Binding of Isaac: Rebirth Wiki
Character Tainted Cain appearance.png
Full red heartFull red heart
Table dividing line 1.png
Challenge Number
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom portrait.png
Justice Justice
Unlock Method

The Hoarder Use Red Key Red Key (etc.) to open the hidden closet in Home Home as Cain Cain

Added in Repentance

Cantripped! is challenge #43. The goal is to defeat Mom Mom. This challenge is unlocked by unlocking Tainted Cain Tainted Cain.

You play as Tainted Cain Tainted Cain, but instead of crafting items from pickups, all pills and tarot cards are replaced with a unique card pickup that gives you a one room or one time (if the item is an Active Item) use of different items. All boss rewards are changed to Starter Deck Starter Deck, increasing the item cards limit by 1, and dropping 3 item cards.

Cain starts with 3 held item cards.


  • Each enemy has a chance to drop an item card after death. This can be used to farm item cards with enemies which can spawn other enemies.
  • Some bonuses from items will remain after leaving the room. Therefore using them has a big influence on the run. This includes:
  • Although there are no treasure rooms, shops don't sell items, and bosses do not drop standard boss items, gaining items in other ways is still possible. You won't lose those items after leaving the room. These ways include but are not limited to:
  • Item cards act like pickups and can be manipulated as such (e.g. duplicated with Rune of Jera Rune of Jera).
  • As in many challenges, Golden Bomb Golden Bombs offer an alternate and powerful way to fight, allowing to pass floors easily.
  • Using Mama Mega! Mama Mega! in a room will still activate it on every room in the floor, making getting through the rest of the floor trivial.
  • Holding onto The Bible The Bible or Plan C Plan C enables the player to instantly kill Mom. This can bypass the need to store several powerful items for the final fight.
  • The player can use a Forget Me Now Forget Me Now in order to gain another Starter Deck Starter Deck, and thus carry more items.
  • Exiting a room with Epiphora Epiphora will make the fire rate increase permanent until Isaac’s tear delay changes.


  • Almost all rooms drop an item card when cleared.
  • Active items that grant an effect upon obtaining them, such as Sharp Key Sharp Key and Remote Detonator Remote Detonator, will not grant that effect.
  • Battery Pack Battery Pack creates multiple item cards instead of batteries.
  • Butter! Butter! has no effect upon activated items used from the bag.
  • Collecting Rock Bottom Rock Bottom will not bypass the loss of any items (or Rock Bottom itself) from disappearing in the next room.
  • Diplopia Diplopia will not duplicate Starter Deck Starter Deck, it will only create an item card.
  • If an item pedestal would have spawned, an item card will spawn instead. This applies to:
    • Book pedestals in the Library Library.
    • Items found in Chests.
    • Item spawned by other items, such as through Eden's Soul Eden's Soul.
    • Items in Angel Room Angel Rooms. If there is more than one item card, taking one of them makes the other(s) disappear.
  • Items for sale in Devil Room Devil Rooms will be replaced with item cards which are surrounded by spikes like consumables in shops affected by A Pound of Flesh A Pound of Flesh.
  • Items in the Shop Shop are transformed into item cards and can be bought for 5 coins.
    • Underground shops generated by Member Card Member Card may provide Item cards as well, available for 6 coins. They may also provide Trinkets as usual.
    • Using Member Card Member Card inside a shop will permanently open the trap door to the underground shop for the current floor only.
  • Items that would generate Cards such as Booster Pack Booster Pack will generate item cards instead.
  • The same item can be encountered more than once and it is possible to have several copies of an item inside the bag.
  • Any familiars spawned with Cambion Conception Cambion Conception or Immaculate Conception Immaculate Conception will be removed at the end of the floor.
  • Any Transformations obtained will last only for the room and cannot be carried over to the rest of the run.
  • Using Glowing Hour Glass Glowing Hour Glass will cause the player to permanently keep any passive items used in the previous room throughout the remainder of the challenge.

Unlockable achievements[]

  • Justice
    Justice - Complete Cantripped (challenge #43).


  • The name of this challenge is a reference to the Magic: the Gathering term "cantrip", meaning a card that draws another card.
  • The item cards in this challenge resemble the treasure cards from The Binding of Isaac: Four Souls.