Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress
5.300.4
May your rage bring power
Triggers the Whore of Babylon effect (+1.5 damage, +0.3 speed) for the current room, but without the need for Isaac to have a half a red heart or less of health.
IV - The Emperor
5.300.5
Challenge me!
Teleports Isaac into the Boss Room of a floor. In Home, this will act as a random teleport.
Teleports Isaac to the Shop. If there is no Shop, this will act as a random teleport. If the Shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
Teleports Isaac to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance). If there is a Planetarium, teleports Isaac there instead.
Reversed Major Arcana Cards[]
These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, a different message, the narrator sound clip reversed, and give different effects.
Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor. The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally; no downside for any character who has no health bar; Tainted Keeper locked to 1 HP.
"Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
Grants the Holy Mantle effect. It lasts for the current room. It lasts until taking damage.
Uno Card Back[]
When on the ground, this card looks like:
Name
ID
Icon
Unlock method
Message
Description
Runes[]
Left Pointing Runes[]
When on the ground, these runes look like:
Name
ID
Icon
Unlock method
Message
Description
Right Pointing Runes[]
When on the ground, these runes look like:
Name
ID
Icon
Unlock method
Message
Description
Other Runes[]
Rune Shards can be encountered only as replacements for runes that have not been unlocked. Once all runes are available, Rune Shards cease to spawn.
Name
ID
Icon
Unlock method
Message
Description
Soul Stones[]
Soul Stones are all unlocked by beating both Hush and Boss Rush as their respective Tainted character. They count as runes for the purposes of duplication with Clear Rune, and Rune Bag and other sources for generation.
Name
ID
Icon
Unlock method
Message
Description
Other[]
These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. These consumables cannot be replicated by either Blank Card or Clear Rune, and Tarot Cloth has no effect on them.
Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the Whore of Babylon.
The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
The Devil card's effect does not stack with multiple uses, nor does it stack with The Book of Belial. It also does not increase the chance of a Devil or Angel Room appearing when used like with the Book of Belial.
Blood of the Martyr grants its additional 1.5x damage multiplier with The Devil card.
Using the Joker card in Womb II or Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Sheol or to the Cathedral. This can be used to skip Mom's Heart and will not count as a kill.
After unlocking It Lives, Devil or Angel Rooms in II, Utero II, and Scarred Womb II no longer contain trapdoors and instead have their normal contents.
Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
If you use the Strength card with only Soul, Black, or Bone Hearts left, and lose the non-Red Hearts while in the same room, you retain the full Red Heart container that Strength grants after you leave.
The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Rooms.
The damage dealt by The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing Host Hat or Pyromaniac.
Using the sun card as ??? or characters with only soul hearts will not grant additional health.
Using the Strength card as ??? will give you a permanent Soul Heart instead of a temporary one. When Keeper has only one Coin Heart, he can use the Strength card to gain a second one which is also permanent.
While Curse of the Maze is active, The Fool, Moon, Hermit, and Stars cards may fail and leave the player in a different room than intended. The Joker card still works normally.
Using the Temperance card can, in rare cases, spawn the Blood Donation Machine directly on the player, forcing them to use it once. Caution should be taken when using Temperance as The Lost (or when on half a heart of health), as this will instantly kill the player regardless of the Holy Mantle.
All teleportation cards except The Fool are unavailable in Greed Mode.
Rune Shards spawn in place of a Rune that hasn't been unlocked yet. Once all Runes are unlocked, Rune Shards no longer appear.
Leaving Trinkets in a Boss Room or a Treasure Room will transform them into a Cracked Key when on the Ascent to Home, if the Red Key is unlocked.
Once Mother is defeated, a unique marked skull will spawn on II or XL. When destroyed, it will always drop The Fool card (Or an identified Telepills if Little Baggy has been picked up).
Using Soul of The Lost and then beating a boss for a completion mark within the same room will not count as a completion mark for The Lost. Instead, the completion mark and achievement will go to the character who used the soul stone.
Esau spawned using Soul of Jacob and Esau spawns with random items based on the pools of the items that Isaac currently holds.
Using The Fool? while having all empty heart containers with soul hearts will cause the soul hearts to all be dropped on the ground, killing the player.
If Tarot Cloth is held, the currently held card will flash, indicating that it is being affected by Tarot Cloth.
If Mega Chests have been unlocked. each Golden Chest spawned by Justice? has a chance of being replaced with a Mega Chest.
Using The Emperor? in Womb I or Corpse I will spawn a boss from the current boss pool.
Using it in the Ascent version of Caves II will teleport you to a extra Mom boss fight. Unlike the normal version, you can exit this fight normally.
It can be used to skip the Boss Rush after touching a pedestal item. After defeating the extra Mom's Heart, leaving the room will lead you to the regular, locked Mom boss room. The door to the Boss Rush will remain open if the timer allows it, but it cannot be restarted.
XIX - The Sun? effect, particularly flight, will persist even through the Knife Piece 2 sequence.
Using The Moon? in ??? will teleport you to the current room.
Using it in Ascent or Home will teleport you to a random room.
Huge Growth - Increase in size 5 times in a single run. Sources of increased size include "One Makes you Larger" pills, XI - Strength, and Magic Mushroom.
The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
IX - The Hermit?'s effect was based directly on the Rune of Fehu from Antibirth. No other Antibirth rune was adapted into Repentance.
The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
A NULL card with ID 0 exists, revealed by the "giveitem k0" Debug Console command. It can't be acquired or used in any way.
Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
Soul of Cain's ability is likely a reference to Red Key being an unlock for Cain in the original Antibirth mod.
Soul of Judas' description and ability are a reference to the Spy from Team Fortress 2.
