Skatole

Skatole is a passive item.

Effects

 * This item causes many Fly enemies to alter their behavior toward Isaac.
 * The following flies transform into a neutral normal Fly: Attack Fly, Dart Fly, Eternal Fly, and Ring Fly.
 * The following flies move slower but will still deal contact damage: Boom Fly, Red Boom Fly, Drowned Boom Fly.
 * The following flies move slower and deal no contact damage: Moter, Level 2 Fly, Full Fly, Pooter, and Super Pooter.
 * Pooters will not fire at Isaac and Moters will not split into Attack Flies.
 * The following flies are completely unaffected, retaining their normal attacks and speed: Large Attack Fly, Swarm Fly, Hush Fly, Sucker, Soul Sucker and Spit.

Trivia

 * Skatole is a mildly toxic white crystalline organic compound that occurs naturally in feces.
 * According to Edmund McMillen's First post-Repentance Lore Stream, Skatole's visual was designed first, with McMillen then working backwards to create an appropriate effect to justify an item that puts a poop on Isaac's head.
 * Skatole was considered as a cosmetic hat for Team Fortress 2, alongside tears,, and . It was dropped as Valve "... didn't want players running around with a wet piece of poop on their heads."
 * This item is used in Scat Man (challenge #36).
 * This item is one of the only five that count towards 2 transformations, the other four being, , and.