Blood Puppy

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Blood   Puppy
Item icon
Item altar
"What a cute little thing!"
Table dividing line 1.png
Item ID
5.100.565
Table dividing line 2.png
Table dividing line 3.png
Collection Grid
(page 5, column 1, row 5)
Unlock Method
Blood Puppy Defeat Mother as Lilith
Added in Repentance

Blood Puppy is a passive item added in The Binding of Isaac: Repentance.

Effects[edit | edit source]

  • Spawns a chasing familiar that deals contact damage to enemies.
  • After killing enough enemies, it transforms into an angry version that spawns in the middle of the room and gains a dash attack but will also attempt to hurt Isaac.
    • After killing even more enemies, the angry version evolves again, the dash attack dealing more damage and being capable of destroying rocks.
    • Dealing 150 damage to the first angry puppy will return it to normal. (Only player-inflicted damage counts)
    • Dealing 450 damage to the evolved angry puppy will return it to normal. (Only player-inflicted damage counts)
  • It will also occasionally drop Red Hearts.


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