A Card Against Humanity
Special Cards |
Rebirth | Suicide King | Chaos Card | Credit Card | Rules Card | A Card Against Humanity |
![]() |
![]() |
![]() |
![]() |
![]() | |
![]() |
![]() |
![]() |
![]() |
![]() |
"Something stinks..."

Pickup ID
5.300.45
Type: Special card

A Card Against Humanity is a special card.
Contents
Effect[edit | edit source]
- Fills the entire room with Poop.
Notes[edit | edit source]
- Poop will not fill tiles with obstacles, even if they have already been destroyed.
- The process is not instant and the room will not get filled if Isaac leaves before it's done filling.
- It is more beneficial to use the card in a large-sized room as it will create more Poop piles.
- Using A Card Against Humanity in the Ultra Greedier fight will result in Golden Poops spawning after defeating the boss.
- Using A Card Against Humanity in the Ultra Greed fight can trap the Gapers after Key Coins appear, preventing Ultra Greed from attacking.
Synergies[edit | edit source]
Hallowed Ground: Spawned Poops have a high chance to turn into White Poop.
Infested! pill: Every pile of Poop spawns a Blue Spider.
Leo/
The Nail/
Thunder Thighs: Allows all the Poop to be easily destroyed.
Lil Larva: Every pile of Poop spawns a Blue Fly.
Midas' Touch: Spawned Poops have a great chance to turn into Golden Poops.
Petrified Poop: Greatly increases the chance of finding a pickup when destroying Poop.
Interactions[edit | edit source]
Brown Cap: All the Poop explodes in a chain reaction once one is destroyed.
Dr. Fetus/
Ipecac: If Isaac has no other means of destroying Poop than his explosive tears, he will have to hurt himself to clear out a path through the Poop unless he has acquired
Pyromaniac or
Host Hat.
Trivia[edit | edit source]
- The item is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
- In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".
- This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.
Poop
![]() ![]() | |||||
---|---|---|---|---|---|
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |