Binding of Isaac: Rebirth Wiki

Added in Repentance

Blood Bombs is a passive item added in The Binding of Isaac: Repentance.


  • Gives Isaac a heart container and heals him for five hearts.
  • Causes Isaac's Bomb Bombs to leave a pool of red creep on the ground when they explode.
    • The creep deals 2 damage per tick (20 per second) and lasts 15 seconds.
    • Leaves one large creep in the middle, and four small creeps on random direction and distance.
      • Multiple creeps do not inflict damage on an enemy simultaneously.
  • If Isaac has no bombs, allows him to place a bomb at the cost of taking half a heart of damage. This prioritizes Red Heart Red Hearts over Soul Heart Soul Hearts.


  • Placing a bomb using health counts as self-damage, and as such, does not affect the chances for a Devil deal, does not trigger Damocles Damocles, nor does it reroll Tainted Eden Tainted Eden.
    • The Lost The Lost / Tainted Lost Tainted Lost will die if a bomb is placed this way.
      • This includes the version of The Lost The Lost you turn into after touching the white fireplace in II.
  • Keeper Keeper / Tainted Keeper Tainted Keeper will take 1 Coin Heart of damage in exchange for 1 bomb.
  • You can remain at zero bombs and leave excess drops of bombs and hearts to maximize resource use for the floor.
  • Placing a bomb using health can let Isaac enter/exit a Curse Room Curse Room without taking soul/black heart damage.
    • But be careful and remember to move quickly upon exiting the Curse room, otherwise you'll take damage from the previous bomb.



  • This is the only bomb-augmenting item that does not give any Bomb Bombs on pickup.
    • The fact that the item gives a heart container and healing instead of bombs may be a hint for the mechanic of using health for bombs, as well as a substitute for actual bombs.
    • The fact that the item heals 5 hearts may be a reference to many bomb effect items (such as Butt Bombs Butt Bombs) that gives Isaac 5 bombs.
  • The fact that the item gives a heart container and heals up to exactly 5 containers, along with the appearance, makes it very similar to Blood Bag Blood Bag.
  • A Blood Donation Machine.png Blood Donation Machine will be shown as a cause of death on Isaac's last will if he dies as a result of placing a bomb and losing all health.