Box of Spiders is an activated item.
Contents
Effects[]
Spawns 1-4 Blue Spiders.- Spawns 4-8 Blue Spiders.
- This item belongs to the Spider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.
Spawns 1-4 
Spawns 4-8 
This item belongs to the Notes[]
- Blue Spiders deal 2.5x Isaac's damage.
- Blue Spiders deal 2x Isaac's damage.
In-game Footage[]
Gallery[]
3DS The icon of Box of Spiders as seen on the lower 3DS screen.
Seeds[]
PC GLVQ 0PMC (Treasure Room adjacent to spawn)
PC 
PHYR RA8L (Treasure Room adjacent to spawn)
Switch 
30WN JFEA (First Golden Treasure Room)
 The Binding of Isaac: Rebirth
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