Spun

After picking up three distinct items from the following list, Isaac turns into a buff berserker and a random pill spawns. Isaac gains +2 damage and +0.15 speed / maximum speed. Maximum speed may never exceed 2.0.

(The items in the following list consist of all of the "syringe" items in the game.)

Seeds
KG4F IN87 (First Boss item & first two treasure rooms for a 2nd floor spun) AGZ1 DPSX (First item room, first shop item, 2nd shop item (after buying first)) 2C1H 8F60 (XL floor, The Virus from Lust, Adrenaline in one of the Treasure Rooms, and Speed Ball by second Boss Room)

Mac VXG4 BN24 (First treasure room, second and third boss room)

Mac 9QYB 6FFL (First two treasure rooms, 2nd Gold treasure room)

PC hard MCR91A1E (First two treasure rooms, lust mini boss room)