I RULE!

I RULE! is challenge #26. Isaac starts off with, , , , , and. The goal is to defeat Mega Satan. The Boss Room containing ??? or The Lamb does not appear.

Difficulty
With a powerful set of items to start with, this is a rather easy challenge after getting used to Mom's Knife. The most difficult challenge here is defeating Mega Satan.

Strategy

 * Since Isaac will likely be stuck with Mom's Knife as his primary method of attacking, finding powerful items and synergies will prove challenging.
 * Entering any Angel/Devil Room that spawns might yield items that synergize with Mom's Knife (such as, , or ).
 * Though risky, the Boss Rush and will both provide additional chances at good items.
 * As a result of beginning the challenge with both Key Pieces, Angel Rooms are much more likely to appear than normal. Due to Angel Room items being generally more useful, it is advised to avoid Devil Rooms altogether.
 * It is somewhat easier to beat this challenge with (which doesn't appear after the Mom fight in Afterbirth †) than it is with, as Isaac is an easier fight than Satan in this challenge. Furthermore, the  can provide many chances at useful items that the  does not.
 * The Red Chests in the Dark Room now offer Devil Deals, granting powerful items at the cost of Red Heart Containers.

Trivia

 * This challenge is a homage to the original The Legend of Zelda, which this game is inspired by.
 * The items given in this challenge are meant to replicate Link's equipment from said game.
 * The title of the challenge is a play on the word "Hyrule", the kingdom in which most Zelda games take place.