A Card Against Humanity

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A   Card   Against   Humanity
Pickup icon
"Something stinks..."
Table dividing line 1.png
Pickup ID
5.300.45
Type:  Special card
Table dividing line 3.png

A Card Against Humanity is a special card.

Effect[edit | edit source]

  • Fills the entire room with Poop.

Notes[edit | edit source]

  • Poop will not fill tiles with obstacles, even if they have already been destroyed.
  • The process is not instant and the room will not get filled if Isaac leaves before it's done filling.
  • It is more beneficial to use the card in a large-sized room as it will create more Poop piles.
  • Using A Card Against Humanity in the Ultra Greedier fight will result in Golden Poops spawning after defeating the boss.
  • Using A Card Against Humanity in the Ultra Greed fight can trap the Gapers after Key Coins appear, preventing Ultra Greed from attacking.

Synergies[edit | edit source]

Interactions[edit | edit source]

  • Added in AfterbirthBrown Cap Brown Cap: All the Poop explodes in a chain reaction once one is destroyed.
  • 15►Dr. Fetus Dr. Fetus/15►Ipecac Ipecac: If Isaac has no other means of destroying Poop than his explosive tears, he will have to hurt himself to clear out a path through the Poop unless he has acquired 15►Pyromaniac Pyromaniac or Added in Afterbirth15►Host Hat Host Hat.

Trivia[edit | edit source]

  • The item is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
  • In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".
    • This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.


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