View source for Achievements

''For tips and strategies on completing achievements, see [[achievement tip]]s.''

'''Achievements''' are unlocked after completing [[Challenge]]s, reaching certain [[completion mark|milestones]], achieving hidden goals, or unlocking certain [[item]]s. In the PC version, every Steam achievement exactly corresponds to one secret in-game, whereas only a handful of secrets are represented by PSN trophies in the Playstation version of the game.

If Isaac is unable to unlock achievements, a small icon of a crossed-out trophy {{no unlocks}} will be displayed below the [[Key]]s counter. Conditions which can disable the ability to unlock achievements include:
* Using a pre-determined [[seed]]. {{dlc|a}} Certain cosmetic and difficulty-increasing [[seed|special seeds]] will still allow unlocks.
* During a [[Challenge]], although the achievement for completing the challenge is unaffected.
* {{dlc|a+}} Playing with any enabled [[mod]] (unless [[Mom]] has been beaten).
* {{dlc|a+}} During [[Victory Lap]]s.
* {{dlc|r}} If the [[Debug Console]] is enabled (unless [[Mom]] has been beaten).

Rebirth has a total of 178 unlockable secrets. {{dlc|a}} [[Afterbirth]] added 98 new secrets, for a total of 276. {{dlc|a+}} [[Afterbirth †]] added 63 new secrets, for a total of 339. {{dlc|a+}} [[Booster Pack #5]] added 64 new secrets, for a total of 403. {{dlc|r}} [[Repentance]] added 234 new secrets, for a total of 637.

At the stats screen, pressing Alt + F2 will sync unlocks with Steam achievements. If Isaac has Steam achievements for secrets that haven't been unlocked in-game, they will be unlocked by doing this.

__FORCETOC__

== All Achievements ==

=== [[The Binding of Isaac: Rebirth|Rebirth]] ===
{{table | achievement |
{{infobox achievement
 | name        = Magdalene
 | link        = Magdalene
 | description = Unlocked a new character.
 | unlocked by = Have 7 or more [[Red Heart]] Containers at one time
 | id          = 1
}} {{infobox achievement
 | name        = Cain
 | link        = Cain
 | description = Unlocked a new character.
 | unlocked by = Hold 55 [[Coin]]s at one time
 | id          = 2
}} {{infobox achievement
 | name        = Judas
 | link        = Judas
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Satan]]
 | id          = 3
}} {{infobox achievement
 | name        = The Womb
 | link        = Womb
 | description = Chapter 4 - The Womb unlocked.
 | unlocked by = Defeat [[Mom]]
 | id          = 4
}} {{infobox achievement
 | name        = The Harbingers
 | link        = The Harbingers
 | description = The horsemen are loose.
 | unlocked by = Defeat [[Mom]]
 | id          = 5
}} {{infobox achievement
 | name        = A Cube of Meat
 | link        = Cube of Meat
 | description = Unlocked a new item. (Also unlocks the {{i|Ball of Bandages}})
 | unlocked by = Defeat [[Mom]]
 | id          = 6
}} {{infobox achievement
 | name        = The Book of Revelations
 | link        = Book of Revelations
 | description = Unlocked a new item.
 | unlocked by = Defeat a [[The Harbingers|Harbinger]]
 | id          = 7
}} {{infobox achievement
 | name        = A Noose
 | link        = Transcendence
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 3 times
 | id          = 8
}} {{infobox achievement
 | name        = The Nail
 | link        = The Nail
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Azazel}}
 | id          = 9
}} {{infobox achievement
 | name        = A Quarter
 | link        = A Quarter
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 8 times
 | id          = 10
}} {{infobox achievement
 | name        = A Fetus in a Jar
 | link        = Dr. Fetus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 9 times
 | id          = 11
}} {{infobox achievement
 | name        = A Small Rock
 | link        = The Small Rock
 | description = Unlocked a new item.
 | unlocked by = Destroy 100 [[Tinted Rock]]s
 | id          = 12
}} {{infobox achievement
 | name        = Monstro's Tooth
 | link        = Monstro's Tooth
 | description = Unlocked a new item.
 | unlocked by = Beat [[Chapter 1]]
 | id          = 13
}} {{infobox achievement
 | name        = Lil' Chubby
 | link        = Little Chubby
 | description = Unlocked a new item.
 | unlocked by = Beat [[Chapter 2]]
 | id          = 14
}} {{infobox achievement
 | name        = Loki's Horns
 | link        = Loki's Horns
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Lokii]]
 | id          = 15
}} {{infobox achievement
 | name        = Something From The Future
 | link        = Steven
 | description = New boss in the basement!
 | unlocked by = Beat {{s|Basement}} 40 times
 | id          = 16
}} {{infobox achievement
 | name        = Something Cute
 | link        = C.H.A.D.
 | description = New boss in the caves!
 | unlocked by = Beat [[Chapter 2]] 30 times
 | id          = 17
}} {{infobox achievement
 | name        = Something Sticky
 | link        = Gish
 | description = New boss in the depths!
 | unlocked by = Beat [[Chapter 3]] 20 times
 | id          = 18
}} {{infobox achievement
 | name        = A Bandage
 | link        = Super Bandage
 | description = Unlocked a new item.
 | unlocked by = Make a Super Bandage Girl by picking up 4 copies of {{i|Ball of Bandages}} in one run; see [[Unlocking Super Meat Boy & Super Bandage Girl]]
 | id          = 19
}} {{infobox achievement
 | name        = A Cross
 | link        = The Relic
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Magdalene}}
 | id          = 20
}} {{infobox achievement
 | name        = A Bag of Pennies
 | link        = Sack of Pennies
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Cain}}
 | id          = 21
}} {{infobox achievement
 | name        = The Book of Sin
 | link        = The Book of Sin
 | description = Unlocked a new item.
 | unlocked by = Defeat all [[7 Deadly Sins]]
 | id          = 22
}} {{infobox achievement
 | name        = Little Gish
 | link        = Little Gish
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Gish]]
 | id          = 23
}} {{infobox achievement
 | name        = Little Steven
 | link        = Little Steven
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Steven]]
 | id          = 24
}} {{infobox achievement
 | name        = Little C.H.A.D.
 | link        = Little C.H.A.D.
 | description = Unlocked a new item.
 | unlocked by = Defeat [[C.H.A.D.]]
 | id          = 25
}} {{infobox achievement
 | name        = A Gamekid
 | link        = The Gamekid
 | description = Unlocked a new item.
 | unlocked by = Visit 10 {{r|Arcade}}s
 | id          = 26
}} {{infobox achievement
 | name        = A Halo
 | link        = The Halo
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom]], [[Mom's Heart]], or [[It Lives!]] using {{i|The Bible}}
 | id          = 27
}} {{infobox achievement
 | name        = Mr. Mega
 | link        = Mr. Mega
 | description = Unlocked a new item.
 | unlocked by = Destroy 10 [[Tinted Rock]]s
 | id          = 28
}} {{infobox achievement
 | name        = The D6
 | link        = The D6
 | description = Isaac now holds the D6!
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|???}}
 | id          = 29
}} {{infobox achievement
 | name        = The Scissors
 | link        = Scissors
 | description = Unlocked a new item.
 | unlocked by = [[death|Die]] 100 times
 | id          = 30
}} {{infobox achievement
 | name        = The Parasite
 | link        = The Parasite
 | description = Unlocked a new item.
 | unlocked by = Pick up any 2 of the following items in a single run: {{i|Bob's Rotten Head}}, {{i|Dead Cat}}, {{i|Cricket's Head}}, and {{i|Tammy's Head}} ({{dlc|r}} Any 2 items that have the [[Item Tags dead|'dead' item tag]])
 | id          = 31
}} {{infobox achievement
 | name        = ???
 | link        = ??? (Character)
 | image       = achievement Blue Baby Character icon.png
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Mom's Heart]] 10 times
 | id          = 32
}} {{infobox achievement
 | name        = Everything Is Terrible!!!
 | description = The game just got harder!
 | unlocked by = Defeat [[Mom's Heart]] 5 times
 | id          = 33
}} {{infobox achievement
 | name        = It Lives!
 | link        = It Lives
 | description = Your future's past waits.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 34
}} {{infobox achievement
 | name        = Mom's Contact
 | link        = Mom's Contacts
 | description = Unlocked a new item.
 | unlocked by = Obtain three [[:category:Yes Mother? items|Yes Mother? items]] in one run
 | id          = 35
}} {{infobox achievement
 | name        = The Necronomicon
 | link        = The Necronomicon
 | description = Unlocked a new item.
 | unlocked by = Use [[XIII - Death]] 4 times
 | id          = 36
}} {{infobox achievement
 | name        = Basement Boy
 | description = Beat basement without taking damage.
 | unlocked by = Beat [[Chapter 1]] without taking damage
 | id          = 37
}} {{infobox achievement
 | name        = Spelunker Boy
 | description = Beat caves without taking damage.
 | unlocked by = Beat [[Chapter 2]] without taking damage
 | id          = 38
}} {{infobox achievement
 | name        = Dark Boy
 | description = Beat depths without taking damage.
 | unlocked by = Beat [[Chapter 3]] without taking damage
 | id          = 39
}} {{infobox achievement
 | name        = Mama's Boy
 | description = Beat womb without taking damage.
 | unlocked by = Beat [[Chapter 4]] without taking damage
 | id          = 40
}} {{infobox achievement
 | name        = Golden God!
 | description = You are the best!!
 | unlocked by = Defeat [[??? (Boss)|???]] and [[The Lamb]]
 | id          = 41
}} {{infobox achievement
 | name        = Eve
 | link        = Eve
 | description = Unlocked a new character.
 | unlocked by = Don't pick up any [[Hearts]] for 2 floors in a row
 | id          = 42
}} {{infobox achievement
 | name        = Mom's Knife
 | link        = Mom's Knife
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Isaac}}
 | id          = 43
}} {{infobox achievement
 | name        = The Razor
 | link        = Razor Blade
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Eve}}
 | id          = 44
}} {{infobox achievement
 | name        = Guardian Angel
 | link        = Guardian Angel
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Magdalene}}
 | id          = 45
}} {{infobox achievement
 | name        = A Bag of Bombs
 | link        = Bomb Bag
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Cain}}
 | id          = 46
}} {{infobox achievement
 | name        = Demon Baby
 | link        = Demon Baby
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Azazel}}
 | id          = 47
}} {{infobox achievement
 | name        = Forget Me Now
 | link        = Forget Me Now
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|???}}
 | id          = 48
}} {{infobox achievement
 | name        = The D20
 | link        = D20
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Isaac}}
 | id          = 49
}} {{infobox achievement
 | name        = Celtic Cross
 | link        = Celtic Cross
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Magdalene}}
 | id          = 50
}} {{infobox achievement
 | name        = Abel
 | link        = Abel
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Cain}}
 | id          = 51
}} {{infobox achievement
 | name        = Curved Horn
 | link        = Curved Horn
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Judas}}
 | id          = 52
}} {{infobox achievement
 | name        = Sacrificial Dagger
 | link        = Sacrificial Dagger
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Eve}}
 | id          = 53
}} {{infobox achievement
 | name        = Bloody Lust
 | link        = Bloody Lust
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Samson}}
 | id          = 54
}} {{infobox achievement
 | name        = Blood Penny
 | link        = Bloody Penny
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Samson}}
 | id          = 55
}} {{infobox achievement
 | name        = Blood Rights
 | link        = Blood Rights
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Samson}}
 | id          = 56
}} {{infobox achievement
 | name        = The Polaroid
 | link        = The Polaroid
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 5 times
 | id          = 57
}} {{infobox achievement
 | name        = Dad's Key
 | link        = Dad's Key
 | description = Unlocked a new item.
 | unlocked by = Pick up both Key Pieces from the [[Angel]]s in one run
 | id          = 58
}} {{infobox achievement
 | name        = Blue Candle
 | link        = The Candle
 | description = Unlocked a new item.
 | unlocked by = Donate 900 coins to the [[Donation Machine]]
 | id          = 59
}} {{infobox achievement
 | name        = Burnt Penny
 | link        = Burnt Penny
 | description = Unlocked a new item.
 | unlocked by = Complete [[Beans!|Beans! (challenge #13)]]
 | id          = 60
}} {{infobox achievement
 | name        = Lucky Toe
 | link        = Lucky Toe
 | description = Unlocked a new item.
 | unlocked by = Blow up 20 [[Shopkeeper]]s
 | id          = 61
}} {{infobox achievement
 | name        = Epic Fetus
 | link        = Epic Fetus
 | description = Unlocked a new item.
 | unlocked by = Complete [[The Family Man|The Family Man (challenge #19)]]
 | id          = 62
}} {{infobox achievement
 | name        = SMB Super Fan
 | link        = SMB Super Fan
 | description = Unlocked a new item.
 | unlocked by = Complete [[It's in the Cards|It's in the Cards (challenge #14)]]
 | id          = 63
}} {{infobox achievement
 | name        = Counterfeit Coin
 | link        = Counterfeit Penny
 | description = Unlocked a new item.
 | unlocked by = Play either [[Shell Game]] or {{dlc|r}} [[Hell Game]] 100 times
 | id          = 64
}} {{infobox achievement
 | name        = Guppy's Hairball
 | link        = Guppy's Hair Ball
 | description = Unlocked a new item.
 | unlocked by = Become [[Guppy]]
 | id          = 65
}} {{infobox achievement
 | name        = A Forgotten Horseman
 | link        = Conquest
 | description = Unlocked a new boss!
 | unlocked by = Take 10 [[Angel Room (Item Pool)|Angel Room items]]
 | id          = 66
}} {{infobox achievement
 | name        = Samson
 | link        = Samson
 | description = Unlocked a new character.
 | unlocked by = Complete 2 floors in a row without taking damage
 | id          = 67
}} {{infobox achievement
 | name        = Something Icky
 | link        = Triachnid
 | description = New boss in the womb!
