Cambion Conception

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Cambion   Conception
Removed in Afterbirth †Item icon
Added in Afterbirth †Item icon
Item altar
"Feed them hate"
Table dividing line 1.png
Item ID
5.100.412
Character Appearance
Character appearance
Table dividing line 2.png
Table dividing line 3.png
Collection Grid
Added in Afterbirth † / Removed in Repentance(page 4, column 7, row 3)
Removed in Afterbirth †(page 4, column 7, row 3)
Added in Repentance(page 4, column 8, row 3)
Unlock Method
Cambion Conception Defeat ??? as Lilith Lilith
Added in Afterbirth

Cambion Conception is an unlockable passive item added in The Binding of Isaac: Afterbirth.

Effects[edit | edit source]

  • Upon taking damage a certain number of times, Isaac gains a permanent demonic familiar. Possible familiars include:
  • The first and second familiars will each spawn after taking damage 15 times. The third and fourth familiars will each spawn after taking damage 30 more times. No further familiars will spawn. As a result, after taking damage 90 times, four out of seven possible familiars will have spawned.
  • Isaac will look progressively more pregnant as he takes damage.

Notes[edit | edit source]

  • Lilith starts with this item by default, even if it hasn't been unlocked.
  • Only one of each type of familiar can be spawned.
  • Familliars that have yet to be unlocked can still spawn.
  • Only actually getting damage counts towards the payout. For example, disrupting the 15►Holy Mantle Holy Mantle shield while keeping your heart containers full will not spawn any familiars.
  • Familiars spawned this way do not count towards transformations nor the collection page.
  • Familiars spawned by the item do not affect item pools, so multiple copies of one familiar can be obtained. For example, a second Incubus can be purchased after Cambion Conception spawns one.
  • If a familiar obtained is a copy of another one you've already obtained, using 15►Box of Friends Box of Friends will only clone one of that familiar, similarly to the Box of Friends's effects on cloned familiars that it spawns.
  • This item is the demonic counterpart to 15►Immaculate Conception Immaculate Conception.
  • Added in Repentance If this item is removed with Reversed Card XVII - The Stars?, it will also remove any familiars already obtained through Cambion Conception.

Interactions[edit | edit source]

  • 15►Caffeine Pill Caffeine Pill: Makes it impossible to tell how far along the pregnancy is.

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • In mythology, a cambion is the offspring of a human and an incubus or succubus.
  • During the development of Afterbirth, Edmund McMillen asked on Twitter what the opposite of 15►Immaculate Conception Immaculate Conception would be called. 27 people replied with suggestions, but none of them were used.


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