Binding of Isaac: Rebirth Wiki

Anemic is a passive item.

Effects[ | ]

  • Upon taking damage, Isaac leaves a trail of red creep that damages enemies until he leaves the room.
    • The creep deals 2 damage per tick (6 damage per second) to enemies that walk over it.
  • (except in Repentance) +5 range.
  • (in Repentance) +1.5 range.

Notes[ | ]

  • The effects of this item do not stack if multiple copies of the item or its effects are acquired; Isaac only gets the range bonus once.
  • Character Lazarus iconLazarus, or anyone holding Collectible Lazarus' Rags iconLazarus' Rags, is resurrected with this item upon his first death.
    • (in Afterbirth † and Repentance) After Backasswards (challenge #31) is beaten, Lazarus will start with Anemic, and Lazarus Risen will have its increased range and creep trail effect permanently active, regardless of whether he possesses the item.

In-game Footage[ | ]

Trivia[ | ]

  • Anemia is a decrease in the blood's ability to carry oxygen. This can either be caused by a decrease in hemoglobin in blood cells, or red blood cells altogether.
  • This item is used in (in Repentance) Bloody Mary (challenge #37).
  • (in Repentance)Collectible Glass Cannon iconGlass Cannon invokes the effects of Anemic for the current room when Isaac takes damage.