Magic Skin

Magic Skin is an activated item added in The Binding of Isaac: Repentance.

Effects

 * Spawns an item from the current room's item pool.
 * Consumes one of Isaac's heart containers, one bone heart, or two soul hearts, replaced by a broken heart container which can never be filled, permanently reducing his maximum possible health.
 * The priority order of hearts that will be consumed is: one heart container, one bone heart, and two soul hearts.
 * After using Magic Skin, if Isaac is not currently holding it, Magic Skin has a chance to replace any item that spawns in the future.
 * The more times Magic Skin is used, the higher chance it will respawn.
 * Each new Magic Skin is fully recharged.

Synergies

 * : Using Spindown Dice on Magic Skin 5 times turns it into.
 * : Allows Isaac to keep Spindown Dice between runs, allowing a theoretically infinite run with enough luck.

Interactions

 * Spawns 2 items and adds 2 broken hearts (removing 2 heart containers or 4 soul hearts) with each use. Two broken hearts are added regardless of Isaac's remaining health. If Isaac already has 11 broken hearts and uses Magic Skin, it will only be used once.
 * Spawns 2 items on every use instead of 1.
 * If Magic Skin has replaced the item in the Treasure Room, it will be shown in the dream sequence.
 * Since Esau Jr.'s health is separate from Isaac's, one character can use Magic Skin at no cost to the other. Future items will still be replaced when playing as the character that hasn't used Magic Skin.
 * Removes all broken hearts as well as items. Magic Skin can still replace items in the Genesis room.
 * Recovers a broken heart when used after using Magic Skin, does not recover soul hearts overwritten by broken hearts, this can kill Isaac. Reentering the room and using Magic Skin will spawn the same item.
 * NO!: Does not prevent Magic Skin from replacing items, despite it being an active item.
 * Isaac can keep Magic Skin in the inactive slot to prevent its respawning while still being able to use another active item.
 * Glitched items spawned by TMTRAINER cannot be replaced by Magic Skin.
 * Absorbing Magic Skin does not prevent future items from being replaced, including items spawned by the absorbed Magic Skin. Additional Magic Skins can be absorbed, allowing multiple items to be spawned per use at the cost of adding more broken hearts.
 * Magic Skin can be spawned by Lemegeton if it has been used in the current run
 * As long as Isaac has this flame, Magic Skin will not respawn/replace items.
 * Revival Items
 * ,, , : If Isaac has 12 broken hearts and dies, he will be revived with a half soul heart.
 * The only hearts Isaac can pick up while in this state are eternal hearts and gold hearts. Going to the next floor while having an eternal heart will remove the temporary soul heart, killing Isaac.
 * If Isaac has 12 broken hearts and dies, he will be revived with one full heart. If the heart is a red heart container, it can be filled after taking a half heart of damage.
 * , Broken Ankh: If Isaac has 12 broken hearts and dies, he will be revived as, with 3 full soul hearts, but cannot be refilled.
 * , : If Isaac has 12 broken hearts and dies, he will be revived as, but without a red heart. If he goes to next room, or goes to next floor, he will instantly die.
 * Missing Poster: No matter how many broken hearts Isaac had, he will be revived as, and taking items will not kill him.

Trivia

 * The item is a reference to the book by French novelist Honoré de Balzac called La Peau de chagrin. In the story, the main character finds a talisman made of donkey skin that grants wishes, but each wish causes the talisman to become smaller, as well as his lifetime. The main character attempts to get rid of the skin, but it always finds a way to return to him.
 * This also may be a reference to the goatskin Jacob uses to trick his father Isaac into thinking he was Esau, thus giving him his blessing along with the divine right God had promised Abraham (Isaac's father), which included inheriting the promised land and having his bloodline bring forth the Messiah.

Seeds
9LWB BQRD (Curse Room adjacent to spawn)