Cards and Runes

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Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.

Runes and special cards are unlocked by completing challenges.

Cards[edit | edit source]

Major Arcana Cards[edit | edit source]

When on the ground, these cards look like: TarotCard.png

Name ID Icon Message Desciption
0 - The Fool 5.300.1 0 - The Fool Where journey begins Teleports Isaac back to the starting room of a floor.
I - The Magician 5.300.2 I - The Magician May you never miss your goal Grants homing tears and Added in Repentance +3 range for the current room (same effect as 15►Telepathy for Dummies Telepathy for Dummies).
II - The High Priestess 5.300.3 II - The High Priestess Mother is watching you Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress 5.300.4 III - The Empress May your rage bring power Triggers the 15►Whore of Babylon Whore of Babylon effect (+1.5 damage, +0.3 speed) for the current room, but without the need for Isaac to have a red heart or less of health.
IV - The Emperor 5.300.5 IV - The Emperor Challenge me! Teleports Isaac into the Boss Room of a floor.
V - The Hierophant 5.300.6 V - The Hierophant Two prayers for the lost Spawns 2 Soul Hearts.
VI - The Lovers 5.300.7 VI - The Lovers May you prosper and be in good health Spawns 2 Red Hearts. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Grants the temporary invulnerability effect of 15►My Little Unicorn My Little Unicorn.
VIII - Justice 5.300.9 VIII - Justice May your future become balanced Spawns one of each consumable drop (a Red Heart, a Key, a Bomb, and a Penny). Hearts have a chance to spawn as either a Half Red Heart or a Double Heart.
IX - The Hermit 5.300.10 IX - The Hermit May you see what life has to offer Teleports Isaac to the Shop. If there is no Shop, this will act as a random teleport. If the Shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
X - Wheel of Fortune 5.300.11 X - Wheel of Fortune Spin the wheel of destiny Spawns an Arcade machine (Slot Machine or Fortune Telling Machine).
XI - Strength 5.300.12 XI - Strength May your power bring rage Grants the effect of 15►Magic Mushroom Magic Mushroom (increases all of Isaac's stats except tears), but adds one (temporary) Red Heart container for the current room as opposed to a permanent one.
XII - The Hanged Man 5.300.13 XII - The Hanged Man May you find enlightenment Removes Isaac's body, allowing him to fly around for the duration of the room (same effect as 15►Transcendence Transcendence).
XIII - Death 5.300.14 XIII - Death Lay waste to all that oppose you Deals 40 damage to all enemies in the room (same effect as 15►The Necronomicon The Necronomicon).
XIV - Temperance 5.300.15 XIV - Temperance May you be pure in heart Spawns a Blood Donation Machine.
Added in Afterbirth Spawns a Devil Beggar in Greed mode.
XV - The Devil 5.300.16 XV - The Devil Revel in the power of darkness Grants Isaac a temporary +2 increase to damage for the current room (same effect as 15►The Book of Belial The Book of Belial).
XVI - The Tower 5.300.17 XVI - The Tower Destruction brings creation Spawns 6 Troll Bombs randomly around the room (same effect as the 15►Anarchist Cookbook Anarchist Cookbook).
XVII - The Stars 5.300.18 XVII - The Stars May you find what you desire Teleports Isaac to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance). Added in RepentanceCan also teleport you to the Planetarium
XVIII - The Moon 5.300.19 XVIII - The Moon May you find all you have lost Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available.
XIX - The Sun 5.300.20 XIX - The Sun May the light heal and enlighten you Restores Isaac's full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room. Added in Repentance Removes Curse of Darkness for the current floor.
XX - Judgement 5.300.21 XX - Judgement Judge lest ye be judged Spawns a Beggar.
XXI - The World 5.300.22 XXI - The World Open your eyes and see Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.

Added in Repentance Reversed Major Arcana Cards[edit | edit source]

These cards share the same names as their counterparts (barring the question marks at the end of their names), but have the sprite upside-down, the narrator sound clip reversed, and give different effects.

