D20

The D20 is an unlockable activated item.

Effects

 * Randomizes all pickups and chests within a room.

Strategy

 * In Greed mode, the D20 is a one-item game breaker as long as the Shop has a Lil' Battery available. Leave behind as many coins and pickups in the arena as possible. After using the D20, avoid opening chests until you have recharged the item. Avoid collecting things that do not spawn pickups, help buy Lil' Batteries, or help open chests. This can often be repeated indefinitely, leading to collecting coins, bombs, and many pedestal items.
 * Due to how the D20 interacts with the, this strategy will not work with , as using the D20 while playing as her will destroy all pickups in the room.
 * However, this can be avoided by removing Book of Virtues using Butter! or The Stars? card.
 * can be used for this strategy if it is found.
 * in D20 mode will also destroy all pickups while also having the.

Trivia

 * In the original The Binding of Isaac, the D20 was unlocked by beating Isaac (boss) as Isaac.

Seeds
ADXY CXCL (Treasure Room adjacent to spawn) 13CR F6FY (Treasure Room adjacent to spawn) Z642 SW3M (Treasure Room adjacent to spawn)