53
|
|
Use Cards and Runes 20 times
|
Draw 3 cards
|
Spawns 3 random cards.
|
Era Walk
|
5.300.54
|
|
Add both the Broken Watch and the Stop Watch to your collection
|
Savor the moment
|
For the current room, enemies are slowed, Isaac's speed is increased by 0.50, and his shot speed is decreased by 1.00.
|
Credit Card[]
When on the ground, this card looks like:
Other Playing Cards[]
When on the ground, these cards look like:
Card Against Humanity[]
When on the ground, this card looks like:
Monopoly Card[]
When on the ground, this card looks like:
Holy Card[]
When on the ground, this card looks like:
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
Holy Card
|
5.300.51
|
|
Defeat Delirium as The Lost
|
You feel protected
|
Grants a shield that blocks the next hostile damage that would be taken in the current room. Has a chance to spawn another Holy Card on use.
Grants a shield that blocks the next hostile damage that would be taken.
|
Uno Card[]
When on the ground, this card looks like:
Runes[]
Left Pointing Runes[]
When on the ground, these runes look like:
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
Rune of Hagalaz
|
5.300.32
|
|
Complete Pitch Black (challenge #1)
|
Destruction
|
Destroys all breakable objects in the room. Does not affect Key Blocks.
|
Rune of Jera
|
5.300.33
|
|
Complete High Brow (challenge #2)
|
Abundance
|
Clones all pickups and Chests in the room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
|
Rune of Ehwaz
|
5.300.34
|
|
Complete Head Trauma (challenge #3)
|
Passage
|
Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to create a trapdoor leading to a Crawl Space instead. Guaranteed to create a trap door to a Crawl Space if used on floor tiles containing certain patterns. Will not create trapdoors if used on the end floor of a challenge.
|
Rune of Dagaz
|
5.300.35
|
|
Complete Darkness Falls (challenge #4)
|
Purity
|
Removes any Curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)
|
Right Pointing Runes[]
When on the ground, these runes look like:
Other Runes[]
Rune Shards can be encountered only as replacements for runes that have not been unlocked. Once 6 runes of any kind (including soul stones) are available, Rune Shards cease to spawn.
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
Black Rune
|
5.300.41
|
|
Defeat Ultra Greedier as Apollyon
|
Void
|
Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades.
|
Rune Shard
|
5.300.55
|
|
Always available
|
It still glows faintly
|
Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away (including Ultra Secret Room), Berkano gives 1 blue fly and spider, Dagaz gives half a Soul Heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup, and Perthro rerolls one item.
|
Soul Stones[]
Soul Stones are all unlocked by beating both Hush and
Boss Rush as their respective Tainted character. They count as runes for the purposes of
Clear Rune and
Rune Bag and can spawn anywhere a rune can.
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
Soul of Isaac
|
5.300.81
|
|
Defeat Hush and Boss Rush as Tainted Isaac
|
Reroll... or not
|
Rerolls the items in the room like The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
|
Soul of Magdalene
|
5.300.82
|
|
Defeat Hush and Boss Rush as Tainted Magdalene
|
Give me your love!
|
Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop Half Red Hearts that disappear in 2 seconds.
|
Soul of Cain
|
5.300.83
|
|
Defeat Hush and Boss Rush as Tainted Cain
|
Opens the unopenable
|
Opens all doors in the room. Additionally, creates a Red Room like the Red Key on all valid walls. This also destroys the mirror located in Downpour / Dross II.
|
Soul of Judas
|
5.300.84
|
|
Defeat Hush and Boss Rush as Tainted Judas
|
Right behind you
|
Increases Isaac's speed and makes him invulnerable for 3 seconds and allows him to pass through enemies. Damages all enemies and destroys all projectiles Isaac ran through when the effect ends, and grants a temporary Damage bonus for each enemy and projectile hit.
|
Soul of ???
|
5.300.85
|
|
Defeat Hush and Boss Rush as Tainted ???
|
Chemical warfare
|
Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Butt Bombs in quick succession. Standing on the creep gives +1.5 Fire Rate and +1 Damage.
|
Soul of Eve
|
5.300.86
|
|
Defeat Hush and Boss Rush as Tainted Eve
|
Your very own murder
|
14 Dead Bird familiars fly in and attack enemies. They leave after all enemies are dead or Isaac leaves the room.
|
Soul of Samson
|
5.300.87
|
|
Defeat Hush and Boss Rush as Tainted Samson
|
Slay a thousand
|
Isaac turns berserk for 10 seconds, replacing his tears with a melee bone club and gaining +0.4 Speed, some Tears, and +3 flat Damage.
