Binding of Isaac: Rebirth Wiki
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Blood may refer to:

Mechanics[ | ]

Some things that aren't items that reference Blood

Challenges[ | ]

Bloody Mary: A Bethany challenge that starts with some blood related items

Environment[ | ]

Blood in title[ | ]

The word "blood" appears in the title of the item.

Collectibles[ | ]

Activated[ | ]

Passive[ | ]

  • Collectible Blood Bag iconBlood Bag, grants increased health.
  • Collectible Blood Clot iconBlood Clot, grants increased damage and range.
  • Collectible Blood of the Martyr iconBlood of the Martyr, grants increased damage and turns Isaac's tears into blood tears.
  • Collectible Bloody Lust iconBloody Lust, after taking damage, grants increased damage for the floor.
  • (except in Rebirth)Collectible Lusty Blood iconLusty Blood, increases damage by 0.5 up to 10 times in the current room each time a monster is defeated.
  • (in Afterbirth † and Repentance)Collectible Bloodshot Eye iconBloodshot Eye, Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
    • Pickup quote states, "Bloody friend"
  • (in Repentance)Collectible Blood Bombs iconBlood Bombs, Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any. Pickup quote states,
    • "Bloody blast + HP up"
  • (in Repentance)Collectible Blood Oath iconBlood Oath, Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.
  • (in Repentance)Collectible Blood Puppy iconBlood Puppy, Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal.
  • (in Repentance)Collectible Bloody Gust iconBloody Gust, When Isaac takes damage, he gains speed and tears for the rest of the floor.
    • ===Trinkets ===

Blood in item pickup quote[ | ]

The word blood appears in the pickup quote of the item.

Activated[ | ]

  • Collectible IV Bag iconIV Bag, drops Pennies at the cost of depleting half of a Red Heart container.
    • Pickup quote states, "Portable blood bank."
  • (in Afterbirth † and Repentance)Collectible Sharp Straw iconSharp Straw, Damages all enemies in the room, has a chance to drop a half soul heart if an enemy is hit.
    • Pickup quote states, "More blood!"

Passive[ | ]

  • Collectible Anemic iconAnemic, after taking damage, grants a trail of red creep for the room.
    • Pickup quote states, "Toxic blood."
    • Anemia is a decrease in the blood's ability to carry oxygen.
  • Collectible Brimstone iconBrimstone, Replaces Isaac's tears with a charged laser.
    • Pickup quote states, "Blood laser barrage"
  • Collectible Leech iconLeech , Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy.
    • Pickup quote states, "Blood sucker."
  • Collectible Headless Baby iconHeadless Baby, Spawns a familiar that follows Isaac, leaving blood creep on the ground.
    • Pickup quote states, "Bloody friend."
  • (in Afterbirth † and Repentance)Collectible Bloodshot Eye iconBloodshot Eye, Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
    • Pickup quote states, "Bloody friend."
  • (in Afterbirth † and Repentance)Collectible Jumper Cables iconJumper Cables, Grants an active item charge every 15 enemies killed.
    • Pickup quote states, "Bloody recharge"
  • (in Afterbirth † and Repentance)Collectible Shard of Glass iconShard of Glass Upon taking damage, Isaac has a chance to drop a full red heart,(except in Repentance) gain 5 range, and leave a trail of damaging red creep for the current room.
    • Pickup quote states, "Blood and guts"
    • (in Repentance)Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. The Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
  • (in Repentance)Collectible A Pound of Flesh iconA Pound of Flesh, Devil deals now cost coins, shop items now cost health, and consumables in shops are surrounded by spikes.
    • Pickup quote states, "Blood money"
  • (in Repentance)Collectible Hungry Soul iconHungry Soul, Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time.
    • Pickup quote states, "Out for Blood "
  • (in Repentance)Collectible Hypercoagulation iconHypercoagulation, After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds.
    • Pickup quote states, "Thick Blooded"
    • Hypercoagulation is a medical condition that causes blood clots to spontaneously form in a person’s blood vessels and prevents them from dissolving properly.
  • (in Repentance)Collectible Vengeful Spirit iconVengeful Spirit After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
    • Pickup quote states, "Hot blooded"

Trinkets[ | ]

Employs blood creep/tears[ | ]

When the item is used, it spawns red tears and/or red creep, to show blood.

Activated[ | ]

  • Collectible The Book of Belial iconThe Book of Belial, grants a damage up for the current room and turns Isaac's tears blood Red.
  • Collectible Scissors iconScissors, Turns Isaac's head into a stationary familiar for the current room which fires tears automatically.
    • (in Repentance)causes Isaac's body to shoot a controllable fountain of blood shots.
  • (except in Rebirth)Collectible Glass Cannon iconGlass Cannon, (except in Repentance)Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
    • (in Repentance)Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage, leaves behind blood red creep behind him, and it becomes the Broken Glass Cannon.

Passive[ | ]

  • Collectible Headless Baby iconHeadless Baby, Spawns a familiar that follows Isaac, leaving blood creep on the ground.
    • Pickup quote states, "Bloody friend."
  • (except in Rebirth)Collectible Kidney Stone iconKidney Stone, Isaac's tears turn blood red, and Randomly while firing tears, Isaac will stop firing and turn red himself, where he will charge and release a lot of 'tears' in one go.
  • (in Afterbirth † and Repentance)Collectible Lead Pencil iconLead Pencil, After every 15 tears fired, Isaac will fire a high-damage cluster of blood red tears.
    • Pickup quote states, " He's a bleeder!"
  • (in Afterbirth † and Repentance)Collectible Haemolacria iconHaemolacria,Tears are now Red and fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
    • Haemolacria is a real condition that causes people to cry blood.
  • (in Repentance)Collectible Hemoptysis iconHemoptysis, Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him.
    • Hemoptysis is the medical term for coughing up blood.
  • (in Repentance)Collectible Akeldama iconAkeldama, While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.
    • Akeldama means 'field of blood' in Aramaic, and the item references the field that Judas spilled his guts out on
  • Collectible Isaac's Heart iconIsaac's Heart Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt.
    • (in Repentance)The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of Blood creep when released.

Bleeding[ | ]

When losing blood, you bleed. here are the few items that reference bleeding.

  • (in Afterbirth † and Repentance)Collectible Backstabber iconBackstabber,Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
  • (in Afterbirth † and Repentance)Collectible Mom's Razor iconMom's Razor, Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
  • (in Afterbirth † and Repentance)Collectible Lead Pencil iconLead Pencil, After every 15 tears fired, Isaac will fire a high-damage cluster of blood red tears.
    • Pickup quote states, " He's a bleeder!"
  • (in Afterbirth † and Repentance)Collectible Shard of Glass iconShard of Glass Upon taking damage, Isaac has a chance to drop a full red heart,(except in Repentance)gain 5 range, and leave a trail of damaging red creep for the current room.
    • Pickup quote states, "Blood and guts"
    • (in Repentance)Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
  • (in Repentance)Collectible Blood Oath iconBlood Oath, Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.
    • Pickup quote states, " Bleed me dry"

Disambig This disambiguation page lists articles associated with the same title. If an internal link referred you here, you may wish to change the link to point directly to the intended article.


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