When Life Gives You Lemons

When Life Gives You Lemons is Challenge #12. Start off with, , and 1 Lemon Party pill. The goal is to defeat Mom. This Challenge is available by default. Treasure rooms are not present.

Difficulty
The lack of Treasure Rooms makes the challenge more difficult than a normal run.

Strategy

 * Lemon Mishap has a small range, making it difficult to use. The Habit and 9 Volt will allow more frequent uses of it but their combination is more important than that. Because every run starts with 9 Volt, any activated item obtained will take less time to recharge. The Habit makes taking damage charge it faster as well. The only catch would be finding a better activated collectible.
 * The Lost Cork is an extremely beneficial trinket in this run, expanding the area of Lemon Mishap and thus making it safer to use since Isaac doesn't need to be as close to the enemy.
 * A good item to find is, simply for being usable every room because of 9 Volt.

Trivia

 * The challenge name is a reference to the proverbial phrase "When life gives you lemons, make lemonade."
 * One of the fortune teller's fortunes is "When life gives you lemons, reroll!"