Soul of Samson's description is a reference to Judges: it is said that Samson killed an army of 1,000 Philistines using a donkey's jawbone.
Soul of Eve's description is a reference to the original description Birthright had when taken as Eve in the original Antibirth mod.
Its effect was also probably inspired by the old original Birthright effect, which caused Eve to sometimes generate extra Dead Birds upon being hit that would persist between rooms.
III - The Empress? will display a pop up saying "The morning sun has vanquished the horrible night" a reference to Castlevania II: Simon's Quest when night turns to day.
This is also a reference to Whore of Babylon's (and by extension III - The Empress) pop up being the day to night message in said game.
When VII - The Chariot? is activated, the statue will sometimes look like Edith, a character from Antibirth that wasn't adapted into Repentance.
The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.
Rune of Hagalaz will open Secret Room doors in L-shaped rooms.
Bug!
Entering a trapdoor created by Rune of Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.
Bug!
Using IV - The Emperor? on ??? (floor) and defeating Monstro will validate the completion mark for Hush.
Bug!
Using IV - The Emperor? on Mausoleum/Gehenna II will teleport Isaac to the floor's Mom fight, however, when this boss is killed, no exit will spawn, likely softlocking Isaac.
Bug!
Using IV - The Emperor? on Caves/Mines/Ashpit II will teleport Isaac to the Mom fight, which will not spawn an exit door, resulting in a softlock. This does not happen in the Ascent.
Bug!
Using IV - The Emperor? on Mausoleum I has a chance to teleport you to the Rotgut fight. Defeat it and the door will lead you to the 3rd phase of the fight.
Bug!
Using IV - The Emperor? on Gehenna I, due to the lack of a alternative variant for Corpse, will teleport Isaac to a green looking Gehenna room without walls where you fight Monstro.
Bug!
Using IV - The Emperor? on Mausoleum/Gehenna II will teleport Isaac to the Mother's fight access room, entering it will crash the game
Bug!
If the Esau spawned by Soul of Jacob and Esau spawns with Birthright, the game will instantly crash.
Bug!
If the Esau spawned with Soul of Jacob and Esau touches the end chest, the game will crash.
Bug!
Using III - The Empress? as Keeper will not grant extra heart containers, but will permanently remove two when the effect wears off.
Sacks
+3 range for the current room (same effect as 
Telepathy for Dummies).
Whore of Babylon effect (+1.5 damage, +0.3 speed) for the current room, but without the need for Isaac to have a half a red heart or less of health.
Home, this will act as a random teleport.
My Little Unicorn.
Magic Mushroom (minus the health restoration) for one room. The added Red Heart container is removed upon leaving the room.
Transcendence).
The Necronomicon).
The Book of Belial).
Anarchist Cookbook).
Reversed Major Arcana Cards[]
Defeat Ultra Greedier as 
Tainted Lost
A Quarter and 
Boom!.
Defeat Ultra Greedier as 
Tainted Judas
The Soul but stronger and with a wider area of effect.
Defeat Ultra Greedier as 
Tainted Lilith
Broken Shovel.
Defeat Ultra Greedier as 
Tainted Eve
Magdalene's hairstyle. Does not stack.
Defeat Ultra Greedier as 
Tainted ???
Defeat Ultra Greedier as 
Tainted Bethany
Defeat Ultra Greedier as 
Tainted Magdalene
Tainted Keeper locked to 1 HP.
Complete Hot Potato (challenge #42)
Complete Cantripped (challenge #43)
Complete Red Redemption (challenge #44)
Defeat Ultra Greedier as 
Tainted Cain
Defeat Ultra Greedier as 
Tainted Samson
Defeat Ultra Greedier as 
Defeat Ultra Greedier as 
Tainted Forgotten
Book of the Dead effect.
Complete DELETE THIS (challenge #45)
Complete Suicide King (challenge #7)
Complete Demo Man (challenge #9)
Huge Growth
Increase in size 5 times in a single run. Sources of increased size include "One Makes you Larger" pills, XI - Strength, and Magic Mushroom
Use cards and runes 20 times
Have both the 
Broken Watch and the 
Stop Watch in your collection
Complete Cursed (challenge #10)
Complete Glass Cannon (challenge #11)
Complete When Life Gives You Lemons (challenge #12)
Complete SPEED! (challenge #22)
Defeat Delirium as 
The Lost
Holy Mantle effect. 
Clear Rune, and 
Rune Bag and other sources for generation.
Blank Card or 
Tarot Cloth has no effect on them.
Open the large version of Mom's Box in Home
Red Key.
Bug!
Rune of Hagalaz will open Secret Room doors in L-shaped rooms.
Rune of Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.
IV - The Emperor? on ??? (floor) and defeating Monstro will validate the completion mark for Hush.
Soul of Jacob and Esau spawns with 
Birthright, the game will instantly crash.
III - The Empress? as Keeper will not grant extra heart containers, but will permanently remove two when the effect wears off.
???, 
Dark Judas, 
Joker in the Mirrored World causes the game to crash
0 - The Fool? will remove all of Isaac's soul hearts and kill him.
XVIII - The Moon? can generate a red room attached to a Secret Room. Isaac will need a bomb to exit, potentially resulting in a softlock.
XVII - The Stars? can remove starting items in challenges.
XVI - The Tower? in a boss room may block all paths to the trap door, resulting in a softlock if no bombs or flight are available.
The Binding of Isaac: Rebirth 
Achievements
Attributes
Bosses
Cards and Runes
Challenges
Chapters
Characters
Co-op
Items
Item pools
Monsters
Objects
Pickups
Pills
Rooms
Seeds
Transformations
Trinkets
