Binding of Isaac: Rebirth Wiki

(except in Rebirth)

Box of Friends is an unlockable activated item added in The Binding of Isaac: Afterbirth.

Effect[ | ]

  • Upon use, it adds one copy of each of Isaac's familiars for the duration of the current room.
  • If Isaac has no familiars, a Collectible Demon Baby iconDemon Baby will spawn for the duration of the current room.

Notes[ | ]

  • Character Lilith iconLilith starts with this item by default, even if it hasn't been unlocked yet.
  • If Isaac has more than one copy of the same familiar, it will still only add one copy.
  • Blue Flies, Blue Spiders, and orbitals (Collectible Halo of Flies iconHalo of Flies, (in Afterbirth † and Repentance)Collectible Leprosy iconLeprosy, etc) are not copied.
    • (in Repentance) It now copies some orbitals.
  • Many familiars can be spawned in Greed mode and Boss RushBoss Rush, as completing waves charges the item.
  • (in Repentance) Familiars with the uniquefamiliar item tag are ignored by Box of Friends. If Isaac has only unique familiars, a Demon Baby is spawned.
  • (in Repentance) The item will cost 10 cents if found in a ShopShop

Synergies[ | ]

  • Collectible Ball of Bandages iconBall of Bandages / Collectible Cube of Meat iconCube of Meat / (in Afterbirth †)Collectible Potato Peeler iconPotato Peeler: Upgrades the cube/ball for the current room. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements.
    • (in Repentance) Cubes of Meat from Collectible Potato Peeler iconPotato Peeler cannot be duplicated or upgraded.
  • (in Repentance)Collectible Blood Puppy iconBlood Puppy: Tames an angry Blood Puppy and spawns another temporary one.
  • Collectible Bob's Brain iconBob's Brain: When used upon entering a room, Box of Friends eliminates the item delay, which allows Isaac to launch Bob's Brain immediately.
  • (in Repentance)Collectible Book of Virtues iconBook of Virtues: Spawns black wisps on the middle ring. After creating a wisp, Box of Friends also gives temporary copies of all of Isaac's wisps, including any extra copies Box of Friends made.
  • Collectible Car Battery iconCar Battery: Adds two copies of each familiar.
  • Collectible Charged Baby iconCharged Baby: All around useful, can charge box of friends mid room to spawn more of itself creating a charging loop.
  • Collectible Daddy Longlegs iconDaddy Longlegs: Familiar will be copied.
  • Collectible Incubus iconIncubus: Creates additional Incubus familiars, which share the same tear modifiers as the player.
  • (in Repentance)Collectible Lil Dumpy iconLil Dumpy: Will copy Lil Dumpy, adding an extra charge to Lil Dumpy's Collectible Holy Mantle iconHoly Mantle-like protection.
    • This process can be repeated to make Isaac near-invincible.
  • Collectible Smart Fly iconSmart Fly: Very useful on Greed mode, as using it will add an attacking fly, killing enemies and bosses very quickly.
  • (in Repentance)Collectible Twisted Pair iconTwisted Pair: Creates additional Twisted Pairs with the same tear modifiers as the player. Multiple twisted pairs will line up horizontally, covering a broader area.

Interactions[ | ]

  • ???'s Soul???'s Soul / Collectible Dead Bird iconDead Bird / Eve's Bird FootEve's Bird Foot / Isaac's HeadIsaac's Head / Collectible Scissors iconScissors: These familiars are not copied.
  • Collectible 1up! icon1up! / (except in Repentance)Collectible Dead Cat iconDead Cat: Familiars are multiplied but do not give Isaac additional lives.
    • (in Repentance)Collectible Dead Cat iconDead Cat: No longer copies the familiar either.
  • (in Repentance)Collectible Abyss iconAbyss: Flies gained from Abyss do not count as familiars for Box of Friends, and are not copied.
  • Collectible Best Bud iconBest Bud: If used before taking damage, the white fly will circle Isaac. However, multiple white flies cannot be spawned, so using Box of Friends after taking damage or using it multiple times in a room creates no effect.
  • (in Afterbirth † and Repentance)Collectible Buddy in a Box iconBuddy in a Box: Creates another randomly generated familiar, rather than copying the same one.
  • Collectible Bumbo iconBumbo: Will spawn a level 1 Bumbo regardless of the original Bumbo's current level.
  • (in Repentance)Collectible Tinytoma iconTinytoma: Сreates an orbital even if it is destroyed. If the copy splits into smaller versions, they will remain when moving between rooms.
  • Collectible Guillotine iconGuillotine: Duplicates the Head circling Isaac's body. Only one head will shoot tears.
    • Considers the second head as an extra copy, granting Isaac a temporary stat boost for the room
  • (in Repentance)Collectible Hallowed Ground iconHallowed Ground: All poop familiars turn into white poop at the same time, and their effects are accumulative. A new poop familiar appears even if the previous poops have been used up.
  • Collectible Isaac's Heart iconIsaac's Heart / Super BumSuper Bum: Not copied. They will not spawn a Collectible Demon Baby iconDemon Baby if no other valid familiars are found, unlike other familiars that aren't copied.
  • Collectible Key Piece 1 iconKey Piece 1 / Collectible Key Piece 2 iconKey Piece 2: Key pieces are multiplied, but do not complete the other half.
    • (in Repentance) Key pieces are not copied.
  • (in Repentance)Collectible Knife Piece 1 iconKnife Piece 1 / Collectible Knife Piece 2 iconKnife Piece 2: Knife pieces and the knife are not copied.
  • (in Afterbirth † and Repentance)Collectible Lil Spewer iconLil Spewer: Creates a random spewer rather than copying the current one.
  • (in Repentance)Collectible Lost Soul iconLost Soul: Cannot be duplicated.
  • (in Rebirth and Afterbirth) Collectible Milk! iconMilk!: The familiar itself doesn't appear, but instead, it decreases tear delay by 2 (effective tears up) when used, without needing to take damage.
    • (in Repentance)No extra tear delay is granted, neither before or after breaking.
  • Collectible Monster Manual iconMonster Manual: Familiars spawned by Monster Manual are not copied. It will still spawn a Collectible Demon Baby iconDemon Baby if a familiar from Monster Manual is generated and there are no other valid familiars that can be duplicated.
  • Collectible Multidimensional Baby iconMultidimensional Baby: Each copy of Multidimensional Baby follows the previous copy with a 2-second ((in Repentance) 0.66-second) delay. Tears shot through multiple babies will only be duplicated once.
  • Pickup generation familiars: The copied familiars will drop pickups independently.
  • (in Repentance)Collectible Quints iconQuints: Existing Quints familiars will not be duplicated, nor more will be created. If Isaac has no other familiars, the generated Demon Baby will hover with the Quints instead of following Isaac.
  • (in Afterbirth † and Repentance)Collectible Shade iconShade: A new follower Shade spawns even if Isaac has already absorbed the original.
  • (in Repentance)XV - The Devil?XV - The Devil?: The Seraphim familiar is not copied.

In-game Footage[ | ]

Trivia[ | ]

  • The Box of Friends seems to resemble the Lament Configuration of the Lemarchand's box from Clive Barker's Hellraiser.
  • This item used to have a recharge time of 2, until an update on November 4, 2015.
    • (in Rebirth and Afterbirth) When playing in Korean, this item still has a recharge time of 2.
  • In the game files this item's sprite is called "Pandora's Box" by mistake.