Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Angry Fly is an unlockable passive item added in The Binding of Isaac: Afterbirth † (Booster Pack #1).


  • Spawns a fly familiar that orbits around a random enemy and deals 2 damage per tick/30 damage per second to enemies it comes in contact with.
    • It will occasionally make a lunge towards the enemy it is orbiting, allowing brief contact even with smaller enemies.
    • If the enemy it is orbiting dies, it starts orbiting a different enemy.
    • If there are no enemies, it orbits Isaac.
  • This item belongs to the Beelzebub set. Collecting three items from this set will transform Isaac into a giant humanoid fly.


  • Angry Fly will orbit around invincible enemies such as Stone Grimace Stone Grimaces without dealing damage.
  • Due to its movement pattern, its actual damage dealt per second is erratic against most enemies and groups of them.
  • Added in Repentance As Tainted Jacob Tainted Jacob, Angry Fly will orbit around Dark Esau Dark Esau.

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