|
Soul of Azazel
|
5.300.88
|
|
Defeat Hush and Boss Rush as Tainted Azazel
|
Demon rage!
|
Activates Mega Blast for 7.5 seconds.
|
Soul of Lazarus
|
5.300.89
|
|
Defeat Hush and Boss Rush as Tainted Lazarus
|
Life after death
|
Isaac dies, and is immediately revived at half a Heart in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage. Has the highest priority of all Revival items.
|
Soul of Eden
|
5.300.90
|
|
Defeat Hush and Boss Rush as Tainted Eden
|
Embrace chaos
|
Uses The D6 and D20. The rerolled items use random pools, as if Chaos were active.
|
Soul of the Lost
|
5.300.91
|
|
Defeat Hush and Boss Rush as Tainted Lost
|
Leave your body behind
|
Isaac "dies" and turns into a ghost for the current room, with all of The Lost's benefits and weaknesses. The Holy Mantle effect gained from this can be stacked with multiple uses.
|
Soul of Lilith
|
5.300.92
|
|
Defeat Hush and Boss Rush as Tainted Lilith
|
Motherhood
|
Adds one permanent familiar from the Baby Shop pool, except Stitches. Can give familiars that Isaac already has. Unique familiars can be received only once.
|
Soul of the Keeper
|
5.300.93
|
|
Defeat Hush and Boss Rush as Tainted Keeper
|
$$$
|
Drops 1-25 random Coins on the ground.
|
Soul of Apollyon
|
5.300.94
|
|
Defeat Hush and Boss Rush as Tainted Apollyon
|
Bringer of calamity
|
Spawns 15 random locusts.
|
Soul of the Forgotten
|
5.300.95
|
|
Defeat Hush and Boss Rush as Tainted Forgotten
|
Skeletal protector
|
Spawns The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies with no consequences if his health run out, and disappears when Isaac leaves the room. The bone swing deals high damage, and reflects tears.
|
Soul of Bethany
|
5.300.96
|
|
Defeat Hush and Boss Rush as Tainted Bethany
|
Friends from beyond
|
Spawns 6 Book of Virtues wisps with random properties.
|
Soul of Jacob and Esau
|
5.300.97
|
|
Defeat Hush and Boss Rush as Tainted Jacob
|
Bound by blood
|
Spawns Esau as a temporary secondary character, controlled at the same time as Isaac. He dies with no consequences if his health runs out, and disappears when Isaac leaves the room. Esau has random items equal to the number of items Isaac has, each based on the pools of the items Isaac's were obtained from.
|
Other[]
These are items other than cards and runes (and Pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon.
These consumables cannot be replicated by either
Blank Card or
Clear Rune, and
Tarot Cloth has no effect on them, but the
D1 will always duplicate these into themselves. Despite this,Deck of Cards can produce all of these items, albeit rarely.
Name
|
ID
|
Icon
|
Unlock method
|
Message
|
Description
|
Dice Shard
|
5.300.49
|
|
Always available
|
D6 + D20
|
Upon use, invokes the effects of The D6 and the D20 at the same time, re-rolling all item pedestals and pickups in the room.
|
Emergency Contact
|
5.300.50
|
|
Always available
|
Help from above
|
When used, will cause two Mom's Hands to come down and grab two random enemies, dealing damage and, if they have 40 or more HP, pinning them to the ground temporarily.
|
Cracked Key
|
5.300.78
|
|
Open Mom's Chest in Home
|
???
|
Creates a room adjacent to a viable wall, like Red Key.
|
Probabilities[]
Cards that spawn as random ones, i.e. with a sub-type of 0, have the following probabilities:
- Any tarot card (1-22) - 66.66%
- A specific tarot card - 3.03%
- Any reverse tarot card (56-77) - 11.22%
- A specific reverse tarot card - 0.51%
- Any face card (23-31) - 7.74%
- A specific face card (23-31) - 0.86%
- Queen of Hearts (79) - 0.86% (same as a specific face card)
- Any special card (42-54) - 3.51%
- A specific special card - 0.27%
- Cracked Key (78) - 0.27% (same as a specific special card)
- Wild Card (80) - 0.27% (same as a specific special card)
- Any rune (32-41) - 3.60%
- Any soul stone (81-97) - 5.95%
- A specific soul stone - 0.35%
- Rune shard (55) - 0.00% (never spawns on a fully completed save file, chosen only as a replacement otherwise)
Notes[]
The game counts runes as cards for the purposes of
Blank Card, and
Tarot Cloth.
