Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
Character Tainted Cain appearance.png
Full red heartFull red heart
Table dividing line 1.png
Challenge Number
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom.png
Justice Justice
Unlock Method

The Hoarder Use the Red Key or Cracked Key in Home as Cain Cain

Added in Repentance

Cantripped! is challenge #43. The goal is to defeat Mom. This challenge is unlocked by unlocking Tainted Cain Tainted Cain.

You play as Tainted Cain Tainted Cain, but instead of crafting items from pickups, all pills and tarot cards are replaced with a unique card pickup that gives you a one room or one time (if the item is an Active Item) use of different items. All boss rewards are changed to 15►Starter Deck Starter Deck, increasing the item cards limit by 1, and dropping 3 item cards.

Cain starts with 3 held item cards.


  • Each enemy has a chance to drop an item card after death. This can be used to farm item cards with enemies which can spawn other enemies.
  • Some bonuses from items will remain after leaving the room. Therefore using them has a big influence on the run. This includes:
  • Although there are no treasure rooms, shops don't sell items, and bosses do not drop standard boss items, gaining items in other ways is still possible. You won't lose those items after leaving the room. These ways include but are not limited to:
  • Item cards act like pickups and can be manipulated as such (e.g. duplicated with Rune of Jera Rune of Jera).
  • As in many challenges, Golden Bombs offer an alternate and powerful way to fight, allowing to pass floors easily.
  • Using 15►Glowing Hour Glass Glowing Hour Glass after leaving a room will give back all items used in that room permanently, allowing to bypass the challenge's limitations. Make sure to apply this strategy with a room containing a maximum amount of cards so you can gain more bonuses.
    • However, if Glowing Hour Glass is used in the first room of the run, the Bag of Crafting is removed. This still causes items and pickups to be replaced as usual, but prevents their activation.
  • Using 15►Mama Mega! Mama Mega! in a room will still activate it on every room in the floor, making getting through the rest of the floor trivial.
  • Holding onto 15►The Bible The Bible or 15►Plan C Plan C enables the player to instantly kill Mom. This can bypass the need to store several powerful items for the final fight.
  • The player can use a 15►Forget Me Now Forget Me Now in order to gain another 15►Starter Deck Starter Deck, and thus carry more items.
  • Exiting a room with 15►Epiphora Epiphora will make the fire rate increase permanent until Isaac’s tear delay changes.


  • Almost all rooms drop an item card when cleared.
  • Active items that grant an effect upon obtaining them, such as 15►Sharp Key Sharp Key and 15►Remote Detonator Remote Detonator, will not grant that effect.
  • 15►Battery Pack Battery Pack creates multiple item cards instead of batteries.
  • Butter! Butter! has no effect upon activated items used from the bag.
  • Collecting 15►Rock Bottom Rock Bottom will not bypass the loss of any items (or Rock Bottom itself) from disappearing in the next room.
  • 15►Diplopia Diplopia will not duplicate 15►Starter Deck Starter Deck, it will only create an item card.
  • If an item pedestal would have spawned, an item card will spawn instead. This applies to:
    • Book pedestals in the Library.
    • Items found in Chests.
    • Item spawned by other items, such as through 15►Eden's Soul Eden's Soul.
    • Items in Angel Rooms. If there is more than one item card, taking one of them makes the other(s) disappear.
  • Items for sale in Devil Rooms will be replaced with item cards which are surrounded by spikes like consumables in shops affected by 15►A Pound of Flesh A Pound of Flesh.
  • Items in the Shop are transformed into item cards and can be bought for 5 coins.
    • Underground shops generated by 15►Member Card Member Card may provide Item cards as well, available for 6 coins. They may also provide Trinkets as usual.
    • Using 15►Member Card Member Card inside a shop will permanently open the trap door to the underground shop for the current floor only.
  • Items that would generate Cards such as 15►Booster Pack Booster Pack will generate item cards instead.
  • The same item can be encountered more than once and it is possible to have several copies of an item inside the bag.
  • Any familiars spawned with 15►Cambion Conception Cambion Conception or 15►Immaculate Conception Immaculate Conception will be removed at the end of the floor.

Unlockable achievements[]


  • The name of this challenge is a reference to the Magic: the Gathering term "cantrip", meaning a card that draws another card.
  • The item cards in this challenge resemble the treasure cards from The Binding of Isaac: Four Souls.


Bug Bug! Using Glowing Hour Glass will restore any passive items used in the previous room as permanent items instead of item cards.


MainPageChallenges.png Challenges MainPageChallenges.png

1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
8. Cat Got Your Tongue 9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards
15. Slow Roll 16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
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Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets