Binding of Isaac: Rebirth Wiki

BFFS! is a passive item.

Effects[ | ]

  • Visually increases the size of all familiars by 25%, and improves the effectiveness of most of them.
    • Doubles the damage of Familiars that deal damage through tears and contact damage.
      • Has no effect on Creep generated by familiars.
    • For pickup-generating familiars, increases the frequency that they drop pickups.
      • Familiars that require clearing a certain number of rooms will require one less room.
      • Familiars that have a random chance to drop items have a higher chance.
      • Familiars that pick up consumables require less, except Collectible Dark Bum iconDark Bum which is unaffected.
    • Some familiars have unique synergies.

Notes[ | ]

  • The size change is only cosmetic: familiars' hitbox for blocking damage or attacking is not affected.
  • Familiars summoned by a trinket or by Collectible Monster Manual iconMonster Manual are also affected by BFFS!.
    • (in Repentance)Wisps are also affected by BFFS!.
  • Blue Flies and Blue Spiders are not affected, they instead benefit from Collectible Hive Mind iconHive Mind.
  • Does not increase the frequency or effectiveness of Status Effects applied by familiars.

Synergies[ | ]

  • Collectible BBF iconBBF/Collectible Bob's Brain iconBob's Brain: Doubles impact damage and increases explosive damage by 25.
  • (in Repentance)Collectible Bird Cage iconBird Cage: Spawns 4 rock waves in an x pattern. Doubles the damage when the bird lands and doubles contact damage. Damage of waves unaffected.
  • (in Repentance)Collectible Blood Oath iconBlood Oath: Adds 2 extra full hearts worth of bonuses if any health is drained.
  • (in Repentance)Collectible Holy Water iconHoly Water: Double water damage and spawns a blue flame at point of impact.
  • (except in Rebirth)Collectible Incubus iconIncubus: Shoots tears that do (except in Repentance) 2x Isaac's damage (in Repentance) 1.5x Isaac's damage. Still deals 2x as Character Lilith iconLilith.
  • (in Repentance)Collectible Isaac's Heart iconIsaac's Heart: Fires additional shots in random directions and leaves a larger puddle of creep. Does not change the heart's size.
  • Collectible Juicy Sack iconJuicy Sack: Spawns an extra Blue Spider.
  • (in Afterbirth † and Repentance)Collectible Lil Spewer iconLil Spewer: Increases the creep pool's size, but not its damage.
  • (in Repentance)Collectible Lost Soul iconLost Soul: Gives the Lost Soul a Collectible Holy Mantle iconHoly Mantle effect.
  • (in Afterbirth † and Repentance)Collectible Mystery Egg iconMystery Egg: Spawns a champion variant of an enemy, even if the enemy normally can't be a champion.
  • (in Repentance)Collectible Stitches iconStitches: On use, fires eight tears from Isaac's original location. The tears synergize with Isaac's tear effects.
  • (except in Rebirth)Collectible Succubus iconSuccubus: The aura's radius increases, but the damage multiplier and damage to enemies remain the same.

Interactions[ | ]

  • (in Repentance)Collectible Blood Puppy iconBlood Puppy: Only increases the damage and size while it isn't hostile.
  • (except in Rebirth)Collectible Evil Eye iconEvil Eye: The eyes are not treated as familiars and therefore will not synergize with BFFS!
  • Collectible Guillotine iconGuillotine/Collectible Scissors iconScissors: Doesn't change the head's size, but still improves its damage.
  • (in Repentance)Collectible Hive Mind iconHive Mind: Does not stack.
  • (in Afterbirth † and Repentance)Collectible Shade iconShade: Retains the increased damage even after being absorbed.

No Effect[ | ]

The following familiars will appear larger, but gain no actual benefits.

In-game Footage[ | ]

Trivia[ | ]

  • BFF stands for Best Friends Forever.
  • This item is used in The Family Man (challenge #19) and (in Repentance) Scat Man (challenge #36).