Even though runes no longer count as cards as of Repentance,
Little Baggy still prevents new runes from appearing except through forced drops (such as from
Mom's Ring or
Clear Rune). Runes that already existed prior to picking up Little Baggy will not be converted.
Starter Deck does not prevent runes/soul stones from generating, will sometimes turn pills into either, and allows holding two of them.
XV - The Devil card's effect does not stack with multiple uses, nor does it stack with
The Book of Belial.
Blood of the Martyr grants its additional 1.5× damage multiplier with XV - The Devil.
- It also does not increase the chance of a
Devil Room or
Angel Room appearing when used like with the Book of Belial.
The damage dealt by II - The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing
Host Hat or
Pyromaniac.
- The foot summoned by The High Priestess still counts as explosion damage, even though
Host Hat or
Pyromaniac won't prevent the damage. This means that the card can destroy rocks and open doors, including the entrance to
Secret Rooms.
- If there are no enemies in a room, II - The High Priestess will target Shopkeepers before targeting Isaac.
Using XI - Strength as
??? will give him a permanent Soul Heart instead of a temporary one.
When
Keeper has only one Coin Heart, he can use XI - Strength to gain a second one which is also permanent.
Both of the mentioned characters will lose the temporary health granted by XI - Strength.
- If Isaac uses XI - Strength card with only Soul, Black, or Bone Hearts left, and loses the non-Red Hearts while in the same room, he retains the full Red Heart Container that XI - Strength grants.
The heart container granted by XI - Strength cannot be used to purchase a devil deal. However, if Isaac has no other red heart containers to spend, then one granted by XI - Strength can be used this way. This also works if the devil deal costs 2 hearts, but Isaac only has 1 before activating the Strength card.
The temporary HP from both the XI - Strength card and III - The Empress? can be used for devil deals, with no restrictions.
- Runes will be replaced with cards if no runes are unlocked.
However, items that normally spawn runes (e.g.
Rune Bag or
Clear Rune) can spawn Rune Shards before any runes are unlocked.
- The Emperor, The Stars, The Hermit, The Moon, and The Moon? will act as a random teleport in cases where there isn't a boss room, treasure room, shop, secret room, or ultra secret room to teleport to.
- Using IV - The Emperor on a
Curse of the Labyrinth floor will teleport Isaac to the second
Boss Room.
- III - The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the
Whore of Babylon.
- The damage bonus is the number of uses squared, e.g. +1.5 × 4 × 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
- Using the Joker card in
Womb /
Utero II will instantly teleport Isaac to the
Devil Room or
Angel Room with a trapdoor leading to
Sheol or to the
Cathedral. This can be used to skip
Mom's Heart and will not count as a kill.
After unlocking It Lives, Devil or Angel Rooms in
Womb /
Utero /
Scarred Womb II no longer contain trapdoors and instead have their normal contents.
- Using the Joker card in
Mausoleum/
Gehenna II after defeating
Mom's Heart will teleport Isaac to an empty
Devil Room or
Angel Room. As such, it is best to use the Joker card either before defeating Mom's Heart, or after entering
Corpse.
- If the Joker card is used on a floor where the
Devil Room or
Angel Room will spawn after the boss fight, it may be smart to intentionally take red heart damage. That way, missing the deal on the current floor will increase the odds of you seeing a deal on the next floor.
- Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on, such as the first floor, or
Corpse II.
- While
Curse of the Maze is active, 0 - The Fool, IV - The Emperor, IX - Hermit, XVII - The Stars, and XVIII - The Moon may fail and leave Isaac in a different room than intended. The Joker card still works normally.
- Using XIV - Temperance can, in rare cases, spawn the
Blood Donation Machine directly on Isaac, forcing him to use it once. This happens more often if Isaac is against a wall when the card is used.
- All teleportation cards except 0 - The Fool,
XVII - The Stars, and
Joker are unavailable in Greed Mode.
- If alternate versions of consumables have been unlocked (for example,
Charged Keys or
Mega Chests), any cards that can spawn that type of consumables (for example, Ace of Spades or
VIII - Justice?) have a chance of being replaced with those rarer consumables.
-
Key Rings are the only exception to this.
- Cards that are explicitly stated to spawn a type of consumable (such as VI - The Lovers spawning red hearts) will almost always drop that exact type of consumable, unless they're used in specific
Secret Room.
