Box of Spiders is an activated item.



  • Dlc nr indicator.png Blue Spiders deal 2.5x Isaac's damage.
    • Dlc r indicator.png Blue Spiders deal 2x Isaac's damage.


  • Dlc r indicator.png Collectible Book of Virtues icon.png Book of Virtues: Spawns wisps instead of spiders, in the outer ring. Wisps summon Blue Spiders when destroyed. One wisp contains one Blue Spider.

In-game Footage


A box full of spiders is an old way of getting your kids to stop misbehaving. The child is handed a box with a supposed gift inside, only to be scared by spiders as punishment.


PC GLVQ 0PMC (Treasure Room adjacent to spawn)

PC Dlc a indicator.png BothIndicator.png PHYR RA8L (Treasure Room adjacent to spawn)

Switch Greedier Mode Indicator.png 30WN JFEA (First Golden Treasure Room)

Community content is available under CC BY-NC-SA 3.0 unless otherwise noted.