Depression

Depression is a passive item added in The Binding of Isaac: Afterbirth †.

Effects

 * Spawns a familiar that follows Isaac and leaves a trail of blue creep that damages enemies.
 * The creep deals 2 damage per tick or 6 damage per second to non-flying enemies.
 * If the cloud touches an enemy, it has a small chance to spawn a damaging Holy Light beam onto the enemy.
 * The light beams deal 20 + Isaac's tear damage per tick and may strike an enemy up to 8 times.

Interactions

 * : Increase cloud size but does not increase damage.

Trivia

 * Depression is the emotional state of low mood and aversion to activity.
 * Depression is also a state of air currents which often result in cloudy and wet weather.