Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
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A breaking run is a community term referring to a scenario where Isaac can create an infinite number of items to get whatever combination of items he wants, making the rest of the run trivial to beat.

Elements of Breaking Runs[]

Breaking runs work by manipulating items to appear from regular pickups in a renewable way, whether they be rerolling pickups, duplicating chests, or endlessly restocking items. Many of the items that enable this can be found in Arcades, Shops, and Super Secret Rooms; anything that lets Isaac make better use of these items and rooms makes it easier for the circumstances required for a breaking run to come together.

Method 1: Blank Card/Clear Rune + Jera + Infinite Charges[]

This can endlessly duplicate Locked Chests with items in them to create an endless amount of items.

With Blank Card + Jera, Lil' Batteries can be duplicated endlessly, and if a chest on the floor has an item in it, all chests duplicated from it will also have items. From this, chests can be duplicated endlessly, creating infinite items. Note that keys will also have to be duplicated to open the chests if they're Locked/Eternal Chests, or bombs if they're Bomb Chests.

Removed in Repentance Method 2: IV Bag + Restock[]

One of the simplest methods of breaking a run, it allows Isaac to buy as many items as he wants from the Shop. This is not possible in Greed mode because Blood Donation Machines cannot spawn in Greed mode, and The Lost The Lost cannot use this because IV Bag ignores 15►Holy Mantle Holy Mantle and will kill him.

  • Added in Repentance This method is no longer possible, due to restock increasing the price of hearts each time they're purchased.
  • Elements:
    • 15►IV Bag IV Bag, obtained from Blood Donation Machines Added in Afterbirth † or Locked Chests.
    • Added in Afterbirth15►Restock Restock, bought from the Shop.

On average, 15►IV Bag IV Bag makes more cash from Red Hearts than it costs to purchase them, and with Restock he can buy endless Red Hearts to make an infinite amount of money. Added in Afterbirth15►Restock Restock also makes the items in the Shop restock when purchased, meaning he can also buy out every item from the shop until Added in Afterbirth15►Chaos Chaos shows up, at which point he can empty every item pool in the game.

Method 3: Pickup Generation on Hit + Damage Source + Cracked Dice[]

This allows Isaac to generate endless pickups, which can then be rerolled into hearts to continue generating more pickups and chests to generate endless items. This method is unavailable to The Lost The Lost, as it requires taking damage to work.

Added in AfterbirthCracked Dice Cracked Dice has a 25% chance to reroll every pickup in the room, and can be fueled by items like 15►Piggy Bank Piggy Bank or 15►IV Bag IV Bag that generate pickups on hit. Once enough pickups are accumulated, the room can completely refill Isaac’s health on each reroll as well as spawn many chests, creating a renewable cycle of item and health generation.

Removed in Repentance Method 4: D20 + Infinite Charges[]

Similar to the previous method, this can create an endless amount of chests, but relies on having active item charges to reroll pickups instead of taking damage. This was the original breaking method back in The Binding of Isaac: Wrath of the Lamb.

After opening a chest, the D20 can reroll all the pickups created by the chest as well as the empty chest itself (unless it had an item) for the chance at more chests. With a way to endlessly recharge the D20, these pickups can be continually rerolled into chests and opened to eventually create an endless supply of coins to buy Lil' Batteries (if using Restock) and chests for items.

Method 5: Added in RepentanceModeling Clay Modeling Clay + Cards/Pills[]

Because Modeling Clay can cycle between item effects by leaving and re-entering rooms constantly, it can be used to constantly reroll cards, then use those cards to spawn items in Secret Rooms that constantly cycle between items due to Added in Repentance15►Glitched Crown Glitched Crown, allowing many powerful and game-breaking items to be acquired (such as Added in Repentance15►Clear Rune Clear Rune, Added in Afterbirth15►Rune Bag Rune Bag, Added in Repentance15►R Key R Key, Added in Repentance15►Spindown Dice Spindown Dice, Added in Afterbirth †15►D Infinity D Infinity, Added in Repentance15►Echo Chamber Echo Chamber, and Added in Repentance15►Death Certificate Death Certificate).

