Cantripped!

Cantripped! is challenge #43. The goal is to defeat Mom. This challenge is unlocked by unlocking.

You play as, but instead of crafting items from pickups, all pills and tarot cards are replaced with a unique card pickup that gives you a one room or one time (if the item is an Active Item) use of different items. All boss rewards are changed to, increasing the item cards limit by 1, and dropping 3 item cards.

Cain starts with 3 held item cards.

Strategy

 * Each enemy has a chance to drop an item card after death. This can be used to farm item cards with enemies which can spawn other enemies.
 * Some bonuses from items will remain after leaving the room. Therefore using them has a big influence on the run. This includes:
 * Pickups and health ups.
 * Mapping effects, such as . This only lasts for the current floor.
 * and damage gained from using.
 * Stat changes from, and.
 * Wisps added by, which remain until destroyed.
 * Familiars spawned by lasts for the current floor.
 * Although there are no treasure rooms, shops don't sell items, and bosses do not drop standard boss items, gaining items in other ways is still possible. You won't lose those items after leaving the room. These ways include but are not limited to:
 * Using a 1-pip or 6-pip Dice Room.
 * Absorbing Trinkets by or.
 * Item cards act like pickups and can be manipulated as such (e.g. duplicated with ).
 * As in many challenges, Golden Bombs offer an alternate and powerful way to fight, allowing to pass floors easily.
 * Using after leaving a room will give back all items used in that room permanently, allowing to bypass the challenge's limitations. Make sure to apply this strategy with a room containing a maximum amount of cards so you can gain more bonuses.
 * However, if Glowing Hour Glass is used in the first room of the run, the Bag of Crafting is removed. This still causes items and pickups to be replaced as usual, but prevents their activation.
 * Using in a room will still activate it on every room in the floor, making getting through the rest of the floor trivial.
 * Holding onto or  enables the player to instantly kill Mom. This can bypass the need to store several powerful items for the final fight.
 * The player can use a in order to gain another, and thus carry more items.
 * Exiting a room with will make the fire rate increase permanent until Isaac’s tear delay changes.

Trivia

 * The name of this challenge is a reference to the Magic: the Gathering term "cantrip", meaning a card that draws another card.
 * The item cards in this challenge resemble the treasure cards from The Binding of Isaac: Four Souls.

Bugs
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