When on the ground, these cards look like: ReverseTarotCard.png

Name ID Icon Unlock method Message Desciption
0 - The Fool? 5.300.56 0 - The Fool? The Fool Defeat Ultra Greedier as Tainted Lost Let go and move on Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Pickups may be spawned as items such as 15►A Quarter A Quarter and 15►Boom! Boom!.
I - The Magician? 5.300.57 I - The Magician? The Magician Defeat Ultra Greedier as Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like 15►The Soul The Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 II - The High Priestess? The High Priestess Defeat Ultra Greedier as Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding 15►Broken Shovel Broken Shovel.
III - The Empress? 5.300.59 III - The Empress? The Empress Defeat Ultra Greedier as Tainted Eve May your love bring protection Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene's hairstyle. Does not stack.
IV - The Emperor? 5.300.60 IV - The Emperor? The Emperor Defeat Ultra Greedier as Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room. The boss will drop a reward, but the room has no trapdoor and can be returned to only with another card.
V - The Hierophant? 5.300.61 V - The Hierophant? The Hierophant Defeat Ultra Greedier as Tainted Bethany Two prayers for the forgotten Spawns 2 Bone Hearts.
VI - The Lovers? 5.300.62 VI - The Lovers? The Lovers Defeat Ultra Greedier as Tainted Magdalene May your heart shatter to pieces Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally.
VII - The Chariot? 5.300.63 VII - The Chariot? The Chariot Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible, immobile statue with extreme fire rate for 10 seconds. Sometimes the statue looks like Edith.
VIII - Justice? 5.300.64 VIII - Justice? Justice Complete Cantripped (challenge #43) May your sins come back to torment you Spawns 2 to 4 Golden Chests.
IX - The Hermit? 5.300.65 IX - The Hermit? The Hermit Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
X - Wheel of Fortune? 5.300.66 X - Wheel of Fortune? Wheel of Fortune Defeat Ultra Greedier as Tainted Cain Throw the dice of fate Invokes a random dice room effect.
XI - Strength? 5.300.67 XI - Strength? Strength Defeat Ultra Greedier as Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage.
XII - The Hanged Man? 5.300.68 XII - The Hanged Man? The Hanged Man Defeat Ultra Greedier as Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus and -0.1 speed. Killed enemies drop random coins.
XIII - Death? 5.300.69 XIII - Death? Death Defeat Ultra Greedier as Tainted Forgotten May life spring forth from the fallen Invokes a 15►Book of the Dead Book of the Dead effect.
XIV - Temperance? 5.300.70 XIV - Temperance? Temperance Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random pills in quick succession.
XV - The Devil? 5.300.71 XV - The Devil? The Devil Defeat Ultra Greedier as Tainted Azazel Bask in the light of your mercy Invokes 15►The Bible The Bible and grants a 15►Seraphim Seraphim familiar and flight for 30 seconds.
XVI - The Tower? 5.300.72 XVI - The Tower? The Tower Defeat Ultra Greedier as Tainted Apollyon Creation brings destruction Spawns 6 clusters of random rocks and other obstacles. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 XVII - The Stars? The Stars Defeat Ultra Greedier as Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item and spawns 2 random items from the current room's item pool.
XVIII - The Moon? 5.300.74 XVIII - The Moon? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob May you remember lost memories Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.
XIX - The Sun? 5.300.75 XIX - The Sun? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob May the darkness swallow all around you Gain 15►Spirit of the Night Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 XX - Judgement? Judgement Defeat Ultra Greedier as Tainted Lazarus May you redeem those found wanting Spawns a Restock Machine.
XXI - The World? 5.300.77 XXI - The World? The World Defeat Ultra Greedier as Tainted Eden Step into the abyss Spawns a trap door to a crawl space.

Playing Cards[edit | edit source]

When on the ground, these cards look like: FaceCard.png

Name ID Icon Message Desciption
2 of Clubs 5.300.23 2 of Clubs Item multiplier Doubles your bombs. If you have no bombs, gives you 2 instead.
2 of Diamonds 5.300.24 2 of Diamonds Item multiplier Doubles your coins. If you have no coins, gives you 2 instead.
2 of Spades 5.300.25 2 of Spades Item multiplier Doubles your keys. If you have no keys, gives you 2 instead.
2 of Hearts 5.300.26 2 of Hearts Item multiplier Doubles Isaac's current number of Red Hearts. Does not affect Eternal Hearts, Soul Hearts, or Black Hearts. Doesn't add new Red Heart containers, just fills empty ones.
Added in Afterbirth † Ace of Clubs 5.300.27 Ace of Clubs Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into Bombs.
Added in Afterbirth † Ace of Diamonds 5.300.28 Ace of Diamonds Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into Pennies.
Added in Afterbirth † Ace of Spades 5.300.29 Ace of Spades Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into Keys.
Added in Afterbirth † Ace of Hearts 5.300.30 Ace of Hearts Convert all Turns all pickups, chests, and Added in Repentance non-boss enemies in the room into random heart pickups.
Joker 5.300.31 Joker ??? Teleports you to the Devil Room or Angel Room.
Suicide King 5.300.46 Suicide King A true ending? Kills Isaac and spawns lots of pickups, items, and/or chests in the same room.
Added in Repentance Queen of Hearts 5.300.79 Queen of Hearts <3 Spawns 1-16 full red hearts.

