Binding of Isaac: Rebirth Wiki

Disambig.png This article is about the trinket. For the item, see Cancer.

Cancer (Trinket) is a trinket.


  • Removed in Repentance -2 tear delay (increased rate of fire)
    • Since this directly affects tear delay instead of changing the tears stat, it allows Isaac's rate of fire to go over the normal maximum rate.
    • Tear delay decreases are more noticeable and are a greater increase to DPS when the tears stat is high.


  • Cancer's tear delay reduction scales with the current tear modifier's fire rate multiplier, the only exception being Chocolate Milk Chocolate Milk.

In-game Footage[]


  • The pickup quote is a tribute to the community of the original game. Due to the usefulness of the trinket in the original The Binding of Isaac, it became a popular joke to consider "getting cancer" as a good thing.


PC CRW3 8MKY (Room under starting room drops Cancer after clearing it)

PC 0BSG MWKL (Room south of the the starting room drops after clearing it)

PC Added in Afterbirth Greed mode only DPJ7 NB4N (Dropped by Crack Jacks in the first Silver Treasure Room)