Immaculate Conception

Immaculate Conception is an unlockable passive item added in The Binding of Isaac: Afterbirth.

Effects

 * Upon picking up enough heart pickups, Isaac gains a permanent angelic familiar and generates a Soul Heart drop. Possible familiars include:
 * All five familiars will spawn in a random order, each after collecting 15 hearts.
 * After all familiars have been spawned, a Soul Heart will still drop every 15 hearts collected.
 * Isaac will look progressively more pregnant as he collects heart pickups.
 * All five familiars will spawn in a random order, each after collecting 15 hearts.
 * After all familiars have been spawned, a Soul Heart will still drop every 15 hearts collected.
 * Isaac will look progressively more pregnant as he collects heart pickups.
 * After all familiars have been spawned, a Soul Heart will still drop every 15 hearts collected.
 * Isaac will look progressively more pregnant as he collects heart pickups.

Interactions

 * : Hearts collected in the jar do not count towards activation.

Trivia

 * This item is the angelic counterpart to.
 * Immaculate Conception refers to the Catholic teaching that the conception of the Virgin Mary was free from original sin.