Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
Special Cards
Rebirth Suicide King Chaos Card Credit Card Rules Card
Added in Afterbirth Afterbirth Added in Afterbirth ? Card Added in Afterbirth Get out of Jail Free Card Added in Afterbirth Emergency Contact Added in Afterbirth Dice Shard
Added in Afterbirth † Afterbirth † Added in Afterbirth † Holy Card Added in Afterbirth † Huge Growth Added in Afterbirth † Ancient Recall Added in Afterbirth † Era Walk

A Card Against Humanity is a special card.


  • Fills the entire room with Poop.


  • Poop will not fill tiles with obstacles, even if they have already been destroyed.
  • The process is not instant and the room will not get fully filled if Isaac leaves before it's done filling.
  • It is more beneficial to use the card in a large-sized room as it will create more poop piles.
  • Using A Card Against Humanity in the Ultra Greedier fight will result in Golden Poops spawning after defeating the boss.
    • Added in Repentance Results in Yellow Poops which only have normal drops.
  • Using A Card Against Humanity in the Ultra Greed fight can trap the Gapers after Key Coins appear, preventing Ultra Greed from attacking.


  • Added in Afterbirth †Hallowed Ground Hallowed Ground: Spawned Poops have a high chance to turn into White Poop.
  • Added in Afterbirth Infested! pill: Every Poop spawns a Blue Spider.
  • Added in AfterbirthLil Larva Lil Larva: Every Poop spawns a Blue Fly.
  • Midas' Touch Midas' Touch: Spawned Poops have a great chance to turn into Golden Poops.
  • Petrified Poop Petrified Poop: Greatly increases the chance of finding a pickup when destroying Poop. It's extremely likely to be obtained when using the card in larger, less obstructed rooms.


  • Added in AfterbirthBrown Cap Brown Cap: All the Poop explodes in a chain reaction once one is destroyed.
  • Dr. Fetus Dr. Fetus/Ipecac Ipecac: If Isaac has no other means of destroying Poop than his explosive tears, he will have to hurt himself to clear out a path through the Poop unless he has acquired Pyromaniac Pyromaniac or Added in AfterbirthHost Hat Host Hat.
  • Added in Repentance Home Home: If used in the living room, the poop will cause the couch and TV to move erratically.


  • The item is a reference to Cards Against Humanity, a satirical card game whose name in turn references "crimes against humanity". Specifically, it refers to the way the first player is chosen: Whoever was the last to poop goes first.
  • In the pop-up (if not disabled) for unlocking this card, the text on it reads "A room full of poop".
    • This actually contradicts the original card game, as black cards are prompts while the white cards are answers to the prompt.