IV Bag

IV Bag is an activated item.

Effects

 * Upon use, causes Isaac to lose half a heart of health (or a full heart in and beyond) while spawning coins.
 * Each use pays out with 1-3 coins.
 * Each use pays out with 1-2 coins on Normal mode or 1 coin on Hard mode.
 * Spawns 0-1 coins instead when used by.

Synergies

 * : Can be used without taking damage, resulting in an infinite amount of coins.
 * Isaac still takes damage from this during The Guardian challenge.
 * : Increases each payout by 0-2 coins.
 * : IV Bag always pays out with 2 coins
 * : Can be alternated between to gain ridiculous amounts of pickups from only a few initial coins or hearts.
 * : Allows for infinite coins once Isaac is at half a red heart (or full red heart in The Womb or beyond) by moving between rooms to reset Scapular's effect.

Interactions

 * No effect.
 * : IV Bag ignores Holy Mantle's protection, resulting in the character taking damage regardless.

Trivia

 * A glitch in the original The Binding of Isaac existed where the player could leave a room and activate the item during the invincibility frames offered during recovery of using the items, effectively spawning infinite coins. This bug has been fixed in The Binding of Isaac: Rebirth.