Magic: The Gathering Card Backs[edit | edit source]

When on the ground, these cards look like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † MagicCard.png

Name ID Icon Message Desciption
Chaos Card 5.300.42 Chaos Card ??? Throws the card to kill anything in its path. Opens normal doors.
Added in Afterbirth † Huge Growth 5.300.52 Huge Growth Become immense! Makes Isaac large for the current room, increasing his range and damage.
Added in Afterbirth † Ancient Recall 5.300.53 Ancient Recall Draw 3 cards Spawns 3 random cards.
Added in Afterbirth † Era Walk 5.300.54 Era Walk Savor the moment For the current room, enemies are slowed, Isaac's speed is increased, and his shot speed is decreased.

Credit Card Back[edit | edit source]

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † CreditCard.png

Name ID Icon Message Desciption
Credit Card 5.300.43 Credit Card Charge it! Converts all items in the Shop or Devil Room into pickups or items on pedestals, allowing them to be picked up for free.

Other Playing Card Backs[edit | edit source]

When on the ground, these cards look like: FaceCard.png

Name ID Icon Message Desciption
Rules Card 5.300.44 Rules Card ??? Displays a cryptic statement on the screen, similar to a Fortune Teller. These messages (often) provide hints on bosses, bonus areas, etc.
Added in Afterbirth ? Card 5.300.48 ? Card Double active When used, copies the effect of Isaac's currently held activated collectible.

Card Against Humanity Back[edit | edit source]

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † HumanityCard.png

Name ID Icon Message Desciption
A Card Against Humanity 5.300.45 A Card Against Humanity Something stinks... Covers the entire room with poop. The process is not instant, and the room will not get filled if you leave it before it's done filling.

Added in Afterbirth Chance Card Back[edit | edit source]

When on the ground, this card looks like: Removed in Afterbirth † FaceCard.png    Added in Afterbirth † ChanceCard.png

Name ID Icon Message Desciption
Get out of Jail Free Card 5.300.47 Get out of Jail Free Card Open Sesame Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.

Added in Afterbirth † Holy Card Back[edit | edit source]

When on the ground, this card looks like: HolyCard.png

Name ID Icon Message Desciption
Holy Card 5.300.51 Holy Card You feel protected Grants the 15►Holy Mantle Holy Mantle effect.

Added in Repentance Uno Card Back[edit | edit source]

When on the ground, this card looks like: WildCardBack.png

Name ID Icon Message Desciption
Wild Card 5.300.80 Wild Card Again When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Runes[edit | edit source]

Left Pointing Runes[edit | edit source]

When on the ground, these runes look like: Rune2.png

Name ID Icon Message Desciption
Rune of Hagalaz 5.300.32 Rune of Hagalaz Destruction Destroys all breakable objects in the room. Does not affect Key Blocks. Added in Repentance Does affect Key Blocks
Rune of Jera 5.300.33 Rune of Jera Abundance Clones all pickups and chests in a room (including Shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for collectibles. Cannot clone other Jera runes and trinkets.
Rune of Ehwaz 5.300.34 Rune of Ehwaz Passage Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.
Rune of Dagaz 5.300.35 Rune of Dagaz Purity Removes any curses from the current floor and grants a Soul Heart. (This will not remove Curse of the Labyrinth.)

Right Pointing Runes[edit | edit source]

When on the ground, these runes look like: Rune1.png

Name ID Icon Message Desciption
Rune of Ansuz 5.300.36 Rune of Ansuz Vision Reveals the whole map, including the Secret Room and the Super Secret Room.
Rune of Perthro 5.300.37 Rune of Perthro Change Rerolls all pedestal items in the room. (This is the same effect as The D6.)
Rune of Berkano 5.300.38 Rune of Berkano Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
Rune of Algiz 5.300.39 Rune of Algiz Resistance Removed in RepentanceGrants a shield which lasts for 30 seconds. Added in RepentanceGrants a shield which lasts for 20 seconds.
Added in Afterbirth Blank Rune 5.300.40 Blank Rune ??? Grants a random rune effect Removed in Repentance(excluding the Black Rune). Has a 25% chance to spawn another Blank Rune upon use. Added in Repentance Now has a chance to activate Black Rune upon use.

