Signs of the Zodiac

The 12 Signs of the Zodiac are featured as passive collectible items based on the 12 astrological signs.

Grants the effect of a random Zodiac sign each floor.

Collecting any three Signs of the Zodiac or, , , ,, , and   unlocks the Planetarium.

Trivia

 * Some of the effects caused by the items in-game are directly related to their astrological significance or symbol. For example, Aquarius is portrayed as a man (Ganymede) bearing water, and in game the item causes Isaac to leave a trail of tears behind him while walking; Libra, which represents weighing scales, balances Isaac's stats.