Azazel's Rage is an unlockable passive item added in The Binding of Isaac: Repentance.
- Isaac builds up rage every time he clears a room, which is indicated by the patch of skin that spreads around his face.
- After four rooms, Isaac's head will start to flash red; upon entering a room with enemies, he will fire a large Brimstone laser for ~3.33 seconds.
- The laser deals Isaac's damage per tick (15x Isaac's damage per second).
The five stages of Azazel's Rage as it slowly overtakes Isaac. The final stage slowly pulses red.
- This item is, most likely, Azazel's severed right horn.
- This item resembles one of the horns of The Beast.