- Using a Black Rune to absorb items in
Boss Rush or
Challenge Rooms counts as taking the items and will cause waves of bosses or enemies to start spawning.
- Using XV - The Devil? during the
Satan fight in Sheol will instantly kill Isaac, as it invokes the Bible effect.
Using the Blank Card with the ? Card teleports Isaac to the
I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
Black Rune, unlike
Void, will grant stat ups for sacrificing active items. This makes Black Rune useful even while holding Void, as any active item that would be detrimental to absorb can instead be absorbed by Black Rune.
If
Tarot Cloth is held, and the currently held card has Tarot Cloth effects, the card will flash, indicating that it will be amplified by Tarot Cloth.
Using any teleport cards while inside of
The Beast fight will simply move Isaac instantly to a different spot in the same room. This also includes the Joker card.
Leaving Trinkets in a
Boss Room or
Treasure Room will transform them into a Cracked Key when on the Ascent to
Home, if the Red Key is unlocked. This allows Isaac to unlock a Tainted Character without needing the Red Key.
If a Black Rune is used while Isaac is holding an item above his head, it will consume the item. This allows him to immediately absorb passive items bought from Devil Rooms, Black Markets, or Shops. This also can be used to give Isaac a chance to see what an unknown item is before deciding if he wants to consume it.
If Isaac uses the Black Rune to absorb items from a room with choice pedestals, it will only absorb one item, and the other item vanishes as if Isaac took it.
The Black Rune can be used to absorb
Knife Piece 1 if
Mother isn't the goal of the run. Can also be used to absorb
Key Piece 1 or
Key Piece 2.
Using the Rune of Jera on a Wild Card will copy the Wild Card, allowing Isaac to infinitely copy any other consumables in the room.
Once
Mother is defeated, a unique marked skull will spawn on
Depths /
Necropolis /
Dank Depths II or XL. When destroyed, it will always drop 0 - The Fool card (or an identified Telepills if
Little Baggy has been picked up).
Soul of Cain's effect can open any door that
Cracked Orb can, including the Strange Door and door to
Mega Satan.
Using Soul of The Lost and then beating a boss for a completion mark within the same room will not count as a completion mark for
The Lost. Instead, the completion mark and achievement will go to the character who used the soul stone.
Soul of the Lost can be used to purchase 1 free Devil Deal item, but doing so will remove all other unpurchased Devil Deals from the room.
Using IV - The Emperor? in
Womb /
Utero/
Scarred Womb /
Corpse I or II will teleport Isaac to a boss fight from the current boss pool.
- Using it in
Sheol /
Cathedral /
Dark Room /
Chest /
The Void /
Home / Error: The given stage ("Black Market") does not exist.will teleport Isaac to a random room.
- Using it in
??? will teleport Isaac to a boss fight from the
Womb boss pool.
- Using it in an
I AM ERROR room will take Isaac to the last room he was in when exited, allowing him to further explore the floor.
- It can be used to skip
Boss Rush after touching a pedestal item. After defeating the extra boss, leaving the room will lead Isaac to the regular, locked
Mom boss room.
Using IV - The Emperor? again on the same floor after defeating the boss it spawns takes Isaac back to the same cleared Boss room.
For the purposes of tracking
Heartbreak's effect on
The Lost /
Tainted Lost, VI - The Lovers? doesn't add any hidden Broken Hearts to their healthbar, allowing them to use the card without penalty.
Items granted by Soul of Lilith do not count as collected, and can still spawn in any pool they're in. Familiars obtained this way contribute toward transformations such as Conjoined.
Soul of Lilith takes its familiars from the Baby Shop item pool; however, when Isaac's stuff is rerolled, those familiars are rerolled in the Treasure Room item pool.
Items granted by Soul of Lilith can be destroyed by
Void /
Abyss for their respective bonuses right after using the soul stone while the pedestal pickup animation is playing.
Characters granted by Souls of the Forgotten / Jacob & Esau can interact with
Blood Donation Machines,
Devil Beggars, and
Hell Games, allowing
The Lost and
Tainted Lost to safely use them without dying, or a form of invulnerability.
Characters granted by Souls of the Forgotten / Jacob & Esau can't be used to leave a room, thus they can't be used to negate damage from exiting a
Curse Room.
- They also cannot pick up items, purchase devil deals, nor can they pick up things such as pills/cards/soul stones. They can pick up hearts, however Soul of the Forgotten can only replenish its bone hearts by collecting a bone heart pickup.
