Azazel's Rage is a passive item added in The Binding of Isaac: Repentance.
- Isaac builds up rage every time he clears a room, which is indicated by the patch of skin that spreads around his face.
- After four rooms, Isaac's head will start to flash red; upon entering a room with enemies, he will fire a large Brimstone laser for ~3.33 seconds.
- The laser deals Isaac's damage per tick (15x Isaac's damage per second).
- The counter for activation will go up during Greed Mode, Challenge Room and Boss Rush waves, but activating the effect still requires leaving the room.
- As the Greed Mode arena has no enemies in it without pressing the button and spawned enemies do not count for triggering the effect, the item is not very useful.
The five stages of Azazel's Rage as it slowly overtakes Isaac. The final stage slowly pulses red.
- This item is, most likely, Azazel's severed right horn.
- This item resembles one of the horns of The Beast.