| Obstacles |
| Rocks | Poops | Fire Places | Cobwebs | TNT | Spikes | Blocks |  Buttons
|
 Dirt Patches
|
 Teleporters
|
Metal Blocks[]
- Blocks movement and projectiles.
- An explosion's blast radius will not extend past it.
Cannot be destroyed or removed.- Can only be destroyed by walking over while Mega Mush is active.
- Can be re-rolled by the D12 into a destructible obstacle.
- Can only be moved over via flying or jumping.
Cannot be destroyed or removed.
Key Blocks[]
- Acts like Metal Blocks.
- Requires a key to unlock.
- Cannot be flown over.
- Small chance to drop a random pickup when unlocked.
- Can be destroyed with a bomb explosion if Broken Padlock is held.
- Can be destroyed without consuming a key by walking over while Mega Mush is active.
Pillars []
- Blocks movement and projectiles like a regular block.
- Cannot be flown over, nor can flying enemies or familiars fly over it.
- Can hide pickups, buttons with beneficial effects (such as opening paths), or enemies behind them.
 The Binding of Isaac: Rebirth
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