Added in Afterbirth † Other Runes[edit | edit source]

Name ID Icon Message Desciption
Black Rune 5.300.41 Black Rune Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades. No effect on shop items.
Added in Repentance Rune Shard 5.300.55 Rune Shard It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Added in Repentance Soul Stones[edit | edit source]

Name ID Icon Message Desciption
Soul of Isaac 5.300.81 Soul of Isaac Reroll... or not Rerolls the items in the room like 15►The D6 The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, all the rerolls are cycled through.
Soul of Magdalene 5.300.82 Soul of Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Soul of Cain Opens the unopenable Creates a red room like 15►Red Key Red Key, for every possible exit.
Soul of Judas 5.300.84 Soul of Judas Right behind you Invokes 15►Dark Arts Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them. After a few seconds, he will attack them all, gaining damage bonuses for each target.
Soul of ??? 5.300.85 Soul of ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 15►Butt Bombs Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.
Soul of Eve 5.300.86 Soul of Eve Your very own murder 14 15►Dead Bird Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Soul of Samson Slay a thousand Isaac turns into a berserk Tainted Samson for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.
Soul of Azazel 5.300.88 Soul of Azazel Demon rage! Activates 15►Mega Blast Mega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Soul of Lazarus Life after death Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, as well, functioning as a minimal extra life.
Soul of Eden 5.300.90 Soul of Eden Embrace chaos Uses 15►The D6 The D6 and 15►D20 D20. The rerolled items use random pools, like 15►Chaos Chaos was active.
Soul of the Lost 5.300.91 Soul of the Lost Leave your body behind Isaac "dies" and turns into The Lost for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room.
Soul of Lilith 5.300.92 Soul of Lilith Motherhood Adds one random familiar item permanently.
Soul of the Keeper 5.300.93 Soul of the Keeper $$$ Spawns ~3-25 random coins.
Soul of Apollyon 5.300.94 Soul of Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Soul of the Forgotten Skeletal protector Spawns The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his two bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Soul of Bethany 5.300.96 Soul of Bethany Friends from beyond Spawns 6 15►Book of Virtues Book of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Soul of Jacob and Esau Bound by blood Spawns Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room.

Added in Afterbirth Other[edit | edit source]

These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon. Added in Repentance These consumables cannot be replicated by either 15►Blank Card Blank Card or 15►Clear Rune Clear Rune, and 15►Tarot Cloth Tarot Cloth has no effect on them.

Name ID Icon Message Desciption
Dice Shard 5.300.49 Dice Shard D6 + D20 Upon use, activates the effects of The D6 and the D20 at the same time.
Emergency Contact 5.300.50 Emergency Contact Help from above When used, will cause two Mom's Hands to come down and grab two random enemies.
Added in Repentance Cracked Key 5.300.78 Cracked Key ??? Creates a room adjacent to a viable wall, like Added in Repentance15►Red Key Red Key.

Notes[edit | edit source]

