Mom's Box

Mom's Box is an activated item added in Afterbirth.

Effects

 * Upon activation, drops a random trinket on the ground.
 * +1 luck while held.
 * While held, doubles the effect of most trinkets.
 * This effect stacks additively with Golden Trinkets, rather than multiplicatively. Holding Mom's Box with a Golden Trinket will cause it to have triple the regular effect, rather than quadruple.
 * This item belongs to the Yes Mother? set. Collecting three items from this set will transform Isaac into his mother.

No Effect
These trinkets are not affected by Mom's Box, listed in alphabetical order.
 * 'M
 * ???'s Soul
 * AAA Battery
 * Adoption Papers
 * Apple Of Sodom
 * Baby-Bender
 * Bag Lunch
 * Bloody Crown
 * Blue Key
 * bob's bladder
 * Brain Worm
 * Broken Magnet
 * Broken Padlock
 * Broken Remote
 * Butter!
 * Butt Penny
 * Callus
 * Counterfeit Penny
 * cracked dice
 * Crow Heart
 * Cursed Penny
 * Cursed Skull
 * Devil's Crown
 * Dim Bulb
 * Door Stop
 * Duct Tape
 * Equality!
 * eve's bird foot
 * expansion pack
 * Extension Cord
 * Filigree Feather
 * Fish Head
 * Fish Tail
 * Flat File
 * flat worm
 * found soul
 * Fragmented Card
 * friendship necklace
 * gilded key
 * Hairpin
 * Holy Crown
 * ice cube
 * Isaac's Head
 * Judas' Tongue
 * Keeper's Bargain
 * Kid's Drawing
 * The Left Hand
 * Liberty Cap
 * Locust of Conquest
 * Locust of Death
 * Locust of Famine
 * Locust of Pestilence
 * Locust of War
 * Lost Cork
 * Louse
 * Lucky Rock
 * Missing Poster
 * Mom's Toenail
 * Monkey Paw
 * myosotis
 * Mysterious Candy
 * Mysterious Paper
 * Nuh uh!
 * Paper Clip
 * Pay to Win
 * Petrified Poop
 * Pinky Eye
 * Pulse Worm
 * rainbow worm
 * RC Remote
 * Ring Worm
 * Rotten Penny
 * Safety Scissors
 * Shiny Rock
 * Sigil of Baphomet
 * Silver Dollar
 * Stem Cell
 * Store Credit
 * Store Key
 * strange key
 * temporary tattoo
 * Tonsil
 * Torn Pocket
 * Vibrant Bulb
 * Walnut
 * Wicked Crown
 * wish bone
 * Wooden Cross
 * Your Soul

Trivia

 * The item description possibly is a reference to the film Seven where the climax of the film involves the protagonist asking the question over and over again "What's in the box?".
 * The item strongly resembles the chest found in Mom's room in Home.
 * This item is used in Pica Run (challenge #41).