Solar System

Solar System is challenge #6. Isaac starts this challenge with, , , and. Isaac will also be blindfolded. The goal is to defeat Mom's Heart. This Challenge is available after unlocking Transcendence.

Difficulty

 * As Isaac is blindfolded, Isaac cannot use tears, and must rely entirely on Distant Admiration, Forever Alone, and bombs to deal damage.

Strategy

 * Because Isaac starts with 3 Fly items, he will also begin the challenge as Beelzebub. This allows Isaac to amass a large number of friendly flies on the Basement floors.
 * The orbiting attack flies can be quite powerful, especially Distant Admiration when used properly. This will require optimization of Isaac's movement to maneuver into position to deal damage, as the flies are constantly moving, and avoid damage simultaneously.
 * Duct Tape can fix the position of the flies around Isaac, somewhat alleviating this.
 * Enemies that explode on death should only be targeted with Forever Alone, as destroying them with Distant Admiration will result in Isaac getting caught in their explosions.
 * Shops can carry and, the former of which affects the damage of the orbiting attack flies and the latter of which affects the damage of the blue flies spawned from Beelzebub as well as the size of the orbiting attack flies.
 * and are good items to buy since they slow enemies down.
 * Obtaining makes the challenge trivial as Isaac's orbiting flies still deal damage while Isaac is invulnerable. Obtaining it is highly unlikely, however, since there is no treasure room present.
 * Obtaining or  grants a full circle of projectile-blocking orbitals around Isaac.
 * Collecting two cubes of meat grants you a tear-shooting homie, that is not affected by the blindfold.
 * Obtaining makes The Harbingers easier to find, allowing Cube of Meat and Ball of Bandages to be found more often.
 * It is not advised to reshuffle Isaac's items. As this will not remove Isaac's Blindfolded status, it is possible to reroll items in such a way that the run can no longer be completed.
 * Obtaining the Rune of Algiz, or  can make killing Mom and Mom's Heart/It Lives! much easier.
 * Devil room deals such as, , and will be ineffective, because of the blindfolded status.
 * now functions despite the Blindfolded status, making this a very valuable item for the challenge.
 * is a useful purchase from the shop as it has a chance to freeze enemies, allowing Isaac to safely use the attack flies against them for the duration of the freeze.
 * Transcendence and other flight items are useless in this challenge because the Beelzebub transformation grants flight by default.
 * Obtaining can be handy for defeating bosses, due to its damage and poison effect. It can also be used to break poop or golden poop to gain health, coins, or bombs.
 * Extension Cord electrifies the orbiting flies, dealing extra damage and destroys fireplaces and poops.
 * helps damage non-flying enemies and bosses.
 * Black Powder is now effective on all enemies and bosses.
 * acts as a replacement for Isaac's tears, thus indirectly removing Isaac's Blindfolded status.
 * can charge and fire regardless of the Blindfolded status, providing Isaac with an easy way to deal damage.
 * can be used to almost guarantee victory as you can use it to stun all enemies in every other room. Pairing this with items that increase the amount of charges and you can assure victory.
 * If you see the Sacrificial Altar, do not use it under any circumstances. You will lose both fly familiars, and be effectively unable to do anything.

Trivia

 * The challenge is a reference to the Solar System; Isaac represents the sun and the flies represent planets.