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 10 times
 | id          = 68
}} {{infobox achievement
 | name        = !Platinum God!
 | description = OMG!
 | unlocked by = [[collection page|Collect]] all non-DLC items in the game, and unlock all of the secrets and [[ending]]s (minus {{c|The Lost}} and his 6 unlockable items)
 | id          = 69
}} {{infobox achievement
 | name        = Isaac's Head
 | link        = Isaac's Head
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Isaac}}
 | id          = 70
}} {{infobox achievement
 | name        = Maggy's Faith
 | link        = Maggy's Faith
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Magdalene}}
 | id          = 71
}} {{infobox achievement
 | name        = Judas' Tongue
 | link        = Judas' Tongue
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Judas}}
 | id          = 72
}} {{infobox achievement
 | name        = ???'s Soul
 | link        = ???'s Soul
 | image       = achievement Blue Baby's Soul_icon.png
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|???}}
 | id          = 73
}} {{infobox achievement
 | name        = Samson's Lock
 | link        = Samson's Lock
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Samson}}
 | id          = 74
}} {{infobox achievement
 | name        = Cain's Eye
 | link        = Cain's Eye
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Cain}}
 | id          = 75
}} {{infobox achievement
 | name        = Eve's Bird Foot
 | link        = Eve's Bird Foot
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Eve}}
 | id          = 76
}} {{infobox achievement
 | name        = The Left Hand
 | link        = The Left Hand
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Pride]] as any character, or [[??? (Boss)|???]] as {{c|Judas}}
 | id          = 77
}} {{infobox achievement
 | name        = The Negative
 | link        = The Negative
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] 5 times
 | id          = 78
}} {{infobox achievement
 | name        = Azazel
 | link        = Azazel
 | description = Unlocked a new character.
 | unlocked by = Make 3 [[Devil Room|Deals with the Devil]] in one run
 | id          = 79
}} {{infobox achievement
 | name        = Lazarus
 | link        = Lazarus
 | description = Unlocked a new character.
 | unlocked by = Have 4 or more [[Soul Heart]]s at one time
 | id          = 80
}} {{infobox achievement
 | name        = Eden
 | link        = Eden
 | description = Unlocked a new character.
 | unlocked by = Complete [[Chapter 4]]
 | id          = 81
}} {{infobox achievement
 | name        = The Lost
 | link        = The Lost
 | description = Unlocked a new character.
 | unlocked by = {{dlc|na}} [[The Lost#Unlocking The Lost in Rebirth|It's complicated]]<br>{{dlc|a}} Die in a {{r|Sacrifice Room}} while holding {{t|Missing Poster}}
 | id          = 82
}} {{infobox achievement
 | name        = Dead Boy
 | description = Beat Chest or Dark Room without taking damage.
 | unlocked by = Complete [[Chapter 6]] without taking damage
 | id          = 83
}} {{infobox achievement
 | name        = The Real Platinum God
 | description = 111% now stop playing!
 | unlocked by = [[Collection Page|Collect]] every non-DLC [[item]], and unlock every secret and [[ending]].
 | id          = 84
}} {{infobox achievement
 | name        = Lucky Rock
 | link        = Lucky Rock
 | description = Destroy 100 rocks.
 | unlocked by = Destroy 100 [[rock]]s
 | id          = 85
}} {{infobox achievement
 | name        = The Cellar
 | link        = The Cellar
 | description = Alt stage to the basement.
 | unlocked by = Beat all {{s|Basement}} bosses ({{dlc|r}} except [[Baby Plum]]) (not restricted to beating bosses ''in'' The Basement)
 | id          = 86
}} {{infobox achievement
 | name        = The Catacombs
 | link        = The Catacombs
 | description = Alt stage to the caves.
 | unlocked by = Beat all {{s|Caves}} bosses ({{dlc|r}} except [[Bumbino]]) (not restricted to beating bosses ''in'' The Caves)
 | id          = 87
}} {{infobox achievement
 | name        = The Necropolis
 | link        = Necropolis
 | description = Alt stage to the depths.
 | unlocked by = Beat all {{s|Depths}} bosses ({{dlc|r}} except [[Reap Creep]]) (not restricted to beating bosses ''in'' The Depths)
 | id          = 88
}} {{infobox achievement
 | name        = Rune of Hagalaz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Pitch Black|Pitch Black (challenge #1)]]
 | id          = 89
}} {{infobox achievement
 | name        = Rune of Jera
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[High Brow|High Brow (challenge #2)]]
 | id          = 90
}} {{infobox achievement
 | name        = Rune of Ehwaz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Head Trauma|Head Trauma (challenge #3)]]
 | id          = 91
}} {{infobox achievement
 | name        = Rune of Dagaz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Darkness Falls|Darkness Falls (challenge #4)]]
 | id          = 92
}} {{infobox achievement
 | name        = Rune of Ansuz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[The Tank|The Tank (challenge #5)]]
 | id          = 93
}} {{infobox achievement
 | name        = Rune of Perthro
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Solar System|Solar System (challenge #6)]]
 | id          = 94
}} {{infobox achievement
 | name        = Rune of Berkano
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Purist|Purist (challenge #20)]]
 | id          = 95
}} {{infobox achievement
 | name        = Rune of Algiz
 | link        = Runes
 | description = Unlocked a new item.
 | unlocked by = Complete [[Cat Got Your Tongue|Cat Got Your Tongue (challenge #8)]]
 | id          = 96
}} {{infobox achievement
 | name        = Chaos Card
 | link        = Chaos Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[Demo Man|Demo Man (challenge #9)]]
 | id          = 97
}} {{infobox achievement
 | name        = Credit Card
 | link        = Credit Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[Cursed!|Cursed! (challenge #10)]]
 | id          = 98
}} {{infobox achievement
 | name        = Rules Card
 | link        = Rules Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[Glass Cannon (Challenge)|Glass Cannon (challenge #11)]]
 | id          = 99
}} {{infobox achievement
 | name        = Card Against Humanity
 | link        = A Card Against Humanity
 | description = Unlocked a new item.
 | unlocked by = Complete [[When Life Gives You Lemons|When Life Gives You Lemons (challenge #12)]]
 | id          = 100
}} {{infobox achievement
 | name        = Swallowed Penny
 | link        = Swallowed Penny
 | description = Unlocked a new item.
 | unlocked by = Complete [[Slow Roll|Slow Roll (challenge #15)]]
 | id          = 101
}} {{infobox achievement
 | name        = Robo-Baby 2.0
 | link        = Robo-Baby 2.0
 | description = Unlocked a new item.
 | unlocked by = Complete [[Computer Savvy|Computer Savvy (challenge #16)]]
 | id          = 102
}} {{infobox achievement
 | name        = Death's Touch
 | link        = Death's Touch
 | description = Unlocked a new item.
 | unlocked by = Complete [[Waka Waka|Waka Waka (challenge #17)]]
 | id          = 103
}} {{infobox achievement
 | name        = Technology .5
 | link        = Tech.5
 | description = Unlocked a new item.
 | unlocked by = Complete [[The Host|The Host (challenge #18)]]
 | id          = 104
}} {{infobox achievement
 | name        = Missing No.
 | link        = Missing No.
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Lazarus}}
 | id          = 105
}} {{infobox achievement
 | name        = Isaac's Tears
 | link        = Isaac's Tears
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Isaac}}
 | id          = 106
}} {{infobox achievement
 | name        = Guillotine
 | link        = Guillotine
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Judas}}
 | id          = 107
}} {{infobox achievement
 | name        = Judas' Shadow
 | link        = Judas' Shadow
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Judas}}
 | id          = 108
}} {{infobox achievement
 | name        = Maggy's Bow
 | link        = Maggy's Bow
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Magdalene}}
 | id          = 109
}} {{infobox achievement
 | name        = Cain's Other Eye
 | link        = Cain's Other Eye
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Cain}}
 | id          = 110
}} {{infobox achievement
 | name        = Black Lipstick
 | link        = Black Lipstick
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Eve}}
 | id          = 111
}} {{infobox achievement
 | name        = Eve's Mascara
 | link        = Eve's Mascara
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Eve}}
 | id          = 112
}} {{infobox achievement
 | name        = Fate
 | link        = Fate
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|???}}
 | id          = 113
}} {{infobox achievement
 | name        = ???'s Only Friend
 | link        = ???'s Only Friend
 | image       = achievement Blue Baby's Only_Friend_icon.png
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|???}}
 | id          = 114
}} {{infobox achievement
 | name        = Samson's Chains
 | link        = Samson's Chains
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Samson}}
 | id          = 115
}} {{infobox achievement
 | name        = Lazarus' Rags
 | link        = Lazarus' Rags
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Lazarus}}
 | id          = 116
}} {{infobox achievement
 | name        = Broken Ankh
 | link        = Broken Ankh
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Lazarus}}
 | id          = 117
}} {{infobox achievement
 | name        = Store Credit
 | link        = Store Credit
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Lazarus}}
 | id          = 118
}} {{infobox achievement
 | name        = Pandora's Box
 | link        = Pandora's Box
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Lazarus}}
 | id          = 119
}} {{infobox achievement
 | name        = Suicide King
 | link        = Suicide King
 | description = Unlocked a new item.
 | unlocked by = Complete [[Suicide King (Challenge)|Suicide King (challenge #7)]]
 | id          = 120
}} {{infobox achievement
 | name        = Blank Card
 | link        = Blank Card
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Eden}}
 | id          = 121
}} {{infobox achievement
 | name        = Book of Secrets
 | link        = Book of Secrets
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Eden}}
 | id          = 122
}} {{infobox achievement
 | name        = Mysterious Paper
 | link        = Mysterious Paper
 | description = Unlocked a new item.
 | unlocked by = Beat [[??? (Boss)|???]] as {{c|Eden}}
 | id          = 123
}} {{infobox achievement
 | name        = Mystery Sack
 | link        = Mystery Sack
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Eden}}
 | id          = 124
}} {{infobox achievement
 | name        = Undefined
 | link        = Undefined
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Eden}}
 | id          = 125
}} {{infobox achievement
 | name        = Satanic Bible
 | link        = Satanic Bible
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Azazel}}
 | id          = 126
}} {{infobox achievement
 | name        = Daemon's Tail
 | link        = Daemon's Tail
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Azazel}}
 | id          = 127
}} {{infobox achievement
 | name        = Abaddon
 | link        = Abaddon
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Azazel}}
 | id          = 128
}} {{infobox achievement
 | name        = Isaac's Heart
 | link        = Isaac's Heart
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|The Lost}}
 | id          = 129
}} {{infobox achievement
 | name        = The Mind
 | link        = The Mind
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|The Lost}}
 | id          = 130
}} {{infobox achievement
 | name        = The Body
 | link        = The Body
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|The Lost}}
 | id          = 131
}} {{infobox achievement
 | name        = The Soul
 | link        = The Soul
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|The Lost}}
 | id          = 132
}} {{infobox achievement
 | name        = The D100
 | link        = D100
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|The Lost}}
 | id          = 133
}} {{infobox achievement
 | name        = Blue Map
 | link        = Blue Map
 | description = Unlocked a new item.
 | unlocked by = Donate 10 Coins to the [[Donation Machine]]
 | id          = 134
}} {{infobox achievement
 | name        = There's Options
 | link        = There's Options
 | description = Unlocked a new item.
 | unlocked by = Donate 50 Coins to the [[Donation Machine]]
 | id          = 135
}} {{infobox achievement
 | name        = Black Candle
 | link        = Black Candle
 | description = Unlocked a new item
 | unlocked by = Donate 150 Coins to the [[Donation Machine]]
 | id          = 136
}} {{infobox achievement
 | name        = Red Candle
 | link        = Red Candle
 | description = Unlocked a new item.
 | unlocked by = Donate 400 Coins to the [[Donation Machine]]
 | id          = 137
}} {{infobox achievement
 | name        = Stop Watch
 | link        = Stop Watch
 | description = Unlocked a new item
 | unlocked by = Donate 999 Coins to the [[Donation Machine]]
 | id          = 138
}} {{infobox achievement
 | name        = Wire Coat Hanger
 | link        = Wire Coat Hanger
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 4 times
 | id          = 139
}} {{infobox achievement
 | name        = Ipecac
 | link        = Ipecac
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 6 times
 | id          = 140
}} {{infobox achievement
 | name        = Experimental Treatment
 | link        = Experimental Treatment
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 7 times
 | id          = 141
}} {{infobox achievement
 | name        = Krampus
 | link        = Krampus
 | description = Unlocked another miniboss!
 | unlocked by = Take 20 [[Devil Room|items from Devil Rooms]]
 | id          = 142
}} {{infobox achievement
 | name        = Head of Krampus
 | link        = Head of Krampus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Krampus]]
 | id          = 143
}} {{infobox achievement
 | name        = Super Meat Boy
 | link        = Cube of Meat
 | description = Built him out of meat cubes.
 | unlocked by = Make a Super Meat Boy by picking up 4 copies of {{i|Cube of Meat}} in one run; see [[Unlocking Super Meat Boy & Super Bandage Girl]]
 | id          = 144
}} {{infobox achievement
 | name        = Butter Bean
 | link        = Butter Bean
 | description = Unlocked a new item.
 | unlocked by = Destroy 100 [[Poop]]s
 | id          = 145
}} {{infobox achievement
 | name        = Little Baggy
 | link        = Little Baggy
 | description = Unlocked a new item.
 | unlocked by = Pick up any 2 of the following items in a single run: {{i|Roid Rage}}, {{i|The Virus}}, {{i|Growth Hormones}}, {{i|Experimental Treatment}}, and {{i|Speed Ball}} ({{dlc|r}} Any 2 items that have the [[Item Tags syringe|'syringe' item tag]])
 | id          = 146
}} {{infobox achievement
 | name        = Blood Bag
 | link        = Blood Bag
 | description = Unlocked a new item.
 | unlocked by = Use the [[Blood Donation Machine]] 30 times
 | id          = 147
}} {{infobox achievement
 | name        = The D4
 | link        = D4
 | description = Unlocked a new item.
 | unlocked by = Blow up 30 [[Slot Machine|Slot Machines]]
 | id          = 148
}} {{infobox achievement
 | name        = Missing Poster
 | link        = Missing Poster
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Isaac}}
 | id          = 149
}} {{infobox achievement
 | name        = Rubber Cement
 | link        = Rubber Cement
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] 2 times
 | id          = 150
}} {{infobox achievement
 | name        = Store Upgrade lv.1
 | link        = Shop#Levels
 | description = Donated 20 pennies to the shop.
 | unlocked by = Donate 20 Coins to the [[Donation Machine]]
 | id          = 151
}} {{infobox achievement
 | name        = Store Upgrade lv.2
 | link        = Shop#Levels
 | description = Donated 100 pennies to the shop.
 | unlocked by = Donate 100 Coins to the [[Donation Machine]]
 | id          = 152
}} {{infobox achievement
 | name        = Store Upgrade lv.3
 | link        = Shop#Levels
 | description = Donated 200 pennies to the shop.
 | unlocked by = Donate 200 Coins to the [[Donation Machine]]
 | id          = 153
}} {{infobox achievement
 | name        = Store Upgrade lv.4
 | link        = Shop#Levels
 | description = Donated 600 pennies to the shop.
 | unlocked by = Donate 600 Coins to the [[Donation Machine]]
 | id          = 154
}} {{infobox achievement
 | name        = Angels
 | link        = Angel
 | description = They are waiting.
 | unlocked by = Complete [[Chapter 6]]
 | id          = 155
}} {{infobox achievement
 | name        = Godhead
 | link        = Godhead
 | description = Unlocked a new item.
 | unlocked by = Earn all {{dlc|na}} 5 / {{dlc|ana+}} 9 (except the cent sign for [[Ultra Greed]]) / {{dlc|a+nr}} 10 / {{dlc|r}} 12 [[Completion Mark]]s on [[Hard mode]] as {{c|The Lost}}
 | id          = 156
}} {{infobox achievement
 | name        = Darkness Falls
 | link        = Darkness Falls
 | description = Unlocked Challenge #4.
 | unlocked by = {{dlc|nr}} Defeat [[Mom's Heart]] 11 times<br>{{dlc|r}} Defeat [[Satan]] and [[??? (Boss)|???]] as {{c|Eve}}
 | id          = 157
}} {{infobox achievement
 | name        = The Tank
 | link        = The Tank
 | description = Unlocked Challenge #5.
 | unlocked by = Have 7 or more [[Red Heart]] Containers at one time
 | id          = 158
}} {{infobox achievement
 | name        = Solar System
 | link        = Solar System
 | description = Unlocked Challenge #6.
 | unlocked by = Defeat [[Mom's Heart]] 3 times
 | id          = 159
}} {{infobox achievement
 | name          = Suicide King 2
 | override name = Suicide King
 | link          = Suicide King (Challenge)
 | description   = Unlocked Challenge #7.
 | unlocked by   = Defeat [[Mom's Heart]] 11 times
 | id            = 160
}} {{infobox achievement
 | name        = Cat Got Your Tongue
 | link        = Cat Got Your Tongue
 | description = Unlocked Challenge #8.
 | unlocked by = Become [[Guppy]]
 | id          = 161
}} {{infobox achievement
 | name        = Demo Man
 | link        = Demo Man
 | description = Unlocked Challenge #9.
 | unlocked by = Defeat [[Mom's Heart]] 9 times
 | id          = 162
}} {{infobox achievement
 | name        = Cursed!
 | link        = Cursed!
 | description = Unlocked Challenge #10.
 | unlocked by = Have 7 or more [[Red Heart]] Containers at one time
 | id          = 163
}} {{infobox achievement
 | name        = Glass Cannon
 | link        = Glass Cannon (Challenge)
 | description = Unlocked Challenge #11.
 | unlocked by = Beat [[The Family Man|The Family Man (challenge #19)]] and defeat [[Lokii]]
 | id          = 164
}} {{infobox achievement
 | name        = The Family Man
 | link        = The Family Man
 | description = Unlocked Challenge #19.
 | unlocked by = Pick up both Key Pieces from the [[Angel]]s in one run
 | id          = 165
}} {{infobox achievement
 | name        = Purist
 | link        = Purist
 | description = Unlocked Challenge #20.
 | unlocked by = Defeat [[Mom]]
 | id          = 166
}} {{infobox achievement
 | name        = Lost Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Isaac}}
 | id          = 167
}} {{infobox achievement
 | name        = Cute Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Magdalene}}
 | id          = 168
}} {{infobox achievement
 | name        = Crow Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Eve}}
 | id          = 169
}} {{infobox achievement
 | name        = Shadow Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Judas}}
 | id          = 170
}} {{infobox achievement
 | name        = Glass Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Cain}}
 | id          = 171
}} {{infobox achievement
 | name        = Wrapped Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = {{dlc|na+}} Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Azazel}}<br>{{dlc|a+}} Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Lazarus}}
 | id          = 172
}} {{infobox achievement
 | name        = Begotten Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = {{dlc|na+}} Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Lazarus}}<br>{{dlc|a+}} Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Azazel}}
 | id          = 173
}} {{infobox achievement
 | name        = Dead Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|???}}
 | id          = 174
}} {{infobox achievement
 | name        = -0- Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|The Lost}}
 | id          = 175
}} {{infobox achievement
 | name        = Glitch Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Eden}}
 | id          = 176
}} {{infobox achievement
 | name        = Fighting Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Samson}}
 | id          = 177
}} {{infobox achievement
 | name        = Lord of the Flies
 | link        = Beelzebub
 | description = You became Lord of the Flies.
 | unlocked by = Become [[Beelzebub]]
 | id          = 178
}}
}}

=== [[The Binding of Isaac: Afterbirth|Afterbirth]] ===
{{table | achievement |
{{infobox achievement
 | dlc         = a
 | name        = Fart Baby
 | link        = Farting Baby
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Isaac}}
 | id          = 179
}} {{infobox achievement
 | dlc         = a
 | name        = Purity
 | link        = Purity
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Magdalene}}
 | id          = 180
}} {{infobox achievement
 | dlc         = a
 | name        = D12
 | link        = D12
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Cain}}
 | id          = 181
}} {{infobox achievement
 | dlc         = a
 | name        = Betrayal
 | link        = Betrayal
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Judas}}
 | id          = 182
}} {{infobox achievement
 | dlc         = a
 | name        = Fate's Reward
 | link        = Fate's Reward
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|???}}
 | id          = 183
}} {{infobox achievement
 | dlc         = a
 | name        = Athame
 | link        = Athame
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Eve}}
 | id          = 184
}} {{infobox achievement
 | dlc         = a
 | name        = Blind Rage
 | link        = Blind Rage
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Samson}}
 | id          = 185
}} {{infobox achievement
 | dlc         = a
 | name        = Maw of the Void
 | link        = Maw of the Void
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Azazel}}
 | id          = 186
}} {{infobox achievement
 | dlc         = a
 | name        = Empty Vessel
 | link        = Empty Vessel
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Lazarus}}
 | id          = 187
}} {{infobox achievement
 | dlc         = a
 | name        = Eden's Blessing
 | link        = Eden's Blessing
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Eden}}
 | id          = 188
}} {{infobox achievement
 | dlc         = a
 | name        = Sworn Protector
 | link        = Sworn Protector
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|The Lost}}
 | id          = 189
}} {{infobox achievement
 | dlc         = a
 | name        = Incubus
 | link        = Incubus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Lilith}}
 | id          = 190
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper now holds... A Penny!
 | link        = Keeper
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Keeper}}
 | id          = 191
}} {{infobox achievement
 | dlc         = a
 | name        = Lil' Chest
 | link        = Lil Chest
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Isaac}}
 | id          = 192
}} {{infobox achievement
 | dlc         = a
 | name        = Censer
 | link        = Censer
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Magdalene}}
 | id          = 193
}} {{infobox achievement
 | dlc         = a
 | name        = Evil Eye
 | link        = Evil Eye
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Cain}}
 | id          = 194
}} {{infobox achievement
 | dlc         = a
 | name        = My Shadow
 | link        = My Shadow
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Judas}}
 | id          = 195
}} {{infobox achievement
 | dlc         = a
 | name        = Cracked Dice
 | link        = Cracked Dice
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|???}}
 | id          = 196
}} {{infobox achievement
 | dlc         = a
 | name        = Black Feather
 | link        = Black Feather
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Eve}}
 | id          = 197
}} {{infobox achievement
 | dlc         = a
 | name        = Lusty Blood
 | link        = Lusty Blood
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Samson}}
 | id          = 198
}} {{infobox achievement
 | dlc         = a
 | name        = Lilith
 | link        = Lilith
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Azazel}}
 | id          = 199
}} {{infobox achievement
 | dlc         = a
 | name        = Key Bum
 | link        = Key Bum
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Lazarus}}
 | id          = 200
}} {{infobox achievement
 | dlc         = a
 | name        = GB Bug
 | link        = GB Bug
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Eden}}
 | id          = 201
}} {{infobox achievement
 | dlc         = a
 | name        = Zodiac
 | link        = Zodiac
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|The Lost}}
 | id          = 202
}} {{infobox achievement
 | dlc         = a
 | name        = Box of Friends
 | link        = Box of Friends
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Lilith}}
 | id          = 203
}} {{infobox achievement
 | dlc         = a
 | name        = Rib of Greed
 | link        = Rib of Greed
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Keeper}}
 | id          = 204
}} {{infobox achievement
 | dlc         = a
 | name        = Cry Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Isaac}}
 | id          = 205
}} {{infobox achievement
 | dlc         = a
 | name        = Red Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Magdalene}}
 | id          = 206
}} {{infobox achievement
 | dlc         = a
 | name        = Green Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Cain}}
 | id          = 207
}} {{infobox achievement
 | dlc         = a
 | name        = Brown Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Judas}}
 | id          = 208
}} {{infobox achievement
 | dlc         = a
 | name        = Blue Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|???}}
 | id          = 209
}} {{infobox achievement
 | dlc         = a
 | name        = Lil' Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Eve}}
 | id          = 210
}} {{infobox achievement
 | dlc         = a
 | name        = Rage Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Samson}}
 | id          = 211
}} {{infobox achievement
 | dlc         = a
 | name        = Black Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Azazel}}
 | id          = 212
}} {{infobox achievement
 | dlc         = a
 | name        = Long Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Lazarus}}
 | id          = 213
}} {{infobox achievement
 | dlc         = a
 | name        = Yellow Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Eden}}
 | id          = 214
}} {{infobox achievement
 | dlc         = a
 | name        = White Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|The Lost}}
 | id          = 215
}} {{infobox achievement
 | dlc         = a
 | name        = Big Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Lilith}}
 | id          = 216
}} {{infobox achievement
 | dlc         = a
 | name        = Noose Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Keeper}}
 | id          = 217
}} {{infobox achievement
 | dlc         = a
 | name        = Rune Bag
 | link        = Rune Bag
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Lilith}}
 | id          = 218
}} {{infobox achievement
 | dlc         = a
 | name        = Cambion Conception
 | link        = Cambion Conception
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Lilith}}
 | id          = 219
}} {{infobox achievement
 | dlc         = a
 | name        = Serpent's Kiss
 | link        = Serpent's Kiss
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Lilith}}
 | id          = 220
}} {{infobox achievement
 | dlc         = a
 | name        = Succubus
 | link        = Succubus
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Lilith}}
 | id          = 221
}} {{infobox achievement
 | dlc         = a
 | name        = Immaculate Conception
 | link        = Immaculate Conception
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Lilith}}
 | id          = 222
}} {{infobox achievement
 | dlc         = a
 | name        = Goat Head Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Lilith}}
 | id          = 223
}} {{infobox achievement
 | dlc         = a
 | name        = Gold Heart
 | link        = Hearts (Pickup)
 | description = Unlocked a new item.
 | unlocked by = Complete [[XXXXXXXXL|XXXXXXXXL (challenge #21)]]
 | id          = 224
}} {{infobox achievement
 | dlc         = a
 | name        = Get out of Jail Free Card
 | link        = Get out of Jail Free Card
 | description = Unlocked a new item.
 | unlocked by = Complete [[SPEED!|SPEED! (challenge #22)]]
 | id          = 225
}} {{infobox achievement
 | dlc         = a
 | name        = Gold Bomb
 | link        = Gold Bomb
 | description = Unlocked a new item.
 | unlocked by = Complete [[Blue Bomber|Blue Bomber (challenge #23)]]
 | id          = 226
}} {{infobox achievement
 | dlc         = a
 | name        = 2 new pills
 | link        = Pill
 | description = Unlocked a new item.
 | unlocked by = Complete [[PAY TO PLAY|PAY TO PLAY (challenge #24)]]
 | id          = 227
}} {{infobox achievement
 | dlc           = a
 | name          = 2 new pills 2
 | override name = 2 new pills
 | link          = Pill
 | description   = Unlocked a new item.
 | unlocked by   = Complete [[Have a Heart|Have a Heart (challenge #25)]]
 | id            = 228
}} {{infobox achievement
 | dlc         = a
 | name        = Poker Chip
 | link        = Poker Chip
 | description = Unlocked a new item.
 | unlocked by = Complete [[I RULE!|I RULE! (challenge #26)]]
 | id          = 229
}} {{infobox achievement
 | dlc         = a
 | name        = Stud Finder
 | link        = Stud Finder
 | description = Unlocked a new item.
 | unlocked by = Complete [[BRAINS!|BRAINS! (challenge #27)]]
 | id          = 230
}} {{infobox achievement
 | dlc         = a
 | name        = D8
 | link        = D8
 | description = Unlocked a new item.
 | unlocked by = Complete [[PRIDE DAY!|PRIDE DAY! (challenge #28)]]
 | id          = 231
}} {{infobox achievement
 | dlc         = a
 | name        = Kidney Stone
 | link        = Kidney Stone
 | description = Unlocked a new item.
 | unlocked by = {{dlc|na+}} Complete [[The Guardian|The Guardian (challenge #30)]]<br>{{dlc|a+}} Complete [[Onan's Streak|Onan's Streak (challenge #29)]]
 | id          = 232
}} {{infobox achievement
 | dlc         = a
 | name        = Blank Rune
 | link        = Blank Rune (Achievement)
 | description = Unlocked a new item.
 | unlocked by = {{dlc|na+}} Complete [[Onan's Streak|Onan's Streak (challenge #29)]]<br>{{dlc|a+}} Complete [[The Guardian|The Guardian (challenge #30)]]
 | id          = 233
}} {{infobox achievement
 | dlc         = a
 | name        = Blue Womb
 | link        = Blue Womb
 | description = Unlocked a hidden chapter.
 | unlocked by = Defeat [[Mom's Heart]] 10 times
 | id          = 234
}} {{infobox achievement
 | dlc         = a
 | name        = 1001%
 | description = Nerd x 1000000
 | unlocked by = Unlock all secrets and [[ending]]s, and [[collection page|collect]] every item in the game
 | id          = 235
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper holds Wooden Nickel
 | link        = Keeper
 | description = Unlocked a new starting item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Keeper}}
 | id          = 236
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper holds Store Key
 | link        = Keeper
 | description = Unlocked a new starting item.
 | unlocked by = Defeat [[Satan]] as {{c|Keeper}}
 | id          = 237
}} {{infobox achievement
 | dlc         = a
 | name        = Deep Pockets
 | link        = Deep Pockets
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Keeper}}
 | id          = 238
}} {{infobox achievement
 | dlc         = a
 | name        = Karma
 | link        = Karma
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Keeper}}
 | id          = 239
}} {{infobox achievement
 | dlc         = a
 | name        = Sticky Nickels
 | link        = Sticky nickel
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Keeper}}
 | id          = 240
}} {{infobox achievement
 | dlc         = a
 | name        = Super Greed Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mom's Heart]] on [[Hard mode]] as {{c|Keeper}}
 | id          = 241
}} {{infobox achievement
 | dlc         = a
 | name        = Lucky Pennies
 | link        = Lucky penny
 | description = Unlocked a new item.
 | unlocked by = Donate 1 Coin to the [[Greed Donation Machine]]
 | id          = 242
}} {{infobox achievement
 | dlc         = a
 | name        = Special Hanging Shopkeepers
 | link        = Special shopkeeper
 | description = Unlocked a secret.
 | unlocked by = Donate 10 Coins to the [[Greed Donation Machine]]
 | id          = 243
}} {{infobox achievement
 | dlc         = a
 | name        = Wooden Nickel
 | link        = Wooden Nickel
 | description = Unlocked a new item.
 | unlocked by = Donate 30 Coins to the [[Greed Donation Machine]]
 | id          = 244
}} {{infobox achievement
 | dlc         = a
 | name        = Cain holds Paperclip
 | link        = Cain
 | description = Unlocked a new starting item.
 | unlocked by = Donate 68 Coins to the [[Greed Donation Machine]]
 | id          = 245
}} {{infobox achievement
 | dlc         = a
 | name        = Everything is Terrible 2!!!
 | link        = Ultra Greed
 | description = Greed just got harder!
 | unlocked by = Donate 111 Coins to the [[Greed Donation Machine]]
 | id          = 246
}} {{infobox achievement
 | dlc         = a
 | name        = Special Shopkeepers
 | link        = Special shopkeeper
 | description = Unlocked a secret.
 | unlocked by = Donate 234 Coins to the [[Greed Donation Machine]]
 | id          = 247
}} {{infobox achievement
 | dlc         = a
 | name        = Eve now holds Razor Blade
 | link        = Eve
 | description = Unlocked a new starting item.
 | unlocked by = Donate 439 Coins to the [[Greed Donation Machine]]
 | id          = 248
}} {{infobox achievement
 | dlc         = a
 | name        = Store Key
 | link        = Store Key
 | description = Unlocked a new item.
 | unlocked by = Donate 666 Coins to the [[Greed Donation Machine]]
 | id          = 249
}} {{infobox achievement
 | dlc         = a
 | name        = Lost holds Holy Mantle
 | link        = The Lost
 | description = Unlocked a new starting item.
 | unlocked by = Donate 879 Coins to the [[Greed Donation Machine]]
 | id          = 250
}} {{infobox achievement
 | dlc         = a
 | name        = Keeper
 | link        = Keeper
 | description = Unlocked a new character.
 | unlocked by = Donate 1000 Coins to the [[Greed Donation Machine]]
 | id          = 251
}} {{infobox achievement
 | dlc         = a
 | name        = Hive Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|???}}
 | id          = 252
}} {{infobox achievement
 | dlc         = a
 | name        = Buddy Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Isaac}}
 | id          = 253
}} {{infobox achievement
 | dlc         = a
 | name        = Colorful Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Magdalene}}
 | id          = 254
}} {{infobox achievement
 | dlc         = a
 | name        = Whore Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Eve}}
 | id          = 255
}} {{infobox achievement
 | dlc         = a
 | name        = Cracked Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Eden}}
 | id          = 256
}} {{infobox achievement
 | dlc         = a
 | name        = Dripping Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Lazarus}}
 | id          = 257
}} {{infobox achievement
 | dlc         = a
 | name        = Blinding Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Use {{i|Blank Card}} while holding {{p|XIX - The Sun}}
 | id          = 258
}} {{infobox achievement
 | dlc         = a
 | name        = Sucky Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Azazel}}
 | id          = 259
}} {{infobox achievement
 | dlc         = a
 | name        = Dark Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Lilith}}
 | id          = 260
}} {{infobox achievement
 | dlc         = a
 | name        = Picky Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Cain}}
 | id          = 261
}} {{infobox achievement
 | dlc         = a
 | name        = Revenge Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Samson}}
 | id          = 262
}} {{infobox achievement
 | dlc         = a
 | name        = Belial Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Judas}}
 | id          = 263
}} {{infobox achievement
 | dlc         = a
 | name        = Sale Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Keeper}}
 | id          = 264
}} {{infobox achievement
 | dlc         = a
 | name        = XXXXXXXXL
 | link        = XXXXXXXXL
 | description = Unlocked Challenge #21.
 | unlocked by = Defeat [[Mom]]
 | id          = 265
}} {{infobox achievement
 | dlc         = a
 | name        = SPEED!
 | link        = SPEED!
 | description = Unlocked Challenge #22.
 | unlocked by = Defeat [[Mom]]
 | id          = 266
}} {{infobox achievement
 | dlc         = a
 | name        = Blue Bomber
 | link        = Blue Bomber
 | description = Unlocked Challenge #23.
 | unlocked by = Destroy 10 [[Tinted Rock]]s and defeat [[Mom's Heart]] 11 times
 | id          = 267
}} {{infobox achievement
 | dlc         = a
 | name        = PAY TO PLAY
 | link        = PAY TO PLAY
 | description = Unlocked Challenge #24.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Cain}}
 | id          = 268
}} {{infobox achievement
 | dlc         = a
 | name        = Have a Heart
 | link        = Have a Heart
 | description = Unlocked Challenge #25.
 | unlocked by = Defeat [[Mom]]
 | id          = 269
}} {{infobox achievement
 | dlc         = a
 | name        = I RULE!
 | link        = I RULE!
 | description = Unlocked Challenge #26.
 | unlocked by = {{dlc|nr}} Defeat [[??? (Boss)|???]] or [[The Lamb]], and defeat [[Satan]] as {{c|Isaac}}<br>{{dlc|r}} Defeat [[Mega Satan]]
 | id          = 270
}} {{infobox achievement
 | dlc         = a
 | name        = BRAINS!
 | link        = BRAINS!
 | description = Unlocked Challenge #27.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 5 times
 | id          = 271
}} {{infobox achievement
 | dlc         = a
 | name        = PRIDE DAY!
 | link        = PRIDE DAY!
 | description = Unlocked Challenge #28.
 | unlocked by = Defeat [[Mom]]
 | id          = 272
}} {{infobox achievement
 | dlc         = a
 | name        = Onan's Streak
 | link        = Onan's Streak
 | description = Unlocked Challenge #29.
 | unlocked by = Defeat [[Mom]]
 | id          = 273
}} {{infobox achievement
 | dlc         = a
 | name        = The Guardian
 | link        = The Guardian
 | description = Unlocked Challenge #30.
 | unlocked by = Defeat [[Mom]]
 | id          = 274
}} {{infobox achievement
 | dlc         = a
 | name        = Generosity
 | link        = Greed machine
 | description = If only everyone was as generous as you are...
 | unlocked by = Donate 999 Coins to the [[Greed Donation Machine]]
 | id          = 275
}} {{infobox achievement
 | dlc         = a
 | name        = Mega
 | link        = Mega Blast
 | description = Unlocked...
 | unlocked by = Defeat [[Mega Satan]] as every character ({{dlc|r}} except [[Tainted characters]])
 | id          = 276
}}
}}

=== [[The Binding of Isaac: Afterbirth †|Afterbirth †]] ===
{{table | achievement |
{{infobox achievement
 | dlc         = a+
 | name        = Backasswards
 | link        = Backasswards
 | description = Unlocked a new challenge.
 | unlocked by = {{dlc|nr}} Defeat [[??? (Boss)|???]] or [[The Lamb]]<br>{{dlc|r}} Defeat [[Mega Satan]]
 | id          = 277
}} {{infobox achievement
 | dlc         = a+
 | name        = Aprils fool
 | link        = Aprils Fool
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mom]]
 | id          = 278
}} {{infobox achievement
 | dlc         = a+
 | name        = Pokey Mans
 | link        = Pokey Mans
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 279
}} {{infobox achievement
 | dlc         = a+
 | name        = Ultra Hard
 | link        = Ultra Hard
 | description = Unlocked a new challenge.
 | unlocked by = {{dlc|nr}} Defeat [[??? (Boss)|???]] or [[The Lamb]]. Possession of {{i|The Polaroid}} / {{i|The Negative}} is required, barring getting to {{s|Dark Room}} through a {{r|Sacrifice Room}}.<br>{{dlc|r}} Defeat [[Mega Satan]]
 | id          = 280
}} {{infobox achievement
 | dlc         = a+
 | name        = PONG
 | link        = Pong
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] 5 times
 | id          = 281
}} {{infobox achievement
 | dlc         = a+
 | name        = D Infinity
 | link        = D Infinity
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Isaac}}
 | id          = 282
}} {{infobox achievement
 | dlc         = a+
 | name        = Eucharist
 | link        = Eucharist
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Magdalene}}
 | id          = 283
}} {{infobox achievement
 | dlc         = a+
 | name        = Silver Dollar
 | link        = Silver Dollar
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Cain}}
 | id          = 284
}} {{infobox achievement
 | dlc         = a+
 | name        = Shade
 | link        = Shade
 | description = Unlocked a new item. 
 | unlocked by = Defeat [[Delirium]] as {{c|Judas}}
 | id          = 285
}} {{infobox achievement
 | dlc         = a+
 | name        = King Baby
 | link        = King Baby
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Delirium]] as {{c|???}}
 | id          = 286
}} {{infobox achievement
 | dlc         = a+
 | name        = Bloody Crown
 | link        = Bloody Crown
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Samson}}
 | id          = 287
}} {{infobox achievement
 | dlc         = a+
 | name        = Dull Razor
 | link        = Dull Razor
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Eve}}
 | id          = 288
}} {{infobox achievement
 | dlc         = a+
 | name        = Eden's Soul
 | link        = Eden's Soul
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Eden}}
 | id          = 289
}} {{infobox achievement
 | dlc         = a+
 | name        = Dark Prince's Crown
 | link        = Dark Prince's Crown
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Azazel}}
 | id          = 290
}} {{infobox achievement
 | dlc         = a+
 | name        = Compound Fracture
 | link        = Compound Fracture
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Lazarus}}
 | id          = 291
}} {{infobox achievement
 | dlc         = a+
 | name        = Euthanasia
 | link        = Euthanasia
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Lilith}}
 | id          = 292
}} {{infobox achievement
 | dlc         = a+
 | name        = Holy Card
 | link        = Holy Card
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|The Lost}}
 | id          = 293
}} {{infobox achievement
 | dlc         = a+
 | name        = Crooked Penny
 | link        = Crooked Penny
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Keeper}}
 | id          = 294
}} {{infobox achievement
 | dlc         = a+
 | name        = Void
 | link        = Void
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|Apollyon}}
 | id          = 295
}} {{infobox achievement
 | dlc         = a+
 | name        = D1
 | link        = D1
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Isaac}}
 | id          = 296
}} {{infobox achievement
 | dlc         = a+
 | name        = Glyph of Balance
 | link        = Glyph of Balance
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Magdalene}}
 | id          = 297
}} {{infobox achievement
 | dlc         = a+
 | name        = Sack of Sacks
 | link        = Sack of Sacks
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Cain}}
 | id          = 298
}} {{infobox achievement
 | dlc         = a+
 | name        = Eye of Belial
 | link        = Eye of Belial
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Judas}}
 | id          = 299
}} {{infobox achievement
 | dlc         = a+
 | name        = Meconium
 | link        = Meconium
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|???}}
 | id          = 300
}} {{infobox achievement
 | dlc         = a+
 | name        = Stem Cell
 | link        = Stem Cell
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Samson}}
 | id          = 301
}} {{infobox achievement
 | dlc         = a+
 | name        = Crow Heart
 | link        = Crow Heart
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Eve}}
 | id          = 302
}} {{infobox achievement
 | dlc         = a+
 | name        = Metronome
 | link        = Metronome
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Eden}}
 | id          = 303
}} {{infobox achievement
 | dlc         = a+
 | name        = Bat Wing
 | link        = Bat Wing
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Azazel}}
 | id          = 304
}} {{infobox achievement
 | dlc         = a+
 | name        = Plan C
 | link        = Plan C
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Lazarus}}
 | id          = 305
}} {{infobox achievement
 | dlc         = a+
 | name        = Duality
 | link        = Duality
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Lilith}}
 | id          = 306
}} {{infobox achievement
 | dlc         = a+
 | name        = Dad's Lost Coin
 | link        = Dad's Lost Coin
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|The Lost}}
 | id          = 307
}} {{infobox achievement
 | dlc         = a+
 | name        = Eye of Greed
 | link        = Eye of Greed
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Keeper}}
 | id          = 308
}} {{infobox achievement
 | dlc         = a+
 | name        = Black Rune
 | link        = Black Rune
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Apollyon}}
 | id          = 309
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Wrath
 | link        = Locust of War
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Apollyon}}
 | id          = 310
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Pestilence
 | link        = Locust of Pestilence
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|Apollyon}}
 | id          = 311
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Famine
 | link        = Locust of Famine
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Apollyon}}
 | id          = 312
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Death
 | link        = Locust of Death
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|Apollyon}}
 | id          = 313
}} {{infobox achievement
 | dlc         = a+
 | name        = Locust of Conquest
 | link        = Locust of Conquest
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Apollyon}}
 | id          = 314
}} {{infobox achievement
 | dlc         = a+
 | name        = Hushy
 | link        = Hushy
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|Apollyon}}
 | id          = 315
}} {{infobox achievement
 | dlc         = a+
 | name        = Brown Nugget
 | link        = Brown Nugget
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Apollyon}}
 | id          = 316
}} {{infobox achievement
 | dlc         = a+
 | name        = Mort Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Apollyon}}
 | id          = 317
}} {{infobox achievement
 | dlc         = a+
 | name        = Smelter
 | link        = Smelter
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] or [[It Lives!]] on [[Hard mode]] as {{c|Apollyon}}
 | id          = 318
}} {{infobox achievement
 | dlc         = a+
 | name        = Apollyon Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Apollyon}}
 | id          = 319
}} {{infobox achievement
 | dlc         = a+
 | name        = New Area
 | link        = The Void
 | description = Unlocked a new area.
 | unlocked by = Defeat [[Hush]]
 | id          = 320
}} {{infobox achievement
 | dlc         = a+
 | name        = Once More with Feeling!
 | link        = Gulp!
 | description = Unlocked a new item.
 | unlocked by = Complete a [[Victory Lap]], defeating [[The Lamb]]
 | id          = 321
}} {{infobox achievement
 | dlc         = a+
 | name        = Hat trick!
 | link        = Ace of Clubs
 | description = Unlocked a new item.
 | unlocked by = Get a 3-win streak
 | id          = 322
}} {{infobox achievement
 | dlc         = a+
 | name        = 5 Nights at Mom's
 | link        = Super special rock
 | description = Unlocked super special rocks.
 | unlocked by = Get a 5-win streak ({{dlc|r}} 3-win streak), using a different character each time
 | id          = 323
}} {{infobox achievement
 | dlc         = a+
 | name        = Sin collector
 | link        = Feels Like I'm Walking on Sunshine!
 | description = Unlocked a new item.
 | unlocked by = Collect every entry in the [[Bestiary]] (bugged v190 - Mobs that don't exist in the bestiary are being counted. This allows Sin Collector to be unlocked without a complete bestiary) <!-- Mobs that don't exist in the bestiary are being counted towards the 281 bestiary total. E.g. Envy is being counted 4 times but only counts for 1 entry in the bestiary. There are 282 entities marked as bestiary in entities2.xml(Minus Moms guts due to 0 basehp). This issue was introduced in v188. -->
 | id          = 324
}} {{infobox achievement
 | dlc         = a+
 | name        = Dedication
 | link        = Horf!
 | description = Unlocked a new item.
 | unlocked by = Participate in 31 [[Daily Challenge]]s (they don't have to be consecutive; it will still count if Isaac dies in the first room)
 | id          = 325
}} {{infobox achievement
 | dlc         = a+
 | name        = ZIP!
 | link        = Ace of Diamonds
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] in under 20 minutes
 | id          = 326
}} {{infobox achievement
 | dlc         = a+
 | name        = It's the Key
 | link        = Ace of Spades (Card)
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] without taking Hearts, Coins, or Bombs through the entire run
 | id          = 327
}} {{infobox achievement
 | dlc         = a+
 | name        = Mr. Resetter!
 | link        = Half soul heart
 | description = Unlocked a new item.
 | unlocked by = Reset 7 times in a row<br>{{plat|Switch}}{{plat|PS4}} Get a minus 10-win streak
 | id          = 328
}} {{infobox achievement
 | dlc         = a+
 | name        = Living on the edge
 | link        = Ace of Hearts
 | description = Unlocked a new item.
 | unlocked by = Complete a Chapter (floors I and II) after {{s|Basement}}, start-to-finish, with only half a Heart total (can use {{c|The Lost}})
 | id          = 329
}} {{infobox achievement
 | dlc         = a+
 | name        = U Broke It!
 | link        = Vurp!
 | description = Unlocked a new item.
 | unlocked by = Obtain 50 items in a run (duplicate passive items/familiars count towards the total, e.g., multiple {{i|Breakfast}})
 | id          = 330
}} {{infobox achievement
 | dlc         = a+
 | name        = Laz Bleeds More!
 | link        = Lazarus
 | description = Unlocked a new starting item.
 | unlocked by = Complete [[Backasswards|Backasswards (challenge #31)]]
 | id          = 331
}} {{infobox achievement
 | dlc         = a+
 | name        = Maggy Now Holds a Pill!
 | link        = Magdalene
 | description = Unlocked a new starting item.
 | unlocked by = Complete [[Aprils Fool|Aprils Fool (challenge #32)]]
 | id          = 332
}} {{infobox achievement
 | dlc         = a+
 | name        = Charged Key
 | link        = Charged Key
 | description = Unlocked a new item.
 | unlocked by = Complete [[Pokey Mans|Pokey Mans (challenge #33)]]
 | id          = 333
}} {{infobox achievement
 | dlc         = a+
 | name        = Samson Feels Healthy!
 | link        = Samson
 | description = Unlocked a new starting item.
 | unlocked by = Complete [[Ultra Hard|Ultra Hard (challenge #34)]]
 | id          = 334
}} {{infobox achievement
 | dlc         = a+
 | name        = Greed's Gullet
 | link        = Greed's Gullet
 | description = Unlocked a new item.
 | unlocked by = Complete [[Pong|Pong (challenge #35)]]
 | id          = 335
}} {{infobox achievement
 | dlc         = a+
 | name        = The Marathon
 | link        = Cracked Crown
 | description = Unlocked a new item.
 | unlocked by = Get a 5-win streak in the [[Daily Challenge]]s ({{dlc|r}} Isaac must have a score above 0 on the score screen)
 | id          = 336
}} {{infobox achievement
 | dlc         = a+
 | name        = RERUN
 | link        = RERUN
 | description = Unlocked the power of RERUN.
 | unlocked by = Complete 3 [[Victory Lap]]s and start a 4th
 | id          = 337
}} {{infobox achievement
 | dlc         = a+
 | name        = Delirious
 | link        = Delirious
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]]
 | id          = 338
}} {{infobox achievement
 | dlc         = a+
 | name        = 1000000%
 | description = Just Stop!
 | unlocked by = [[Collection Page (Afterbirth †)|Collect]] every item in the game, unlock all secrets and [[ending]]s, and complete the [[Bestiary]]
 | id          = 339
}} {{infobox achievement
 | dlc         = a+
 | name        = Apollyon
 | link        = Apollyon
 | description = Unlocked a new character.
 | unlocked by = Defeat [[Mega Satan]]
 | id          = 340
}} {{infobox achievement
 | dlc         = a+
 | name        = Greedier!
 | link        = Greedier Mode
 | description = New mode unlocked!
 | unlocked by = Donate 500 Coins to the [[Greed Donation Machine]]
 | id          = 341
}} {{infobox achievement
 | dlc         = a+
 | name        = Burning Basement
 | link        = Burning Basement
 | description = Alt stage to the basement.
 | unlocked by = Defeat [[Mom's Heart]] 11 times
 | id          = 342
}} {{infobox achievement
 | dlc         = a+
 | name        = Flooded Caves
 | link        = Flooded Caves
 | description = Alt stage to the caves.
 | unlocked by = Defeat [[It Lives!]] 16 times
 | id          = 343
}} {{infobox achievement
 | dlc         = a+
 | name        = Dank Depths
 | link        = Dank Depths
 | description = Alt stage to the depths.
 | unlocked by = Defeat [[It Lives!]] 21 times
 | id          = 344
}} {{infobox achievement
 | dlc         = a+
 | name        = Scarred Womb
 | link        = Scarred Womb
 | description = Alt stage to the womb.
 | unlocked by = Defeat [[It Lives!]] 30 times
 | id          = 345
}} {{infobox achievement
 | dlc         = a+
 | name        = Something wicked this way comes!
 | link        = The Binding of Isaac: Afterbirth#Bosses
 | description = Unlocked new bosses!
 | unlocked by = Defeat [[??? (Boss)|???]] as 3 different [[Character]]s
 | id          = 346
}} {{infobox achievement
 | dlc         = a+
 | name        = Something wicked this way comes+!
 | link        = The Binding of Isaac: Afterbirth †#Bosses
 | image = Achievement_Something_Wicked_This_Way_Comes_†_icon.png
 | description = Unlocked even more bosses!
 | unlocked by = Defeat [[??? (Boss)|???]] as 6 different [[Character]]s
 | id          = 347
}} {{infobox achievement
 | dlc         = a+
 | name        = The gate is open!
 | link        = Monsters#Afterbirth †
 | description = Unlocked new enemies!
 | unlocked by = Defeat [[The Lamb]]
 | id          = 348
}} {{infobox achievement
 | dlc         = a+
 | name        = Black Hole
 | link        = Black Hole
 | description = Unlocked a new item.
 | unlocked by = Defeat 20 [[Portal]]s
 | id          = 349<br>{{plat|PS4}}&nbsp;340
}} {{infobox achievement
 | dlc         = a+
 | name        = Mystery Gift
 | link        = Mystery Gift
 | description = Unlocked a new item.
 | unlocked by = Destroy 500 [[rock]]s
 | id          = 350<br>{{plat|PS4}}&nbsp;341
}} {{infobox achievement
 | dlc         = a+
 | name        = Sprinkler
 | link        = Sprinkler
 | description = Unlocked a new item.
 | unlocked by = Beat [[Chapter 1]] without taking damage
 | id          = 351<br>{{plat|PS4}}&nbsp;342
}} {{infobox achievement
 | dlc         = a+
 | name        = Angry Fly
 | link        = Angry Fly
 | description = Unlocked a new item.
 | unlocked by = Become [[Beelzebub]]
 | id          = 352<br>{{plat|PS4}}&nbsp;343
}} {{infobox achievement
 | dlc         = a+
 | name        = Bozo
 | link        = Bozo
 | description = Unlocked a new item.
 | unlocked by = Destroy 5 [[rainbow poop]]s
 | id          = 353<br>{{plat|PS4}}&nbsp;344
}} {{infobox achievement
 | dlc         = a+
 | name        = Broken Modem
 | link        = Broken Modem
 | description = Unlocked a new item.
 | unlocked by = Complete 7 [[Daily Challenge]]s (by touching the trophy at the end)
 | id          = 354<br>{{plat|PS4}}&nbsp;345
}} {{infobox achievement
 | dlc         = a+
 | name        = Buddy in a Box
 | link        = Buddy in a Box
 | description = Unlocked a new item.
 | unlocked by = Pick up 5 [[familiar]]s in a single run
 | id          = 355<br>{{plat|PS4}}&nbsp;346
}} {{infobox achievement
 | dlc         = a+
 | name        = Fast Bombs
 | link        = Fast Bombs
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Little Horn]] 20 times
 | id          = 356<br>{{plat|PS4}}&nbsp;347
}} {{infobox achievement
 | dlc         = a+
 | name        = Lil Delirium
 | link        = Lil Delirium
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] for the 1st time
 | id          = 357<br>{{plat|PS4}}&nbsp;348
}} {{infobox achievement
 | dlc         = a+
 | name        = Hairpin
 | link        = Hairpin
 | description = Unlocked a new item.
 | unlocked by = Recharge using [[Lil' Battery|Lil' Batteries]] 20 times
 | id          = 358<br>{{plat|PS4}}&nbsp;349
}} {{infobox achievement
 | dlc         = a+
 | name        = Wooden Cross
 | link        = Wooden Cross
 | description = Unlocked a new item.
 | unlocked by = Sleep in a [[bed]]
 | id          = 359<br>{{plat|PS4}}&nbsp;350
}} {{infobox achievement
 | dlc         = a+
 | name        = Butter!
 | link        = Butter!
 | description = Unlocked a new item.
 | unlocked by = Complete 2 [[Victory Lap]]s and start a 3rd
 | id          = 360<br>{{plat|PS4}}&nbsp;351
}} {{infobox achievement
 | dlc         = a+
 | name        = Huge Growth
 | link        = Huge Growth
 | description = Unlocked a new item.
 | unlocked by = Increase in size 5 times in a single run via {{i|Magic Mushroom}}, "One Makes you Larger" pills, {{p|XI - Strength}}, etc.
 | id          = 361<br>{{plat|PS4}}&nbsp;352
}} {{infobox achievement
 | dlc         = a+
 | name        = Ancient Recall
 | link        = Ancient Recall
 | description = Unlocked a new item.
 | unlocked by = Use [[Cards and Runes]] 20 times
 | id          = 362<br>{{plat|PS4}}&nbsp;353
}} {{infobox achievement
 | dlc         = a+
 | name        = Era Walk
 | link        = Era Walk
 | description = Unlocked a new item.
 | unlocked by = Have both the {{i|Broken Watch}} and the {{i|Stop Watch}} unlocked
 | id          = 363<br>{{plat|PS4}}&nbsp;354
}} {{infobox achievement
 | dlc         = a+
 | name        = Coupon
 | link        = Coupon
 | description = Unlocked a new item.
 | unlocked by = Purchase anything from {{r|Shop}}s, {{r|Devil Room}}s, and/or {{r|Black Market}}s 50 times
 | id          = 364<br>{{plat|PS4}}&nbsp;355
}} {{infobox achievement
 | dlc         = a+
 | name        = Telekinesis
 | link        = Telekinesis
 | description = Unlocked a new item.
 | unlocked by = Beat [[Chapter 2]] without taking damage
 | id          = 365<br>{{plat|PS4}}&nbsp;356
}} {{infobox achievement
 | dlc         = a+
 | name        = Moving Box
 | link        = Moving Box
 | description = Unlocked a new item.
 | unlocked by = Use {{i|Pandora's Box}} in {{s|Dark Room}}
 | id          = 366<br>{{plat|PS4}}&nbsp;357
}} {{infobox achievement
 | dlc         = a+
 | name        = Jumper Cables
 | link        = Jumper Cables
 | description = Unlocked a new item.
 | unlocked by = Pick up any 2 of the following items/trinkets in a single run: {{i|9 Volt}}, {{i|The Battery}}, {{i|Car Battery|n}}, {{t|AAA Battery}}, and {{t|Watch Battery|n}} ({{dlc|r}} Any 2 items that have the [[Item Tags battery|'battery' item tag]])
 | id          = 367<br>{{plat|PS4}}&nbsp;358
}} {{infobox achievement
 | dlc         = a+
 | name        = Leprosy
 | link        = Leprosy
 | description = Unlocked a new item.
 | unlocked by = Beat [[Chapter 3]] without taking damage
 | id          = 368<br>{{plat|PS4}}&nbsp;359
}} {{infobox achievement
 | dlc         = a+
 | name        = Technology Zero
 | link        = Technology Zero
 | description = Unlocked a new item.
 | unlocked by = Pick up any 2 [[Tech (disambiguation)|technology]] items in a single run ({{dlc|r}} Any 2 items that have the [[Item Tags tech|'tech' item tag]])
 | id          = 369<br>{{plat|PS4}}&nbsp;360
}} {{infobox achievement
 | dlc         = a+
 | name        = Filigree Feather
 | link        = Filigree Feather
 | description = Unlocked a new item.
 | unlocked by = Acquire both {{i|Key Piece 1}} and {{i|Key Piece 2}}
 | id          = 370<br>{{plat|PS4}}&nbsp;361
}} {{infobox achievement
 | dlc         = a+
 | name        = Mr. ME!
 | link        = Mr. ME!
 | description = Unlocked a new item.
 | unlocked by = Open 20 [[Locked Chest]]s
 | id          = 371<br>{{plat|PS4}}&nbsp;362
}} {{infobox achievement
 | dlc         = a+
 | name        = 7 Seals
 | link        = 7 Seals
 | description = Unlocked a new item.
 | unlocked by = Defeat all 5 [[Harbinger]]s
 | id          = 372<br>{{plat|PS4}}&nbsp;363
}} {{infobox achievement
 | dlc         = a+
 | name        = Angelic Prism
 | link        = Angelic Prism
 | description = Unlocked a new item.
 | unlocked by = Defeat an [[Angel]] 10 times
 | id          = 373<br>{{plat|PS4}}&nbsp;364
}} {{infobox achievement
 | dlc         = a+
 | name        = Pop!
 | link        = Pop!
 | description = Unlocked a new item.
 | unlocked by = Beat [[Chapter 4]] without taking damage
 | id          = 374<br>{{plat|PS4}}&nbsp;365
}}{{infobox achievement
 | dlc         = a+
 | name        = Door Stop
 | link        = Door Stop
 | description = Unlocked a new item.
 | unlocked by = Blow up doors and {{r|Secret Room}} walls 50 times
 | id          = 375<br>{{plat|PS4}}&nbsp;366
}} {{infobox achievement
 | dlc         = a+
 | name        = Death's List
 | link        = Death's List
 | description = Unlocked a new item.
 | unlocked by = Take 25 [[Devil Room|Deals with the Devil]]
 | id          = 376
}} {{infobox achievement
 | dlc         = a+
 | name        = Haemolacria
 | link        = Haemolacria
 | description = Unlocked a new item.
 | unlocked by = Acquire {{i|Blood Clot}} 10 times
 | id          = 377
}} {{infobox achievement
 | dlc         = a+
 | name        = Lachryphagy
 | link        = Lachryphagy
 | description = Unlocked a new item.
 | unlocked by = Collect 10 "Tears Up" items or pills in one run
 | id          = 378
}} {{infobox achievement
 | dlc         = a+
 | name        = Schoolbag
 | link        = Schoolbag
 | description = Unlocked a new item.
 | unlocked by = Enter every {{r|Shop}} from [[Chapter 1]] through [[Chapter 3]] in one run
 | id          = 379
}} {{infobox achievement
 | dlc         = a+
 | name        = Trisagion
 | link        = Trisagion
 | description = Unlocked a new item.
 | unlocked by = Take 25 [[Angel Room (Item Pool)|Angel Rooms items]]
 | id          = 380
}} {{infobox achievement
 | dlc         = a+
 | name        = Extension Cord
 | link        = Extension Cord
 | description = Unlocked a new item.
 | unlocked by = Have {{i|The Battery}}, {{i|9 Volt}}, and {{i|Car Battery|n}} in Isaac's collection
 | id          = 381
}} {{infobox achievement
 | dlc         = a+
 | name        = Flat Stone
 | link        = Flat Stone
 | description = Unlocked a new item.
 | unlocked by = Acquire {{i|Rubber Cement}} 5 times
 | id          = 382
}} {{infobox achievement
 | dlc         = a+
 | name        = Sacrificial Altar
 | link        = Sacrificial Altar
 | description = Unlocked a new item.
 | unlocked by = Take 50 [[Devil Room|Deals with the Devil]]
 | id          = 383
}} {{infobox achievement
 | dlc         = a+
 | name        = Lil Spewer
 | link        = Lil Spewer
 | description = Unlocked a new item.
 | unlocked by = Have Isaac die to his own explosion from {{i|Ipecac}}, {{i|Bob's Rotten Head}}, or a [[Horf!]] pill
 | id          = 384
}} {{infobox achievement
 | dlc         = a+
 | name        = Blanket
 | link        = Blanket
 | description = Unlocked a new item.
 | unlocked by = Sleep in 10 [[bed]]s
 | id          = 385
}} {{infobox achievement
 | dlc         = a+
 | name        = Marbles
 | link        = Marbles
 | description = Unlocked a new item.
 | unlocked by = Use 5 [[Gulp!]] pills in one run ({{i|Placebo}} uses count)
 | id          = 386
}} {{infobox achievement
 | dlc         = a+
 | name        = Mystery Egg
 | link        = Mystery Egg
 | description = Unlocked a new item.
 | unlocked by = Spawn three charmed enemies in the same room
 | id          = 387
}} {{infobox achievement
 | dlc         = a+
 | name        = Rotten Penny
 | link        = Rotten Penny
 | description = Unlocked a new item.
 | unlocked by = Have 20 [[Blue Fly|Blue Flies]] at the same time
 | id          = 388
}} {{infobox achievement
 | dlc         = a+
 | name        = Baby-Bender
 | link        = Baby-Bender
 | description = Unlocked a new item.
 | unlocked by = Use {{p|I - The Magician}} or {{i|Telepathy for Dummies}} while already having [[homing tears]]
 | id          = 389
}} {{infobox achievement
 | dlc         = a+
 | name        = The Forgotten
 | link        = The Forgotten
 | description = Unlocked a new character.
 | unlocked by = [[The Forgotten#Unlocking the Forgotten|It's complicated]]
 | id          = 390
}} {{infobox achievement
 | dlc         = a+
 | name        = Bone Heart
 | link        = Hearts (Pickup)
 | description = Unlocked a new item.
 | unlocked by = [[The Forgotten#Unlocking the Forgotten|It's complicated]]
 | id          = 391
}} {{infobox achievement
 | dlc         = a+
 | name        = Marrow
 | link        = Marrow
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Mom's Heart]] or [[It Lives!]] on [[Hard mode]] as {{c|The Forgotten}}
 | id          = 392
}} {{infobox achievement
 | dlc         = a+
 | name        = Slipped Rib
 | link        = Slipped Rib
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|The Forgotten}}
 | id          = 393
}} {{infobox achievement
 | dlc         = a+
 | name        = Pointy Rib
 | link        = Pointy Rib
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Satan]] as {{c|The Forgotten}}
 | id          = 394
}} {{infobox achievement
 | dlc         = a+
 | name        = Jaw Bone
 | link        = Jaw Bone
 | description = Unlocked a new item.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|The Forgotten}}
 | id          = 395
}} {{infobox achievement
 | dlc         = a+
 | name        = Brittle Bones
 | link        = Brittle Bones
 | description = Unlocked a new item.
 | unlocked by = Defeat [[The Lamb]] as {{c|The Forgotten}}
 | id          = 396
}} {{infobox achievement
 | dlc         = a+
 | name        = Divorce Papers
 | link        = Divorce Papers
 | description = Unlocked a new item.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|The Forgotten}}
 | id          = 397
}} {{infobox achievement
 | dlc         = a+
 | name        = Hallowed Ground
 | link        = Hallowed Ground
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Hush]] as {{c|The Forgotten}}
 | id          = 398
}} {{infobox achievement
 | dlc         = a+
 | name        = Finger Bone
 | link        = Finger Bone
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|The Forgotten}}
 | id          = 399
}} {{infobox achievement
 | dlc         = a+
 | name        = Dad's Ring
 | link        = Dad's Ring
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|The Forgotten}}
 | id          = 400
}} {{infobox achievement
 | dlc         = a+
 | name        = Book of the Dead
 | link        = Book of the Dead
 | description = Unlocked a new item.
 | unlocked by = Defeat [[Delirium]] as {{c|The Forgotten}}
 | id          = 401
}} {{infobox achievement
 | dlc         = a+
 | name        = Bone Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|The Forgotten}}
 | id          = 402
}} {{infobox achievement
 | dlc         = a+
 | name        = Bound Baby
 | link        = Babies
 | description = Unlocked a new co-player baby.
 | unlocked by = Defeat [[Mega Satan]] as {{c|The Forgotten}}
 | id          = 403
}}
}}
=== [[The Binding of Isaac: Repentance|Repentance]] ===
{{table | achievement |
{{infobox achievement
 | dlc         = r
 | name        = Bethany
 | link        = Bethany
 | description = Beat Hard mode as Lazarus without losing a life
 | unlocked by = Defeat [[Mom's Heart]]/[[It Lives!]] on [[hard mode]] as {{c|Lazarus}}, without [[death|dying]] at all
 | id          = 404
}} {{infobox achievement
 | dlc         = r
 | name        = Jacob and Esau
 | link        = Jacob and Esau
 | description = You are just like your father...
 | unlocked by = Defeat [[Mother]]
 | id          = 405
}} {{infobox achievement
 | dlc         = r
 | name        = The Planetarium
 | link        = Planetarium
 | description = Kids shouldn't believe in fortunes...
 | unlocked by = Collect any 3 items with the [[Item Tags stars|'stars' item tag]] in a single run
 | id          = 406
}} {{infobox achievement
 | dlc         = r
 | name        = A Secret Exit
 | link        = Downpour
 | description = Complete ??? 3 times.
 | unlocked by = Defeat [[Hush]] 3 times
 | id          = 407
}} {{infobox achievement
 | dlc         = r
 | name        = Forgotten Lullaby
 | link        = Forgotten Lullaby
 | description = Get that song out of her head.
 | unlocked by = Blow up [[The Siren]]'s skull after defeating her
 | id          = 408
}} {{infobox achievement
 | dlc         = r
 | name        = Fruity Plum
 | link        = Fruity Plum
 | description = Defeat Baby Plum 10 times.
 | unlocked by = Defeat [[Baby Plum]] 10 times
 | id          = 409
}} {{infobox achievement
 | dlc         = r
 | name        = Plum Flute
 | link        = Plum Flute
 | description = Make a new friend!
 | unlocked by = Allow [[Baby Plum]] to escape instead of defeating her
 | id          = 410
}} {{infobox achievement
 | dlc         = r
 | name        = Rotten Heart
 | link        = Rotten Heart
 | description = Enter the Corpse...
 | unlocked by = Enter {{s|Corpse}} for the first time
 | id          = 411
}} {{infobox achievement
 | dlc         = r
 | name        = Dross
 | link        = Dross
 | description = Defeat all bosses in Downpour.
 | unlocked by = Defeat all bosses in {{s|Downpour}}
 | id          = 412
}} {{infobox achievement
 | dlc         = r
 | name        = Ashpit
 | link        = Ashpit
 | description = Defeat all bosses in the Mines.
 | unlocked by = Defeat all bosses in {{s|Mines}}
 | id          = 413
}} {{infobox achievement
 | dlc         = r
 | name        = Gehenna
 | link        = Gehenna
 | description = Defeat all bosses in the Mausoleum.
 | unlocked by = Defeat all bosses in {{s|Mausoleum}}
 | id          = 414
}} {{infobox achievement
 | dlc         = r
 | name        = Red Key
 | link        = Red Key
 | description = The other side is calling...
 | unlocked by = Open Mom's Chest in {{s|Home}}
 | id          = 415
}} {{infobox achievement
 | dlc         = r
 | name        = Wisp Baby
 | link        = Co-op#Repentance babies
 | description = Beat the game in Hard mode with Bethany.
 | unlocked by = Defeat [[Mom's Heart]] or [[It Lives!]] on [[Hard mode]] as {{c|Bethany}}
 | id          = 416
}} {{infobox achievement
 | dlc         = r
 | name        = Book of Virtues
 | link        = Book of Virtues
 | description = Complete the Cathedral with Bethany.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Bethany}}
 | id          = 417
}} {{infobox achievement
 | dlc         = r
 | name        = Urn of Souls
 | link        = Urn of Souls
 | description = Complete Sheol with Bethany.
 | unlocked by = Defeat [[Satan]] as {{c|Bethany}}
 | id          = 418
}} {{infobox achievement
 | dlc         = r
 | name        = Blessed Penny
 | link        = Blessed Penny
 | description = Complete the Chest with Bethany.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Bethany}}
 | id          = 419
}} {{infobox achievement
 | dlc         = r
 | name        = Alabaster Box
 | link        = Alabaster Box
 | description = Complete the Dark Room with Bethany.
 | unlocked by = Defeat [[The Lamb]] as {{c|Bethany}}
 | id          = 420
}} {{infobox achievement
 | dlc         = r
 | name        = Beth's Faith
 | link        = Beth's Faith
 | description = Complete Boss Rush with Bethany.
 | unlocked by = Complete the {{r|Boss Rush}} as {{c|Bethany}}
 | id          = 421
}} {{infobox achievement
 | dlc         = r
 | name        = Soul Locket
 | link        = Soul Locket
 | description = Beat Greed mode with Bethany.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Bethany}}
 | id          = 422
}} {{infobox achievement
 | dlc         = r
 | name        = Divine Intervention
 | link        = Divine Intervention
 | description = Complete ??? with Bethany.
 | unlocked by = Defeat [[Hush]] as {{c|Bethany}}
 | id          = 423
}} {{infobox achievement
 | dlc         = r
 | name        = Vade Retro
 | link        = Vade Retro
 | description = Beat Greedier mode with Bethany.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Bethany}}
 | id          = 424
}} {{infobox achievement
 | dlc         = r
 | name        = Star of Bethlehem
 | link        = Star of Bethlehem
 | description = Beat the Void with Bethany.
 | unlocked by = Defeat [[Delirium]] as {{c|Bethany}}
 | id          = 425
}} {{infobox achievement
 | dlc         = r
 | name        = Hope Baby
 | link        = Co-op#Repentance babies
 | description = Beat everything in Hard mode with Bethany.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Bethany}}
 | id          = 426
}} {{infobox achievement
 | dlc         = r
 | name        = Glowing Baby
 | link        = Co-op#Repentance babies
 | description = Defeat Mega Satan with Bethany.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Bethany}}
 | id          = 427
}} {{infobox achievement
 | dlc         = r
 | name        = Double Baby
 | link        = Co-op#Repentance babies
 | description = Beat the game in Hard mode with Jacob and Esau.
 | unlocked by = Defeat [[Mom's Heart]] or [[It Lives!]] on [[Hard mode]] as {{c|Jacob and Esau}}
 | id          = 428
}} {{infobox achievement
 | dlc         = r
 | name        = The Stairway
 | link        = The Stairway
 | description = Complete the Cathedral with Jacob and Esau.
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]] as {{c|Jacob and Esau}}
 | id          = 429
}} {{infobox achievement
 | dlc         = r
 | name        = Red Stew
 | link        = Red Stew
 | description = Complete Sheol with Jacob and Esau.
 | unlocked by = Defeat [[Satan]] as {{c|Jacob and Esau}}
 | id          = 430
}} {{infobox achievement
 | dlc         = r
 | name        = Birthright
 | link        = Birthright
 | description = Complete the Chest with Jacob and Esau.
 | unlocked by = Defeat [[??? (Boss)|???]] as {{c|Jacob and Esau}}
 | id          = 431
}} {{infobox achievement
 | dlc         = r
 | name        = Damocles
 | link        = Damocles
 | description = Complete the Dark Room with Jacob and Esau.
 | unlocked by = Defeat [[The Lamb]] as {{c|Jacob and Esau}}
 | id          = 432
}} {{infobox achievement
 | dlc         = r
 | name        = Rock Bottom
 | link        = Rock Bottom
 | description = Complete Boss Rush with Jacob and Esau.
 | unlocked by = Complete {{r|Boss Rush}} as {{c|Jacob and Esau}}
 | id          = 433
}} {{infobox achievement
 | dlc         = r
 | name        = Inner Child
 | link        = Inner Child
 | description = Beat Greed mode with Jacob and Esau.
 | unlocked by = Defeat [[Ultra Greed]] as {{c|Jacob and Esau}}
 | id          = 434
}} {{infobox achievement
 | dlc         = r
 | name        = Vanishing Twin
 | link        = Vanishing Twin
 | description = Complete ??? with Jacob and Esau.
 | unlocked by = Defeat [[Hush]] as {{c|Jacob and Esau}}
 | id          = 435
}} {{infobox achievement
 | dlc         = r
 | name        = Genesis
 | link        = Genesis
 | description = Beat Greedier mode with Jacob and Esau.
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Jacob and Esau}}
 | id          = 436
}} {{infobox achievement
 | dlc         = r
 | name        = Suplex!
 | link        = Suplex!
 | description = Complete the Void with Jacob and Esau.
 | unlocked by = Defeat [[Delirium]] as {{c|Jacob and Esau}}
 | id          = 437
}} {{infobox achievement
 | dlc         = r
 | name        = Solomon's Baby
 | link        = Co-op#Repentance babies
 | description = Beat everything in Hard mode with Jacob and Esau.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s as {{c|Jacob and Esau}}
 | id          = 438
}} {{infobox achievement
 | dlc         = r
 | name        = Illusion Baby
 | link        = Co-op#Repentance babies
 | description = Defeat Mega Satan with Jacob and Esau.
 | unlocked by = Defeat [[Mega Satan]] as {{c|Jacob and Esau}}
 | id          = 439
}} {{infobox achievement
 | dlc         = r
 | name        = Meat Cleaver
 | link        = Meat Cleaver
 | description = Complete the Corpse with Isaac.
 | unlocked by = Defeat [[Mother]] as {{c|Isaac}}
 | id          = 440
}} {{infobox achievement
 | dlc         = r
 | name        = Options?
 | link        = Options?
 | description = Complete the final chapter with Isaac.
 | unlocked by = Defeat [[The Beast]] as {{c|Isaac}}
 | id          = 441
}} {{infobox achievement
 | dlc         = r
 | name        = Yuck Heart
 | link        = Yuck Heart
 | description = Complete the Corpse with Magdalene.
 | unlocked by = Defeat [[Mother]] as {{c|Magdalene}}
 | id          = 442
}} {{infobox achievement
 | dlc         = r
 | name        = Candy Heart
 | link        = Candy Heart
 | description = Complete the final chapter with Magdalene.
 | unlocked by = Defeat [[The Beast]] as {{c|Magdalene}}
 | id          = 443
}} {{infobox achievement
 | dlc         = r
 | name        = Guppy's Eye
 | link        = Guppy's Eye
 | description = Complete the Corpse with Cain.
 | unlocked by = Defeat [[Mother]] as {{c|Cain}}
 | id          = 444
}} {{infobox achievement
 | dlc         = r
 | name        = A Pound of Flesh
 | link        = A Pound of Flesh
 | description = Complete the final chapter with Cain.
 | unlocked by = Defeat [[The Beast]] as {{c|Cain}}
 | id          = 445
}} {{infobox achievement
 | dlc         = r
 | name        = Akeldama
 | link        = Akeldama
 | description = Complete the Corpse with Judas.
 | unlocked by = Defeat [[Mother]] as {{c|Judas}}
 | id          = 446
}} {{infobox achievement
 | dlc         = r
 | name        = Redemption
 | link        = Redemption
 | description = Complete the final chapter with Judas.
 | unlocked by = Defeat [[The Beast]] as {{c|Judas}}
 | id          = 447
}} {{infobox achievement
 | dlc         = r
 | name        = Eternal D6
 | link        = Eternal D6
 | description = Complete the Corpse with ???.
 | unlocked by = Defeat [[Mother]] as {{c|???}}
 | id          = 448
}} {{infobox achievement
 | dlc         = r
 | name        = Montezuma's Revenge
 | link        = Montezuma's Revenge
 | description = Complete the final chapter with ???.
 | unlocked by = Defeat [[The Beast]] as {{c|???}}
 | id          = 449
}} {{infobox achievement
 | dlc         = r
 | name        = Bird Cage
 | link        = Bird Cage
 | description = Complete the Corpse with Eve.
 | unlocked by = Defeat [[Mother]] as {{c|Eve}}
 | id          = 450
}} {{infobox achievement
 | dlc         = r
 | name        = Cracked Orb
 | link        = Cracked Orb
 | description = Complete the final chapter with Eve.
 | unlocked by = Defeat [[The Beast]] as {{c|Eve}}
 | id          = 451
}} {{infobox achievement
 | dlc         = r
 | name        = Bloody Gust
 | link        = Bloody Gust
 | description = Complete the Corpse with Samson.
 | unlocked by = Defeat [[Mother]] as {{c|Samson}}
 | id          = 452
}} {{infobox achievement
 | dlc         = r
 | name        = Empty Heart
 | link        = Empty Heart
 | description = Complete the final chapter with Samson.
 | unlocked by = Defeat [[The Beast]] as {{c|Samson}}
 | id          = 453
}} {{infobox achievement
 | dlc         = r
 | name        = Devil's Crown
 | link        = Devil's Crown
 | description = Complete the Corpse with Azazel.
 | unlocked by = Defeat [[Mother]] as {{c|Azazel}}
 | id          = 454
}} {{infobox achievement
 | dlc         = r
 | name        = Lil Abaddon
 | link        = Lil Abaddon
 | description = Complete the final chapter with Azazel.
 | unlocked by = Defeat [[The Beast]] as {{c|Azazel}}
 | id          = 455
}} {{infobox achievement
 | dlc         = r
 | name        = Tinytoma
 | link        = Tinytoma
 | description = Complete the Corpse with Lazarus.
 | unlocked by = Defeat [[Mother]] as {{c|Lazarus}}
 | id          = 456
}} {{infobox achievement
 | dlc         = r
 | name        = Astral Projection
 | link        = Astral Projection
 | description = Complete the final chapter with Lazarus.
 | unlocked by = Defeat [[The Beast]] as {{c|Lazarus}}
 | id          = 457
}} {{infobox achievement
 | dlc         = r
 | name        =  'M
 | link        =  'M
 | description = Complete the Corpse with Eden.
 | unlocked by = Defeat [[Mother]] as {{c|Eden}}
 | id          = 458
}} {{infobox achievement
 | dlc         = r
 | name        = Everything Jar
 | link        = Everything Jar
 | description = Complete the final chapter with Eden.
 | unlocked by = Defeat [[The Beast]] as {{c|Eden}}
 | id          = 459
}} {{infobox achievement
 | dlc         = r
 | name        = Lost Soul
 | link        = Lost Soul
 | description = Complete the Corpse with the Lost.
 | unlocked by = Defeat [[Mother]] as {{c|The Lost}}
 | id          = 460
}} {{infobox achievement
 | dlc         = r
 | name        = Hungry Soul
 | link        = Hungry Soul
 | description = Complete the final chapter with the Lost.
 | unlocked by = Defeat [[The Beast]] as {{c|The Lost}}
 | id          = 461
}} {{infobox achievement
 | dlc         = r
 | name        = Blood Puppy
 | link        = Blood Puppy
 | description = Complete the Corpse with Lilith.
 | unlocked by = Defeat [[Mother]] as {{c|Lilith}}
 | id          = 462
}} {{infobox achievement
 | dlc         = r
 | name        = C Section
 | link        = C Section
 | description = Complete the final chapter with Lilith.
 | unlocked by = Defeat [[The Beast]] as {{c|Lilith}}
 | id          = 463
}} {{infobox achievement
 | dlc         = r
 | name        = Keeper's Sack
 | link        = Keeper's Sack
 | description = Complete the Corpse with Keeper.
 | unlocked by = Defeat [[Mother]] as {{c|Keeper}}
 | id          = 464
}} {{infobox achievement
 | dlc         = r
 | name        = Keeper's Box
 | link        = Keeper's Box
 | description = Complete the final chapter with Keeper.