Items granted to Esau when summoned from the Soul of Jacob and Esau will remove those items from their respective pools as if the player had obtained them. This also prevents future uses of the soul stone from giving that item to Esau.
When the Soul of Jacob and Esau is used, some items given to Esau will also apply to Isaac for the floor. This happens with
Black Candle and mapping items such as
The Compass, for example.
- If Esau is given
PHD, pills will remain identified for the rest of the run, even if negative pills aren't converted into positive ones.
Items granted to the player by
Eden's Blessing are considered starting items by the effect of "XVII - The Stars?". Thus, only the first item picked up within the current run is removed.
Before using the IX - The Hermit? card, dropping every unwanted card/pill/rune/trinket from the floor into the same room can generate heaps of extra money.
As
Tainted Lost, every card has a roughly 10% chance to be replaced with a Holy Card.
[]
Gallery[]
-

The pop-up that appears whenever III - The Empress? activates.
Trivia[]
- The appearance of the tarot cards seems to be based on the Universal Tarot of Marseille deck produced by Lo Scarabeo, most clearly seen with the card backs as well as the splash image that appears when using The Sun.
- The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
IX - The Hermit?'s effect was based directly on the Rune of Fehu from Antibirth. No other Antibirth rune was adapted into Repentance.
- The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
- The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
- Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
- The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
- A NULL card with ID 0 exists, revealed by the "giveitem k0" Debug Console command. It can't be acquired or used in any way.
Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
Soul of Cain's ability is likely a reference to
Red Key being an unlock for
Cain in the original Antibirth mod.
Soul of Judas' description and ability are a reference to the Spy from Team Fortress 2.
Soul of Samson's description is a reference to Judges: it is said that Samson killed an army of 1,000 Philistines using a donkey's jawbone.
Soul of Eve's description is a reference to the original description
Birthright had when taken as
Eve in the original Antibirth mod.
- Its effect was also probably inspired by the old original
Birthright effect, which caused
Eve to sometimes generate extra
Dead Birds upon being hit that would persist between rooms.
III - The Empress? will display a pop up saying "The morning sun has vanquished the horrible night", a reference to Castlevania II: Simon's Quest when night turns to day.
- This is also a reference to
Whore of Babylon's (and by extension III - The Empress) pop up being the day to night message in said game.
When VII - The Chariot? is activated, the statue will sometimes look like Edith, a character from Antibirth that wasn't adapted into Repentance.
The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a contrary meaning to its upright variant.
- XVII - The Stars in actual tarot decks is just referred to as XVII - The Star.
Rune Shards exist to counteract players who purposely avoided unlocking less useful runes. For example, prior to Repentance, it was possible to purposely avoid all rune unlocks except Jera, to make exploits involving Jera and
Blank Card much easier. With the inclusion of the Rune Shard, avoiding rune unlocks to prioritize another is no longer possible.
Voiceovers[]
Major Arcana Cards[]
Playing Cards[]
Runes and Soul Stones[]
Other cards and consumables[]
Bugs[]
Bug!
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Using XVI - The Tower? in a Boss Room may block all paths to the trap door, resulting in a softlock if no bombs or flight are available.
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Bug!
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Using XVI - The Tower? can also trap certain familiars over the rocks such as Lost Fly until Isaac leaves the room.
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Bug!
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Any blue flies, blue spiders, friendly enemies, locusts, orbital bones, and wisps created by cards, runes, and soul stones can be multiplied when Glowing Hourglass teleports Isaac in a way that does not move him to a different room from the one he is currently in (such as by teleporting to the previous room then using it again).
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Bug!
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Entering the Knife Piece 2 area while under the effects of XIX - The Sun? will cause a visual bug wherein Isaac will revert to his default appearance but still be capable of flight and spectral tears.
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Bug!
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If an activated collectible on a pedestal is touched and then rerolled with Soul of Isaac, the alternate item(s) will also count as "already picked up": they will not drop pickups, grant health or transformations they normally would.
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Bug!
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If multiple Souls of the Forgotten / Jacob & Esau are used in the same room, only 1 Forgotten/Esau will be removed after leaving the room. For every room that is left, one copy of them will disappear.
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Bug!
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Using a Black Rune in a room with exactly one pickup and one item while being near the fly limit won't suck the item.
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Bug!
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Using IV - The Emperor? in a black market on Corpse II will result in a softlock trapping the player between the beaten boss room, crawlspace and black market.
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