Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Box of Friends is an unlockable activated item added in The Binding of Isaac: Afterbirth.


  • Upon use, it adds one copy of each of Isaac's familiars for the duration of the current room.
  • If Isaac has no familiars, a Demon Baby Demon Baby will spawn for the duration of the current room.


  • Lilith Lilith starts with this item by default, even if it hasn't been unlocked yet.
  • If Isaac has more than one copy of the same familiar, it will still only add one copy.
  • Blue Flies, Blue Spiders, and orbitals (Halo of Flies Halo of Flies, Added in Afterbirth †Leprosy Leprosy, etc) are not copied.
    • Added in Repentance It now copies some orbitals.
  • Many familiars can be spawned in Greed mode and Boss Rush Boss Rush, as completing waves charges the item.
  • Added in Repentance Familiars with the uniquefamiliar item tag are ignored by Box of Friends. If Isaac has only unique familiars, a Demon Baby is spawned.


  • Ball of Bandages Ball of Bandages / Cube of Meat Cube of Meat / Added in Afterbirth †Potato Peeler Potato Peeler: Upgrades the cube/ball for the current room. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements.
    • Added in Repentance Cubes of Meat from Potato Peeler Potato Peeler cannot be duplicated or upgraded.
  • Bob's Brain Bob's Brain: When used upon entering a room, Box of Friends eliminates the item delay, which allows Isaac to launch Bob's Brain immediately.
  • Added in RepentanceBook of Virtues Book of Virtues: Spawns black wisps on the middle ring. After creating a wisp, Box of Friends also gives temporary copies of all of Isaac's wisps, including any extra copies Box of Friends made.
  • Car Battery Car Battery: Adds two copies of each familiar.
  • Charged Baby Charged Baby: All around useful, can charge box of friends mid room to spawn more of itself creating a charging loop.
  • Daddy Longlegs Daddy Longlegs: Familiar will be copied.
  • Incubus Incubus: Creates additional Incubus familiars, which share the same tear modifiers as the player.
  • Multidimensional Baby Multidimensional Baby: Each copy of Multidimensional Baby follows the previous copy with a 2.5-second delay.
  • Smart Fly Smart Fly: Very useful on Greed mode, as using it will add an attacking fly, killing enemies and bosses very quickly.
  • Added in RepentanceTwisted Pair Twisted Pair: Creates additional Twisted Pairs with the same tear modifiers as the player. Multiple twisted pairs will line up horizontally, covering a broader area.


  • 1up! 1up! / Dead Cat Dead Cat: Familiars are multiplied but do not give Isaac additional lives.
  • Added in RepentanceAbyss Abyss: Flies gained from Abyss do not count as familiars for Box of Friends, and are not copied.
  • Best Bud Best Bud: If used before taking damage, the white fly will circle Isaac. However, multiple white flies cannot be spawned, so using Box of Friends after taking damage or using it multiple times in a room creates no effect.
  • Added in Afterbirth †Buddy in a Box Buddy in a Box: Creates another randomly generated familiar, rather than copying the same one.
  • Bumbo Bumbo: Will spawn a level 1 Bumbo regardless of the original Bumbo's current level.
  • Dead Bird Dead Bird / Eve's Bird Foot Eve's Bird Foot / Isaac's Head Isaac's Head / ???'s Soul ???'s Soul: These familiars are not copied.
  • Guillotine Guillotine: Duplicates the Head circling Isaac's body. Only one head will shoot tears.
  • Removed in Afterbirth † Added in Afterbirth †Hallowed Ground Hallowed Ground: All poop familiars turn into white poop at the same time, and their effects are accumulative. A new poop familiar appears even if the previous poops have been used up.
  • Isaac's Head Isaac's Head: Not copied.
  • Isaac's Heart Isaac's Heart / Super Bum: Not copied. They will not spawn a Demon Baby Demon Baby if no other valid familiars are found, unlike other familiars that aren't copied.
  • Key Piece 1 Key Piece 1 / Key Piece 2 Key Piece 2: Key pieces are multiplied, but do not complete the other half.
    • Added in Repentance Key pieces are not copied.
  • Added in RepentanceKnife Piece 1 Knife Piece 1 / Knife Piece 2 Knife Piece 2: Knife pieces and the knife are not copied.
  • Added in Afterbirth †Lil Spewer Lil Spewer: Creates a random spewer rather than copying the current one.
  • Removed in Afterbirth † Milk! Milk!: The familiar itself doesn't appear, but instead, it decreases tear delay by 2 (effective tears up) when used, without needing to take damage.
    • Added in RepentanceNo extra tear delay is granted, neither before or after breaking.
  • Monster Manual Monster Manual: Familiars spawned by Monster Manual are not copied. It will still spawn a Demon Baby Demon Baby if a familiar from Monster Manual is generated and there are no other valid familiars that can be duplicated.
  • Pickup generation familiars: The copied familiars will drop pickups independently.
  • Added in RepentanceQuints Quints: Existing Quints familiars will not be duplicated, nor more will be created. If Isaac has no other familiars, the generated Demon Baby will hover with the Quints instead of following Isaac.
  • Added in Afterbirth †Shade Shade: A new follower Shade spawns even if Isaac has already absorbed the original.
  • Scissors Scissors: Not copied.
  • Added in RepentanceXV - The Devil? XV - The Devil?: The Seraphim familiar is not copied.

In-game Footage[]


  • The Box of Friends seems to resemble the Lament Configuration of the Lemarchand's box from Clive Barker's Hellraiser.
  • This item used to have a recharge time of 2, until an update on November 4, 2015.
    • Removed in Afterbirth † When playing in Korean, this item still has a recharge time of 2.
  • In the game files this item's sprite is called "Pandora's Box" by a mistake.


Switch Greedier mode only WL8W DS4S (First Golden Treasure Room)