Panic Button

Panic Button is a trinket added in The Binding of Isaac: Repentance.

Effects

 * Activates Isaac's active item just before damage would be taken.
 * This still uses the item's charges so if the item is not charged, the trinket will do nothing.
 * Single-use items will be consumed.

Interactions

 * Any self-damaging item: Self-damage occurs before enemy damage, making it almost impossible to lose Devil/Angel Room chances.
 * : Triggers the effect on hit, at the cost of every hit making Isaac take full-heart damage.
 * / : Isaac farts before being hit, knocking back enemies and projectiles.
 * : Activates the item and gives Isaac invincibility frames before being hit, making it work similarly to every two rooms. If combined with  or AAA Battery, works every room, just like Holy Mantle.
 * : If consumed with, Every time isaac is hit, If it's charged, he is sent back to the previous room without taking damage.
 * : Makes Isaac immune to contact and tear damage while moving.
 * : Upon getting hit, activates the IV Bag instead, causing red heart damage and producing money.
 * : Causes a highly-damaging explosion to occur every time Isaac is hit, similarly to Swallowed M80.
 * : Isaac gains a damage boost every time he's hit, acting similarly to except only for the current room, at the cost of every hit making Isaac take full-heart damage.
 * : Has a chance to spawn additional wheels upon taking damage that last only for the current room. This is most likely a bug.
 * : Isaac will teleport before damage is taken, making him much harder to hit.
 * : Triggers his active item whenever The Body touches something that would damage The Soul, regardless of damage taken.
 * : Telekinesis will automatically block any incoming shots, but the push is not strong enough to prevent contact damage.
 * : Since the effect is triggered before taking damage, Panic Button will waste the charge with no benefit unless Isaac is already missing Red health.