Binding of Isaac: Rebirth Wiki
Special Cards
Rebirth Suicide King Chaos Card Credit Card Rules Card
Added in Afterbirth Afterbirth ? Card Get out of Jail Free Card Emergency Contact Dice Shard
Added in Afterbirth † Afterbirth † Holy Card Huge Growth Ancient Recall Era Walk
Added in Repentance Repentance Cracked Key

A Card Against Humanity is a special card.


  • Fills the entire room with Poop Poop.


  • Poop will not fill tiles with obstacles, even if they have already been destroyed.
  • The process is not instant and the room will not get fully filled if Isaac leaves before it's done filling.
  • It is more beneficial to use the card in a large-sized room as it will create more poop piles.
  • Using A Card Against Humanity in the Added in Afterbirth † Ultra Greedier Ultra Greedier fight will result in Golden Poop Golden Poops spawning after defeating the boss.
    • Added in Repentance Results in Yellow Poops which only have normal drops.
  • Using A Card Against Humanity in the Added in Afterbirth Ultra Greed Ultra Greed fight can trap the Added in Afterbirth Greed Gaper Greed Gapers after Added in Afterbirth Ultra Greed Coin (Key) Key Coins appear, preventing Ultra Greed from attacking.


  • Added in Afterbirth †Hallowed Ground Hallowed Ground: Spawned Poops have a high chance to turn into White Poop.
  • Added in Afterbirth Infested! pill: Every Poop spawns a Blue Spider.
  • Added in AfterbirthLil Larva Lil Larva: Every Poop spawns a Blue Fly.
  • Midas' Touch Midas' Touch: Spawned Poops have a great chance to turn into Golden Poops.
  • Butt Penny Butt Penny: Spawned Poops drop coins 20% more often.
  • Added in Afterbirth †Meconium Meconium: Many spawned poops are black and can drop black hearts.
  • Petrified Poop Petrified Poop: Pickup drop rate set to 50%. It's extremely likely to be obtained when using the card in larger, less obstructed rooms.


  • Added in AfterbirthBrown Cap Brown Cap: All the Poop explodes in a chain reaction once one is destroyed.
  • Dr. Fetus Dr. Fetus/Ipecac Ipecac: If Isaac has no other means of destroying Poop than his explosive tears, he will have to hurt himself to clear out a path through the Poop unless he has acquired Pyromaniac Pyromaniac or Added in AfterbirthHost Hat Host Hat.


  • The item is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
  • In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".
    • This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.
  • Added in Repentance Home Home If used in the living room, the poop will cause the couch and TV to move erratically.

Bug Bug! Using this card in the TV room in Home will move the sofa and the TV to the nearest empty space (Which would be where Isaac is standing as that's the only space that doesn't get filled with poop). If Isaac tries to approach where they were previously then he will be violently pushed back. Destroying the poop will return them back to normal.

If the poop is not destroyed before sleeping in Mom's bed then Isaac will have to stand below where the TV was teleported to in order to activate the Dogma fight. If Dogma is summoned before destroying the poop then the TV will glitch inside the Dogma fight and push Isaac around, possibly making him touch Dogma and get hit multiple times