To start, gather all the cards/pills on the floor and drop them outside the Shop, and then constantly leave and re-enter the Shop. When Modeling Clay mimics 15►Little Baggy Little Baggy and 15►Starter Deck Starter Deck, it will transform the cards/pills into new ones. This can be done indefinitely until they become cards you want, at which point you’ll drop them in a Secret Room.

Once you have all the cards you want in the Secret Room, leave and re-enter it until Modeling Clay mimics Added in Repentance15►Echo Chamber Echo Chamber. Once it does, use all the cards you left in the room, starting with ones that spawn stage elements that can spawn items (such as machines, beggars, and chests), then moving to ones that spawn resources, and ending with ones that have neutral effects.

Finally, once you’ve used all the cards and all the item-spawning stage elements have been made, leave and re-enter the Secret Room until Modeling Clay mimics Added in Repentance15►Glitched Crown Glitched Crown. Once it does, you can open all the chests and play the machines/beggars, and any items they spawn will also cycle between 4 extra Secret Room items to choose from.

If you’re not able to get enough cards to start a breaking run on the current floor, don’t worry; Echo Chamber will remember the cards you used on earlier floors, allowing you to resume where you left off on later floors.

Cards you’re looking for include ones that:

Unique Advantages[]

Breaking runs are able to reroll through entire item pools, allowing them to get combinations of any items they want. Aside from making runs easy, this carries with it some unique advantages.

  • Added in Afterbirth †15►Mama Mega! Mama Mega! lets Isaac open the doors to Boss Rush or ??? without having to meet their time limits. It can be obtained from Shops or Bomb Bums (which can be spawned by using XX - Judgement continuously), meaning breaking runs can complete Boss Rush, Hush, and/or Delirium with a run that’s as powerful as they want it to be.
  • Picking up multiple copies of Added in Afterbirth15►Eden's Blessing Eden's Blessing makes it so Isaac starts with that many random items at the start of the next run, up to a maximum of ten; if ten or more Eden’s Blessings were picked up, all leftover items to be given will instead go to the next run, and so on and so forth until there are no more random items to be given. With the use of Added in Afterbirth15►Glowing Hour Glass Glowing Hour Glass, Added in Afterbirth †15►Crooked Penny Crooked Penny, Added in Afterbirth †15►Schoolbag Schoolbag, and an endless supply of Little Batteries, an indefinite amount of Eden’s Blessings can be picked up, and Isaac can start every run thereon with ten more items.
  • Added in Repentance15►R Key R Key lets Isaac go back to the start of a new run while retaining all his items and unlocks. Breaking runs create R Keys in a Secret Room, hold them in a Added in Afterbirth †15►Moving Box Moving Box, and use them at the end of a path to go after achievements on multiple paths with the same build.
  • Added in Afterbirth †15►Clicker Clicker transforms Isaac into another unlocked character, and completion marks earned will be for the character transformed into. This means once a breaking run has Clicker, it can earn completion marks for any character. Added in Repentance Note that normal characters cannot transform into tainted characters, or vice versa.
    • Added in RepentanceThe prevention from transforming between tainted and normal characters can be circumvented if you are playing as a tainted character. If you are doing, for example, the Tainted Cain method, if you craft 15►Ankh Ankh, 15►Lazarus' Rags Lazarus' Rags, or 15►Judas' Shadow Judas' Shadow, if you die and revive, you will be resurrected as a non tainted character, and using the clicker will swap between non tainted characters. Note that there is no item to turn you into a tainted character as a non tainted one.


  • All breaking runs will eventually lead into the Treasure Room item pool when their original item pools are emptied, then eventually create only 15►Breakfast Breakfast once the Treasure Room is emptied of items. Breakfast is a sign that a breaking run has become as powerful as it can be (unless Chaos is involved).
  • Removed in Repentance 15►9 Volt 9 Volt should be avoided if 15►Sharp Plug Sharp Plug is being used to endlessly recharge an active item; 9 Volt prevents an active item from reaching 0 charges, which is required for Sharp Plug to be used.

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