  • Removed in Repentance The game counts runes as cards for the purposes of 15►Starter Deck Starter Deck, 15►Blank Card Blank Card, and Added in Afterbirth †15►Tarot Cloth Tarot Cloth.
  • Added in Afterbirth Using the Blank Card with the ? Card teleports the player to the I AM ERROR room of the current floor. This consumes both the Blank Card and the ? Card.
  • The Empress card's effect can be stacked with multiple uses of the same card (including uses by Blank Card), and also stacks with the 15►Whore of Babylon Whore of Babylon.
    • The damage bonus is the number of uses squared, e.g. +1.5 * 4 * 4 damage for using the card via a Blank Card, with Tarot Cloth and Car Battery equipped.
  • The Devil card's effect does not stack with multiple uses, nor does it stack with 15►The Book of Belial The Book of Belial. It also does not increase the chance of a Devil or Angel Room appearing when used like with the Book of Belial.
  • Using the Joker card in The Womb The Womb II or Utero Utero II will instantly teleport the player to the Devil Room or Angel Room with a trapdoor leading to Sheol Sheol or to the Cathedral Cathedral. This can be used to skip Mom's Heart and will not count as a kill.
    • Added in Afterbirth After unlocking It Lives, Devil or Angel Rooms in The Womb II, Utero II, and Scarred Womb Scarred Womb II no longer contain trapdoors and instead have their normal contents.
  • Using The Joker card can allow Isaac to encounter Devil Rooms or Angel Rooms on floors they otherwise cannot appear on.
  • If you use the Strength card with only Soul, Black, or Bone Hearts left, and lose the non-Red Hearts while in the same room, you retain the full Red Heart container that Strength grants after you leave.
  • The foot summoned by The High Priestess can destroy rocks and open doors, including the entrance to Secret Rooms.
  • Removed in Repentance The damage dealt by The High Priestess counts as explosion damage, meaning it will not damage Isaac when possessing Added in Afterbirth15►Host Hat Host Hat or 15►Pyromaniac Pyromaniac.
  • Using the Strength card as ??? will give you a permanent Soul Heart instead of a temporary one. Added in Afterbirth When Keeper has only one Coin Heart, he can use the Strength card to gain a second one which is also permanent.
  • While Curse of the Maze is active, The Fool, Moon, Hermit, and Stars cards may fail and leave the player in a different room than intended. The Joker card still works normally.
  • Using the Temperance card can, in rare cases, spawn the Blood Donation Machine directly on the player, forcing them to use it once. Caution should be taken when using Temperance as The Lost (or when on half a heart of health), as this will instantly kill the player regardless of the 15►Holy Mantle Holy Mantle.
  • All teleportation cards except The Fool are unavailable in Greed Mode.
  • Added in Repentance Rune Shards spawn in place of a Rune that hasn't been unlocked yet. Once all Runes are unlocked, Rune Shards no longer appear.
  • Added in Repentance Leaving Trinkets in a Boss Room or a Treasure Room will transform them into a Cracked Key when on the Ascent back Home.
  • Added in Repentance There is a unique marked skull that will spawn on Depths II or XL. It is marked by a tiny black cross, and when blown up will always drop The Fool card (Or an identified Telepills if Little Baggy has been picked up).

Unlockable Achievements[edit | edit source]

Trivia[edit | edit source]

  • The runes and their names ingame are based on the Elder Futhark alphabet system and its reconstructed Proto-Germanic names. In popular culture, runes often signify that something is in some way magical.
  • The Suicide King card is a nickname for the King of Hearts, referred to as such because its artwork depicts a king who seems to be sticking a sword into his own head.
  • Added in Afterbirth The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game Cards Against Humanity.
  • Ancient Recall, Era Walk, Huge Growth, and Chaos Card are all based on cards from Magic: The Gathering.
    • The Chaos Card is a reference to the card "Chaos Orb", which also instantly destroys enemies that it touches.
    • Added in Afterbirth † The "Ancient Recall" card is a reference to the card "Ancestral Recall", which also draws three cards.
    • Added in Afterbirth † The "Era Walk" card is a reference to the card "Time Walk", which allows players to take an extra turn.
    • Added in Afterbirth † The "Huge Growth" card is a reference to the card "Giant Growth", which buffs creatures summoned in the game. Its message might be a reference to the card "Become Immense", a card with a similar effect to Giant Growth.
  • Added in Afterbirth † Many cards were given new unique back sprites in Booster Pack #5, some originating from Antibirth.
  • Added in Repentance The "Soul of Judas" description and ability are a reference to the Spy from Team Fortress 2.
  • Added in Repentance The "Soul of Eve" description and ability refer to how a group of crows is called a murder.
  • Added in Repentance The "Soul of Cain"'s ability is likely a reference to 15►Red Key Red Key being an unlock for Cain in the original Antibirth mod.
  • Added in Repentance The Reverse Tarot Cards refer to tarot card readings, where a reversed card has a different meaning to an upright one.
  • Typing the command "giveitem k0" into the Debug Console will reveal a secret usable item called "NULL". Executing the command, however, does not give anything.

Gallery[edit | edit source]

Bugs[edit | edit source]

Bug Bug! Added in Afterbirth † / Removed in Repentance Hagalaz will open Secret Room doors in L-shaped rooms.
Bug Bug! Added in Repentance Entering a trapdoor created by Ehwaz on Corpse II will result in a black screen. Continuing after this will result in the floor restarting. Completion mark for Mother will not be received even if you have defeated her prior to entering the trapdoor.


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets