Binding of Isaac: Rebirth Wiki

A Card Against Humanity is a special card.

Effect[ | ]

  • Fills the entire room with PoopPoop.

Notes[ | ]

  • Poop will not fill tiles with obstacles, even if they have already been destroyed.
  • The process is not instant and the room will not get fully filled if Isaac leaves before it's done filling.
  • It is more beneficial to use the card in a large-sized room as it will create more poop piles.
  • (in Afterbirth † and Repentance) Using A Card Against Humanity in the Boss Ultra Greedier ingameUltra Greedier fight will result in Golden PoopGolden Poops spawning after defeating the boss.
    • (in Repentance) Results in Yellow Poops which only have normal drops.
  • (except in Rebirth) Using A Card Against Humanity in the Boss Ultra Greed ingameUltra Greed fight can trap the Greed GaperGreed Gapers after Ultra Greed Coin (Key)Key Coins appear, preventing Ultra Greed from attacking.

Synergies[ | ]

  • (in Afterbirth † and Repentance)Collectible Hallowed Ground iconHallowed Ground: Spawned Poops have a high chance to turn into White Poop.
  • (except in Rebirth) Infested! pill: Every Poop spawns a Blue Spider.
  • (except in Rebirth)Lil LarvaLil Larva /(in Repentance) Character ??? (Character) icon???: Every Poop spawns a Blue Fly.
  • Collectible Midas' Touch iconMidas' Touch: Spawned Poops have a great chance to turn into Golden Poops.
  • Butt PennyButt Penny: Spawned Poops drop coins 20% more often.
  • (in Afterbirth † and Repentance)MeconiumMeconium: Many spawned poops are black and can drop black hearts.
  • Petrified PoopPetrified Poop: Pickup drop rate set to 50%. It's extremely likely to be obtained when using the card in larger, less obstructed rooms.

Interactions[ | ]

  • (except in Rebirth)Brown CapBrown Cap: All the Poop explodes in a chain reaction once one is destroyed.
  • Collectible Dr. Fetus iconDr. Fetus/Collectible Ipecac iconIpecac: If Isaac has no other means of destroying Poop than his explosive tears, he will have to hurt himself to clear out a path through the Poop unless he has acquired Collectible Pyromaniac iconPyromaniac or (except in Rebirth)Collectible Host Hat iconHost Hat.

Trivia[ | ]

  • The card is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
    • This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.
  • In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".

Bugs[ | ]

Bug Bug! (in Repentance) Using this card in the TV room in Home will move the sofa and the TV to the nearest empty space (Which would be where Isaac is standing as that's the only space that doesn't get filled with poop). If Isaac tries to approach where they were previously then he will be violently pushed back. Destroying the poop will return them back to normal.

If the poop is not destroyed before sleeping in Mom's bed then Isaac will have to stand below where the TV was teleported to in order to activate the Dogma fight. If Dogma is summoned before destroying the poop then the TV will glitch inside the Dogma fight and push Isaac around, possibly making him touch Dogma and get hit multiple times