Binding of Isaac: Rebirth Wiki

Box of Spiders is an activated item.

Effects[ | ]

Notes[ | ]

  • (except in Repentance) Blue Spiders deal 2.5x Isaac's damage.
  • (in Repentance) Blue Spiders deal 2x Isaac's damage.

Synergies[ | ]

Interactions[ | ]

  • (in Repentance)Collectible Book of Virtues iconBook of Virtues: Spawns wisps instead of spiders, in the outer ring. Wisps summon Blue Spiders when destroyed. One wisp contains one Blue Spider.

In-game Footage[ | ]

Gallery[ | ]

Trivia[ | ]

  • A box full of spiders is an old way of getting your kids to stop misbehaving. The child is handed a box with a supposed gift inside, only to be scared by spiders as punishment.