Binding of Isaac: Rebirth Wiki

Breath of Life is an activated item.


  • Holding the active item button will gradually deplete the charge bar. As the charge gets closer to zero, Isaac turns bluer over time.
    • Added in Afterbirth † Once the invincibility takes effect, Isaac starts flashing rapidly.
  • Gives a brief moment of invincibility when the charge bar hits zero. If the spacebar is held for an additional second after hitting zero, Isaac will take damage.
    • Added in Repentance While Isaac is invincible, he deals 3.5 contact damage to enemies and beams of light will strike down enemies touching Isaac, similar to Added in AfterbirthHoly Light Holy Light, dealing 15 damage.
      • While not time based, invincibility from Breath of Life is otherwise identical to damage immunity granted by the shield effect.
  • The item will recharge on its own but cannot be used again until it is fully charged (even if you didn't fully deplete the charge bar).


  • While difficult to use in combat, it is very helpful for using Blood Donation Machines, Confessional and Devil Beggars without losing any life. In order to do this, you have to activate it slightly longer when you're invincible, lest you take damage.
    • Added in Repentance Can not be used to prevent damage from the door to the Mausoleum.
  • Similarly, it can be used to cross over spikes and enter Curse Rooms without taking damage.


  • Added in RepentanceBook of Virtues Book of Virtues: Creates a wisp after it's been held long enough for Isaac to take damage.
  • Removed in RepentanceIsaac's Heart Isaac's Heart: When held down too long, Breath of Life no longer damages Isaac, resulting in infinite invincibility.
  • Added in Afterbirth †Void Void: Using Void with Breath of Life will immediately grant invincibility frames.


In-game Footage[]



  • The Breath of Life refers to God breathing life into the soil to create the first human.
  • Breath of Life initially had a different animation, almost exactly alike to Chocolate Milk's effect. However, this animation has one frame of Isaac holding his breath that isn't found in Chocolate Milk's sprites. It even has its own .anim2 file, paralleling Chocolate Milk's. The finished effect for Breath of Life is a gradual change of Isaac's skin tone, from perky pink to hold-my-breath blue.
  • Depleting the skill's charge turns Isaac a similar color to ???/Blue Baby, who is implied to be Isaac after suffocating in his toy chest.


Bug Bug! Removed in Afterbirth † This item does not work with Broken Remote.
Bug Bug! Replacing this item with another active item, switching into another active item with Added in Afterbirth †Schoolbag Schoolbag, or directly remove it via debug console while holding active item key cause Isaac to take damage (even if the charge bar isn't depleted at all).


PC 9YXJ B6M0 (Found in Angel Room in The Catacombs 1)

PC S8PG 8NLE (Found in Angel Room after defeating the boss in The Caves I)

PC SMJ3 0TLY (Found in Angel Room after defeating the boss in The Catacombs I)

PC 1ATQ LTG7 (Found in Angel Room after defeating Mom)

PC S4FP ER7Y (Found in Angel Room after defeating Mom)

PC Added in Afterbirth † Normal and hard modes only SSJ6 26QB (Found inside the Angel Room after defeating the boss in Necropolis I)

PC NKF0 PZFZ (Found in Angel Room in Utero I)

PS4 4RVE W694 (Found in Angel Room after defeating the boss in The Womb I)

Vita R7ZV 8PTB (Found inside the Angel Room after defeating the boss in The Catacombs II)

3DS LTSQ HWAL (Found inside the Angel Room after defeating the boss in The Catacombs I)