Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Buddy in a Box is an unlockable passive item added in The Binding of Isaac: Afterbirth † (Booster Pack #1).


  • Grants a familiar with random tear effects, fire rate, and damage.
    • The familiar's damage scales from ~2-6, and tear delay scales from ~12-30.
    • The familiar takes the appearance of a random co-op baby.
    • The familiar is randomized upon entering a new floor.
  • Added in Repentance This item belongs to the Conjoined set. Collecting three items from this set will transform Isaac into a three-faced version of himself.


  • The tear effects available are the same as on the Fruit Cake Fruit Cake item.
  • The familiar's tear appearance isn't linked to the normal effect such tears would have.
  • Some tear effects like Proptosis Proptosis and Tiny Planet Tiny Planet do not have their associated stat boosts and thus are very ineffective.
  • Familiars with the Serpent's Kiss Serpent's Kiss effect can drop Black Heart Black Hearts when an enemy is killed.
  • Familiars will not do contact damage.
  • Added in Repentance The familiar will change upon exiting the Knife Piece 2 Knife Piece 2 area. (possibly a bug)


In-game Footage[]


  • Buddy in a Box is based on this Steam Workshop item by Ashkait and Scayze.
  • This is the only way of seeing co-op babies in-game outside of co-op.
  • Added in Repentance The re-texture makes it look like a Funko Pop Figurine Box.


Switch Greedier mode only GQHY GCE6 (First Golden Treasure Room)