Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

Azazel's Rage is a passive item added in The Binding of Isaac: Repentance.


  • Isaac builds up rage every time he clears a room, which is indicated by the patch of skin that spreads around his face.
  • After four rooms, Isaac's head will start to flash red; upon entering a room with enemies, he will fire a large Brimstone Brimstone laser for ~3.33 seconds.
    • The laser deals Isaac's damage per tick (15x Isaac's damage per second).


  • The counter for activation will go up during Greed Mode, Challenge Room and Boss Rush waves, but activating the effect still requires leaving the room.
    • As the Greed Mode arena has no enemies in it without pressing the button and spawned enemies do not count for triggering the effect, the item is not very useful.

In-game Footage[]



  • This item is, most likely, Azazel Azazel's severed right horn.
  • This item resembles one of the horns of The Beast.