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Isaac turns into Bob after picking up three distinct items in the following list. In this form, Isaac gains a green trail of poisonous creep that deals 2 damage per tick or 6 damage per second, and Dlc r indicator.png becomes immune to Poison.

Activated Collectibles

Name ID Icon Quote Description Dlc r indicator.png Quality
Bob's Rotten Head 5.100.42 Reusable ranged bomb Upon use, Isaac holds a poison bomb which can be thrown in the cardinal directions and explodes on impact. 1

Passive Collectibles

Name ID Icon Quote Description Dlc r indicator.png Quality
Bob's Brain 5.100.273 Collectible Bob's Brain icon.png Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Bob's Curse 5.100.140 Collectible Bob's Curse icon.png +5 poison bombs Gives 5 bombs and grants Isaac's bombs a poison effect. Dlc r indicator.png Gives Isaac immunity to poison. 1
Ipecac 5.100.149 Collectible Ipecac icon.png Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. 4

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