 | unlocked by = Defeat [[The Beast]] as {{c|Keeper}}
 | id          = 465
}} {{infobox achievement
 | dlc         = r
 | name        = Lil Portal
 | link        = Lil Portal
 | description = Complete the Corpse with Apollyon.
 | unlocked by = Defeat [[Mother]] as {{c|Apollyon}}
 | id          = 466
}} {{infobox achievement
 | dlc         = r
 | name        = Worm Friend
 | link        = Worm Friend
 | description = Complete the final chapter with Apollyon.
 | unlocked by = Defeat [[The Beast]] as {{c|Apollyon}}
 | id          = 467
}} {{infobox achievement
 | dlc         = r
 | name        = Bone Spurs
 | link        = Bone Spurs
 | description = Complete the Corpse with the Forgotten.
 | unlocked by = Defeat [[Mother]] as {{c|The Forgotten}}
 | id          = 468
}} {{infobox achievement
 | dlc         = r
 | name        = Spirit Shackles
 | link        = Spirit Shackles
 | description = Complete the final chapter with the Forgotten.
 | unlocked by = Defeat [[The Beast]] as {{c|The Forgotten}}
 | id          = 469
}} {{infobox achievement
 | dlc         = r
 | name        = Revelation
 | link        = Revelation
 | description = Complete the Corpse with Bethany.
 | unlocked by = Defeat [[Mother]] as {{c|Bethany}}
 | id          = 470
}} {{infobox achievement
 | dlc         = r
 | name        = Jar of Wisps
 | link        = Jar of Wisps
 | description = Complete the final chapter with Bethany.
 | unlocked by = Defeat [[The Beast]] as {{c|Bethany}}
 | id          = 471
}} {{infobox achievement
 | dlc         = r
 | name        = Magic Skin
 | link        = Magic Skin
 | description = Complete the Corpse with Jacob and Esau.
 | unlocked by = Defeat [[Mother]] as {{c|Jacob and Esau}}
 | id          = 472
}} {{infobox achievement
 | dlc         = r
 | name        = Friend Finder
 | link        = Friend Finder
 | description = Complete the final chapter with Jacob and Esau.
 | unlocked by = Defeat [[The Beast]] as {{c|Jacob and Esau}}
 | id          = 473
}} {{infobox achievement
 | dlc         = r
 | name        = The Broken
 | link        = Tainted Isaac
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Isaac}}
 | id          = 474
}} {{infobox achievement
 | dlc         = r
 | name        = The Dauntless
 | link        = Tainted Magdalene
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Magdalene}}
 | id          = 475
}} {{infobox achievement
 | dlc         = r
 | name        = The Hoarder
 | link        = Tainted Cain
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Cain}}
 | id          = 476
}} {{infobox achievement
 | dlc         = r
 | name        = The Deceiver
 | link        = Tainted Judas
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Judas}}
 | id          = 477
}} {{infobox achievement
 | dlc         = r
 | name        = The Soiled
 | link        = Tainted ???
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|???}}
 | id          = 478
}} {{infobox achievement
 | dlc         = r
 | name        = The Curdled
 | link        = Tainted Eve
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Eve}}
 | id          = 479
}} {{infobox achievement
 | dlc         = r
 | name        = The Savage
 | link        = Tainted Samson
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Samson}}
 | id          = 480
}} {{infobox achievement
 | dlc         = r
 | name        = The Benighted
 | link        = Tainted Azazel
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Azazel}}
 | id          = 481
}} {{infobox achievement
 | dlc         = r
 | name        = The Enigma
 | link        = Tainted Lazarus
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Lazarus}}
 | id          = 482
}} {{infobox achievement
 | dlc         = r
 | name        = The Capricious
 | link        = Tainted Eden
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Eden}}
 | id          = 483
}} {{infobox achievement
 | dlc         = r
 | name        = The Baleful
 | link        = Tainted Lost
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|The Lost}}
 | id          = 484
}} {{infobox achievement
 | dlc         = r
 | name        = The Harlot
 | link        = Tainted Lilith
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Lilith}}
 | id          = 485
}} {{infobox achievement
 | dlc         = r
 | name        = The Miser
 | link        = Tainted Keeper
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Keeper}}
 | id          = 486
}} {{infobox achievement
 | dlc         = r
 | name        = The Empty
 | link        = Tainted Apollyon
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Apollyon}}
 | id          = 487
}} {{infobox achievement
 | dlc         = r
 | name        = The Fettered
 | link        = Tainted Forgotten
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|The Forgotten}}
 | id          = 488
}} {{infobox achievement
 | dlc         = r
 | name        = The Zealot
 | link        = Tainted Bethany
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Bethany}}
 | id          = 489
}} {{infobox achievement
 | dlc         = r
 | name        = The Deserter
 | link        = Tainted Jacob
 | description = ???
 | unlocked by = Use {{i|Red Key|n}} or a {{p|Cracked Key|n}} to open the hidden closet in {{s|Home}} as {{c|Jacob and Esau}}
 | id          = 490
}} {{infobox achievement
 | dlc         = r
 | name        = Glitched Crown
 | link        = Glitched Crown
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Isaac}}
 | id          = 491
}} {{infobox achievement
 | dlc         = r
 | name        = Belly Jelly
 | link        = Belly Jelly
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Magdalene}}
 | id          = 492
}} {{infobox achievement
 | dlc         = r
 | name        = Blue Key
 | link        = Blue Key
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Cain}}
 | id          = 493
}} {{infobox achievement
 | dlc         = r
 | name        = Sanguine Bond
 | link        = Sanguine Bond
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Judas}}
 | id          = 494
}} {{infobox achievement
 | dlc         = r
 | name        = The Swarm
 | link        = The Swarm
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted ???}}
 | id          = 495
}} {{infobox achievement
 | dlc         = r
 | name        = Heartbreak
 | link        = Heartbreak
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Eve}}
 | id          = 496
}} {{infobox achievement
 | dlc         = r
 | name        = Larynx
 | link        = Larynx
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Samson}}
 | id          = 497
}} {{infobox achievement
 | dlc         = r
 | name        = Azazel's Rage
 | link        = Azazel's Rage
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Azazel}}
 | id          = 498
}} {{infobox achievement
 | dlc         = r
 | name        = Salvation
 | link        = Salvation
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Lazarus}}
 | id          = 499
}} {{infobox achievement
 | dlc         = r
 | name        = TMTRAINER
 | link        = TMTRAINER
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Eden}}
 | id          = 500
}} {{infobox achievement
 | dlc         = r
 | name        = Sacred Orb
 | link        = Sacred Orb
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Lost}}
 | id          = 501
}} {{infobox achievement
 | dlc         = r
 | name        = Twisted Pair
 | link        = Twisted Pair
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Lilith}}
 | id          = 502
}} {{infobox achievement
 | dlc         = r
 | name        = Strawman
 | link        = Strawman
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Keeper}}
 | id          = 503
}} {{infobox achievement
 | dlc         = r
 | name        = Echo Chamber
 | link        = Echo Chamber
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Apollyon}}
 | id          = 504
}} {{infobox achievement
 | dlc         = r
 | name        = Isaac's Tomb
 | link        = Isaac's Tomb
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Forgotten}}
 | id          = 505
}} {{infobox achievement
 | dlc         = r
 | name        = Vengeful Spirit
 | link        = Vengeful Spirit
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Bethany}}
 | id          = 506
}} {{infobox achievement
 | dlc         = r
 | name        = Esau Jr.
 | link        = Esau Jr.
 | description = ???
 | unlocked by = Defeat [[The Beast]] as {{c|Tainted Jacob}}
 | id          = 507
}} {{infobox achievement
 | dlc         = r
 | name        = Bloody Mary
 | link        = Bloody Mary
 | description = Unlocked a new challenge.
 | unlocked by = Unlock {{c|Bethany}}, {{i|Blood Bag}}, and [[It Lives!]]
 | id          = 508
}} {{infobox achievement
 | dlc         = r
 | name        = Baptism by Fire
 | link        = Baptism by Fire
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Satan]] as {{c|Bethany}}, defeat [[Mom's Heart]] 11 times, and unlock {{t|Maggy's Faith}}
 | id          = 509
}} {{infobox achievement
 | dlc         = r
 | name        = Isaac's Awakening
 | link        = Isaac's Awakening
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mother]]
 | id          = 510
}} {{infobox achievement
 | dlc         = r
 | name        = Seeing Double
 | link        = Seeing Double
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mother]]
 | id          = 511
}} {{infobox achievement
 | dlc         = r
 | name        = Pica Run
 | link        = Pica Run
 | description = Unlocked a new challenge.
 | unlocked by = Defeat [[Mom's Heart]] 11 times and unlock {{i|Marbles}}
 | id          = 512
}} {{infobox achievement
 | dlc         = r
 | name        = Hot Potato
 | link        = Hot Potato
 | description = Unlocked a new challenge.
 | unlocked by = Unlock {{c|Tainted Forgotten}}
 | id          = 513
}} {{infobox achievement
 | dlc         = r
 | name        = Cantripped!
 | link        = Cantripped!
 | description = Unlocked a new challenge.
 | unlocked by = Unlock {{c|Tainted Cain}}
 | id          = 514
}} {{infobox achievement
 | dlc         = r
 | name        = Red Redemption
 | link        = Red Redemption
 | description = Unlocked a new challenge.
 | unlocked by = Unlock {{c|Tainted Jacob}}
 | id          = 515
}} {{infobox achievement
 | dlc         = r
 | name        = DELETE THIS
 | link        = DELETE THIS
 | description = TODO: remove this achievement
 | unlocked by = Unlock {{c|Tainted Eden}}
 | id          = 516
}} {{infobox achievement
 | dlc         = r
 | name        = Dirty Mind
 | link        = Dirty Mind
 | description = Complete Challenge 36.
 | unlocked by = Complete [[Scat Man|Scat Man (challenge #36)]]
 | id          = 517
}} {{infobox achievement
 | dlc         = r
 | name        = Sigil of Baphomet
 | link        = Sigil of Baphomet
 | description = Complete Challenge 37.
 | unlocked by = Complete [[Bloody Mary|Bloody Mary (challenge #37)]]
 | id          = 518
}} {{infobox achievement
 | dlc         = r
 | name        = Purgatory
 | link        = Purgatory
 | description = Complete Challenge 38.
 | unlocked by = Complete [[Baptism by Fire|Baptism by Fire (challenge #38)]]
 | id          = 519
}} {{infobox achievement
 | dlc         = r
 | name        = Spirit Sword
 | link        = Spirit Sword
 | description = Complete Challenge 39.
 | unlocked by = Complete [[Isaac's Awakening|Isaac's Awakening (challenge #39)]]
 | id          = 520
}} {{infobox achievement
 | dlc         = r
 | name        = Broken Glasses
 | link        = Broken Glasses
 | description = Complete Challenge 40.
 | unlocked by = Complete [[Seeing Double|Seeing Double (challenge #40)]]
 | id          = 521
}} {{infobox achievement
 | dlc         = r
 | name        = Ice Cube
 | link        = Ice Cube
 | description = Complete Challenge 41.
 | unlocked by = Complete [[Pica Run|Pica Run (challenge #41)]]
 | id          = 522
}} {{infobox achievement
 | dlc         = r
 | name        = Charged Penny
 | link        = Charged Penny
 | description = They will charge you up... for a small fee.
 | unlocked by = Donate to [[Battery Bum]]s until they pay out with an [[Battery Bum (Item Pool)|item]] 5 times
 | id          = 523
}} {{infobox achievement
 | dlc         = r
 | name        = The Fool
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Lost}}
 | id          = 524
}} {{infobox achievement
 | dlc         = r
 | name        = The Magician
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Judas}}
 | id          = 525
}} {{infobox achievement
 | dlc         = r
 | name        = The High Priestess
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Lilith}}
 | id          = 526
}} {{infobox achievement
 | dlc         = r
 | name        = The Empress
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Eve}}
 | id          = 527
}} {{infobox achievement
 | dlc         = r
 | name        = The Emperor
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted ???}}
 | id          = 528
}} {{infobox achievement
 | dlc         = r
 | name        = The Hierophant
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Bethany}}
 | id          = 529
}} {{infobox achievement
 | dlc         = r
 | name        = The Lovers
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Magdalene}}
 | id          = 530
}} {{infobox achievement
 | dlc         = r
 | name        = The Chariot
 | link        = Reverse tarot cards
 | description = Complete Challenge 42.
 | unlocked by = Complete [[Hot Potato|Hot Potato (challenge #42)]]
 | id          = 531
}} {{infobox achievement
 | dlc         = r
 | name        = Justice
 | link        = Reverse tarot cards
 | description = Complete Challenge 43.
 | unlocked by = Complete [[Cantripped!|Cantripped (challenge #43)]]
 | id          = 532
}} {{infobox achievement
 | dlc         = r
 | name        = The Hermit
 | link        = Reverse tarot cards
 | description = Complete Challenge 44.
 | unlocked by = Complete [[Red Redemption|Red Redemption (challenge #44)]]
 | id          = 533
}} {{infobox achievement
 | dlc         = r
 | name        = Wheel of Fortune
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Cain}}
 | id          = 534
}} {{infobox achievement
 | dlc         = r
 | name        = Strength
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Samson}}
 | id          = 535
}} {{infobox achievement
 | dlc         = r
 | name        = The Hanged Man
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Keeper}}
 | id          = 536
}} {{infobox achievement
 | dlc         = r
 | name        = Death
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Forgotten}}
 | id          = 537
}} {{infobox achievement
 | dlc         = r
 | name        = Temperance
 | link        = Reverse tarot cards
 | description = INVALID_DESCRIPTION
 | unlocked by = Complete [[DELETE THIS|DELETE THIS (challenge #45)]]
 | id          = 538
}} {{infobox achievement
 | dlc         = r
 | name        = The Devil
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Azazel}}
 | id          = 539
}} {{infobox achievement
 | dlc         = r
 | name        = The Tower
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Apollyon}}
 | id          = 540
}} {{infobox achievement
 | dlc         = r
 | name        = The Stars
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Isaac}}
 | id          = 541
}} {{infobox achievement
 | dlc         = r
 | name        = The Sun and the Moon
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Jacob}}
 | id          = 542
}} {{infobox achievement
 | dlc         = r
 | name        = Judgement
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Lazarus}}
 | id          = 543
}} {{infobox achievement
 | dlc         = r
 | name        = The World
 | link        = Reverse tarot cards
 | description = ???
 | unlocked by = Defeat [[Ultra Greedier]] as {{c|Tainted Eden}}
 | id          = 544
}} {{infobox achievement
 | dlc         = r
 | name        = Old Capacitor
 | link        = Old Capacitor
 | description = Kill 10 Battery Bums.
 | unlocked by = Kill 10 [[Battery Bum]]s
 | id          = 545
}} {{infobox achievement
 | dlc         = r
 | name        = Brimstone Bombs
 | link        = Brimstone Bombs
 | description = Kill Hornfel before he escapes!
 | unlocked by = After breaking [[Hornfel]]'s minecart, kill him before he can escape 
 | id          = 546
}} {{infobox achievement
 | dlc         = r
 | name        = Mega Mush
 | link        = Mega Mush
 | description = Beat everything in Hard Mode as every character.
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s for all non-Tainted [[characters]]
 | id          = 547
}} {{infobox achievement
 | dlc         = r
 | name        = Mom's Lock
 | link        = Mom's Lock
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Isaac}}
 | id          = 548
}} {{infobox achievement
 | dlc         = r
 | name        = Dice Bag
 | link        = Dice Bag
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Isaac}}
 | id          = 549
}} {{infobox achievement
 | dlc         = r
 | name        = Holy Crown
 | link        = Holy Crown
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Magdalene}}
 | id          = 550
}} {{infobox achievement
 | dlc         = r
 | name        = Mother's Kiss
 | link        = Mother's Kiss
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Magdalene}}
 | id          = 551
}} {{infobox achievement
 | dlc         = r
 | name        = Gilded Key
 | link        = Gilded Key
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Cain}}
 | id          = 552
}} {{infobox achievement
 | dlc         = r
 | name        = Lucky Sack
 | link        = Lucky Sack
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Cain}}
 | id          = 553
}} {{infobox achievement
 | dlc         = r
 | name        = Your Soul
 | link        = Your Soul
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Judas}}
 | id          = 554
}} {{infobox achievement
 | dlc         = r
 | name        = Number Magnet
 | link        = Number Magnet
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Judas}}
 | id          = 555
}} {{infobox achievement
 | dlc         = r
 | name        = Dingle Berry
 | link        = Dingle Berry
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted ???}}
 | id          = 556
}} {{infobox achievement
 | dlc         = r
 | name        = Ring Cap
 | link        = Ring Cap
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted ???}}
 | id          = 557
}} {{infobox achievement
 | dlc         = r
 | name        = Strange Key
 | link        = Strange Key
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Eve}}
 | id          = 558
}} {{infobox achievement
 | dlc         = r
 | name        = Lil Clot
 | link        = Lil Clot
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Eve}}
 | id          = 559
}} {{infobox achievement
 | dlc         = r
 | name        = Temporary Tattoo
 | link        = Temporary Tattoo
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Samson}}
 | id          = 560
}} {{infobox achievement
 | dlc         = r
 | name        = Swallowed M80
 | link        = Swallowed M80
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Samson}}
 | id          = 561
}} {{infobox achievement
 | dlc         = r
 | name        = Wicked Crown
 | link        = Wicked Crown
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Azazel}}
 | id          = 562
}} {{infobox achievement
 | dlc         = r
 | name        = Azazel's Stump
 | link        = Azazel's Stump
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Azazel}}
 | id          = 563
}} {{infobox achievement
 | dlc         = r
 | name        = Torn Pocket
 | link        = Torn Pocket
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Lazarus}}
 | id          = 564
}} {{infobox achievement
 | dlc         = r
 | name        = Torn Card
 | link        = Torn Card
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Lazarus}}
 | id          = 565
}} {{infobox achievement
 | dlc         = r
 | name        = Nuh Uh!
 | link        = Nuh Uh!
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Eden}}
 | id          = 566
}} {{infobox achievement
 | dlc         = r
 | name        = Modeling Clay
 | link        = Modeling Clay
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Eden}}
 | id          = 567
}} {{infobox achievement
 | dlc         = r
 | name        = Kid's Drawing
 | link        = Kid's Drawing
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Lost}}
 | id          = 568
}} {{infobox achievement
 | dlc         = r
 | name        = Crystal Key
 | link        = Crystal Key
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Lost}}
 | id          = 569
}} {{infobox achievement
 | dlc         = r
 | name        = The Twins
 | link        = The Twins
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Lilith}}
 | id          = 570
}} {{infobox achievement
 | dlc         = r
 | name        = Adoption Papers
 | link        = Adoption Papers
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Lilith}}
 | id          = 571
}} {{infobox achievement
 | dlc         = r
 | name        = Keeper's Bargain
 | link        = Keeper's Bargain
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Keeper}}
 | id          = 572
}} {{infobox achievement
 | dlc         = r
 | name        = Cursed Penny
 | link        = Cursed Penny
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Keeper}}
 | id          = 573
}} {{infobox achievement
 | dlc         = r
 | name        = Cricket Leg
 | link        = Cricket Leg
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Apollyon}}
 | id          = 574
}} {{infobox achievement
 | dlc         = r
 | name        = Apollyon's Best Friend
 | link        = Apollyon's Best Friend
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Apollyon}}
 | id          = 575
}} {{infobox achievement
 | dlc         = r
 | name        = Polished Bone
 | link        = Polished Bone
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Forgotten}}
 | id          = 576
}} {{infobox achievement
 | dlc         = r
 | name        = Hollow Heart
 | link        = Hollow Heart
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Forgotten}}
 | id          = 577
}} {{infobox achievement
 | dlc         = r
 | name        = Expansion Pack
 | link        = Expansion Pack
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Bethany}}
 | id          = 578
}} {{infobox achievement
 | dlc         = r
 | name        = Beth's Essence
 | link        = Beth's Essence
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Bethany}}
 | id          = 579
}} {{infobox achievement
 | dlc         = r
 | name        = RC Remote
 | link        = RC Remote
 | description = ???
 | unlocked by = Defeat [[Isaac (Boss)|Isaac]], [[??? (Boss)|???]], [[Satan]], and [[The Lamb]] as {{c|Tainted Jacob}}
 | id          = 580
}} {{infobox achievement
 | dlc         = r
 | name        = Found Soul
 | link        = Found Soul
 | description = ???
 | unlocked by = Defeat [[Mother]] as {{c|Tainted Jacob}}
 | id          = 581
}} {{infobox achievement
 | dlc         = r
 | name        = Member Card
 | link        = Member Card
 | description = Spend 40+ pennies in a single shop.
 | unlocked by = Spend 40+ coins in a single {{r|Shop}}
 | id          = 582
}} {{infobox achievement
 | dlc         = r
 | name        = Golden Razor
 | link        = Golden Razor
 | description = Obtain 99 pennies. Then spend every single one of them.
 | unlocked by = In a single run, obtain 99 Coins, then spend all of them. 
 | id          = 583
}} {{infobox achievement
 | dlc         = r
 | name        = Spindown Dice
 | link        = Spindown Dice
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Isaac}}
 | id          = 584
}} {{infobox achievement
 | dlc         = r
 | name        = Hypercoagulation
 | link        = Hypercoagulation
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Magdalene}}
 | id          = 585
}} {{infobox achievement
 | dlc         = r
 | name        = Bag of Crafting
 | link        = Bag of Crafting
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Cain}}
 | id          = 586
}} {{infobox achievement
 | dlc         = r
 | name        = Dark Arts
 | link        = Dark Arts
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Judas}}
 | id          = 587
}} {{infobox achievement
 | dlc         = r
 | name        = IBS
 | link        = IBS
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted ???}}
 | id          = 588
}} {{infobox achievement
 | dlc         = r
 | name        = Sumptorium
 | link        = Sumptorium
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Eve}}
 | id          = 589
}} {{infobox achievement
 | dlc         = r
 | name        = Berserk!
 | link        = Berserk!
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Samson}}
 | id          = 590
}} {{infobox achievement
 | dlc         = r
 | name        = Hemoptysis
 | link        = Hemoptysis
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Azazel}}
 | id          = 591
}} {{infobox achievement
 | dlc         = r
 | name        = Flip
 | link        = Flip
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Lazarus}}
 | id          = 592
}} {{infobox achievement
 | dlc         = r
 | name        = Corrupted Data
 | link        = Corrupted Data
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Eden}}
 | id          = 593
}} {{infobox achievement
 | dlc         = r
 | name        = Ghost Bombs
 | link        = Ghost Bombs
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Lost}}
 | id          = 594
}} {{infobox achievement
 | dlc         = r
 | name        = Gello
 | link        = Gello
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Lilith}}
 | id          = 595
}} {{infobox achievement
 | dlc         = r
 | name        = Keeper's Kin
 | link        = Keeper's Kin
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Keeper}}
 | id          = 596
}} {{infobox achievement
 | dlc         = r
 | name        = Abyss
 | link        = Abyss
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Apollyon}}
 | id          = 597
}} {{infobox achievement
 | dlc         = r
 | name        = Decap Attack
 | link        = Decap Attack
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Forgotten}}
 | id          = 598
}} {{infobox achievement
 | dlc         = r
 | name        = Lemegeton
 | link        = Lemegeton
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Bethany}}
 | id          = 599
}} {{infobox achievement
 | dlc         = r
 | name        = Anima Sola
 | link        = Anima Sola
 | description = ???
 | unlocked by = Defeat [[Delirium]] as {{c|Tainted Jacob}}
 | id          = 600
}} {{infobox achievement
 | dlc         = r
 | name        = Mega Chest
 | link        = Mega Chest
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Isaac}}
 | id          = 601
}} {{infobox achievement
 | dlc         = r
 | name        = Queen of Hearts
 | link        = Queen of Hearts
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Magdalene}}
 | id          = 602
}} {{infobox achievement
 | dlc         = r
 | name        = Gold Pill
 | link        = Pills
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Cain}}
 | id          = 603
}} {{infobox achievement
 | dlc         = r
 | name        = Black Sack
 | link        = Black Sack
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Judas}}
 | id          = 604
}} {{infobox achievement
 | dlc         = r
 | name        = Charming Poop
 | link        = Charming Poop
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted ???}}
 | id          = 605
}} {{infobox achievement
 | dlc         = r
 | name        = Horse Pill
 | link        = Pills
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Eve}}
 | id          = 606
}} {{infobox achievement
 | dlc         = r
 | name        = Crane Game
 | link        = Crane Game
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Samson}}
 | id          = 607
}} {{infobox achievement
 | dlc         = r
 | name        = Hell Game
 | link        = Hell Game
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Azazel}}
 | id          = 608
}} {{infobox achievement
 | dlc         = r
 | name        = Wooden Chest
 | link        = Wooden Chest
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Lazarus}}
 | id          = 609
}} {{infobox achievement
 | dlc         = r
 | name        = Wild Card
 | link        = Wild Card
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Eden}}
 | id          = 610
}} {{infobox achievement
 | dlc         = r
 | name        = Haunted Chest
 | link        = Haunted Chest
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Lost}}
 | id          = 611
}} {{infobox achievement
 | dlc         = r
 | name        = Fool's Gold
 | link        = Fool's Gold
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Lilith}}
 | id          = 612
}} {{infobox achievement
 | dlc         = r
 | name        = Golden Penny
 | link        = Golden Penny
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Keeper}}
 | id          = 613
}} {{infobox achievement
 | dlc         = r
 | name        = Rotten Beggar
 | link        = Rotten Beggar
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Apollyon}}
 | id          = 614
}} {{infobox achievement
 | dlc         = r
 | name        = Golden Battery
 | link        = Golden Battery
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Forgotten}}
 | id          = 615
}} {{infobox achievement
 | dlc         = r
 | name        = Confessional
 | link        = Confessional
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Bethany}}
 | id          = 616
}} {{infobox achievement
 | dlc         = r
 | name        = Golden Trinket
 | link        = Golden Trinket
 | description = ???
 | unlocked by = Defeat [[Mega Satan]] as {{c|Tainted Jacob}}
 | id          = 617
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Isaac
 | link        = Soul of Isaac
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Isaac}}
 | id          = 618
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Magdalene
 | link        = Soul of Magdalene
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Magdalene}}
 | id          = 619
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Cain
 | link        = Soul of Cain
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Cain}}
 | id          = 620
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Judas
 | link        = Soul of Judas
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Judas}}
 | id          = 621
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of ???
 | link        = Soul of ???
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted ???}}
 | id          = 622
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Eve
 | link        = Soul of Eve
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Eve}}
 | id          = 623
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Samson
 | link        = Soul of Samson
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Samson}}
 | id          = 624
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Azazel
 | link        = Soul of Azazel
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Azazel}}
 | id          = 625
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Lazarus
 | link        = Soul of Lazarus
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Lazarus}}
 | id          = 626
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Eden
 | link        = Soul of Eden
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Eden}}
 | id          = 627
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of the Lost
 | link        = Soul of the Lost
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Lost}}
 | id          = 628
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Lilith
 | link        = Soul of Lilith
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Lilith}}
 | id          = 629
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of the Keeper
 | link        = Soul of the Keeper
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Keeper}}
 | id          = 630
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Apollyon
 | link        = Soul of Apollyon
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Apollyon}}
 | id          = 631
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of the Forgotten
 | link        = Soul of the Forgotten
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Forgotten}}
 | id          = 632
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Bethany
 | link        = Soul of Bethany
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Bethany}}
 | id          = 633
}} {{infobox achievement
 | dlc         = r
 | name        = Soul of Jacob and Esau
 | link        = Soul of Jacob and Esau
 | description = ???
 | unlocked by = Defeat [[Hush]] and {{r|Boss Rush}} as {{c|Tainted Jacob}}
 | id          = 634
}} {{infobox achievement
 | dlc         = r
 | name        = A Strange Door
 | link        = A Strange Door
 | description = Where could it lead to?
 | unlocked by = Defeat [[Mother]]
 | id          = 635
}} {{infobox achievement
 | dlc         = r
 | name        = Death Certificate
 | link        = Death Certificate
 | description = ...
 | unlocked by = Earn all [[Hard mode]] [[Completion Mark]]s for all [[characters]], including tainted ones
 | id          = 636
}} {{infobox achievement
 | dlc         = r
 | name        = Dead God
 | description = 
 | unlocked by = Unlock all the other achievements and [[Collection Page (Repentance)|collect]] every item in the game
 | id          = 637
}}
}}

== PlayStation Trophies ==
{{trophy list}}

== Trivia ==
* Each achievement is color-coded based on the requirements for unlocking their respective secrets:
** Tan: Miscellaneous unlocks
** Tan with blood stain: [[Mom's Heart]]/[[It Lives!]] [[Hard Mode]] unlocks
** Olive-Green: Character unlocks
** Dark Red: Mom's Heart/{{s|Womb}} ending unlocks
** Grey: [[Isaac (Boss)|Isaac]] unlocks
** Black: [[Satan]] unlocks
** Dark Blue: [[??? (Boss)|???]] unlocks
** Purple: [[The Lamb]] unlocks
** Pale Green: {{r|Boss Rush}} unlocks
** Pale Blue: [[Hush]] unlocks
** Orange Yellow: [[Greed Mode]] unlocks
** Orange Yellow with blood stain: [[Greedier mode]] unlocks
** White: [[Delirium]] unlocks
** Red: [[Mega Satan]] unlocks
** Bright Yellow: All [[Hard Mode]] marks (most are tan)/Damageless floor/100% unlocks
** Brighter Yellow: [[Greed Donation Machine]] unlocks
** Bluish Purple: [[Challenge]] unlocks
** Dark Green with bloodstain: [[Mother]] unlocks
** Orange: [[The Beast]] unlocks
** Bright Purple: Tainted Character unlocks
* Despite being a Boss Rush unlock for {{c|Lazarus}}, {{i|Missing No.}}'s achievement color is bluish purple, a color normally used for challenge-related unlocks.
* Achievements 37-41 and 83 have a typo on their pop-ups, and read "achieveved".
* {{dlc|a+}} Although not technically an achievement, getting 1000000% for all 3 [[Save File Completion|save files]] will result in a special 3,000,000%!!! [[Savefile Images|graphic on the save file]] selection screen.
* {{dlc|a+}} The 5 Nights at Mom's achievement is a reference to [[wikipedia:Five Nights at Freddy's (series)|Five Nights at Freddy's]].
* {{dlc|a+}} The Mr. Resetter achievement may be a reference to Mr. Resetti from the [[wikipedia:Animal Crossing|Animal Crossing]] series.
* {{dlc|a+}} The Something Wicked This Way Comes quote is most likely a reference to the same quote from one of the witches from Shakespeare's play "Macbeth."
* {{dlc|a+}} [[Booster Pack #5]] added 64 secrets. Interestingly, this is a single secret more than Afterbirth+'s original count of 63 secrets. Thus, this update more than doubled the amount of secrets added to the game.
* {{plat|PS4}} {{dlc|a+}} Achievements 340-348 don't exist in the PS4 version, resulting in the content already being "unlocked" even on new save files.

== Bugs ==
{{bug|dlc=r|{{Achievement|The Marathon}}, which unlocks {{t|Cracked Crown}}, is currently unattainable: the wins are not counted properly. It can still be achieved in Afterbirth+ and transferred over to a Repentance save file.}}
{{bug|dlc=r|{{i|Clear Rune}} must be unlocked and collected to attain {{Achievement|!Platinum God!}} and {{Achievement|The Real Platinum God}} despite being a Repentance item. This is likely due to its ID being in the range of Rebirth items.}}

{{nav|fr=Succès}}