Cain is a character unlocked by obtaining 55 or more coins at once in a run.
Cain starts with two Red Heart containers, one key, and 
Lucky Foot.
Cain also starts with a 
Paper Clip trinket after 68 coins have been donated to the Greed Donation Machine.
Notes
- Cain can only shoot tears from his right eye. This affects certain items:
Blood Clot and Chemical Peel have a 50% chance to do increased damage and Technology 2 will prevent him from firing normal tears, even tear-changing effects like Brimstone. Also, the R U a Wizard? pill will cause Cain to fire tears to his right exclusively. - Abel's tears become red and deal 7.5 damage when held by Cain.
Unlockable Achievements
Trivia
- Cain appeared in the original Binding of Isaac and required the same coin count to unlock.
- Cain is a reference to the Biblical story of Cain and Abel, in which Cain commits the first murder by killing Abel.
- Abel also appears as an item in Rebirth.
- Glass Baby could be a reference to Cain having a glass eye.
 Characters
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 The Binding of Isaac: Rebirth
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