D4

The D4 is a special unlockable activated item.

Effect

 * Upon use, re-rolls each of Isaac's passive items into new ones.
 * The new items will be drawn from the Treasure Room item pool.
 * The game attempts to match the new item to the pool where the item it replaces was acquired but this is glitched, see the Bugs section.
 * If the item has no pool (gained as a starting item, fixed drops such as a from a Blood Donation Machine or  from Lust, or gained via the debug console), the Treasure Room pool is used.
 * New items are drawn from the pools the original items were from.
 * If health upgrade items are removed by a reroll the health they granted is subtracted.
 * can avoid this health subtraction by dropping health items for full inventory before rerolling.

Trivia

 * The image of the D4 that appears on activation is incorrect; it shows the numbers 9, 7, and 8 on the right face of the dice, when it should depict numbers consistent with the left face (i.e. 1 at the top, 3 at the front, and 4 at the right).

Seeds
F4BR 0P86 (Treasure Room adjacent to spawn) DMM6 TWQV 30TN DBY4 (Treasure Room adjacent to spawn) 89EX S9KG (Treasure Room south of spawn) 7VC9 TRMS (Treasure Room adjacent to spawn) ZDA0 CMV4 (First Treasure Room)